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Jayanto, Imam
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Journal : CHEMISTRY PROGRESS

 1 
KARAKTERISASI NANOPARTIKEL EKSTRAK ETANOL KAYU MANIS (Cinnamomum burmanii) DENGAN KITOSAN SODIUM TRIPOLIFOSFAT SEBAGAI KANDIDAT ANTIOKSIDAN Antasionasti, Irma; Jayanto, Imam; Abdullah, Surya Sumantri; Siampa, Jainer Pasca
CHEMISTRY PROGRESS Vol 13, No 2 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.13.2.2020.31392

Abstract

Ekstrak etanol kayu manis memiliki kandungan fenol yang tinggi yang berpotensi sebagai antioksidan tetapi memiliki bioavailabilitas yang rendah pada kondisi ukuran partikel yang besar. Oleh karena itu, dilakukan analisis karakteristik nanopartikel ekstrak etanol kayu manis. Tujuan penelitian untuk membuat dan mengevaluasi karakteristik nanopartikel ekstrak kayu manis sebagai kandidat antioksidan secara in vitro. Preparasi nanopartikel ekstrak etanol kayu manis dengan metode gelasi ionik. Nanopartikel ekstrak etanol kayu manis memiliki ukuran partikel sebesar 400,3 nm dengan potential zeta +6,60 mV. Spektra Fourier Transform Infrared (FTIR) menunjukkan adanya gugus hidroksil dan gugus amida dari kitosan dan gugus fosfat dari STPP. Studi aktivitas antioksidan secara in vitro dengan metode 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) dan reduksi besi III menunjukkan bahwa nanopartikel ekstrak etanol kayu manis memiliki aktivitas antioksidan yang lebih kecil dibandingkan ekstrak tetapi masih dalam kategori sangat kuat. Aktivitas antioksidan yang diberikan dipengaruhi oleh kandungan total fenolik dan total flavonoid secara berturut-turut sebesar 75,685 ± 1,408 % EAG dan 60,546 ± 0,670 % EK untuk ekstrak etanol kayu manis serta 61,845 ± 0,529 % EAG dan 57,939 ± 0,446 % EK untuk nanopartikel ekstrak etanol kayu manis. Penerapan teknologi nanopartikel pada ekstrak etanol kayu manis melalui ikat silang antara kitosan-TPP dapat mempertahankan aktivitas antioksidannya.ABSTRACT Ethanol extract of cinnamon has a high phenol content which is potential as an antioxidant but has a low bioavailability under conditions of large particle size. Therefore, nanoparticles were prepared for the ethanol extract of cinnamon. The aim of this research was to make and evaluate the characteristics of cinnamon nanoparticles as antioxidant candidates in vitro. The cinnamon nanoparticles were prepared using the ionic gelation method. Cinnamon nanoparticles has a particle size of 400,3 nm with a zeta potential of +6,60 mV. Fourier Transform Infrared (FTIR) spectra showed the presence of a hydroxyl and amida group from chitosan and a phosphate group from STPP. In vitro antioxidant activity studies with the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method and ferric reducing activity power showed that cinnamon nanoparticle has smaller antioxidant activity than the extract but is still in the very strong category. The antioxidant activity given is influenced by the total phenolic and total flavonoids content 75.685 ± 1.408% EAG and 60.546 ± 0.670% EK for cinnamon ethanol extract. and 61.845 ± 0.529% EAG and 57.939 ± 0.446% EK for cinnamon ethanol extract nanoparticles, respectively The application of nanoparticle technology to the ethanol extract of cinnamon through chitosan-TPP cross-linking can maintain its antioxidant activity.
Co-Authors Abdullah, Surya Sumantri Adelfia Papu Agus Suyatno Alamri, Firdaus Anggraeni, Inda Permata Antasionasti, Irma Anwar, Muh. Abduh. Aslah, Aprilia Ayhuan, Jeckson Badu, Nindi Badu, Nindi S. Bambang Purwoko Boky, Harmita Daimunon, Regita DEWI SARTIKA Djunaedi Djunaedi Durya, Ngurah Pandji Mertha Agung Edi, Hosea Jaya Fatimah Malini Lubis Fatimawali . Gagola, Mariana Cristi Ayu Gayatri Citraningtyas Gde Bayu Surya Parwita Gumilar, Bobi Hamzah , Ramadhani Hasymi, Liana Fitriani Herny E.I. Simbala Hosea Jaya Edy Ibrahim, Mozart Malik Jolanda, Shinta Juliawati, Ni Waya Mega Juliawati, Ni Wayan M. Kambey, Bella Karlah L. R. Mansauda Karundeng, Glorya Kawulusan, Kerin Sophia Amelia Clairent Klemens Mere Kondoj, Inchristy Victoria Kumowal, Selphina Kusuma Dewi, Ratih Puspita Langi, Regita LAUNTU, ANSIR Lolo, Widya Astuti LUBIS, AMINAH Mahendra Kusuma Nugraha Massie, Aprilia Meilani Jayanti Mohzana Mumu, Preisdy Aprilia Nangaro, Alfred Nangaro, Jesica Nekky Rahmiyati Ningtyas, Harfiahani Indah Rakhma Nurnoviyati, Ikhda Nurul Mardiati Pakpahan, Kevin Yosua Paputungan, Ayu Paputungan, Ayu Natasya Paulina yamlean Pratiwi, Ageng I. Purwaka Hari Prihanto Ramli, Akhmad Rizal Rizal Safitransyah, Rahmad Puja saputri, tiara Sari, Elmi Sari, Elmi N. Siampa, Jainer Pasca Sigar, Meivie Hanna Solly Aryza Sri Sudewi, Sri Sutrisna, Agung Tampa’i, Randy Tirta Mulyadi Tresna, Indra Cahya Tuloli, Riska Tulung, Gerald Tulung, Gerald N. P. Tunggal, Ryan Irwanto Turama, Dwilanda E. Vitarani Dwi Ananda Ningrum Wenur, Tezalonika Masye Flora Intanpermata Wewengkang, Defny Wewengkang, Defny S Widdhi Bodhi Widya Astuty Lolo, Widya Astuty Wiyono, Weny I.