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All Journal CHEMPUBLISH JOURNAL Majalah Farmaseutik CHEESA: Chemical Engineering Research Articles Jurnal Kreativitas PKM Pharmaceutical Journal of Indonesia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Inovasi Farmasi Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi dan Sains Indonesia (JFSI) Environmental and Toxicology Management (ETM) Gemakes: Jurnal Pengabdian Kepada Masyarakat FASKES : Jurnal Farmasi, Kesehatan, dan Sains JI-KES (Jurnal Ilmu Kesehatan)
Muadifah, Afidatul
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Antibacterial Activity of Combination of Betel Leaf Extract and Star Fruit Using Hydroextraction Method Tilarso, Dara Pranidya; Muadifah, Afidatul; Handaru, Windu; Pratiwi, Putri Indah; Khusna, Mursyidah Lathifatul; Tarigan, Indra Lasmana
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.21736

Abstract

Antibacterial compounds are bioactive substances capable of inhibiting bacterial growth by disrupting the metabolism and cellular processes of pathogenic microorganisms. Natural plant-derived compounds have been widely explored for their antibacterial properties, with star fruit (Averrhoa bilimbi L.) and betel leaf (Piper betle) recognized for their potent antimicrobial effects. This study aimed to evaluate the antibacterial activity of a combination of star fruit and betel leaf extracts against Escherichia coli and Staphylococcus aureus, two clinically significant bacterial pathogens. The extraction process was performed using hydro-extraction at different temperatures (40°C, 50°C, 60°C, and 90°C) to determine the optimal conditions for bioactive compound yield. Antibacterial activity was assessed using the disc diffusion method, measuring inhibition zones to indicate bacterial susceptibility. The results demonstrated that the optimal inhibitory effect occurred at 50°C, producing an inhibition zone of 19.75 mm for Staphylococcus aureus and 11.75 mm for Escherichia coli. These findings suggest that temperature plays a critical role in maximizing the antibacterial potential of plant extracts. The study highlights the potential application of star fruit and betel leaf extracts as natural antibacterial agents, particularly against Gram-positive and Gram-negative bacteria. Further research is recommended to explore the mechanism of action, phytochemical composition, and potential synergy of these extracts in antimicrobial formulations.
Comparative Study of Macerated and Soxhlet-Extracted Moringa Oleifera Leaf Extracts: LC-MS-Based Metabolomic Profiling, Antioxidant Activity, and In Silico Target Prediction Muadifah, Afidatul; Sulastri, Sulastri; Sowe, Momodou Salieu; Lintang, Anggun; Warni, Tri
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36870

Abstract

Moringa leaves (Moringa oleifera L.) are rich in secondary metabolites such as flavonoids, alkaloids, tannins, saponins, and terpenoids, which function as natural antioxidants. This study aimed to analyze the metabolite profile of M. oleifera leaf extracts obtained through two extraction techniques using LC-MS, evaluate their antioxidant activity via the DPPH assay, and predict the interaction between NADPH oxidase (as a receptor) and key plant-derived compounds through molecular docking. LC-MS results indicated that the maceration method yielded 101 secondary metabolites, with flavonoid derivatives comprising 70.99% of the extract, dominated by five key compounds including Kaempferol 3-O-robinobioside and Luteolin-7-glucoside. In contrast, the Soxhlet method resulted in 83 identified compounds, with a higher proportion of flavonoids (75.61%), and prominent compounds including quercetin-3-O-glucoside and Kaempferol 3-(6G-malonylneohesperidoside). Antioxidant testing with DPPH at concentrations of 10, 50, and 100 ppm revealed the Soxhlet extract had a stronger activity (IC₅₀ = 14.328 ppm) compared to the macerated extract (IC₅₀ = 32.092 ppm), with statistically significant differences (p < 0.05). Molecular docking demonstrated that Kaempferol 3-(6G-malonylneohesperidoside) exhibited the strongest binding affinity to NADPH oxidase (-10.1 kcal/mol), followed by other flavonoid derivatives. These findings underscore the antioxidant potential of M. oleifera, particularly from Soxhlet extraction, and suggest its promising application in pharmaceutical development as a natural antioxidant source.
Secondary Metabolites of The Fabaceae Plant Family A Review of Extraction Methods, Molecules and Bioactivity Sowe, Momodou Salieu; Etonihu, Anayo Christian; Tarigan, Indra Lasmana; Muadifah, Afidatul
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.36964

Abstract

Traditional medicine helps manage and treat various illnesses worldwide, particularly in Africa and Asia. For example, Traditional Indonesian Medicine (Jamu), Traditional Indian Medicine (Ayurveda), and Traditional African Medicine use a range of indigenous herbs to treat health conditions like fevers, malaria, diarrhea, diabetes mellitus, Asthma, and hypertension. Alkaloids, flavonoids, saponins, terpenoids, and polyphenols are bioactive substances with anti-inflammatory, antibacterial, and antioxidant effects in plants. The Fabaceae family consists of flowering plants, peas, legumes, woody trees, and shrubs. Fabaceae plants are widely used across Africa and Asia for traditional medicinal purposes. In addition, Fabaceae plants have significant economic value as a source of wood for the timber industry. This review highlights extraction methods, isolated molecules, and antimicrobial and antioxidant activity of Fabaceae plants found in Africa and Asia. We also detailed secondary metabolite molecules extracted from Fabaceae plant body parts and their identified bioactivities. This review compiles scientific information on the phytochemicals and pharmacological properties of plants in the Fabaceae family that could be useful for future drug candidate investigations.
Aktivitas Antioksidan, Fenolik Total dan Flavonoid Ekstrak Etanol Cangkang Kerang Simping dan Cangkang Telur: Antioxidant Activity, Total Phenolic and Flavonoids of Ethanol Extracts of Scallop Shells and Egg Shells Ngibad, Khoirul; Muadifah, Afidatul; Sukmawati, Datin An Nisa
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 6 No. 1 (2024): Volume 6, No.1, Desember 2024
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v6i1.6389

Abstract

Cangkang kerang simping dan cangkang telur yang sering dianggap limbah berpotensi sebagai sumber antioksidan alami, mendukung kesehatan dan pengurangan limbah. Penelitian ini bertujuan mengidentifikasi aktivitas antioksidan, kadar fenolik, dan flavonoid dalam ekstrak etanol cangkang kerang simping dan cangkang telur. Ekstraksi dilakukan dengan merendam serbuk cangkang dalam etanol dan memekatkannya menggunakan rotary evaporator. Aktivitas antioksidan diukur dengan metode DPPH, sementara kadar flavonoid dan fenolik dianalisis menggunakan spektrofotometri UV-Vis dengan kuersetin dan asam galat sebagai standar. Cangkang telur memiliki kandungan flavonoid dan fenolik yang lebih tinggi dibandingkan cangkang kerang, yang mendukung potensinya sebagai sumber antioksidan yang lebih efektif. Cangkang kerang simping dan cangkang telur memiliki potensi sebagai sumber antioksidan alami, dengan cangkang telur menunjukkan efektivitas lebih tinggi karena kandungan flavonoid dan fenoliknya yang lebih tinggi. Temuan ini membuka peluang pemanfaatan cangkang kerang dan telur dalam produk nutraseutikal dan makanan fungsional untuk kesehatan
Pemberdayaan Masyarakat Desa Bendiljati Wetan tentang Pembuatan Ramuan Saintifikasi Jamu untuk Penyakit Hipertensi Huda, Choirul; Putri, Amalia Eka; Muadifah, Afidatul; Sari, Trianita; Santoso, Arif
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 9 (2025): Volume 8 No 9 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i9.18124

Abstract

ABSTRAK Penelitian ini bertujuan untuk memperkenalkan manfaat ramuan saintifikasi jamu sebagai penurun tekanan darahtinggi melalui program penyuluhan di Desa Bendiljati wetan. Penyuluhan ini bertujuan untuk mengedukasi masyarakattentang cara pembuatan serta manfaat kesehatan ramuan saintifikasi jamu, dan untuk meningkatkan potensiwirausaha di desa melalui pengembangan sediaan ramuan jamu kering siap saji. Penyuluhan dilakukan denganceramah, pembagian leaflet, dan demonstrasi produk. Evaluasi dan monitoring dilakukan dengan kuesioner sebelum dan setelah penyuluhan. Program penyuluhan efektif dalam meningkatkan pengetahuan masyarakat tentang manfaatramuan saintifikasi jamu untuk penyakit hipertensi. Tingkat pemahaman meningkat setelah penyuluhan, menunjukkanpotensi pengembangan produk herbal lokal. Diperlukan monitoring lebih lanjut untuk memastikan pemanfaatan yang berkelanjutan dari pengetahuan yang diberikan.  Perlu adanya kerjasama lintas sector untuk mendukungpengembangan potensi local seperti ini. Kata Kunci: Hipertensi, Saintifikasi Jamu Hipertensi, Penyuluhan  ABSTRACT This research aims to introduce the benefits of scientifically certified juice as a lowering of high blood pressure through a disinfection program in the village of Bendiljati wetan. The purpose of the initiative is to educate the public about how to make and health benefits of scientific herbs, and to enhance the potential of entrepreneurs in the village through the development of the supply of ready-made dry herbs. Delivery is done with lectures, leaflet sharing, and product demonstrations. Evaluation and monitoring is done with questionnaires before and after the examination. The design program is effective in raising public awareness of the benefits of the scientific herb for hypertension. The level of understanding increased after the decontamination, indicating the potential for the development of local herbal products. Further monitoring is needed to ensure the sustainable use of the knowledge provided. We need cross-sectoral cooperation to support the development of local potential like this. Keywords: Hypertension, Scientific Diagnosis of Hypertension.
Teknologi Tepat Guna Mesin Pembuat Kompos Giling dan Pelet Berbasis Kotoran Sapi dan Garbage dalam Mendukung SDGs di Kelurahan Srengat Muadifah, Afidatul; Martha, Rahma Diyan; Mashudi, Mashudi; Ulayya, Nida Asma; Kharisma, Mei Nabila Revina
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 10 (2025): Volume 8 No 10 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i10.22190

Abstract

ABSTRAK Peningkatan jumlah limbah organik, khususnya kotoran hewan dan garbage, menjadi tantangan tersendiri dalam pengelolaan lingkungan di berbagai daerah, termasuk di Kelurahan Srengat. Di sisi lain, potensi limbah tersebut belum dimanfaatkan secara optimal sebagai sumber daya yang bernilai ekonomis dan ekologis. Pengolahan kotoran sapi dan garbage menjadi kompos giling dan pelet merupakan salah satu solusi untuk menyelesaikan permasalahan prioritas mitra POKTAN “Mulyo Tani” Kelurahan Srengat yaitu dengan mengedukasi dan transfer ilmu pengetahuan tentang teknologi tepat guna mesin pembuat kompos giling dan pelet guna meningkatkan keberdayaan mitra dalam aspek produksi pupuk. Metode yang digunakan meliputi pelatihan, pendampingan teknis, dan implementasi langsung alat di lapangan. Hasil kegiatan menunjukkan adanya penurunan timbunan limbah organik sebesar 60,5% dalam satu masa tanam (±3 bulan), serta peningkatan signifikan pada aspek produksi, yaitu dari 2,5 kuintal menjadi 14,2 kuintal kompos giling dan pelet per masa tanam. Selain itu, terjadi pergeseran praktik pertanian mitra dari yang semula bergantung pada pupuk anorganik menuju sistem pertanian berkelanjutan berbasis input lokal. Program ini tidak hanya meningkatkan kapasitas teknis dan ekonomi mitra, tetapi juga menciptakan model pengelolaan limbah ternak dan garbage yang ramah lingkungan dan dapat direplikasi. Dengan demikian, program PMP ini terbukti efektif dalam mendorong kemandirian, keberlanjutan, dan keberdayaan kelompok tani berbasis teknologi tepat guna.   Kata Kunci: Kelurahan Srengat, Kompos Giling Dan Pelet, Kotoran Hewan, Mesin Kompos, Teknologi Tepat Guna.  ABSTRACT The increasing volume of organic waste, particularly livestock manure, presents a growing environmental management challenge in rural areas, including Srengat Sub-district. Despite its potential, this waste has not been optimally utilized as a valuable economic and ecological resource. This community service program aimed to empower the “Mulyo Tani” farmer group through the introduction of appropriate technology—specifically, a compost grinding and pelletizing machine—to transform cow manure and household garbage into ground compost and organic pellets. The intervention involved structured training sessions, hands-on technical assistance, and the direct implementation of the equipment. Results indicate a 60.5% reduction in unprocessed organic waste over a single planting cycle (approximately three months), along with a significant increase in compost production from 2.5 to 14.2 quintals per cycle. Moreover, a behavioral shift was observed among the farmers, transitioning from reliance on chemical fertilizers to adopting a sustainable, locally sourced agricultural input system. This program not only enhanced the technical and economic capabilities of the farmer group but also established a replicable, environmentally friendly agricultural waste management model. The outcomes demonstrate that the PMP initiative effectively supports farmer independence, sustainability, and empowerment through the adoption of appropriate technology. Keywords: Srengat Sub-District, Compost and Pellets, Livestock Manure, Composting Machine, Appropriate Technology
A review of application of natural products as fungicides for chili Ngibad, Khoirul; Muadifah, Afidatul; Jannah Triarini, Lailatul; Rizki Amalia, Laily; Karel Damayanti, Novita
Environmental and Toxicology Management Vol. 1 No. 2 (2021): Green chemistry for environmental problem solutions
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.365 KB) | DOI: 10.33086/etm.v1i2.2022

Abstract

Anthracnose disease in chillies is a serious problem for farmers. So far, synthetic fungicides have been used as solution for the treatment of this disease. However, the side effects of synthetic fungicides to  public health and environment raised awareness on  alternative fungicides derived from natural resources. This paper aims to review plants that  are  potential as an alternative to fungicides for chili plantation, fabrication of test solutions, in vitro and in vivo fungicide test. Many plants  were investigated as alternatives to plant-based fungicide. The utilization of leaves as samples including rhizomes, roots, tubers, weevils, seeds, fruit, flowers and  other parts of the plant. The extract fabrication method used as a fungicide test include: maceration method, gradual fractionation method, and decoction method. The maceration method is the method most widely used to extract fungicidal active compounds from plants. Some studies that carried out in vitro tests were unable to compare with synthetic fungicides so it was not possible to determine their effectiveness for plant-based fungicide for chillies when compared to synthetic fungicides. In vitro Extract of 80% alcohol and 10%/60% n-hexane of pacar cina (Aglaia odorata L.) leaves can be compared with the performance of propineb 0.2%. In addition, the 60% and 70% kirinyuh (Chromolaena odorata L.) leaf extracts were also able to match Acrobat 0.2% performance in vitro. Based on the in vivo test, suren (Toona sureni Merr) leaf extract and nut bulbs can be used as an alternative to vegetable / natural fungicides to help overcome the problem of anthracnose in chilies.
Calcium Reduction Using Variations of Thickness and Retention Time of Cocoa Shell Activated Carbon Muadifah, Afidatul; Santoso, Arif; Ngibad, Khoirul; Martha, Rahma Diyan; Kholifah, Siti Nurriyatul
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.24768

Abstract

High levels of hardness can lead to increased cases of kidney stones. Hardness levels can be reduced by using activated carbon from the cocoa rind as an adsorbent. The purpose of this research was to determine the variation of activated carbon thickness and optimum retention time in reducing the calcium content of dug well water, to determine the percent decrease in calcium ion levels at the optimum variation, and to determine the significance of the difference in the decreased in calcium levels between the treatment groups. The research method used the principle of adsorption of activated carbon from cocoa shells to calcium ions, which are activated by KOH. There were ten treatment samples with different variations of activated carbon thickness and retention time. The results showed that the thickness of activated carbon of 60 cm with a retention time of 50 minutes had the optimum ability to reduce the calcium content of dug well water. The percentage decrease in calcium levels reached 89,041 % with a decreased concentration of 234 ppm. The result of the statistical test showed a significance value of 0,05. The conclusion of the research is that activated carbon of cocoa shells can reduce calcium levels to the levels of soft water hardness, with variations in activated carbon thickness and retention time having a significant effect.
Uji Efektivitas Antioksidan Moisturizer Ekstrak Daun Randu (Ceiba Pentandra (L.) Gaertn.) dengan Metode DPPH Muadifah, Afidatul; Tilarso, Dara Pranidya; Putri, Amalia Eka; Sowe, Momodou Salieu
Chempublish Journal Vol. 8 No. 1 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i1.33234

Abstract

Dry skin can often cause psychological discomfort. Moisturizer is a preparation that is used to improve dry skin. Kapok plant (Ceiba pentandra L. Gaertn) can be used as an active ingredient of moisturizer and can be used as a treatment, where the chemical content in kapok leaves are flavonoids, saponins, alkaloids, phenolic compounds, tannins and terpenoids as antioxidants. This study aims to determine the antioxidant activity of kapok leaf extract and moisturizer preparations with DPPH method using UV-Vis spectrophotometer, physical quality of preparations and antioxidant activity of moisturizer preparations using DPPH method. Kapok leaf extract was made in various concentrations, namely 20 ppm, 40 ppm and 60 ppm. The IC50 value of kapok leaf extract is 67.4007 ppm which has strong antioxidant activity. Then variations in the concentration of kapok leaf extract were put into the formulation of moisturizer preparations, the results of moisturizer preparations of kapok leaf extract and vitamin C met the requirements of the physical quality test. The moisturizer preparation was continued and tested for antioxidant activity using the DPPH method with ascorbic acid as a comparison. The results of the IC50 value on the kapuk leaf extract moisturizer preparation are 110.065 ppm which is classified as having moderate antioxidant activity and while the vitamin C moisturizer preparation is 9.8417 ppm which is classified as having very strong antioxidant activity.
UPAYA PENINGKATAN PERILAKU PENCEGAHAN DAN PENGENDALIAN PENYAKIT DHF UNTUK MENDUKUNG PROGRAM KESMAS DI DESA TANGGUNGGUNUNG Nurjanah, Mutia Hariani; Kumalasari, Nurul Chamidah; Safitri, Yunita Diyah; Martha, Rahma Diyan; Santoso, Arif; Muadifah, Afidatul; Imanez, Ketzia Adrian
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 5 (2024): Vol. 5 No. 5 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i5.34405

Abstract

Dengue haemoragic fever (DHF) nama lain demam berdarah merupakan infeksi virus yang ditularkan melalui gigitan nyamuk Aedes albopictus dan Aedes aegypti. Demam berdarah telah meningkat secara signifikan dalam dekade terakhir seiring dengan pergerakan manusia, peningkatan populasi, dan terjadinya perubahan iklim. Di Indonesia, penyakit DHF mendapat perhatian serius dari seorang pakar kesehatan masyarakat, dimana beliau menjelaskan cara mencegah penularan dengan pendekatan yang efektif dan efisien. Tujuan diadakannya kegiatan kesehatan masyarakat ini ialah memberikan edukasi kepada masyarakat terkait pencegahan penyakit DHF yang disebabkan oleh gigitan nyamuk yang mengandung virus dengue. Hasil yang diperoleh dari kegitan ini adalah dengan cara menjaga lingkungan, menjaga imunitas, perilaku preventif dan pengendalian vector demam berdarah. Kesimpulan dari pengmas ini adalah adanya peningkatan pengetahuan dan pemahaman masyarakat desa Tanggunggunung yang baik dalam upaya mencegah penyakit DHF.
Co-Authors Arif Santoso Choirul Huda Danar Danar Datin An Nisa Sukmawati Etonihu, Anayo Christian Handaru, Windu Hariani Nurjanah, Mutia Ima, Ernisa Afidatul Imanez, Ketzia Adrian Indah Pratiwi, Putri Indra Lasmana Tarigan Jannah Triarini, Lailatul Jovanncha, Czellicya Karel Damayanti, Novita Kharisma, Mei Nabila Revina Kholifah, Siti Nurriyatul Khusna, Mursyidah Lathifatul Kristijono, Ary Kumalasari, Nurul Chamidah Lestari, Nasa Bela Dwi Lintang, Anggun Maida, Margarita Claudya MARTHA, RAHMA DIYAN Mashudi Mashudi Ngibad, Khoirul Nurjanah, Mutia Hariani Parbuntari, Hesty Pratiwi, Putri Indah Putri, Amalia Eka Rahma Diyan Martha Rahmawati, Desti Linda Dwi Rizki Amalia, Laily Safitri, Yunita Diyah Salsabila, Nabila Putri Sandi Mahesa Yudhantara Sari, Trianita Sowe, Momodou Salieu Sulastri Sulastri Susanto, Nindita Clourisa Clourisa Amaris Tilarso, Dara Tilarso, Dara Pranidya Ulayya, Nida Asma Ummah, Ratih Salimil Warni, Tri Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Wiwik Handayani