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All Journal Journal of Food and Pharmaceutical Science Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Folia Medica Indonesiana Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Journal of Islamic Medicine Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal of Food and Pharmaceutical Sciences Journal of Tropical Pharmacy and Chemistry Journal of Research on Community Engagement
Yen Yen Ari Indrawijaya
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Majalah Obat Tradisional

 1 
The Activity of Purple Sweet Potato Leaves (Ipomea batatas Ver.) Extract to Calcium Oxalate Concentration of Male Rat (Rattus novergicus) Roihatul Mutiah; Avin Ainur Fitrianingsih; Yen Yen Ari Indrawijaya; Nabila Rahmadani
Majalah Obat Tradisional Vol 25, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.49423

Abstract

Purple sweet potato leaves (Ipomea batatas Ver.) has been proven to have anti-lithiasis effects in vitro in treating kidney stone disease. This is due to the high content of potassium in the leaves. The study aimed to analyze the effect of purple sweet potato leaf extract on kidney stone decay in male white rats induced by ethylene glycol 0.75% and ammonium chloride 2% for 10 days. In this study, 24 mice were divided into 6 groups: normal or without induction group, positive control, negative control, dose group 300 mg/200-gram body weight, 400 mg/200-gram body weight, and 500 mg/200-gram body weight. The parameters observed were calcium levels in the urine tested using Atomic Absorption Spectrophotometry, oxalate levels in urine tested using UV VIS Spectrophotometer. The results of this study indicate that purple sweet potato leaf extract at a dose of 500 mg/200-gram body weight can increase the levels of calcium and oxalate in the urine of rats compared with negative controls.
In Silico Study on the Effect of Heliannuol A, B, C, D, E Compounds of Sunflower (Helianthus annuus L.) on Dual PI3K/mTOR (5OQ4) Enzyme Roihatul Mutiah; Yen Yen Ari Indrawijaya; Tanaya Jati Dharma; Jamilah Damaiyanti
Majalah Obat Tradisional Vol 26, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.57411

Abstract

Heliannuol is a sesquiterpene that has a benzoxepine ring, oxepin. Many derivatives of benzoxepine compounds show anticancer activity by inhibiting the phosphoinositide 3-kinase (PI3K) enzyme. These enzymes play a role in cell proliferation and growth. The study aims to predict the physicochemical properties using Lipinski’s Rule of Five parameters on phosphoinositide 3- kinase (PI3K/Mtor; PDB 5OQ4) enzyme and the toxicity of Heliannuol A, B, C, D, E compounds. The process uses the pkCSM online tool. The validation of receptor 5OQ4 is done using the value parameter RMSD < 2 (Å). Protox online tool dan pkCSM online tool is employed to predict the toxicity using parameter LD50, skin sensitization, Ames toxicity, hepatotoxicity, and toxicity class. The interaction of ligan and enzyme is tested using Molegro Virtual Docker 6.0. Heliannoul A, B, C, D, E compounds fulfill Lipinski’s Rule of Five. The receptor 5OQ4 is known valid using the value of RMSD 0,923 (Å). Heliannuol A, B, C, D, E compounds inhibit Dual PI3K / mTOR enzyme less than Bimiralisib. As a result of the toxicity test of compounds Helliannouls A, B, C, E, and Bimiralisib compounds are included in class 4, while Helliannouls D compounds are included in class 5.
Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N) Roihatul Mutiah; Chamlah Ayatillah; Yen yen Ari Indrawijaya; Arief Suryadinata
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.70124

Abstract

Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV. These considerations are used in this study using Non-structural Protein (NSP), namely NSP3 and NSP5 in SARS CoV-2, which have a role in viral replication and transcription. This study aims to predict the physicochemical properties according to the five rules of Lipinski's using swissADME. Prediction of toxicity with LD50 classification using the Protox II online tool. Catechin compound activity based on ligand interaction with NSP3 (PDB ID: 6W6Y) and NSP5 (PDB ID: 6M2N) receptors using Molegro Virtual Docker (MVD) 6.0. The results showed the predictions of physicochemical properties of the (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG), and (-)-epicatechin (EC) compounds fulfilled the five rules of Lipinski's. Catechin compounds have toxicity at levels 4 and 6. The activity of catechin compounds on NSP3 (PDB ID: 6W6Y) and NSP5 (PDB ID: 6M2N) receptors indicated that all catechin compounds had inhibitory activity. The best potential activity compound is (-)-epigallocatechin-3-gallate (EGCG) with a rerank score of -102.8200 and -134.1800 Kcal/mol so that EGCG can be recommended as a candidate for the SARS CoV-2 antiviral compound.
Co-Authors A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Abdul Hakim Ach. Nashichuddin Alfiyah Laily Inayatin Alifah Nurin Zuhdina Ami Fini Faqiha Amrulloh, Muhammad Firman Ana Fikrotus Zakia Ana Rahmawati Anik Listiyana Annisa, Rahmi Arief Suryadinata Avin Ainur Fitrianingsih Chamlah Ayatillah Daffa Dhiya Ulhaq Dina Puspa Melianti Endang Retnowati Fidia Rizkiah Inayatilah Fidia Rizkiah Inayatillah Firdausy, Alif Firman Futna Naufa Hadya, Chorida Muhjatul Hajar Sugihantoro Hariz, Muhammad Fawaz Hibbatullah Hibbbatullah Huwaida, Fadhila Isma Inayatillah, Fidia Rizkiah Irawati, Santia Ismea Munawaroh Jamilah Damaiyanti Lestari, Nia Ayu Ma'arif Z.A, Burhan Ma'arif, Burhan Ma'arif, Burhan Mazidah, Lilik Khoiriyatul Meilina Ratna Dianti Muhammad Aminuddin, Muhammad Muhammad Amiruddin Muhammad Zainuddin Munawaroh, Ismea Mustofa, Muhammad Ragib Nabila Rahmadani Nur Hasan, Yuliono Trika Nurlaili Susanti Octavia, Nur Ika Prida Ayudianti Rahman, Gilang Mauladi Rahmi Annisa Ramadhani D.A., Ria Retno Susilowati Ria Ramadhani Dwi Atmaja Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Siti Maimunah Suharjono, Suharjono Tanaya Jati Dharma Taufik, Imam Ulfah, Jauza Weka Sidha Bhagawan Wiraningtias, Novia Beta Wirda Anggraini Yuwono Yuwono Zuhdina, Alifah Nurin