Tarigan, Amira Permatasari
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Sumatera Utara/Universitas Sumatera Utara Hospital, Medan

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Affect Decreasing Lung Function in Laundry Installation Worker At Rumah Sakit Umum Pusat H. Adam Malik, Medan Wina Elizabeth Octaria Saragih; Nuryunita Nainggolan; Amira Permatasari Tarigan
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.165

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Background: Data from International Labor Organization (ILO) at 2005 shows that there are 250 million case of diseases that related to occupation which can also cause 300.000 death in the world with annual incidence rate of work related lung disease around 1:1000 worker. Laundry worker was included as group that has risk of having occupational pneumoconiosis. Method: This is a descriptive study using total sampling with sample number 24 patient, this study was done in Laundry Installation of Rumah Sakit Umum Pusat Haji Adam Malik Medan on November 2016. Examination was done by using questionnaire, physical examination, daily PEF (before and after working) for 14 days, spirometry, total room dust, total room bacterial colonization. Factors (age, sex, working duration, smoking history, p.2,5 dust exposure, bacterial exposure, safety equipment usage, and nutritional status) that had potential of affecting the decreasing lung function was assessed. Result: From PEF examination, we found mean variability 3.1%. from all worker, there are 9 workers that had decreasing lung function ≥3, 1%. From examination result of 9 sample, decreasing lung function mostly caused by smoking (55%) and p.2,5 dust exposure (66%) Conclusion: Smoking and p.2,5 dust exposure is the most common factors that affected decreasing lung function in laundry worker. (J Respir Indo 2018; 38(2): 109-14)
Correlation of Ceramic Dust Content in Workplace with Lung Function in Ceramics Industry Workers of X Company, Mabar, Medan Endy Todo Sirait; Amira Permatasari Tarigan; Nuryunita Nainggolan; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.187

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Background: Workers in the ceramics industry are often exposed to silica content which is unwittingly inhaled and deposited in the lungs. Macrophages will release Interleukin 8 (IL-8), a chemoattractant that causes neutrophil recruitment to the alveoli and releases proteolytic enzymes that damage the lung parenchyma and cause a decrease in lung function. This study aimed to determine whether dust level correlate with IL-8 serum in ceramic industry workers. Method: This research is an analytic study with a cross-sectional design conducted in March–June 2019 in the X Ceramic Industry in Mabar, Medan. Personal Dust Sampler was used to measure dust level of the study subjects at work sites. Lung function was measured by spirometry. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software. Results: A total of 35 male workers were divided into 3 working sections, 11 (31.4%) in the pre-compression section, 13 (37.1%) in the compression section and 11 (31.4%) in the sintering section. Dust levels at each working section were 24.8, 29.2, and 6.11, respectively. The lung function examination showed restrictive impairment in 21 subjects (60%). Statistical analysis showed that the higher the level of dust in the workplace, the lower the value of Forced Expiratory Volume 1 (FEV1) and Forced Vital Capacity (FVC) values, although this correlation was not statistically significant (r = -0.03 and -0.22 respectively; p> 0.05). Conclusion: There was no significant relationship between workplace dust levels and lung function in ceramic workers.
Correlation Between Wood Dust Levels with Interleukin-8 in Blood Serum Wood Processing Workers at X Company, Tanjung Morawa Jubilette Windy Hutabarat; Nuryunita Nainggolan; Amira Permatasari Tarigan; Putri Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i1.94

Abstract

Backgrounds: Wood dust exposure can stimulate proinflammatory cytokines and increase IL-8 levels, which is a foreign body in the body will be phagocytosis by macrophages and excrete mediators such as chemokines, cytokines, and chemoattractants which can cause inflammation. Duration of exposure, number and size of wood dust in the respiratory tract of wood industry workers are associated with various pulmonary disorders such as, COPD, occupational asthma, allergic rhinitis, decreased pulmonary function and pulmonary fibrosis. The aim this study is determine correlation between wood dust levels with interleukin-8 in blood serum among wood processing workers at x company, Tanjung Morawa-North Sumatera. Methods: A cross-sectional study which involved 40 workers from 3 different locations namely cutting, sanding and drafting. Cumulative wood dust exposure was calculated by measuring the dust content at the work site using Dusttrak TSI. IL-8 serum levels were measured using the ELISA technique. The Spearman correlation test was used. Results: Out of 40 workers those who worked in the cutting section were 15 people (37,5%), sanding section were 15 people (37,5%) and drafting section were 10 people (25%). The average level of wood dust PM 2,5 was 5,23 mg/m3while PM10 was 8,24 mg/m3 and the mean level of IL-8 in serum was 163,3 ng/L. This study find that there is a strong correlation between wood dust and IL-8 serum (r = 0,683; p
The Association of Working Duration with Lung Function and Chest X-Ray Results in Ceramic Industry Workers of Company X, Mabar Medan Marini Puspita Sari; Amira P Tarigan; Nuryunita Nainggolan; Putri C Eyanoer; Agus Dwi Susanto; Erlangga Samoedro; Caecilia Marliana
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.158

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Background: Ceramics industry workers are often exposed to silica materials from ceramics. The aim of this study was to determine the association between silica exposure withlung function test and chest x-ray (CXR) results of the workers. Methods: This was an analytical study with cross-sectional design conducted in the Ceramic Industry X in Mabar, Medan City. The dust level in the work station was measured using Personal Dust Sampler. Lung function was measured by spirometry and CXR was evaluated using the ILO interpretations. Results: About 35 male workers were included as subjects, divided into 3 working stations namely precompression section of 11 subjects (31.4%), compression section of 13 subjects (37.1%) and 11 subjects (31.4%) in the sintering section. Dust levels in each work location are 24.8, 29.2, and 6.11 respectively. Of all subjects, 9 (25.7%) had respiratory symptoms, 21 (60%) had restriction in lung function and 8 (22.8%) had abnormal CXR (6 pneumoconiosis and 2 tuberculosis). There were no association between dust levels with lung function and CXR (P>0.05), but there was a significant correlation between duration of work with lung function. The FEV1 and FVC values of subjects working
The Relationship between Tyr113His Epoxidized Hydrolase Enzyme Gene Polymorphisms and the Incidence of Smoking Lung Cancer Lucia Aktalina; Amira Permatasari Tarigan; Noni Novisari Soeroso; Yahwardiah Siregar; Ozar Sanuddin
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.163

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Background: This study aims to determine the relationship between the gene polymorphism of the enzyme Epoxid Hydrolase (EPHX) Tyr113His and the tendency of smokers to suffer from lung cancer. The EPHX Tyr113His gene polymorphism is a change in one nucleotide base of the EPHX gene to produce enzymes with decreased function by 50%. EPHX plays a role in the metabolism of chemical compounds in cigarette smoke, especially Benzo (a) Pyren (BaP), which becomes a carcinogen in the body. Methods: This study is a case-control study design conducted from October 2016 to February 2017. Venous blood was taken from 35 people with lung cancer at RSUP H Adam Malik Medan and 35 healthy smokers. The genotype examination of the EPHX gene was carried out using the PCR-RFLP method in the USU FK Integrated Laboratory. Results: The genotype frequency of heterozygous variant T/C and homozygous variant C/C in case groups was 83.3% and 16.7%, respectively. The frequency of the T allele in the case group was 41.67% and the C allele was 58.33%. Whereas in the control, the frequency was heterozygous variant T/C (80%) and homozygous variant C/C (20%). The frequency of the T allele in the control group was 40% and the C allele was 60%. There were no homozygous wildtype T/T genotypes in the two groups. There was no significant difference in the genetic distribution and allele distribution of the EPHX enzyme between case and control groups. Conclusion: There is no relationship between EPHX Tyr113His enzyme gene polymorphisms and the incidence of lung cancer in smoking. J Respir Indo 2018; 38(2): 93-9)
The Relationship Between Bacterial Pattern with Degree of Airflow Limitation FEV1 in Acute Exacerbation of COPD at Adam Malik General Hospital and Pirngadi Hospital Rianti Tarigan; Amira P Tarigan; Dian Dwi Wahyuni; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 39, No 3 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v39i3.66

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Background: Respiratory tract infections are the leading cause of acute exacerbation of COPD (AECOPD). The aim of this study was to investigate the relationship between bacterial pattern and the degree of airflow limitation (FEV1) in patients with acute exacerbation of COPD at Adam Malik General Hospital and Pirngadi Hospital, also the sensitive antibiotics according to the susceptibility test. Methods: This was a cross sectional study of all patients admitted to Adam Malik and Pirngadi Hospital with AECOPD from September 2015 until September 2016. In all 45 subjects who fulfilled the inclusion criteria, the spirometry was examination undergone to evaluate the degree of severity of COPD according to GOLD 2017. In each sample sputum expectoration, the gram smear was made. Barttlet criteria was used to calculate the amount of epithelial cells and PMN. The sample was then grown on blood agar medium. Bacterial susceptibility test to antibiotics was conducted using VITEC 2 methods. Results: From 45 patients, 30 patients (66,7%) had positive sputum cultures. The most frequently isolated pathogen was Streptococcus pneumonia (26,7%). The most sensitive antibiotic was Amikacin (100%). There were no correlation between the in degree of airflow limitation FEV1 and bacterial sputum culture result. There were no significant differences between gram positive or negative bacteria with the degree of airflow limitation. Conclusion: The incidence of bacterial infection based on positive sputum culture in AECOPD was about 66,7% Streptococcus pneumonia was the most common pathogen and Amikacin was the most sensitive antibiotic. There were no significant correlation between the degree of airflow limitation FEV1 with the positive or negative sputum culture and also with the result of gram staining. (J Respir Indo. 2019; 39(3):204-9)
Effects of Lower Limb Endurance Training on Maximal Oxygen Uptake (VO2 max) in Chronic Obstructive Pulmonary Disease Andika Pradana; Amira P Tarigan; Tari Mediyanti; Erna Mutiara; Pandiaman Pandia
Jurnal Respirologi Indonesia Vol 37, No 4 (2017)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.517 KB) | DOI: 10.36497/jri.v37i4.82

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Background: Patients with COPD exhibit muscle atrophy and dysfunction which lead into decondition state. This will in turn decrease maximal oxygen uptake (VO2 max) in tissues. Considered as the best predictor of cardiorespiratory endurance and survival, VO2max can be attenuated by aerobic training. This study aimed to assess the effects of lower-limb endurance training on VO2 max in COPD patient. Methods: An experimental study was conducted on 20 COPD patients in group C and D in June–July 2017 at USU Hospital. Patients were prescribed lower-limb exercise by stationary cycling with individualized dose, twice a week for 4 weeks, ranging from 5-20 minutes/session. VO2 max measurement was calculated pre-and post-intervention using Nury’s Formula specifically designed for Indonesian (r=0,68; P
The Comparison of TGF-β Levels in Post Pulmonary Tuberculosis Patients with and Without Smoking History in Haji Adam Malik General Hospital Medan Shilvanna Litania; Amira P. Tarigan; Fajrinur Syarani
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.110

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Backgrounds: Pulmonary tuberculosis (TB) and smoking related disease such as chronic obstructive of lung disease (COPD) are major health problem around the world, particularly in developing countries such as Indonesia. Chronic airway obstruction as impact of TB may results during or after completion of TB treatment. Transforming growth factor beta (TGF-β) is a cytokine which contributes to fibro genesis in post-TB treatment. The aim of this study was to compare the TGF-β in post-TB patients with and without smoking history. Methods: This was an analytic study with cross sectional design, conducted from October 2016 to February 2017 in RSUP H. Adam Malik Medan. All subjects had recovered from TB, confirmed by clinical, radiological and bacteriological examination. Smoking history of the subjects was assessed using Brinkman Index. The TGF-β measurement was performed using venous blood sample processed through Enzyme Link Immunosorbent Assay (ELISA) by means of TGF-β kit. Results: This study included post-pulmonary TB patients, of which 26 subjects were smokers and 25 were non-smokers, consisted of 31 males and 20 females. The mean TGF-β level of all samples was 6690.5±4913.4 mg/ml. The mean TGF-β level in smokers was 6621.5±4856.7 mg/ml, while in non-smokers 6762.2±5071 mg/ml. Statistical analysis using Mann-Whitney test revealed that there were no significant differences of TGF-β level in smokers and non-smokers among post-pulmonary TB patients (P=0.618). Conclusions: There were no significant differences of TGF-β level in smokers and non-smokers among post-pulmonary TB patients. (J Respir Indo. 2020; 40(3): 139-43)
Effect of Lower Extremity Exercise on The Borg Scale in Chronic Obstructive Pulmonary Disease Ghamal Arif Hanafiah; Amira P Tarigan; Pandiaman Pandia; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.141

Abstract

COPD patients tend to experience complaints shortness of breath, limb muscle fatigue and distress in an effort in activities that result in a decrease in quality of life and inhibit daily activities. This situation will eventually cause the patients to experience fatigue faster and fall into a deconditioning state. The Borg scale is a way to measure the intensity level of physical activity using a ratio scale size. This study aimed to assess the effect of lower limb endurance training on the Borg Scale of COPD patients. A quasi-experimental study conducted on 20 patients with COPD group C and D which underwent lower extremity resistance training. The Borg scale was assessed before and after training, with statistical analysis performed by the Mann Whitney-Test. There was an effect on lower extremity resistance training on the Borg Scale of COPD patients in the form of a significant decrease in the Borg Scale value where in the effort parameters. Before training, the Borg Scale score of COPD patients was 9 and 15, decreased to 1 and 13 after training. While tired feet, before training was 5 which decreases to 3 after training and shortness of breath, before training is 7 which decreases to 4 after training. There is a significant improvement in the value of the Borg Scale of COPD patients after undergoing a lower limb endurance training program. There were no significant Borg scale differences between Group C and Group D after undergoing a lower limb endurance training program.
HUBUNGAN INDEKS MASSA TUBUH TERHADAP SKALA SESAK NAPAS PADA PENDERITA PENYAKIT PARU OBSTRUKTIF KRONIS STABIL PRIA Zulkarnain Zulkarnain; A P Tarigan
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol 2 No 1 (2019): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.294 KB) | DOI: 10.35451/jkf.v2i1.190

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COPD is an obstructive pulmonary disease that impact significantly in patients’ quality of life. Dyspnea as a main complaint in COPD patients often occur when the patients do simple thing in their daily life. There are few factors contribute to this condition. From few studies, cachexia as late manifestation of COPD often associated with worse manifestation of dyspnea. The aim of this study is to know whether there was a correlation between body mass index (BMI) and dyspnea scale in COPD patients. This is an analytical study with cross sectional design that involved 34 male participants with diagnosis of COPD. Body mass index was measured by Bioelectrical Impedance Analysis (BIA) and Borg scale was used to measure the dyspnea scale. Spearman Test was used to analyze the correlation between BMI and dyspnea scale. In this study, the majority of patients were obesity (44.1%), but it had slight difference from underweight state (41.2%). Median of BORG scale was 3.0 with range 1-7. From analysis, there was no significant correlation between BMI and dyspnea scale with p-value > 0.05. So, it was concluded that there was no significant correlation between BMI and dyspnea scale in COPD patients. It might be because of few confounding factor that can contribute to this condition.
Co-Authors Afiatika Ahsani Afniwati Agus Dwi Susanto Andika Pradana Andika Pradana Andika Pradana Andika Pradana Andriani, Rizki Apriani, Fitri Ardinata, Dedi - Armi Mawaddah Aznan Lelo Bayani, Sri Caecilia Marliana Chandra F Zendrato Christine, Tamara Dalimunthe, Muhammad Bayhaqi Damayanti, Siti Darmawan, Nengah Deneuve, Olivia Monica Dewi Elizadiani Suza ELMAN BOY Elmeida Effendy Endang Susilawati Endang Susilawati Endy Todo Sirait Erna Mutiara Erna, Mutiara Evi Karota Fajrinur Syarani Febrina Susanti Firdaus, Ruby Fotarisman Zaluchu, Fotarisman Ghamal Arif Hanafiah Girsang, Isah Masdiana Harahap, Juliandi Helyanna Helyanna Hisham Farouk Hutabarat, Eva Susanti Debora Jefri, Budi Jubilette Windy Hutabarat Juliandi Juliandi Kawati, Salma Merda Listyoko, Aditya Sri Lucia Aktalina M. Sinaga, Bintang Yinke Marini Puspita Sari Martina Evelyn R.H Maryaningsih, Maryaningsih Miranda, Melly Monica, Nanda Soraya Muhammad Amin Nahrisyah, Putri Nainggolan, Nuryunita Nani Andriani Nasution, Nurromsyah Nasution, Syafiah Amalina Noni Novisari Soeroso Nurul Citta Banu Putri Nuryunita Nainggolan Orita Satria Ozar Sanuddin Pandia, Pandiaman Pandiaman Pandia Pandiaman Pandia Pandiaman, Pandia Pendiaman Pandia Pinem, Agung Haganta Pohan, Indah Triana Sari Putra, M Yusuf Adira Putri C Eyanoer Putri Chairani Eyanoer, Putri Chairani Putri Eyanoer Raffael, Frans Rahmah, Lestari Ramadhani, Adini Arifah Ratna Akbari Ganie, Ratna Akbari Resti, Riska Rhinsilva, Ella Rianti Tarigan Rifda Hayati Rika Endah Nurhidayah Rina Amelia Rocky Malindo Sidabutar S*, Erfiyani Salma Merda Kawati Samoedro, Erlang Santi Syafril, Santi Saragih, M. Khairul Aswin Sembiring, Rosita Juwita Septiani Waruwu Shilvanna Litania Sihombing, Benny Simanjuntak, Donal Anjar Sinaga, Sudirman Parningotan Sri Sumartiningsih Susanthy Djajalaksana Syahrani, Fajrinur Syarani, Fajrinur Tambunan, Adrian Nurrachman Tari Mediyanti Tarigan, Setia Putra Taufik Ashar Tri Setia Negara Sinulingga Ulfa hasanah Vera, Yeni Vinda Sari Ermiza Nasution Wahyuni, Arlinda Sari Wilson Arthur Zein Wina Elizabeth Octaria Saragih Wiwien Heru Wiyono Yahwardiah Siregar Yessi Andriani Zainal Yetty Machrina Yusni Yusni Zulkarnain Zulkarnain Zulkarnain Zulkarnain