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Immunomodulatory Activity of Xestospongia sp. Ethanolic Extract Towards Interferon-gamma (IFN- γ) and Tumor Necrosis Factor-alpha (TNF-α) Levels in Wistar Male Rats Fristiohady, Adryan; Jumadil; Wahyuni; Malaka, Muh. Hajrul; Harnita, Wa Ode; Sadarun, Baru; Yodha, Agung Wibawa Mahatva; Saripuddin; Purnama, La Ode Muhammad Julian; Sahidin, Idin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15231

Abstract

Xestospongia sp. is one of marine sponge belongs to demosponges class that mainly found in Southeast Sulawesi and the secondary metabolites contained in Xestospongia sp. suspected to have immunomodulatory activity. A previous study exhibited the immunomodulatory of Xestospongia sp. ethanolic extract (XEE) at dose of 300 and 400 mg/Kg BW by affecting the phagocytic activity of macrophages. Thus, this study aims to investigate the effect of XEE towards interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) at dose of 300 and 400 mg/Kg BW. Wistar male rats are divided into 4 groups (n=6) randomly and treated for 7 days orally each as follow: group I (XEE dose of 300 mg/KgBW); group II (XEE dose of 400 mg/KgBW); group III (0.5% NaCMC); and group IV (commercial phylantii extract). On day 8, animals were infected with Staphylococcus aureus and left for 1 hour. Animals were sacrificed and the blood was drawn by cardiac puncture (3 mL), followed by analyzed under ELISA Kit for IFN-γ and TNF-α. Collected data were analyzed statistically using SPSS®. The IFN-γ levels obtained were 350.113; 392.970; 118.416; and 61.958 ρg/mL, respectively and the TNF-α were 2808; 1308; 778; and 845.5 ρg/mL, respectively. According to results obtained, both doses of XEE are affecting the IFN-γ and TNF-α levels (p<0.05) compared to group III as negative control, and group IV as positive control. As conclusion, XEE of both doses is increasing IFN-γ and TNF-α levels of animals that respond to phagocytic activity
Patterns of Qur'anic Study Approaches for Preventing Radicalism in Singapore Muchtar, M. Ilham; Amin, Saifuddin; Jumadil
QOF Vol. 8 No. 1 (2024)
Publisher : Institut Agama Islam Negeri (IAIN) Keiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30762/qof.v8i1.2184

Abstract

This study explores the paradigms and approaches employed in Quranic studies to mitigate radicalism in Singapore. A qualitative descriptive methodology was utilised to examine the patterns of Quranic study. The primary and secondary data sources comprised the Muslim community in the country, alongside relevant literature including books, journals, and research reports. Data collection methods included interviews, documentation, and observation, with subsequent analysis conducted using qualitative data analysis techniques. The findings reveal that while the Muslim community generally enjoys the freedom of religious practice and access to Islamic educational institutions and organisations, the government has instituted regulations to ensure that Quranic study promotes moderate thought, openness, and interreligious harmony. Although the city provides a conducive environment for Quranic studies, measures are in place to maintain social harmony and prevent potential radicalisation. The Majlis Ugama Islam Singapura (MUIS) mandates requirements for preachers, including obtaining permits, demonstrating speaker competency, ensuring appropriate content, providing security assurance, and securing location permits. MUIS employs three main approaches in Quranic study: 1) categorising preachers based on their knowledge, experience, and skills; 2) using interpretive methods such as thematic, linguistic analysis, historical, and comparative approaches, which are regularly evaluated; and 3) monitoring the content of the material through reporting mechanisms and documentation from the start to the end of activities. The study concludes that the approach to Quranic study in the country plays a significant role in shaping understanding and the application of Islamic teachings, underpinned by the values of moderation and religious tolerance.
Model Ketahanan Pangan Berbasis Peternakan Lokal: Solusi Ketersediaan Daging Tanpa Impor Jumadil
ARMADA : Jurnal Penelitian Multidisiplin Vol. 3 No. 4 (2025): ARMADA : Jurnal Penelitian Multidisplin, April 2025
Publisher : LPPM Sekolah Tinggi Ilmu Ekonomi 45 Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/armada.v3i4.1614

Abstract

Ketahanan pangan merupakan isu strategis yang sangat penting bagi kedaulatan suatu negara. Salah satu tantangan utama dalam mewujudkan ketahanan pangan di Indonesia adalah ketergantungan pada impor daging untuk memenuhi kebutuhan konsumsi nasional. Penelitian ini bertujuan untuk merumuskan model ketahanan pangan berbasis peternakan lokal sebagai solusi alternatif dalam menjamin ketersediaan daging secara berkelanjutan tanpa bergantung pada impor. Pendekatan yang digunakan dalam penelitian ini adalah deskriptif-kualitatif dengan metode studi literatur dan analisis data sekunder dari berbagai sumber terpercaya. Hasil penelitian menunjukkan bahwa penguatan peternakan lokal, terutama skala kecil dan menengah, memiliki potensi besar dalam menopang ketersediaan daging nasional. Faktor-faktor kunci yang mendukung keberhasilan model ini meliputi: penguatan kelembagaan peternak, peningkatan akses pembiayaan dan teknologi, dukungan kebijakan pemerintah, serta pengembangan rantai pasok dan pasar yang efisien. Model ketahanan pangan ini juga mengintegrasikan aspek keberlanjutan lingkungan, sosial, dan ekonomi. Dengan optimalisasi potensi sumber daya lokal, pengembangan peternakan berbasis komunitas, dan pemanfaatan teknologi tepat guna, Indonesia dapat meningkatkan produksi daging domestik secara signifikan. Penelitian ini merekomendasikan pembentukan sinergi antara pemerintah, peternak, swasta, dan lembaga riset untuk merealisasikan model peternakan lokal sebagai fondasi ketahanan pangan nasional. Implikasi dari penerapan model ini adalah berkurangnya ketergantungan terhadap impor daging, meningkatnya kesejahteraan peternak lokal, dan terwujudnya kemandirian pangan nasional.
An Investigation of the Student's Reading Comprehension Difficulties at Ma Al - Muslimun NWDI Tegal Meninting, Batulayar, Lombok Barat Jumadil; Sukarni, Sri; Aprionoto
Arus Jurnal Sosial dan Humaniora Vol 4 No 3: Desember (2024)
Publisher : Arden Jaya Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57250/ajsh.v4i3.897

Abstract

The purpose of this study was to determine the most difficult aspects of reading comprehension, especially in descriptive texts experienced by class X students of MA AL Muslimun NWDI Tegal and the factors that cause these difficulties. This study uses a qualitative method, where tests and interviews are used as instruments in data collection. The subjects of this study were class X students of MA AL Muslimun NWDI Tegal Sigi in the 2024/2025 academic year. The test was given to 10 students and consisted of 15 questions divided into five types of questions, namely main ideas, finding references, understanding vocabulary, making conclusions, and detailed information. Then, the researcher interviewed 5 students by giving them 10 questions. The test results showed that the most difficult aspects faced by class X students of MA AL Muslimun NWDI were understanding long sentences, understanding main ideas, understanding grammar, in concluding the contents of vocabulary text readings. While the findings of the interviews, however, indicated that both internal and external variables contributed to students' challenges in comprehending texts. Lack of reading methods, a small vocabulary, and little student motivation are internal issues. The environment of the learner is an example of an external component.
TINDAK TUTUR ILOKUSI, FUNGSI, DAN IMPLIKATURNYA DALAM WACANA IKLAN RESTAURANT DI SENGGIGI Jupri; Jumadil
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 4 No. 3 (2023)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v4i3.1701

Abstract

Wacana digunakan sebagai media penyampaian pesan, termasuk Wacana Iklan Restoran di daerah Senggigi. Maksud yang dituturkan oleh penutur dapat disampaikan secara tersurat maupun tersirat. Secara pragmatis fungsi tuturan merupakan fungsi yang diacu oleh maksud tuturan di dalam pemakaiannya untuk berkomunikasi. Masalah yang diteliti adalah; jenis tindak tutur ilokusi apa yang terdapat dalam wacana iklan Restaurant Senggigi; fungsi pragmatis tindak tutur ilokusi apa yang terdapat dalam wacana iklan Restaurant Senggigi, dan; apa saja implikatur yang terdapat dalam wacana iklan Restaurant Senggigi. Pendekatan yang digunakan adalah pendekatan teoretis dan metodologis. Pendekatan teoretis yang digunakan adalah pendekatan pragmatik, sedangkan pendekatan metodologis yang digunakan adalah pendekatan kualitatif dan deskriptif. Data yang digunakan adalah penggalan wacana iklan, pengumpulan data metode simak dan teknik catat. Analisis data dengan metode heuristik. Sumber datanya adalah wacana iklan berupa baliho, spanduk, dan poster di Restaurant di daerah Senggigi selama Bulan Desember 2022 sampai Maret 2023. Dari hasil analisis data dalam penelitian ini ditemukan ada tiga tindak tutur, yaitu (1) jenis tindak tutur ilokusi (1) tindak tutur ilokusi asertif, (2) tindak tutur ilokusi ekpresif, (3) tindak tutur ilokusi komisif, (4) tindak tutur ilokusi direktif, dan (5) tindak tutur ilokusi isbati. Fungsi pragmatis tindak tutur ilokusi yang ditemukan (1) tindak tutur asertif menyatakan ada delapan dan fungsi mengklaim ada dua, (2) tindak tutur ekpresif fungsi menyanjung ada enam, (3) tindak tutur komisif fungsi menawarkan ada tiga dan fungsi menjanjikan ada satu, (4) tindak tutur direktif fungsi merekomendasi ada sepuluh, fungsi menyarankan ada lima, dan fungsi mengajak ada empat, dan (5) tindak tutur isbati fungsi memberi nama ada tiga. Implikatur ditemukan implikatur yang memberi pernyataan dan ajakan. Berdasarkan temuan tersebut disimpulkan bahwa terdapat tindak tutur ilokusi beserta fungsi pragmatisnya juga implikatur. Ini berarti Wacana Iklan Restoran Senggigi sebagai salah satu bentuk wacana iklan yang menunjukkan adanya interaksi. Adapun saran yang diberikan (1) calon peneliti khusunya bidang bahasa, hendaknya melakukan penelitian secara menyeluruh serta peneliti pada khususnya guna pengembangan kebahasan lebih lanjut, sehingga maksud dan tujuan dalam bertutur yang disampaikan dapat dimengerti oleh banyak pihak, (2) pembaca, hasil penelitian ini dapat dijadikan sebagai bahan acuan atau rujukan sekaligus penambah wawasan tentang fenomena-fenomena bahasa yang terjadi di masyarakat, dan (3) pembuat wacana iklan persuasif hendaknya menggunakan tindak tutur direktif merekomendasi, untuk merekomendasikan tempat, rasa, harga, dan menu yang disajikan berbeda dengan yang lain.
Pengembangan Ensiklopedia Jamur Makroskopis Sebagai Media Pembelajaran Mardin, Herinda; H. Husain, Ilyas; D. Mamu, Hartono; Jumadil
Jurnal Biogenerasi Vol. 9 No. 1 (2024): Terbit volume 9 nomor 1 tahun 2024
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v9i1.3171

Abstract

The aim of this research is to test the feasibility of developing a macroscopic mushroom encyclopedia as a learning medium. This research is Research and Development (R&D) research. The research procedure adapted the ADDIE development model. The adaptation of the ADDIE model in this research was carried out at the encyclopedia validation stage. The encyclopedia validation test was carried out by two expert validators, namely a material expert validator and a media expert validator. Next, validators are asked to provide a general assessment and suggestions regarding the encyclopedia that has been developed, whether the encyclopedia is valid or invalid. Validation of the macroscopic fungal encyclopedia is in the very feasible category with a percentage of 92% by media expert validators and a percentage of 91% by material expert validators. The results of the validity test show the category is very feasible, which means that the resulting encyclopedia media does not need to be revised and is suitable for testing.
Study of Urban Growth Center Development Factors and Simulation The Mamminasata Urban Area Rasyidi, Emil Salim; Jumadil; Syafri; Rahman, Rahmawati; Rusneni; Hamsinah; Jibran, Muh. Khalil
Jurnal Penelitian Pendidikan IPA Vol 10 No 4 (2024): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i4.6380

Abstract

Urban growth starts from a center and affects the surrounding areas, this is due to the emergence of additional centers that will each function as growth poles, to study the dynamics related to urban growth center information, several data and extraction and analysis methods are needed. This study examines several methods of extracting information on urban growth centers from Landsat 8 OLI/TIRS in 2013 and 2023 by utilizing the spectral resolution of Landsat imagery in the Mamminasata area, and integrating spatial modeling to simulate the growth centers of the Mamminasata area in the next 10 years (2043). The results of this research classification method show an accuracy rate of 71.48%. The results of the determinant factor test show that the most influential factors are the distance from the center of shops, slope, then the distance from the university, and the distance from the main road in 2013-2023 Mamminasata Urban Area. The results of this variable drive test are then used in spatial simulations using the markov chain simulation method in the LCM module and show an increase in the area of the growth center in the Mamminasata region, for the entire scope of the Mamminasata region, the Makassar City area shows the highest intensity of regional growth centers and becomes the center of growth in the Mamminasata urban area. The planning concept applied to the results of this study is based on resources, geographic location, and factors affecting the growth center.
MODELING THE DISTRIBUTION OF HEAVY METAL CONCENTRATIONS OF Cu (COPPER) IN THE JENEBERANG RIVER, MAKASSAR CITY : PEMODELAN SEBARAN KONSENTRASI LOGAM BERAT Cu (TEMBAGA) DI SUNGAI JENEBERANG, KOTA MAKASSAR A.Aprilya Musfirah Tul Azizah; Fikruddin, Muhammad; Akrim, Djusdil; Anggraini, Nani; Jumadil
JEBE: Journal of Environment Behavior and Engineering Vol. 3 No. 2 (2025): Journal of Environmental Behavior and Engineering
Publisher : Program Studi Teknik Lingkungan Universitas Bosowa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56326/jebe.v3i2.7909

Abstract

Pencemaran logam berat dapat menimbulkan pengaruh negatif terhadap lingkungan perairan terutama organisme yang hidup di dalamnya dan manusia yang mengonsumsi organisme tercemar. Logam Cu (Tembaga) merupakan logam esensial yang keberadaanya dalam jumlah tertentu sangat dibutuhkan oleh organisme hidup, namun dalam jumlah yang berlebihan akan menimbulkan efek racun. Dalam penelitian ini dilakukan pengolahan dan analisis data secara kuantitatif deskriptif. Metode ini digunakan untuk menguraikan konsentrasi Cu (Tembaga) dan memproyeksikan sebaran Cu (Tembaga) pada Sungai Jeneberang. Hasil pengukuran yang memiliki konsentrasi tinggi terjadi pada titik yang letaknya paling dekat dengan muara karena merupakan daerah pertemuan antara sungai dan laut yang dimana hampir semua zat pencemar mengalir pada muara. Sedangkan dari hasil analisis dengan aplikasi MIKE 21 ECOLab memproyeksikan penyebaran Cu (Tembaga) berdasarkan angin, kecepatan arus, debit, kondisi fisik-kimia dan lain-lain.
MODELING OF WATER QUALITY IN THE PAMPANG RIVER, MAKASSAR CITY, USING THE QUAL2KW APPLICATION: PEMODELAN KUALITAS AIR SUNGAI PAMPANG KOTA MAKASSAR DENGAN MENGGUNAKAN APLIKASI QUAL2Kw Muh Syawal; Akrim, Djusdil; Jumadil; Anggraini, Nani
JEBE: Journal of Environment Behavior and Engineering Vol. 3 No. 2 (2025): Journal of Environmental Behavior and Engineering
Publisher : Program Studi Teknik Lingkungan Universitas Bosowa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56326/jebe.v3i2.8024

Abstract

The Pampang River is a tributary of the Tallo River that plays an important role as a source of clean water, irrigation, and support for community activities in Makassar City and its surroundings. However, increased industrial and residential activities around the river have caused a decline in water quality. This study aims to determine the water quality conditions of the Pampang River and analyze the distribution pattern of pollutants using the QUAL2Kw application. The research method involved collecting water samples at several points, followed by analysis of water quality parameters, including Total Suspended Solids (TSS), Dissolved Oxygen (DO), Biological Oxygen Demand (BOD), Chemical Oxygen Demand (COD), pH, Total Coliform, and E. Coli. The results of the study show that several water quality parameters still meet quality standards, such as TSS, pH, Total Coliform, and E. Coli. However, the DO, BOD, and COD parameters exceed the established quality standards, indicating a fairly high organic pollutant load in the Pampang River. Modeling results using QUAL2Kw show that water quality fluctuations are influenced by daily changes in conditions, such as temperature and sunlight intensity, which affect dissolved oxygen concentrations and the decomposition of organic matter. This study is expected to serve as a reference for the government and the community in their efforts to manage and control pollution in the Pampang River, as well as to support strategic planning to maintain the sustainability of water quality.
Pengembangan Buku Kontekstual Kehidupan Sehari-Hari bagi Siswa Slow Learner dalam Membaca Permulaan Jumadil; Mumpuniarti; Ernisa Purwandari
JPK (Jurnal Pendidikan Khusus) Vol. 21 No. 1 (2025): Jurnal Pendidikan Khusus
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini bertujuan untuk: (1) mengidentifikasi kebutuhan siswa slow learner kelas I SD dalam membaca permulaan, (2) mengembangkan buku kontekstual berbasis kehidupan sehari-hari yang telah divalidasi oleh ahli, dan (3) menguji efektivitas penggunaannya dalam meningkatkan kemampuan membaca permulaan. Metode yang digunakan adalah Research and Development (RnD) dengan model ADDIE melalui tahap analisis, desain, pengembangan, implementasi, dan evaluasi. Buku dikembangkan sesuai kebutuhan dan karakteristik siswa serta mengacu pada kurikulum dan RPP. Hasil validasi menunjukkan kategori “layak” dengan skor 83,96% (ahli materi) dan 84,35% (ahli media). Uji efektivitas menggunakan Paired Sample t-Test menunjukkan peningkatan signifikan (p < 0,001) kemampuan membaca permulaan dengan rata-rata kenaikan ±23,85 poin. Hasil ini diperkuat oleh effect size (Cohen’s d dan Hedges’ g) yang menunjukkan efek sangat besar. Dengan demikian, buku kontekstual efektif digunakan sebagai media pembelajaran membaca permulaan bagi siswa slow learner kelas 1 SD.