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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Jurnal Pendidikan Kimia (JPKim) Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Science Midwifery Journal of Health Sciences and Medicine Jurnal Ilmiah Medicamento Jurnal Pengabdian UNDIKMA Hydrogen: Jurnal Kependidikan Kimia Jurnal Locus Penelitian dan Pengabdian Jurnal Farmasi Indonesia Usadha Kartika : Jurnal Ilmiah Farmasi
Ketut Agus Adrianta
Universitas Mahasaraswati Denpasar
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Uji Aktivitas Antiinflamasi serta Toksisitas Senyawa Peristrophine terhadap Reseptor Prostaglandin Sintase 2 (PTGS2) secara In Silico Gunawan, I Putu Windra; Santoso, Puguh; Pramitha, Dewa Ayu Ika; Adrianta, Ketut Agus
Usadha Vol 1 No 1 (2021): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia merupakan salah satu negara yang banyak memiliki kasus penyakit yang diakibatkan oleh inflamasi. Rasa sakit atau nyeri sering menjadi penyebab gangguan aktivitas sehari-hari. Inflamasi merupakan suatu respon dari tubuh yang terjadi akibat cedera maupun infeksi. Peristrophine adalah salah satu turunan senyawa antosianin yang berasal dari tanaman magenta (Peristrophe bivalvis L. Merr). Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antiinflamasi dan nilai LD50 dari senyawa peristrophine secara komputasi. Metode dalam penelitian ini dilakukan secara in silico untuk meminimalisir terjadinya kegagalan pada uji in vivo ataupun in vitro. Bahan yang digunakan dalam penelitian ini menggunakan data makromolekul yang dipakai sebagai reseptor yang didapatkan dari situs web Protein Data Bank (PDB) dengan PDB ID 5IKR menggunakan native ligand asam mefenamat sebagai senyawa pembanding. Hasil yang diperoleh dari penelitian ini adalah senyawa peristrophine memiliki nilai aktivitas sebesar -6.90 kkal/mol pada asam amino Tyr 385A dengan nilai toksisitas 650,974 mg/kg, sedangkan asam mefenamat memiliki nilai aktivitas sebesar -7.58 kkal/mol dengan nilai toksisitas 595.50 mg/kg. Dari hasil yang didapat, seyawa peristrophine diprediksi memiliki aktivitas farmakologi sebagai antiinflmasi.
Pelatihan Pembuatan Sabun Kopi dan Edukasi Cuci Tangan untuk Menekan Penularan Penyakit di Sekolah Dasar Wibawa, Agung Ari Chandra; Adrianta, Ketut Agus; Sari, Ni Wayan Suryani Puspita
Jurnal Pengabdian UNDIKMA Vol. 5 No. 3 (2024): August
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v5i3.12215

Abstract

The service activity aims to increase students' knowledge and skills in processing natural coffee ingredients into soap to prevent disease transmission in the school environment. The method of implementing this service used training and education. This service partner was SD Negeri 5 Subagan, Karangasem District, Karangasem Regency, Bali Province. The evaluation instruments used in this service activity were pre-test and post-test instruments. The data analysis technique used statistical analysis, namely the Wilcoxon test (P<0.05). The results of this service showed that students' knowledge and skills have increased in processing coffee into soap. In addition, students' understanding of the importance of washing hands with soap increased. It could be seen from the significant increase (P<0.05) incorrect answers in students' pre-test and post-test scores.
Molecular docking of sterol derivatives in Tagetes erecta Linn. as an antiatherosclerotic agents through activation of PPARγ and LXRα receptors Rahadi, I Wayan Surya; Ratnadewi, Ni Kadek Ayu Mas; Adrianta, Ketut Agus
Jurnal Pendidikan Kimia Vol. 16 No. 2 (2024): August
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v16i2.57455

Abstract

Atherosclerosis is a condition characterized by inflammation in the arteries, which is linked with the accumulation of lipids and alterations in metabolism. Considering that atherosclerosis is the main factor causing death in the world, it is necessary to carry out immediate prevention and treatment to reduce the risk of developing clinical severity. The creation of foam cells, which originate from macrophages, is considered a key element in cardiovascular ailments, particularly in the advancement of atherosclerosis. Two types of the nuclear receptors known as Peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor α (LXRα), which serve as a primary regulator of cholesterol, intracellular lipid homeostasis and they are instrumental in the process of reverse cholesterol transport (RCT). Activation of these receptors could potentially decrease foam cell formation, consequently lowering the risk of atherogenesis and reducing cardiovascular disease risk. This research aims to determine sterol derivative compounds in Tagetes erecta Linn. which have the best interaction and potential as anti-atherosclerosis through peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor α (LXRα) activation. The analysis of this study is using docking molecular analysis. The parameters observed in this study were docking score, visualization results, absorption, distribution, metabolism, excretion profile, and toxicity value. The molecular docking outcomes indicate that β-sitosterol and 7β-hydroxysitosterol possess the most favorable binding energy values. They exhibit a positive pharmacokinetic profile, with the exception of gastrointestinal absorption and respiratory toxicity.
Transfer knowledge teknologi formulasi granul untuk diversifikasi produk pengusaha sarang walet Suena, Ni Made Dharma Shantini; Juliadi, Debby; Suradnyana, I Gede Made; Antari, Ni Putu Udayana; Adrianta, Ketut Agus
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 6 No 2 (2023)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v6i2.19396

Abstract

Mitra program pengabdian kepada masyarakat ini adalah termasuk dalam kategori masyarakat yang bergerak ke arah ekonomi produktif yang melakukan usaha pengolahan sarang walet berupa jelly konsentrat sarang walet dalam skala industri rumah tangga dengan Merk “Maha Birdnest Bali” yang berlokasi di Denpasar, Bali. Mitra memiliki ternakan sarang walet di daerah Banggai-Sulawesi Tengah. Program pengabdian dengan metode Service Learning ini dirancang untuk memberikan manfaat kepada mitra dalam usahanya memasarkan produk olahan sarang walet dengan menginovasikannya menjadi bentuk granul sarang walet (GSW) yang memiliki ketahanan lebih lama, serta lebih nyaman dan praktis baik saat didistribusikan maupun saat dikonsumsi oleh konsumen. Pelaksanaan program pengabdian berupa transfer knowledge produksi GSW dan pendampingan produksi kepada mitra, serta penyediaan video tutorial produksi GSW bagi mitra. Program pengabdian ini memberikan manfaat nyata bagi peningkatan mutu produk Mitra, dari sisi inovasi bentuk dan rasa, peningkatan ketahanan, dan berpeluang besar meningkatkan omset dan produktivitas mitra. Program pengabdian berencana akan dilanjutkan berupa workshop atau pelatihan produksi GSW dan pengendalian-penjaminan mutu (quality control-quality assurance) bagi tenaga produksi untuk dapat terus menerus memproduksi produk yang berkualitas di tempat usaha mitra.
Analysis Antioxidant of Fractions Cocoa Beans (Theobroma Cacao L.) as Potential Herbal Medicine Wibawa, Agung Ari Chandra; Pramitha, Dewa Ayu Ika; Sanjiwani, Ni Made Sukma; Adrianta, Ketut Agus
Hydrogen: Jurnal Kependidikan Kimia Vol. 12 No. 4 (2024): August 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i4.12548

Abstract

The cocoa seeds of the Gumbrih-Bali region are a natural commodity with great potential for development or processing by local communities. The purpose of this research is to provide information about the antioxidant potential contained in cocoa seeds. Testing the antioxidant capacity in this study uses the Uv-Vis spectrophotometry method at 517 nm wavelengths. Free radical scavanger is measured with control absorption and samples was analyzed with regression curve. The research results proved that the antioxidant (AAI) in the n-butanol fraction show result very strong ability of 4.64 compared to the 0.42 ethyl acetate fraction and 0.46 n-hexane fraction. These results prove that the potential chemical content of cocoa seeds is high in polar solvents (n-butanol fractions) such as flavonoid compounds. Furthermore, this research will be used as a basis for developing natural herbal ingredients such as cocoa which can be consumed in the community to prevent degenerative diseases.
Effectiveness of Artocarpus heterophyllus lamk. serum in eliminating dark spot in the guinea pig melasma model due to UV-a exposure Mas Tiari, Ida Ayu Dwi Putri; Mardiyanti Putri, Ni Putu Kania; Marliani, Ni Luh Setia; Sari, Ni Made Elma Agustini; Malelak, Julia Eva; Adrianta, Ketut Agus
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1639

Abstract

Indonesia's high UV-A exposure significantly contributes to skin hyperpigmentation conditions such as melasma. This study investigated the effectiveness of Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum in reducing dark spots in a guinea pig model of melasma induced by UV-A radiation. Crude extracts were prepared and purified from Jackfruit (Artocarpus heterophyllus Lamk.) leaves, then formulated into serums at 4% and 5% concentrations. These formulations underwent physical quality evaluations, including organoleptic properties, pH, homogeneity, spread ability, adhesion, and viscosity. Anti-hyperpigmentation effects were assessed using Masson Fontana staining on UV-A-exposed guinea pigs treated for 14 days. The results demonstrated a reduction in melanin content, with mean values of 17.97±1.68 (negative control), 1.17±0.28 (positive control), 3.56±2.77 (4% serum), and 2.56±1.25 (5% serum). Histological analysis showed that fibroblast proliferation and epidermal hyperplasia were significantly reduced with serum treatment. These effects are attributed to the flavonoid content in Jackfruit (Artocarpus heterophyllus Lamk.) leaves, which exhibit antioxidant and anti-melanogenesis properties. In conclusion, Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum, particularly at 5% concentration, is effective in reducing melasma-related hyperpigmentation and may offer a safer alternative to synthetic treatments.
Anti-Aging Efficacy of Mangrove Leaf Extract Cream Assessed by SPF and Collagen Density Enhancement: In Vitro and In Vivo Approaches Wardani, I Gusti Agung Ayu Kusuma; Adrianta, Ketut Agus; Udayani, Ni Nyoman Wahyu; Amaral, Meriana Barreto; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13138

Abstract

Background: Excessive ultraviolet (UV) exposure is a major contributor to skin photoaging through oxidative stress, inflammation, and collagen degradation. Mangrove leaf extract (Xylocarpus granatum J. Koenig) contains bioactive compounds with potential photoprotective properties. In this study, the extract was formulated into an oil-in-water (O/W) cream suitable for cosmetic applications.Objective: This study aimed to determine the in vitro sun protection factor (SPF), percentage of erythema transmission (%Te), and percentage of pigmentation transmission (%Tp) of the mangrove leaf extract cream, and to evaluate its effectiveness on UVB-exposed guinea pig skin using collagen density as an anti-aging biomarker.Methods: In vitro assessments of SPF, %Te, and %Tp were performed using UV–Vis spectrophotometry. In vivo evaluation was conducted using 20 guinea pigs to examine the effect of the cream on collagen density through histopathological analysis of UVB-exposed skin.Results: The mangrove leaf extract cream exhibited strong photoprotective activity, with SPF values ranging from 20.68 ± 0.51 to 33.70 ± 0.67, %Te values from 3.13 ± 0.08 to 1.75 ± 0.03, and %Tp values from 4.40 ± 0.12 to 3.31 ± 0.03. Furthermore, the cream significantly increased collagen density (71.77 ± 5.27–81.02 ± 0.96) compared with the positive control (52.16 ± 2.32) (p < 0.05).Conclusions: The mangrove leaf extract cream provides effective protection against UVB radiation, characterized by high-protection SPF, extra-protection %Te, and sunblock-level %Tp. The 5% formulation significantly enhanced collagen density, supporting its potential as a natural anti-aging active ingredient for photoaging prevention through improved UV protection and dermal structure.
Efektivitas Stick Herbal Usada Bali sebagai Antioksidan dan Anti-Inflamasi pada Mencit Putih Jantan yang Diinduksi Karagenan Adrianta, Ketut Agus; Bisama, I Putu Werda; Udayani, Ni Nyoman Wahyu; Suena, Ni Made Dharma Shantini; Wibawa, Agung Ari Chandra
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.71522

Abstract

: Inflamasi disebabkan oleh terlepasnya mediator pro inflamasi di dalam tubuh, seperti TNF-α, caspase-3, dan prostaglandin. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan dan antiinflamasi dari stick herbal Usada Bali yang mengandung rimpang kencur, bunga cengkeh, dan daun kelor pada mencit putih jantan yang diinduksi karagenan. Penelitian dilakukan dengan rancangan penelitian eksprimental laboratorium, dimana dalam pengujian antioksidan digunakan penelitian in-vtiro DPPH dengan instrument spektrofotometri UV-Vis, sedangkan pengujian antiinflamasi berupa penelitian in-vivo dengan rancangan randomize pre test and postest with control group design dan menggunakan hewan coba dengan rincian pembagian kelompok sebagai berikut: Kelompok 1 (P1) adalah kelompok perlakuan plasebo, kelompok 2 (P2) adalah kelompok perlakuan yang diberikan natrium diklofenak, kelompok 3 (P3) adalah kelompok perlakuan yang diberikan Stick Herbal Usada Bali. Pengujian antioksidan memberikan hasil bahwa sampel memiliki nilai IC50 82,285 µg/mL dengan kategori (kuat) dan nilai Antioxidant Activity Index 0,469 dengan katagori (sedang). Pengujian antiinflamasi berdasarkan analisis SPSS menunjukkan bahwa terdapat perbedaan bermakna antara kelompok kontrol negatif dengan kelompok perlakuan Stick Herbal Usada Bali dengan nilai p=0,000 (p<0,05), serta tidak terdapat perbedaan bermakna antara kelompok positif dengan kelompok perlakuan Stick Herbal Usada Bali p=0,222 (p>0,05). Efektivitas antioksidan dan antiinflamasi Stick Herbal Usada Bali dipengaruhi oleh senyawa yang terkandung di dalamnya yaitu flavonoid dan saponin yang diketahui memiliki khasiat sebagai antioksidan dan antiinflamasi. Sehingga, dapat disimpulkan bahwa Stick Herbal Usada Bali berpotensi sebagai alternatif terapi antiinflamasi dan memiliki efektivitas sebagai antioksidan.
Co-Authors Agung Ari Chandra Wibawa Amaral, Meriana Barreto Bagus Komang Satriyasa Berata, Putu Febryana Suryaputri Bisama, I Putu Werda Debby Juliadi Desak Ketut Ernawati Desak Made Wihandani Dewa Ayu Ika Pramitha Dwi Arymbhi Sanjaya Fitria Megawati Fridayana, Ni Luh Gede Erica Gamaliel Agripa Gunawan, I Putu Windra Herleeyana Meriyani I Made Jawi I Nyoman Gede Tri Sutrisna IGAA Kusuma Wardani Kamalia, Made Gek Adisti Mahaputra, I Putu Yudistira Malelak, Julia Eva Mardiyanti Putri, Ni Putu Kania Marliani, Ni Luh Setia Mas Tiari, Ida Ayu Dwi Putri Mendra, Ni Nyoman Yudianti Meriyani, Herleeyana Nggaba, Ellenoire Rambu Kabeba Hammu Ni Made Dharma Shantini Suena Ni Made Sukma Sanjiwani Ni Nyoman Wahyu Udayani Ni Putu Aryati Suryaningsih Ni Putu Siska Sugiantari Ni Putu Udayana Antari Noviani, Lusy Nyoman Budiartha Siada Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Rahadi, I Wayan Surya Ratnadewi, Ni Kadek Ayu Mas RR. Asih Juanita Samidya, Ni Wayan Rias Sari, Ni Made Elma Agustini Sari, Ni Wayan Suryani Puspita Suradnyana, I Gede Made Sutema, Ida Ayu Manik Partha Veryanti, Putu Rika Wardani, I Gusti Agung Ayu Kusuma Widowati, I Gusti Ayu Rai - Yeni Cendana