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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia MEDISAINS Majalah Obat Tradisional Jurnal Pendidikan Kimia (JPKim) Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) JPSCR : Journal of Pharmaceutical Science and Clinical Research Abditani : Jurnal Pengabdian Masyarakat Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Aisyah : Jurnal Ilmu Kesehatan Science Midwifery Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Journal of Health Sciences and Medicine Jurnal Ilmiah Medicamento Jurnal Pengabdian UNDIKMA Hydrogen: Jurnal Kependidikan Kimia Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian kepada Masyarakat Wahana Usada Jurnal Locus Penelitian dan Pengabdian Jurnal Farmasi Indonesia Gema Lingkungan Kesehatan Usadha Kartika : Jurnal Ilmiah Farmasi Indonesian Journal of Global Health Research
Ketut Agus Adrianta
Universitas Mahasaraswati Denpasar
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Antioxidant Activity of VCO-Clove Topical Oil and Predictive Interaction toward Prostaglandin-endoperoxide Synthase 2 Pramitha, Dewa Ayu Ika; Wibawa, Agung Ari Chandra; Adrianta, Ketut Agus; Samidya, Ni Wayan Rias
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.48983

Abstract

Pain is a prevalent symptom of various diseases, characterized by subjective sensory and emotional experiences, often triggered by nerve irritation and pain receptor activation. Prostaglandins play a crucial role as chemical mediators in pain mechanisms. Clove oil-based liniment is commonly used for pain relief, with eugenol as its main active compound. This study investigates the antioxidant activity of VCO-clove liniment with different clove proportions using the DPPH method and evaluates the analgesic potential of eugenol through its interaction with the PTGS2 receptor through in-silico analysis. VCO-clove liniment was formulated with varying clove weight ratio (1:10, 5:10, and 10:10 w/v). Antioxidant activity was evaluated in-vitro using DPPH assay, while the interaction between eugenol and PTGS2 (PDB code: 5KIR) was predicted using molecular docking. The results demonstrated that the 10:10 ratio exhibited the highest antioxidant activity, with an IC50 value of 40.33 µg/mL and an antioxidant activity index (AAI) of 0.99, classified as moderate. In-silico analysis revealed strong binding between eugenol and PTGS2, with a binding energy of -5.22 kcal/mol, suggesting its analgesic potential. In conclusion, VCO-clove liniment shows promise as an antioxidant and analgesic agent, with the 10:10 ratio displaying optimal antioxidant properties, and eugenol contributing significantly to its analgesic effects through PTGS2 interaction.
Skrining Fitokimiadan Uji Aktivitas Ekstrak Buah Dewandaru (Eugeniauniflora .L) pada Hewan Coba yang Di Induksi Aloksan Santoso, Puguh; Nggaba, Ellenoire Rambu Kabeba Hammu; Udayani, Ni Nyoman Wahyu; Adrianta, Ketut Agus; Putra, I Made Agus Sunadi
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 7 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i7.4681

Abstract

Diabetes melitus merupakan gangguan metabolik kronis yang ditandai dengan kadar glukosa darah yang melebihi ambang normal. Tingginya angka penderita diabetes mendorong pengembangan pengobatan alternatif berbasis bahan alam. Salah satu tanaman potensial adalah buah dewandaru (Eugenia uniflora) yang mengandung senyawa bioaktif seperti flavonoid dan asam fenolat yang diketahui memiliki efek hipoglikemik. Penelitian ini bertujuan untuk menguji efektivitas ekstrak etanol buah dewandaru dalam menurunkan kadar glukosa darah pada mencit (Mus musculus) yang diinduksi aloksan. Penelitian ini menggunakan desain eksperimental Pretest-Posttest Only Control Group Design. Ekstrak buah dewandaru diperoleh melalui metode maserasi dan diberikan pada 24 ekor mencit yang dibagi menjadi 4 kelompok (masing-masing 6 ekor). Kelompok 1 (kontrol negatif) hanya menerima aloksan, kelompok 2 (kontrol positif) menerima glibenklamid 5 mg, kelompok 3 menerima ekstrak 100 mg/kgBB, dan kelompok 4 menerima ekstrak 200 mg/kgBB. Kadar glukosa darah diukur pada hari ke-3 (pretest) dan hari ke-14 (posttest) menggunakan glukometer. Data dianalisis dengan uji normalitas Shapiro-Wilk dan uji Paired T-Test menggunakan SPSS 26. Hasil penelitian menunjukkan adanya penurunan kadar glukosa darah yang signifikan (p < 0,05) pada kelompok mencit yang diberi ekstrak 100 mg/kgBB dan 200 mg/kgBB dibandingkan kelompok kontrol. Temuan ini menunjukkan bahwa ekstrak buah dewandaru berpotensi sebagai agen antidiabetes alami, sehingga penelitian lanjutan untuk isolasi senyawa aktif dan uji keamanan jangka panjang sangat dianjurkan.
Pemanfaatan Toga Usadha Bali bagi Pemuda Desa Adat Bitera Gianyar Menuju Era Normal Baru Ketut Agus Adrianta; I Gusti Agung Ayu Kusuma Wardhani; Ni Nyoman Wahyu Udayani; Agung Ari Chandra Wibawa
Jurnal Pengabdian UNDIKMA Vol. 4 No. 1 (2023): February
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v4i1.5843

Abstract

This community service aims to increase knowledge and skills for the youth of the Bitera Gianyar traditional village regarding the use of TOGA (family medicinal plants) as well as provide training and assistance in making plant-based hand sanitizers in the yard of the house that can be used and used for preventive efforts against transmission the Covid-19 virus. The service method used was in the form of participatory training and small group discussions (SGD). The activity evaluation instrument was carried out using a questionnaire and statistically analyzed using a paired t-test. This community service activity increased participants' knowledge by 45.84%. The service participants, in general, understood the importance of vaccination for the human body and how to use materials around the environment as natural hand sanitizers. Increasing the ability and knowledge of the Bitera Gianyar traditional village's youth is expected to change people's behavior; henceforth, the participants will become agents of change who will influence their environment to adopt a healthy lifestyle.
Uji Aktivitas Antiinflamasi serta Toksisitas Senyawa Peristrophine terhadap Reseptor Prostaglandin Sintase 2 (PTGS2) secara In Silico Gunawan, I Putu Windra; Santoso, Puguh; Pramitha, Dewa Ayu Ika; Adrianta, Ketut Agus
Usadha Vol 1 No 1 (2021): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia merupakan salah satu negara yang banyak memiliki kasus penyakit yang diakibatkan oleh inflamasi. Rasa sakit atau nyeri sering menjadi penyebab gangguan aktivitas sehari-hari. Inflamasi merupakan suatu respon dari tubuh yang terjadi akibat cedera maupun infeksi. Peristrophine adalah salah satu turunan senyawa antosianin yang berasal dari tanaman magenta (Peristrophe bivalvis L. Merr). Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antiinflamasi dan nilai LD50 dari senyawa peristrophine secara komputasi. Metode dalam penelitian ini dilakukan secara in silico untuk meminimalisir terjadinya kegagalan pada uji in vivo ataupun in vitro. Bahan yang digunakan dalam penelitian ini menggunakan data makromolekul yang dipakai sebagai reseptor yang didapatkan dari situs web Protein Data Bank (PDB) dengan PDB ID 5IKR menggunakan native ligand asam mefenamat sebagai senyawa pembanding. Hasil yang diperoleh dari penelitian ini adalah senyawa peristrophine memiliki nilai aktivitas sebesar -6.90 kkal/mol pada asam amino Tyr 385A dengan nilai toksisitas 650,974 mg/kg, sedangkan asam mefenamat memiliki nilai aktivitas sebesar -7.58 kkal/mol dengan nilai toksisitas 595.50 mg/kg. Dari hasil yang didapat, seyawa peristrophine diprediksi memiliki aktivitas farmakologi sebagai antiinflmasi.
Molecular docking activity of peristrophe bivalvis on non small cell lung cancer Puguh Santoso; Ketut Agus Adrianta; Agung Ari Chandra Wibawa; I Wayan Suardi Adi Gunawan
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1505.7 KB) | DOI: 10.30604/jika.v8i2.1935

Abstract

Cancer is a genetic disease in which cells are unable to control their functions normally. As cancer develops, old cells will survive when they should die, and new cells will grow when they are not needed. These extra cells can divide endlessly and can form growths called tumors . This research was carried out to know whether peristrophine, apioside, and pelargonidin 3-Sambubioside compounds could be developed as a drug in Non-Small Cell Lung Cancer (NSCLC) with the in silico method at the ROS1 receptor with the Protein Data Bank code 3ZBF with the native ligand crizotinib. Peristrophine, apioside, and pelargonidin 3-Sambubioside compounds have an affinity for ROS1 protein with binding energies of -6.12 kcal/mol on peristrophine, -6.74 kcal/mol on apioside, and -7.54 kcal/mol of pelargonidin 3-Sambubioside. Peristrophine, apioside, and pelargonidin 3-Sambubioside have a molecular mechanism in inhibiting ROS1 in Non-Small Cell Lung Cancer (NSCLC) through the formation of hydrogen bonds in the protein ROS1. From Lipinski's analysis, the peristrophine test compound has met the requirements and seen from the LD50 value of the peristrophine test compound, apioside and pelargonidin 3-Sambubioside has the same toxicity class as the comparison compound, namely crizotinib at class 4 toxicity.
Pelatihan Pembuatan Sabun Kopi dan Edukasi Cuci Tangan untuk Menekan Penularan Penyakit di Sekolah Dasar Wibawa, Agung Ari Chandra; Adrianta, Ketut Agus; Sari, Ni Wayan Suryani Puspita
Jurnal Pengabdian UNDIKMA Vol. 5 No. 3 (2024): August
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v5i3.12215

Abstract

The service activity aims to increase students' knowledge and skills in processing natural coffee ingredients into soap to prevent disease transmission in the school environment. The method of implementing this service used training and education. This service partner was SD Negeri 5 Subagan, Karangasem District, Karangasem Regency, Bali Province. The evaluation instruments used in this service activity were pre-test and post-test instruments. The data analysis technique used statistical analysis, namely the Wilcoxon test (P<0.05). The results of this service showed that students' knowledge and skills have increased in processing coffee into soap. In addition, students' understanding of the importance of washing hands with soap increased. It could be seen from the significant increase (P<0.05) incorrect answers in students' pre-test and post-test scores.
Molecular docking of sterol derivatives in Tagetes erecta Linn. as an antiatherosclerotic agents through activation of PPARγ and LXRα receptors Rahadi, I Wayan Surya; Ratnadewi, Ni Kadek Ayu Mas; Adrianta, Ketut Agus
Jurnal Pendidikan Kimia Vol. 16 No. 2 (2024): August
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v16i2.57455

Abstract

Atherosclerosis is a condition characterized by inflammation in the arteries, which is linked with the accumulation of lipids and alterations in metabolism. Considering that atherosclerosis is the main factor causing death in the world, it is necessary to carry out immediate prevention and treatment to reduce the risk of developing clinical severity. The creation of foam cells, which originate from macrophages, is considered a key element in cardiovascular ailments, particularly in the advancement of atherosclerosis. Two types of the nuclear receptors known as Peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor α (LXRα), which serve as a primary regulator of cholesterol, intracellular lipid homeostasis and they are instrumental in the process of reverse cholesterol transport (RCT). Activation of these receptors could potentially decrease foam cell formation, consequently lowering the risk of atherogenesis and reducing cardiovascular disease risk. This research aims to determine sterol derivative compounds in Tagetes erecta Linn. which have the best interaction and potential as anti-atherosclerosis through peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor α (LXRα) activation. The analysis of this study is using docking molecular analysis. The parameters observed in this study were docking score, visualization results, absorption, distribution, metabolism, excretion profile, and toxicity value. The molecular docking outcomes indicate that β-sitosterol and 7β-hydroxysitosterol possess the most favorable binding energy values. They exhibit a positive pharmacokinetic profile, with the exception of gastrointestinal absorption and respiratory toxicity.
Transfer knowledge teknologi formulasi granul untuk diversifikasi produk pengusaha sarang walet Suena, Ni Made Dharma Shantini; Juliadi, Debby; Suradnyana, I Gede Made; Antari, Ni Putu Udayana; Adrianta, Ketut Agus
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 6 No 2 (2023)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v6i2.19396

Abstract

Mitra program pengabdian kepada masyarakat ini adalah termasuk dalam kategori masyarakat yang bergerak ke arah ekonomi produktif yang melakukan usaha pengolahan sarang walet berupa jelly konsentrat sarang walet dalam skala industri rumah tangga dengan Merk “Maha Birdnest Bali” yang berlokasi di Denpasar, Bali. Mitra memiliki ternakan sarang walet di daerah Banggai-Sulawesi Tengah. Program pengabdian dengan metode Service Learning ini dirancang untuk memberikan manfaat kepada mitra dalam usahanya memasarkan produk olahan sarang walet dengan menginovasikannya menjadi bentuk granul sarang walet (GSW) yang memiliki ketahanan lebih lama, serta lebih nyaman dan praktis baik saat didistribusikan maupun saat dikonsumsi oleh konsumen. Pelaksanaan program pengabdian berupa transfer knowledge produksi GSW dan pendampingan produksi kepada mitra, serta penyediaan video tutorial produksi GSW bagi mitra. Program pengabdian ini memberikan manfaat nyata bagi peningkatan mutu produk Mitra, dari sisi inovasi bentuk dan rasa, peningkatan ketahanan, dan berpeluang besar meningkatkan omset dan produktivitas mitra. Program pengabdian berencana akan dilanjutkan berupa workshop atau pelatihan produksi GSW dan pengendalian-penjaminan mutu (quality control-quality assurance) bagi tenaga produksi untuk dapat terus menerus memproduksi produk yang berkualitas di tempat usaha mitra.
Analysis Antioxidant of Fractions Cocoa Beans (Theobroma Cacao L.) as Potential Herbal Medicine Wibawa, Agung Ari Chandra; Pramitha, Dewa Ayu Ika; Sanjiwani, Ni Made Sukma; Adrianta, Ketut Agus
Hydrogen: Jurnal Kependidikan Kimia Vol. 12 No. 4 (2024): August 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i4.12548

Abstract

The cocoa seeds of the Gumbrih-Bali region are a natural commodity with great potential for development or processing by local communities. The purpose of this research is to provide information about the antioxidant potential contained in cocoa seeds. Testing the antioxidant capacity in this study uses the Uv-Vis spectrophotometry method at 517 nm wavelengths. Free radical scavanger is measured with control absorption and samples was analyzed with regression curve. The research results proved that the antioxidant (AAI) in the n-butanol fraction show result very strong ability of 4.64 compared to the 0.42 ethyl acetate fraction and 0.46 n-hexane fraction. These results prove that the potential chemical content of cocoa seeds is high in polar solvents (n-butanol fractions) such as flavonoid compounds. Furthermore, this research will be used as a basis for developing natural herbal ingredients such as cocoa which can be consumed in the community to prevent degenerative diseases.
Effectiveness of Artocarpus heterophyllus lamk. serum in eliminating dark spot in the guinea pig melasma model due to UV-a exposure Mas Tiari, Ida Ayu Dwi Putri; Mardiyanti Putri, Ni Putu Kania; Marliani, Ni Luh Setia; Sari, Ni Made Elma Agustini; Malelak, Julia Eva; Adrianta, Ketut Agus
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1639

Abstract

Indonesia's high UV-A exposure significantly contributes to skin hyperpigmentation conditions such as melasma. This study investigated the effectiveness of Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum in reducing dark spots in a guinea pig model of melasma induced by UV-A radiation. Crude extracts were prepared and purified from Jackfruit (Artocarpus heterophyllus Lamk.) leaves, then formulated into serums at 4% and 5% concentrations. These formulations underwent physical quality evaluations, including organoleptic properties, pH, homogeneity, spread ability, adhesion, and viscosity. Anti-hyperpigmentation effects were assessed using Masson Fontana staining on UV-A-exposed guinea pigs treated for 14 days. The results demonstrated a reduction in melanin content, with mean values of 17.97±1.68 (negative control), 1.17±0.28 (positive control), 3.56±2.77 (4% serum), and 2.56±1.25 (5% serum). Histological analysis showed that fibroblast proliferation and epidermal hyperplasia were significantly reduced with serum treatment. These effects are attributed to the flavonoid content in Jackfruit (Artocarpus heterophyllus Lamk.) leaves, which exhibit antioxidant and anti-melanogenesis properties. In conclusion, Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum, particularly at 5% concentration, is effective in reducing melasma-related hyperpigmentation and may offer a safer alternative to synthetic treatments.
Co-Authors Agung Ari Chandra Wibawa Agung Ari Chandra Wibawa Agung Ari Chandra Wibawa Agung Ari Chandra Wibawa Agung Nova Mahendra Agung Wiwiek Indrayani Anak Agung Cahaya Dayita Nariswari Bagus Komang Satriyasa Berata, Putu Febryana Suryaputri Debby Juliadi Desak Ketut Ernawati Desak Made Wihandani Dewa Ayu Ika Pramitha Dewa Ayu Ika Pramitha Dwi Arymbhi Sanjaya Fitria Megawati Fridayana, Ni Luh Gede Erica Gamaliel Agripa Gunawan, I Putu Windra Herleeyana Meriyani I Gede Made Suradnyana I Gusti Agung Ayu Kusuma Wardhani I Made Agus Sunadi Putra I Made Jawi I Nyoman Gede Tri Sutrisna I Putu Werda Bisama I Wayan Suardi Adi Gunawan I Wayan Surya Rahadi Ida Bagus Ideyogiswara IGAA Kusuma Wardani Kadek Ayu Puspa Pratiwi Kamalia, Made Gek Adisti Lusy Noviani Made Dwik Lestari Mahaputra, I Putu Yudistira Malelak, Julia Eva Mardiyanti Putri, Ni Putu Kania Marliani, Ni Luh Setia Mas Tiari, Ida Ayu Dwi Putri Megawati, Fitria Mendra, Ni Nyoman Yudianti Meriana Barreto Amaral Nggaba, Ellenoire Rambu Kabeba Hammu Ni Kadek Ayu Mas Ratnadewi Ni Komang Puja Pertiwi Ni Luh Kade Arman Anita Dewi Ni Luh Putu Anggie Pramesthi Putri Ni Luh Putu Tris Yoga Cahyani Ni Made Dharma Shantini Suena Ni Made Maharianingsih Ni Made Sukma Sanjiwani Ni Nyoman Sri Budayanti Ni Nyoman Wahyu Udayani Ni Putu Aryati Suryaningsih Ni Putu Ayu Widya Anggreni Ni Putu Leona Yorita Dewi Ni Putu Putri Cahya Anggreni Ni Putu Refina Dharma Yanti Ni Putu Siska Sugiantari Ni Putu Udayana Antari Nyoman Budiartha Siada Nyoman Budiartha Siada Puguh Santoso Puguh Santoso Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Putu Windra Gunawan Rahadi, I Wayan Surya Ratnadewi, Ni Kadek Ayu Mas RR. Asih Juanita Samidya, Ni Wayan Rias Sari, Ni Made Elma Agustini Sari, Ni Wayan Suryani Puspita Shiendy Ayu Puspita Suradnyana, I Gede Made Susianti, Luh Sutema, Ida Ayu Manik Partha Veryanti, Putu Rika Wardani, I Gusti Agung Ayu Kusuma Wartana Putra, I Gusti Ngurah Agung Windra Widowati, I Gusti Ayu Rai - Wiguna, I Putu Bagus Artha Yanti, Ni Komang Semara Yeni Cendana Yowani, Anak Agung Sagung Iswarani