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Efficacy of Solvent Type on Antioxidant Activity of Artocarpus heterophyllus Leaves Extract: A Scoping Review Ida Bagus Ideyogiswara; Bagus Komang Satriyasa; Agung Nova Mahendra; Agung Wiwiek Indrayani; Ketut Agus Adrianta
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2347

Abstract

Jackfruit leaves (Artocarpus heterophyllus) contain various bioactive compounds that have the potential as natural antioxidants. The antioxidant activity of jackfruit leaf extract is influenced by the type of solvent used during the extraction process. Objective to identify the effectiveness of various types of solvents on the antioxidant activity of jackfruit leaf extract. This study used a scoping review method by reviewing articles from PubMed, ScienceDirect, and Google Scholar in 2020–2025 Searching strategy using the keywords "Artocarpus heterophyllus" OR "jackfruit leaves" AND "antioxidant activity" OR "antioxidant capacity" AND solvent OR "solvent type" OR "extraction solvent" . Included articles were English-language primary studies published between 2020 and 2025. A total of 11 articles that met the inclusion criteria were analyzed descriptively. The data were analyzed descriptively and presented in tabular form to identify patterns of findings related to the effectiveness of various solvent types on the antioxidant activity of Artocarpus heterophyllus leaf extrac. Ethanol and hydroethanol solvents showed higher antioxidant activity than other solvents. Strong antioxidant activity is related to the high content of phenolic and flavonoid compounds that were successfully extracted. The type of solvent affects the antioxidant activity of jackfruit leaf extract, with ethanol and hydroethanol being the most effective solvents in extracting bioactive antioxidant compounds.
Efektivitas Stick Herbal Usada Bali sebagai Antioksidan dan Anti-Inflamasi pada Mencit Putih Jantan yang Diinduksi Karagenan Ketut Agus Adrianta; I Putu Werda Bisama; Ni Nyoman Wahyu Udayani; Ni Made Dharma Shantini Suena; Agung Ari Chandra Wibawa
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.71522

Abstract

: Inflamasi disebabkan oleh terlepasnya mediator pro inflamasi di dalam tubuh, seperti TNF-α, caspase-3, dan prostaglandin. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan dan antiinflamasi dari stick herbal Usada Bali yang mengandung rimpang kencur, bunga cengkeh, dan daun kelor pada mencit putih jantan yang diinduksi karagenan. Penelitian dilakukan dengan rancangan penelitian eksprimental laboratorium, dimana dalam pengujian antioksidan digunakan penelitian in-vtiro DPPH dengan instrument spektrofotometri UV-Vis, sedangkan pengujian antiinflamasi berupa penelitian in-vivo dengan rancangan randomize pre test and postest with control group design dan menggunakan hewan coba dengan rincian pembagian kelompok sebagai berikut: Kelompok 1 (P1) adalah kelompok perlakuan plasebo, kelompok 2 (P2) adalah kelompok perlakuan yang diberikan natrium diklofenak, kelompok 3 (P3) adalah kelompok perlakuan yang diberikan Stick Herbal Usada Bali. Pengujian antioksidan memberikan hasil bahwa sampel memiliki nilai IC50 82,285 µg/mL dengan kategori (kuat) dan nilai Antioxidant Activity Index 0,469 dengan katagori (sedang). Pengujian antiinflamasi berdasarkan analisis SPSS menunjukkan bahwa terdapat perbedaan bermakna antara kelompok kontrol negatif dengan kelompok perlakuan Stick Herbal Usada Bali dengan nilai p=0,000 (p<0,05), serta tidak terdapat perbedaan bermakna antara kelompok positif dengan kelompok perlakuan Stick Herbal Usada Bali p=0,222 (p>0,05). Efektivitas antioksidan dan antiinflamasi Stick Herbal Usada Bali dipengaruhi oleh senyawa yang terkandung di dalamnya yaitu flavonoid dan saponin yang diketahui memiliki khasiat sebagai antioksidan dan antiinflamasi. Sehingga, dapat disimpulkan bahwa Stick Herbal Usada Bali berpotensi sebagai alternatif terapi antiinflamasi dan memiliki efektivitas sebagai antioksidan.
Anti-Aging Efficacy of Mangrove Leaf Extract Cream Assessed by SPF and Collagen Density Enhancement: In Vitro and In Vivo Approaches I Gusti Agung Ayu Kusuma Wardani; Ketut Agus Adrianta; Ni Nyoman Wahyu Udayani; Meriana Barreto Amaral; Ni Made Dharma Shantini Suena
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13138

Abstract

Background: Excessive ultraviolet (UV) exposure is a major contributor to skin photoaging through oxidative stress, inflammation, and collagen degradation. Mangrove leaf extract (Xylocarpus granatum J. Koenig) contains bioactive compounds with potential photoprotective properties. In this study, the extract was formulated into an oil-in-water (O/W) cream suitable for cosmetic applications.Objective: This study aimed to determine the in vitro sun protection factor (SPF), percentage of erythema transmission (%Te), and percentage of pigmentation transmission (%Tp) of the mangrove leaf extract cream, and to evaluate its effectiveness on UVB-exposed guinea pig skin using collagen density as an anti-aging biomarker.Methods: In vitro assessments of SPF, %Te, and %Tp were performed using UV–Vis spectrophotometry. In vivo evaluation was conducted using 20 guinea pigs to examine the effect of the cream on collagen density through histopathological analysis of UVB-exposed skin.Results: The mangrove leaf extract cream exhibited strong photoprotective activity, with SPF values ranging from 20.68 ± 0.51 to 33.70 ± 0.67, %Te values from 3.13 ± 0.08 to 1.75 ± 0.03, and %Tp values from 4.40 ± 0.12 to 3.31 ± 0.03. Furthermore, the cream significantly increased collagen density (71.77 ± 5.27–81.02 ± 0.96) compared with the positive control (52.16 ± 2.32) (p < 0.05).Conclusions: The mangrove leaf extract cream provides effective protection against UVB radiation, characterized by high-protection SPF, extra-protection %Te, and sunblock-level %Tp. The 5% formulation significantly enhanced collagen density, supporting its potential as a natural anti-aging active ingredient for photoaging prevention through improved UV protection and dermal structure.
Co-Authors Agung Ari Chandra Wibawa Agung Ari Chandra Wibawa Agung Ari Chandra Wibawa Agung Ari Chandra Wibawa Agung Nova Mahendra Agung Wiwiek Indrayani Anak Agung Cahaya Dayita Nariswari Bagus Komang Satriyasa Berata, Putu Febryana Suryaputri Debby Juliadi Desak Ketut Ernawati Desak Made Wihandani Dewa Ayu Ika Pramitha Dewa Ayu Ika Pramitha Dwi Arymbhi Sanjaya Fitria Megawati Fridayana, Ni Luh Gede Erica Gamaliel Agripa Gunawan, I Putu Windra Herleeyana Meriyani I Gede Made Suradnyana I Gusti Agung Ayu Kusuma Wardhani I Made Agus Sunadi Putra I Made Jawi I Nyoman Gede Tri Sutrisna I Putu Werda Bisama I Wayan Suardi Adi Gunawan I Wayan Surya Rahadi Ida Bagus Ideyogiswara IGAA Kusuma Wardani Kadek Ayu Puspa Pratiwi Kamalia, Made Gek Adisti Lusy Noviani Made Dwik Lestari Mahaputra, I Putu Yudistira Malelak, Julia Eva Mardiyanti Putri, Ni Putu Kania Marliani, Ni Luh Setia Mas Tiari, Ida Ayu Dwi Putri Megawati, Fitria Mendra, Ni Nyoman Yudianti Meriana Barreto Amaral Nggaba, Ellenoire Rambu Kabeba Hammu Ni Kadek Ayu Mas Ratnadewi Ni Komang Puja Pertiwi Ni Luh Kade Arman Anita Dewi Ni Luh Putu Anggie Pramesthi Putri Ni Luh Putu Tris Yoga Cahyani Ni Made Dharma Shantini Suena Ni Made Maharianingsih Ni Made Sukma Sanjiwani Ni Nyoman Sri Budayanti Ni Nyoman Wahyu Udayani Ni Putu Aryati Suryaningsih Ni Putu Ayu Widya Anggreni Ni Putu Leona Yorita Dewi Ni Putu Putri Cahya Anggreni Ni Putu Refina Dharma Yanti Ni Putu Siska Sugiantari Ni Putu Udayana Antari Nyoman Budiartha Siada Nyoman Budiartha Siada Puguh Santoso Puguh Santoso Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Putu Windra Gunawan Rahadi, I Wayan Surya Ratnadewi, Ni Kadek Ayu Mas RR. Asih Juanita Samidya, Ni Wayan Rias Sari, Ni Made Elma Agustini Sari, Ni Wayan Suryani Puspita Shiendy Ayu Puspita Suradnyana, I Gede Made Susianti, Luh Sutema, Ida Ayu Manik Partha Veryanti, Putu Rika Wardani, I Gusti Agung Ayu Kusuma Wartana Putra, I Gusti Ngurah Agung Windra Widowati, I Gusti Ayu Rai - Wiguna, I Putu Bagus Artha Yanti, Ni Komang Semara Yeni Cendana Yowani, Anak Agung Sagung Iswarani