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All Journal Medula Juke JK Unila (Jurnal Kedokteran Universitas Lampung) Indian Journal of Forensic Medicine & Toxicology Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal EduHealth Indonesian Journal of Cancer Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Majority JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Asep Sukohar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Pemberian Ekstrak Lidah Buaya Konsentrasi 25%,50%, 75%, dan 100% terhadap Jumlah Makrofag pada Radang Mukosa Mulut Tikus Putih Jantan Galur Sprague Dawley Novita Carolia; Asep Sukohar
Jurnal Kedokteran Universitas Lampung Vol 1, No 2 (2016): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v1i2.1622

Abstract

Daun lidah buaya dapat bertindak sebagai anti-inflamasi dengan menghambat integrin tertentu. Tanaman ini mengandung berbagai macam unsur dan zat yang dipercaya berfungsi sebagai agen antiinflamasi, antara lain asam salisilat, vitamin, polisakarida dan asam lemak. Disamping itu terdapat pula indometasin yang dapat mengurangi edema, menghambatenzim siklooksigenase dan menghambat motilitas dari leukosit polymorpho nuclear (PMN) yang bila jumlahnya berlebihan dapat merusak jaringan. Rancangan penelitian ini adalah penelitian eksperimental. Penelitian ini menggunakan 30 ekor tikus putih jantan galur Sprague Dawley yang dibagi menjadi 5 kelompok yang terdiri dari 1 kelompok kontrol negatif (diolesi aqudest) dan 4 kelompok perlakuan ( diolesi ekstrak lidah buaya masing-masing 25%, 50%, 75%, dan 100%). Reratajumlah makrofag kelompok kontrol (aquadest), kelompok 1, Kelompok 2, kelompok 3, dan kelompok 4 berturut turut sebanyak 16,15 , 15,95 , 14,88, 14,8, dan 14,2. Simpulan: terdapat perbedaan bermakna jumlah rerata makrofag antar kelompok (p= 0,014). Konsentrasi ekstrak lidah buaya yang paling efektif sebagai antiinflamasi pada radang mukosa mulut adalah 100%. [JK Unila. 2016; 1(2)]Kata kunci: lidah buaya, makrofag, stomatitis
Peran Asam Klorogenat Terhadap Ekspresi Gen; miRNA 146 A, Caspase 3, Cyclin D1, dan Kematian Sel Kanker Hepatoseluler Model Cell Lines Hep-G2 ASEP SUKOHAR; HENING HERAWATTI; ARIEF B WITARTO
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (636.82 KB) | DOI: 10.33371/ijoc.v8i1.276

Abstract

Chlorogenic acid (CA) is the active compound isolated from medicinal plants, can be used as a chemopreventive agents of hepatocellular cancer (HCC). It works as an exogenous antioxidant and inhibit growth of cancer cells through the inhibition of free radicals. The purpose of this study is to know mechanism of CA in inhibition to growth of Hep-G2 through apoptosis stimulation. In vitro study was performed Hep-G2 cells. The samples were divided into the control group treatment and experiment group expose to 727, 500 and 250 ?M and 3 times repetition. Expression of miRNA 146 A, caspase 3 and cyclin D1 examined by RT-PCR CFX-96. Samples were analysed at 0, 8, 18, and 24 hours after exposure CA. The data were statistically tested by repeated measurement, pearson, and multivariate regression. The results showed that cell death of Hep-G2 were increase as the dose increase and time, at 8 hours after exposure CA cell death of Hep-G2 increased as much as 35,68, 37,75, 40,86%. At 18 hours cell death of Hep-G2 increased as much as 54,56, 56,48, and 59,73%. At 24 hours cell death of Hep-G2 increased as much as 67,73, 69,37, and 72,16%. The lowest expression miRNA 146 A in group 24 hours after exposure at doses of 727 ?M CA (0,85), followed by 500 ?M (1,28) and the highest expression at a dose of 250 ?M (1,61). The result of repeated measurement test: miRNA 146 A and caspase 3 at 8th and 18th hours was significantly different to the 24th with p<0.05. The expression of caspase 3 increase from 0-24 hours, the highest expression of caspase 3 in group 18 hours after exposure at doses CA at 750 ?M (3,86). After 18 hours, expression caspase 3 decreased and the lowest in group 24 hours after exposure: at a dose of 250 ?M (1,52). Expression of cyclin D1 decrease from 0-24 hours with the highest expression at 0 hours (4,35) at a dose of 250 ?M and the lowest expression at 24 hours after exposure to CA (0,32) at a dose of 727 AK ?M.
Medication Error pada Tahap Prescribing, Transcribing, Dispensing dan Administration Eka Ananda Laksana Putri; Asep Sukohar; Ervina Damayanti
Medula Vol 13 No 4 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.667

Abstract

Medication Error is any error that occurs in the treatment process, endangers the patient and can actually be prevented. According to WHO, the number of incidents of medication errors shows that this is a global problem. This error occurs both in the process of prescribing (prescribing), reading the prescription (transcribing), preparation to drug delivery (dispensing), as well as in the process of drug use (administering). In this journal review, issues related to Medication Errors are collected and then reviewed again to see definitions, terminology, events, influencing factors, ways of prevention and legal consequences related to Medication Errors. Medication error can be a very fundamental clinical problem. Factors that influence Medication Error include the complexity of clinical cases, lack of knowledge of doctors and pharmacists, factors related to drugs, communication, workload and unsupportive work systems. In prevention, pharmacists have an important role because they collaborate directly with doctors who write prescriptions. Automation and computers, rules and policies, standards and protocols, checklists and double check systems, and greater caution and vigilance can be used to reduce medication Error. Patients are protected by law because they are consumers of health services. The relationship between doctors and patients involves legal aspects, namely civil and criminal. Criminal law only applies to errors and negligence if the patient dies or becomes disabled as a result of the medical treatment provided whereas civil lawsuits can be filed when the patient suffers a loss even if the fault is minor.
Potensi Kunyit (Curcuma longa) sebagai Antidiare pada Pediatri: Tinjauan Pustaka. Mutiara Nauli Br. Sitinjak; Asep Sukohar; Andi Nafisah Tendri Adjeng; Zulpakor Oktoba; Afna Nur Afni Palogan
Jurnal Kedokteran Universitas Lampung Vol 7, No 1 (2023): JURNAL KEDOKTERAN UNIVERSITAS LAMPUNG
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila71%p

Abstract

Diare merupakan salah satu penyebab utama kematian pada balita di Indonesia. Diare dapat disebabkan oleh infeksi virusparasit, atau bakteri. Salah satu bakteri yang menjadi penyebab utama diare pada pediatri di negara berkembang adalahDiarrheagenic Escherichia coli (DEC). Pengobatan diare dapat dilakukan dengan pengobatan modern dan tradisionalPengobatan modern dengan pemberian antibiotik oral relatif mahal dan dapat menyebabkan efek samping pada tubuhSementara itu, pengobatan tradisional dengan memanfaatkan tanaman herbal mudah didapat dan relatif murah. Salah satutanaman yang digunakan dalam mengobati diare adalah kunyit (Curcuma longa). Senyawa aktif dalam kunyit yaitukurkumin berperan sebagai antibakteri, sehingga ekstrak rimpang kunyit (Curcuma longa) dapat digunakan sebagaalternatif pengobatan diare. Tinjauan pustaka ini bertujuan untuk memberi penjelasan tentang potensi ekstrak rimpangkunyit sebagai antidiare dilihat dari aktivitas antibakteri senyawa kurkumin berdasarkan studi literatur yang diperolehpeneliti dalam kurun waktu tertentu. Metode yang digunakan dengan melakukan pencarian literatur yang relevan dengantopik penelitian ini baik nasional maupun internasional dengan menggunakan database Pubmed, Research Gate, danGoogle Scholar. Pada tahap pencarian artikel jurnal dipilih 16 artikel dengan pembatasan waktu yaitu sejak 2011 hingga2023.Kata Kunci: Curcumin domestica, diare, Escherichia coli, pediatri
Efek Pemberian Minyak Buah Merah pada Penurunan Parasitemia pada Mencit yang Diinfeksi dengan Plasmodium berghei Elma Sandya Putri; Jhons Fatriyadi Suwandi; Hanna Mutiara; Asep Sukohar
MAJORITY Vol 10 No 2 (2021): MAJORITY
Publisher : Majority

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Malaria is one of the endemic infectious disease cases in several areas in Indonesia. Indonesia had the highest malaria incidence in Southeast Asia. High levels of morbidity and mortality and antimalarial resistance problems encourage the need to find new antimalarial agents, such as red fruit. Red fruit contains many antioxidants and has been reported to have effect of reducing parasitemia. This study aims to determine the effects of red fruit oil on reducing parasitemia in mice infected with Plasmodium berghei. This experimental study with a post-test only control group design used 32 mice as samples and divided it into 8 groups (control group (aquadest); chloroquine group 0.5 mg / grBB, red fruit oil group doses of 0.1 cc, 0.2 cc and 0.4 cc; combination group of red fruit oil doses of 0.1 cc, 0.2 cc and 0.4 cc, with chloroquine 0.5 mg/grBB). Research data was processed using Mann-Whitney test and Kruskal Wallis test because the data didn’t meet one way ANOVA test requirements. The results showed effect of red fruit oil on decreasing parasitemia in mice infected with Plasmodium berghei (p
Efek Suplementasi Madu terhadap Penurunan Frekuensi Diare Akut pada Anak di RSUD Dr. H. Abdul Moeloek Bandar Lampung Nidia Putri Meisuri; Roro Rukmi Windi Perdani; Hanna Mutiara; Asep Sukohar
MAJORITY Vol 9 No 2 (2020): MAJORITY
Publisher : Majority

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diarrheal diseases is still health problems of the world with high number of mortality and morbidity. Traditional medicine which has a bitter taste and antibacterial effect, one of which has the effect of antibacterial honey, bitter taste and antioxidants. This study to find out the potential effects of honey supplementation on reducing the frequency of acute diarrhea in children in the Dr. H. Abdul Moeloek. This study used quasi-experimental design with nonequivalent control group design. Subjects of study were children with acute diarrhea who were divided into two intervention groups and control group, each group amounted to 15 respondents. Data obtained directly from research subjects through primery data. From the data obtained then the analysis is performed using unpaired samples t-test. This study indicates the frequency of first-day acute diarrhea of intervention group was more than control group. The frequency of acute diarrhea on the second, third and fourth days in intervention group was less than children who were controls group. The statistical test results show the potential effects of honey supplementation on decreasing frequency of acute diarrhea. Provision of honey supplementation was proven to reduce the frequency of acute diarrhea in the Dr. H Abdul Moeloek Hospital Bandar Lampung.
Training on Processing Banana Peel Waste into Eco-enzyme and Eco-enzyme Soap to Implement Zero Waste in Kunjir Tourism Village Asep Sukohar; Dwi Aulia Ramdini; Citra Yuliyanda Pardilawati; Afriyani Afriyani; Nurhayati Nurhayati
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.233-242.2024

Abstract

Eco-enzyme is one of the solutions for waste organic management to become a higher-value product. As a tourist village, Kunjir village is one of the banana producers, where it needs help with garbage or banana waste from plantations. This waste can damage beauty and pollute the environment. Therefore, this engagement in community activity in waste organic management from banana peels is necessary to implement zero waste and a healthy environment. We aimed to improve the knowledge and skills of the local community in waste management. Banana peels become eco-enzyme and soap that contains eco-enzyme products. The eco-enzyme information was delivered first and then followed by practice or simulation. Twenty-five respondents were dominated by household wives, with ages 31-40 years as much as 36%, 41-50 years 28%, 51-60 years 25%, and 21-30 years 12%. According to the measurement of the initial score, 48% of respondents have good knowledge, and 92% have improved after following the training. We conclude that 44% of the total score of respondents was improved. Through this training, it is hoped that we can improve banana waste processing and improve our skills in processing eco-enzyme organic waste into a liquid rich in benefits, especially as a cleaning agent. This activity is essential in initiating waste management and implementing a healthy environment. Furthermore, it can encourage self-resilience and the development of a tourist village.
Faktor-Faktor yang Mempengaruhi Residif Kanker Payudara Lala Putri Andela; Asep Sukohar; Ari Wahyuni
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4366

Abstract

Breast cancer is a malignant tumor that grows in the breast tissue and invades the area around the breast and can spread throughout the body. Breast cancer is the most frequently diagnosed cancer in women worldwide with 2,26 million new cases and caused 684,996 deaths worldwide in 2020. Breast cancer is ranked fifth as the loading cause of cancer death. The first rank is occupied by lung cancer. Meanwhile, in women, breasr cancer is the main cause of death due to cancer. The presence of a lumo or thickening in the breast is the most common sign and symptom, while signs and symptoms of advanced breast cancer include sunken skin, retraction or deviation of the nipple and pain, tenderness or bleeding from the nipple. Breast cancer treatment has changed over the years, both surgically and medically. Different surgical approaches to treat breast tumors include mastectomu alone or with reconstruction, either primary or delayed or Breast Conserving Therapy (BCT) aimed at reducing the risk of local postoperative recurrence. A recurrence can be characterized by weight loss, shortness, fatigue, jaundice, easy bruising or bleeding, loss of appetite, difficulty swallowing, blood in the urine or stool, and the presence of new lumps.
KAJIAN LITERATUR : FAKTOR – FAKTOR YANG MEMENGARUHI KETERSEDIAAN OBAT DI PUSKESMAS Diva Meylia; Rasmi Zakiah Oktarlina; Nurma Suri; Asep Sukohar
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 14 No. 2 (2025): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5455/nutricia.v14i2.11860

Abstract

Ketersediaan obat di Puskesmas merupakan aspek krusial dalam pelayanan kesehatan. Kajian literatur ini bertujuan untuk mengidentifikasi faktor-faktor yang memengaruhi ketersediaan obat di Puskesmas. Metode yang digunakan adalah kajian literatur dengan pencarian artikel menggunakan database Google dan Google Scholar. Kriteria inklusi meliputi artikel yang dipublikasikan tahun 2012-2025 berbahasa Inggris atau Indonesia dan tersedia dalam bentuk full paper yang dapat diakses dengan mudah. Hasil kajian dari 10 artikel yang dianalisis menunjukkan bahwa ketersediaan obat di Puskesmas dipengaruhi oleh beberapa faktor utama yakni metode perencanaan yang tepat, efisiensi sistem pengelolaan, sistem dan prosedur yang terstandarisasi, monitoring tingkat ketersediaan, peran aktif pengelola obat dan dokter, kualitas pendampingan dan supervisi, interaksi antar pemangku kepentingan serta kualitas pelayanan. Disimpulkan bahwa ketersediaan obat dipengaruhi oleh berbagai faktor yang saling terkait dan membutuhkan perbaikan simultan pada semua aspek. Sehingga optimalisasi ketersediaan obat dapat tercapai.
Risk Factors Causing Overweight and Obesity in Children and Adolescents Putri Nabilla Rachmadini; Ervina Damayanti; Citra Yuliyanda Pardilawati; Asep Sukohar
Jurnal EduHealth Vol. 16 No. 01 (2025): Jurnal EduHealt, Edition January - March, 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Child and adolescent obesity is an increasing global health problem. It has long-term impacts, including an increased risk of non-communicable diseases such as diabetes, hypertension and cardiovascular disorders in adulthood. This study aims to identify risk factors that contribute to obesity in children and adolescents. The meta-analysis used was a literature review through Science Direct, Pubmed, and Google Scholar databases. A total of 59 articles were identified and 18 articles published between 2018 and 2024 that met the inclusion and exclusion criteria were included in this study. The data obtained showed that the main risk factors included unhealthy eating habits, minimal physical activity, as well as the influence of genetic factors, excessive use of electronic devices, and unsupportive social and family environments. In addition, economic and cultural factors also play an important role in influencing eating habits and physical activity. In conclusion, childhood and adolescent obesity is caused by a complex interaction between individual, environmental and social factors. Prevention efforts require a multidisciplinary approach that focuses on education, promotion of healthy lifestyles, and support from the social environment .
Co-Authors AB Witarto Ade Marantika Afna Nur Afni Palogan Afriyani Afriyani Agustina Rajendra Putri Ahmad Syah Putra Airlangga Damara Ambarwati, Endah Annisa Tamara Panjaitan Ari Wahyuni Arief B Witarto Aulia Ghina Sabila Cantika Tara Sabilla Chintia Dwi Tanasa Citra Yuliyanda Pardilawati Danang hafizfadillah Denny Habiburrohman Dhia Insyirah Antoni Dina Tri Amalia Diva Meylia DWi Aulia Ramdini Dwita Oktaria Efriyan Imantika Eka Ananda Laksana Putri Elma Sandya Putri Ervina Damayanti Evi Kurniawaty FF Wirakusumah H Herawati Hanna Mutiara HENING HERAWATTI Hs Sastramihardja Iswandi Darwis Jhons Fatriyadi Suwandi Junando, Mirza Karimah Ihda Husnayain Khairun Nisa Lala Putri Andela Lani Hartanti Linda Septiani Mallarangeng, Andi Nafisah Tendri Adjeng Merry Indah Sari Muhammad Maulana Muhammad Ricky Ramadhian Muhammad Rifki Pratama Mutiara Nauli Br. Sitinjak Nidia Putri Meisuri Novita Carolia Nurhayati Nurhayati Nurulia Astri Oktafany, Oktafany Oktoba, Zulpakor Putra, Pandya Fisatama Putri Nabilla Rachmadini Ramdini, Dwi Aulia Rasmi Zakiah Oktarlina Reval Hidayat Rika Lisiswanti Risti Graharti Roro Rukmi Windi Perdani, Roro Rukmi Setiawan - Silvia Sekar Ardi Nurjana Suharmanto Suharmanto Sultan Mahathir Bastha Suri, Nurma TA Larasati Tiwuk Susantiningsih Tri Umiana Soleha Vania Putri Risyhade Zahra Nur Sa'diyyah Zihan Zetira