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All Journal Jurnal Veteriner Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Hesti Wira Sakti Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Keluwih: Jurnal Kesehatan dan Kedokteran Sainstech Farma: Jurnal Ilmu Kefarmasian Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Bina Pengabdian Kepada Masyarakat Jurnal Inkofar Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Indonesian Journal of Cancer Jurnal Farmasi Sains dan Praktis SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Mestaka: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Bangsa Herbal Medicine Journal GEMBIRA (Pengabdian Kepada Masyarakat) PEDAMAS (Pengabdian Kepada Masyarakat) Borneo Journal of Pharmacy Science and Technology: Jurnal Pengabdian Masyarakat JCSE: Journal of Community Service and Empowerment Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Jurnal Kefarmasian Indonesia Journal of Tropical Pharmacy and Chemistry Masyarakat: Jurnal Pengabdian
Teodhora, Teodhora
Fakultas Farmasi, Institut Sains Dan Teknologi Nasional, Jakarta
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Ekspresi Glukosa Transporter-2 di Sel Beta Pankreas dan Sel Hepatosit Tikus yang Diinduksi Diabetes Mellitus teodhora teodhora
Pharmaceutical Journal of Indonesia Vol. 6 No. 2 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.006.02.9

Abstract

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This disease is based on classification related to pancreatic damage in total or partial so that the impact on insulin production. Glucose transporter is a protein that can glucose uptake from outside cell into cell and provides an important role in the body's glucose homeostasis. Glucose transporter-2 (GLUT-2) is found in the pancreas, liver, and kidney. Parameters used are the expression and amount of GLUT-2 density in pancreatic β cells and in hepatocyte cells in normal and diabetic Rat. Used Wistar strain male white rats. An immunohistochemistry (IHC) staining technique was performed to observe the expression of GLUT-2 and the macbiophotonics image J program to determine total density of GLUT-2. GLUT-2 is marked in brown in the cell nucleus surrounded by cytoplasm. The results showed an increased in GLUT-2 expression in hepatocyte cells with a total density of 25,447,052 and a decreased in GLUT-2 expression in pancreatic β cells with a total density of 5,074,544 by Streptozotocin 50 mg/kg BB-Nicotinamide 100 mg/kg BB (STZ-NA) Intraperitonial routes in induced DM rat. STZ-NA induced triggers damage in pancreatic β cells and significantly influences the expression of GLUT-2 protein. High blood glucose levels give different GLUT-2 activity in hepatocyte cells due to the effects of induced agent.
Co-Authors Agung Endro Nugroho Ainun Wulandai Ainun Wulandari Akhatik, Nurul Amalia Khoirunnisa Andini, Issri Mila Nova Annisa Aulia Rahmawati Arsa, Imalia Aulia Rahimi Azizah, Shandy Barakatun Nisak Chori Azizah Dea Selia Devi Purwita Sari Dienillah, Qonita Dini Juliana Diny Auliya Mawarni Djuhariah, Yayah Siti Dwi Okta Mellya Eka Putri Maliawati Elva Asrida Sipayung Elzius Fransiscus Lumban Gaol Erna Yanti Erwi Putri Setyaningsih Eva Oktavia Fathin Hamida Febriani , Amelia Febriani, Amelia Firdaus Firdaus Fitria Rahayu Fitria Yustisiani Gaol, Elzius Fransiscus Lumban Gunawan Pamudji Widodo Herdini Herdini , Herdini Hervianti Nurfitria Nugrahani Hirim Hotma Uli Aprianis Ika Maruya Kusuma Jaya, Rendy Indra Jessica Khairunnisa Karina Sinungan, Ulfa Mutia Kinanthi Kusumawardhani Krisnawati, Indah Kusuma , Ika Maruya Kusuma, Ika Maruya Lestiana, Elina Lidia Anggita Ramadhani Lili Musnelina Maigoda, Tonny Cortis Maliawati, Eka Putri Manalu, Rosario Trijuliamos Marsa Falihah Muh. Faris Hidayat Muhammad Furqan Mulandita Munawarohthus Sholikha Munawarohthus Sholikhah Musnelina , Lili Ni’matul Khoeriyah Nopianti, Hermila Nugrahani, Hervianti Nurfitria Nurul Akhatik Pontoan, Jenny Pratiwi Ally Florentina Pratiwi, Ritha Widya Pujiastuti, Fitria Putri, Elvina Triana Rachmatiah, Tiah Ratna Nilam Cahya Refdanita Refdanita Refdanita Refdanita Refdanita Refdanita Refdanita Risma Eka Putri Ritha Widyapratiwi Rogahang, Preisilia Rosario Trijuliamos Manalu Rosario Trijuliamos Manalu Saiful Bahri Saiful Bahri Saputra, Richi Andika Setiadi, Fandy Rezha Shella Utami Sholikhah , Munawarohthus Sister Sianturi Siswati Siswati Siti Fadila Azahra Soehartati, Tri Sonia Mutiara Subaryanti Subaryanti, Subaryanti Suci Tiara Syafriana, Vilya Tanama, Celin Gracela Teti Indrawati Teti Indrawati Tiah Rachmatiah Tri Soehartati Veryanti, Putu Rika Welisa, Selfina Junita Widyapratiwi , Ritha Widyapratiwi, Ritha Windiarto, Henriko Suryo Wulandari , Ainun Yayah Siti Djuhariah Yunisa Simehete Zabitha Zahwa Zahra, Aishah Az