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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Meditory : The Journal of Medical Laboratory Klinikal Sains (Jurnal Analis Kesehatan) Jambura Journal of Health Sciences and Research Jurnal Medika Malahayati Husada Mahakam: Jurnal Kesehatan JURNAL ANALIS LABORATORIUM MEDIK Borneo Journal of Medical Laboratory Technology Medicra (Journal of Medical Laboratory Science/Technology) Health Care : Jurnal Kesehatan Jurnal Kesehatan dan Pembangunan Jurnal Kesehatan Tambusai Jurnal Sains dan Kesehatan Borneo Journal of Science and Mathematics Education Journal of Sustainability Science and Technology Gema Kesehatan
Kesuma, Suryanata
Poltekkes Kemenkes Kalimantan Timur
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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GAMBARAN KADAR CRP PADA MENCIT ALERGI SETELAH TREATMENT INFUSA DAUN KETEPENG Firmansyah, Adi; I Gede Andika Sukarya; Suryanata Kesuma
Jurnal Kesehatan dan Pembangunan Vol 14 No 1 (2024): Jurnal Kesehatan dan Pembangunan
Publisher : LPPM STIKes Mitra Adiguna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52047/jkp.v14i27.269

Abstract

Allergy is a hypersensitivity reaction that arises due to exposure to allergens. Allergens will bind to IgE attached to mast cells and cause these cells to release various chemicals in the blood. One of them is, histamine which causes most allergic reactions. Allergic reactions can cause inflammation or inflammation. Inflammatory stimulation will later stimulate the release of C-Reactive Protein (CRP). CRP is an inflammatory maker that is produced and synthesized in the liver. Ketepeng leaf infusion has the potential to stimulate an immune response because it contains chemical compounds, namely alkaloids, saponins, flavonoids, tannins, and anthracino. Flavonoids contained in this plant function to provide anti-inflammatory, antiallergic, antioxidant and antifungal effects. The purpose of this study was to determine the effectiveness of ketepeng leaves (Cassia alata L) by examining CRP (C-Reactive Protein) levels in Ovalbumin-allergic mice (Mus musculus). This type of research is Univariate, which is a method for making an overview of the state of the object being examined through data or sampling samples. The results of this study found that in group 2 after being given ovalbumin, CRP levels increased by 181.33 mg/L and in group 3, after being given ketepeng leaf infusion, CRP levels decreased by 48 mg/L. The conclusion of this study is that ketepeng leaf infusion can reduce CRP levels in mice with ovalbumin allergy and there is an effect of increasing CRP levels in mice given ovalbumin of 181.33 mg/L and a decrease in CRP levels after the treatment of ketepeng leaf infusion of 48 mg/L .
Evaluasi Pemeriksaan Kreatinin dengan Penundaan 12 Jam pada Pasien Diabetes Melitus Kesuma, suryanata; Eka Farpina, Eka Farpina; Sultan, Sultan
Jurnal Sains & Kesehatan Vol 3 No 1 (2024): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v3i1.264

Abstract

Clinical laboratories must always pay attention to the quality of service and quality of examination. The clinical laboratory will provide information in the form of examination results to clinicians so that they can be used to make a diagnosis and follow up treatment of patients. Clinicians always expect the results of the examination to be precise and accurate according to the patient's condition at that time. Examination results and precise measurements can minimize errors in determining the diagnosis of the patient's disease at that time. The purpose of this study was to find out the clinical differences in delaying immediate and delayed 12-hour creatinine checks in patients with diabetes mellitus. The type of research used in this research is descriptive, the specimens used are serum, the data collection technique uses primary data, Mindray Chemistry Analyzers BS240, data processing in this study uses MicrosoftExcel. The results of this study showed an average of 0.9 mg/dL on immediate examination and a 12-hour delay of 0.6 mg/dL. The accuracy (d%) of the immediate creatinine check against a 12-hour delay was -24.8%. Precision (CV%) on immediate creatinine examination against a 12-hour delay of 20.0% andtotalerror on immediate creatinine examination against a 12- hour delay of 64.8%. Based on these results indicate that there are differences   in   clinical   results   in   the   immediate   creatinine examination and a delay of 12 hours.
Evaluasi Pemeriksaan Kreatinin Dengan Penundaan 12 Jam Pada Pasien Diabetes Melitus: Evaluation Of Creatinine Screening With 12-hour Delay In Diabetes Mellitus Patients Suryanata Kesuma; Eka Farpina; Sultan Sultan
Borneo Journal of Medical Laboratory Technology Vol. 6 No. 2 (2024): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v6i2.7096

Abstract

Laboratorium klinik harus selalu memperhatikan mutu pelayanan dan mutu pemeriksaan. Laboratorium klinik akan memberikan informasi berupa hasil pemeriksaan kepada para klinisi sehingga dapat digunakan untuk menegakkan diagnosis dan tindak lanjut pengobatan terhadap pasien. Para klinisi selalu mengharapkan hasil pemeriksaan merupakan hasil yang tepat dan akurat sesuai dengan kondisi pasien saat itu. Hasil pemeriksaan dan pengukuran yang tepat dapat memperkecil kesalahan dalam menentukan diagnosis penyakit yang diderita pasien saat itu. Tujuan penelitian ini adalah mengetahui perbedaan klinis penundaan pemeriksaan kreatinin segera dan ditunda 12 jam pada pasien diabetes melitus. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif, spesimen yang digunakan adalah serum, teknik pengumpulan data menggunakan data primer, data diperoleh dengan melakukan pemeriksaan kadar kreatinin menggunakan alat Chemistry Analyzer Mindray BS240, pengolahan data pada penelitian ini menggunakan Microsoft Excel. Hasil dari penelitian ini didapatkan rata-rata pada pemeriksaan segera sebesar 0.9 mg/dL dan penundaan 12 jam sebesar 0.6 mg/dL. Akurasi (d%) pada pemeriksaan kreatinin segera terhadap penundaan 12 jam sebesar -24.8%. Presisi (CV%) pada pemeriksaan kreatinin segera terhadap penundaan 12 jam sebesar 20.0% dan total error pada pemeriksaan kreatinin segera terhadap penundaan 12 jam sebesar 64.8%. Berdasarkan hasil tersebut menunjukkan bahwa adanya perbedaan hasil secara klinis pada pemeriksaan kreatinin segera dan penundaan selama 12 jam.
EVALUASI PENGGUNAAN SERUM DAN PLASMA YANG DISIMPAN PADA TABUNG CLOTING ACTIVATOR DAN NAF SELAMA 6 DAN 24 JAM PARAMETER GLUKOSA DARAH Dwi Setiyo Prihandono; Suryanata Kesuma; Effie Raissa Widyadari
Jambura Journal of Health Sciences and Research Vol 6, No 3 (2024): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i3.21870

Abstract

Pemeriksaan laboratorium klinik akan memiliki mutu yang baik apabila ketepatan (akurasi) dan ketelitiannya (presisi) juga baik. Salah satu parameter pemeriksaan yang dilakukan di laboratorium adalah pemeriksaan kadar glukosa darah. Kebaruan dari penelitian ini karena meneliti tentang evaluasi penggunaan serum dan plasma yang disimpan pada tabung cloting activator dan NaF selama 6 dan 24 jam parameter glukosa darah. Tujuan penelitian ini untuk menganalisis rata-rata persentase penurunan, akurasi, presisi, dan total error pada pemeriksaan glukosa menggunakan tabung cloting activator dan tabung NaF selama segera, 6, dan 24 jam. Sampel dalam penelitian ini adalah darah mahasiswa jurusan teknologi laboratorium medis Poltekkes Kemenkes Kaltim sebanyak 40 spesimen. Data hasil diolah menggunakan aplikasi Microsoft excel. Hasil penelitian ini didapatkan rata-rata persentase penurunan tabung cloting activator 6 dan 24 jam sebesar 17,2% dan 24%. Rata-rata persentase penurunan tabung NaF 6 dan 24 jam sebesar 14,3% dan 20,9%. Akurasi pemeriksaan glukosa menggunakan tabung cloting activator 6 jam terhadap tabung cloting activator segera, tabung cloting activator 24 jam terhadap tabung cloting activator segera, tabung NaF 6 jam terhadap tabung NaF  segera, tabung NaF 24 jam terhadap tabung NaF segera sebesar -17,2%, -24.1%, -14.4%, dan -21.0%. Presisi pemeriksaan sebesar 8,3%, 10,6%, 7,2%, dan 7,3%. Total error pemeriksaan sebesar 33,5%, 44,7%, 28,7%, dan 35,4%. Kesimpulan bahwa terdapat perbedaan klinis pada pemeriksaan glukosa menggunakan tabung cloting activator dan tabung NaF selama 6, dan 24 jam. 
Design, Construction and Expression of Spike Highly Conserved Region (HCR) SARS-CoV-2 and Cholera Toxin Subunit B Fusion Protein in Lactococcus lactis NZ3900: Construction of recombinant plasmid in Lactococcus lactis Kesuma, Suryanata; Adianingsih, Oktavia Rahayu; Winarsih, Sri; Widodo, Nashi; Yurina, Valentina
Journal of Tropical Life Science Vol. 15 No. 2 (2025): In Press
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/2xf1qp96

Abstract

Prevention of SARS-CoV-2 transmission has primarily been achieved through vaccination, which is generally administered via injection and may cause discomfort. No commercially available SARS-CoV-2 vaccines can be administered via the mucosal route. However, recent advancements have demonstrated that vaccination with Lactococcus lactis enables vaccine delivery through the mucosa. A promising target for SARS-CoV-2 vaccine materials is the highly conserved region (HCR) of the SARS-CoV-2 spike (SARS-CoV-2 HCR Spike). Vaccine efficacy is enhanced by adding Cholera Toxin Subunit B (CTB) as an adjuvant. HCR and CTB proteins were recombinantly fused using a synthetic gene with optimized codons. This study aimed to construct a fusion protein of the SARS-CoV-2 spike protein and CTB in L. lactis strain NZ3900. The construction and expression of fusion proteins were analyzed using sequencing and protein electrophoresis. Codon optimization resulted in a Codon Adaptation Index value of 0.93 and a GC content of 27.06%. The cloning results revealed the formation of L. lactis colonies expressing the Fusion protein of the SARS-CoV-2 HCR Spike and CTB, which formed yellow colonies on the selection Elicker medium. PCR and sequencing confirmed the presence of the hcr-ctb gene, with a length of 981 bp and 100% sequence similarity. The Fusion protein of the SARS-CoV-2 HCR Spike and CTB was successfully expressed with a molecular weight of >35 kDa. In conclusion, we successfully constructed a Fusion protein of the SARS-CoV-2 HCR Spike and CTB in L. lactis NZ3900 as a potential vaccine candidate for oral administration to prevent SARS-CoV-2 infection.
Co-Authors Adi Firmansyah Agus Rudi Hartono Agus Rudi Hartono Amalia Diah Suci Rahmah Anggrieni, Nurul Armiah Gita Anggraini DESI WAHYUNI Didi Irwadi Dwi Setiyo Prihandono Dwi Wulan Sari Effie Raissa Widyadari Eka Farpina Eka Farpina, Eka Farpina Elita Octavia Farhan Baehaki I Gede Andika Sukarya Irawiraman, Hadi Lamri Lamri Lamri Lamri Liah Kodariah Mahdiah Syumarliyanty Marezha Aulia Putri Sugiarsono Maulida Maulida Julia Saputri Nanda Nur Adha Sari Febriyanti Nashi Widodo Nia Ardelia Nursalinda Kusumawati Nurul Alidasyah Nurul Hikmah Oktavia Rahayu Adianingsih Patricia Aleksandra Putri Sekar Sari Rahmad Rezaldy Silvi Marshela Siti Rodiyah Sresta Azahra Sri Winarsih Sultan Sultan Sultan Sultan Suparno Putera Makkadafi Suparno Putera Makkadafi Supri Hartini Tatang Abdullah VALENTINA YURINA