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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan MPI (Media Pharmaceutica Indonesiana) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Biodjati Jurnal Biologi Tropis SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan MATAPPA: Jurnal Pengabdian Kepada Masyarakat JOPS (Journal Of Pharmacy and Science) Jurnal Serambi Engineering Surya Abdimas PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmu Kesehatan Jurnal Riset Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian BERNAS: Jurnal Pengabdian Kepada Masyarakat BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Farmagazine Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Journal of Tropical Food and Agroindustrial Technology Jurnal Farmasi Sains dan Praktis Journal of Biotechnology and Natural Science Jurnal Pengabdian Masyarakat Kesosi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Jurnal Abdimas Mahakam Journal of Pharmascience
Paula Mariana Kustiawan
Universitas Muhammadiyah Kalimantan Timur
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Uji Aktivitas Antioksidan Madu Lebah Kelulut (Heterotrigona itama) Asal Samarinda Menggunakan Metode DPPH (2,2-diphenyl-1-picrylhydrazil) Ainul Andriani; Rendri Arista Avimaro; Paula Mariana Kustiawan
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.25326

Abstract

Radiasi ultraviolet, polusi udara, dan asap rokok dapat memicu pembentukan radikal bebas yang disebut juga Reactive Oxygen Spesies (ROS). Oleh karena itu, diperlukan senyawa antioksidan yang dapat meredam efek negatif dari radikal bebas. Salah satu bahan alam yang mengandung antioksidan adalah madu lebah kelulut. Madu kelulut (Heterotrigona itama) asal Samarinda masih sedikit dilakukan kajian. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan madu H. itama yang berasal dari Samarinda, Kalimantan Timur. Metode yang digunakan adalah pengujian uji tabung fitokimia untuk mengetahui golongan senyawanya dan metode DPPH (2,2-diphenyl-1-picrylhydrazyl) menggunakan spektrofotometri UV-Vis untuk uji antioksidannya. Hasil penelitian menunjukkan bahwa madu H. itama mengandung metabolit sekunder seperti flavonoid, tannin, dan alkaloid serta nilai IC50 sebesar 44,82 ppm dimana masuk dalam kategori mengandung aktivitas antioksidan kuat. Madu H. itama tersebut memiliki potensi dikembangkan menjadi alternatif dalam menjaga daya tahan tubuh dari radikal bebas.
Exploring Antidiabetic Properties of Stingless Bee Pollen and Kasturi Mango (Mangifera casturi) Leaves: Comparative Review Chantika Noor Khalifah; Paula Mariana Kustiawan
Jurnal Biologi Tropis Vol. 26 No. 2 (2026): April - Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i2.11550

Abstract

The absence of a comparative biochemical analysis between stingless bee pollen and Mangifera casturi leaves prevents the optimization of their synergistic potential in diabetes management. This study aims to evaluate the bioactive profiles and compare the antidiabetic mechanisms of these dua natural products. The investigation utilized a systematic literature review by retrieving peer reviewed articles from PubMed, Scopus, ScienceDirect, and Google Scholar. The selection process followed the PRISMA 2020 framework to ensure a transparent and reproducible screening of literature. Data analysis involved a comparative thematic synthesis to evaluate the correlation between phytochemical groups and glycemic control. Results demonstrate that both materials share homologous flavonoid compounds that improve insulin sensitivity and mitigate oxidative stress. Stingless bee pollen provides superior pancreatic β cell protection while Mangifera casturi shows higher inhibition of carbohydrate hydrolyzing enzymes. This study concludes that both materials offer significant antidiabetic efficacy through complementary molecular pathways. These findings provide a scientific foundation for the development of evidence based complementary medicine. Future research should prioritize clinical trials to determine the optimal dosage for human application.
Identification of Secondary Metabolites and Antibacterial Activity of Non Polar Fraction from Heterotrigona itama Propolis Aziz, Abdul; Yuliawan, Veggy Nadya; Kustiawan, Paula Mariana
Journal of Fundamental and Applied Pharmaceutical Science Vol. 2 No. 1 (2021): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v2i1.12406

Abstract

Propolis is one of the natural products produced by kelulut bees and is still not widely used. The type of stingless bee that is the prima donna in the community is Heterotrigona itama. This study aims to determine the phytochemical content of the n-hexane fraction of Heterotrigona itama bee propolis collected from Kutai Kartanegara, East Kalimantan. The n-hexane fraction was obtained from the methanol extract of H. itama propolis by the liquid-liquid partition method. After obtaining the n-hexane fraction, the research continued with a qualitative phytochemical test to identify the compound and determine total phenolic. Antibacterial activity was determined by the agar well diffusion method with a serial concentration in Escherichia coli bacteria. Qualitative phytochemical analysis in the form of color changes showed that the n-hexane fraction of H. itama propolis contained flavonoids, alkaloids, saponins, and tannins. Based on the results, the total phenolic content of the n-hexane fraction sample was 490 mgGAE/100 g. It caused the n-hexane fraction to have lower phenolic content than the methanol extract (792 mg GAE100 g). Furthermore, this result indicated that the non-polar fraction was not substantial enough to extracted phenolic compounds. It correlated to the antibacterial activity of the n-hexane fraction, which was very weak (2  mm ± 1.5) at  200µg/mL concentration.
Formulation and Evaluation of a Combination Gel of Singkil Leaves Extract and Stingless Bee Propolis for Burns Armia, Argadhika Rizqy; Pramesthi, Asri Dwi Endah Dewi; Kustiawan, Paula Mariana
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.28439

Abstract

Burn injuries remain a significant public health concern due to high morbidity and risk of complications. Natural products such as Singkil leaves (Premna corymbosa Rottl. & Willd.), rich in flavonoids, and stingless bee propolis (Heterotrigona itama), recognized for their anti-inflammatory, antioxidant, and antimicrobial activities, demonstrate potential to enhance wound repair. This study aimed to formulate a topical gel combining both extracts and to evaluate its physicochemical characteristics and in vivo burn wound-healing activity. Three gel formulations with different extract ratios were prepared and assessed for organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesion, and syneresis. Burn wound healing was evaluated using male Wistar rats. Overall, all formulations fulfilled the physicochemical requirements for topical gels and demonstrated satisfactory physical stability. Formula F1 (75% propolis:25% Premna corymbosa) exhibited the lowest viscosity and acceptable spreadability. Formula F2 (50:50) provided the most balanced rheological profile, with the highest spreadability among all formulations. Meanwhile, Formula F3 (25% propolis:75% Premna corymbosa) showed the greatest adhesion and superior burn wound-healing activity, reducing wound diameter by 42.43%, a result statistically comparable to the positive control. These findings suggest that increasing the proportion of Premna corymbosa extract contributed positively to biological activity while maintaining suitable physicochemical characteristics. These findings indicate that the combined extract gel possesses strong potential as a natural topical therapeutic candidate for burn wound management.
Peningkatan Pengetahuan dan Perilaku Hidup Bersih dan Sehat dalam Upaya Pencegahan Kecacingan pada Anak Sekolah SD 015 Samarinda Ulu Mistahul Khalil Gibran; Rendra Kurniawan; Nur Fadhilah; Nurwandah Muftadah; Aulia Rahman; Nurhikmah Nurhikmah; Paula Mariana Kustiawan
Jurnal Pengabdian Masyarakat Kesosi Vol. 9 No. 1 (2026): Januari: Jurnal Abdimas KESOSI
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesetiakawanan Sosial Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/abdimas.v9i1.398

Abstract

Worm infections remain a common health issue among elementary school-aged children in Indonesia, especially in environments where the implementation of Clean and Healthy Living Behaviors (PHBS) is not optimal. This community service activity aims to improve knowledge and PHBS behaviors as an effort to prevent worm infections among students at SD Negeri 015 Samarinda Ulu. The activity was carried out using a participatory-educative approach through several stages: coordination with the school, interactive counseling using educational media, hand-washing demonstrations following WHO guidelines, and evaluation through pre-test and post-test. The results showed a significant increase in the students' knowledge levels. Before the activity, most students were in the medium and low knowledge categories, which then significantly increased to 92.8% in the high category after health education was provided. In addition to the knowledge improvement, this activity also encouraged positive behavioral changes, such as the habit of washing hands before meals and after activities, as well as regularly maintaining nail hygiene. Overall, this activity proved effective in raising awareness, shaping attitudes, and strengthening healthy living behaviors from an early age in elementary school children as a preventive measure against ongoing worm infections in the community.
Co-Authors Aat Arafat Abdul Aziz Abdul Aziz Abdul Aziz Abdullah, Nur Laras Suci Adimas Dwi Tyassandi Agnes Monica Ahmad Suwandi Ahmad Suwandi Ainul Andriani Aisyah Amalia Aisyah Nabila Aisyah, Novia Misnawati Aisyiyah, Novia Misnawati al farauqi, Mohamad dziqie aulia Al Khairy Siregar , Khalish Arsy Aldo Pratama Alfin Syahrian Dwi Nugraha Amilia, Andini Nur Andini Nur Amilia Anis Siti Nurrohkayati Anisa Rahmadani Annisa Aulia Annisa Nurul Safitri Arbainsyah Arbainsyah Armia, Argadhika Rizqy Aryantinur Azizah Asmiranda Agustinur Aulia Rahman Ayu Mentari, Ika Azzah Fatimah Zulfa Azzah Fatimah Zulfa Azzah Fatimah Zulfa Bambang Mego Hantoro Basyir, Ahmad Bunga Putri Sari Chaerul Fadly Mochtar Chairin Hanifa , Deasy Nur Chanchao, Chanpen Chantika Noor Khalifah Clara Vinny Amalia Deasy Nur Chairin Hanifa Deasy Nur Chairin Hanifa Defi Lusi Anggraeni Deswita Maharani Dewi , Dea Puspita Dinata, Reviana Amalia Diniatik Egi Liani Puspita Evita Novi Yanti Fadhillah, Reza Nur Fauziah, Fenty Fauziyah, Nur Fenty Fauziah Frederika Erwina Rani Hairunnisa, Indah Halida Suryadini Harlinda Kuspradini Helni Helni Ichsan, Muhammad Nor Ika Ayu Mentari Indah Hairunisa Irfan Muris Setiawan Irsa Nur Hanifah Jati Pratiwi Jubaidi Jundy Eko Wahyudi Kafka Navisa Suwarno Khairun Nisa Khalish Arsy Al Khairy Siregar Khalish Arsy Al Khairy Siregar Latipah, Asslia Johar Lestari, Ika Widya Luthfiyah Mega Srikandi Dimar Mardiana Mardiana Meliyana Dwi Pangesti Mistahul Khalil Gibran Muhammad Ali Syahbana Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Alib Batistuta Muhammad Bayu , Radityo Muhammad Nor Ichsan Nanda Daru Wahdini Nindya Ila Syafira Ramelan Norma Lisa Novia Misnawati Aisyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Fadhilah Nur Supianti Nurfadillah, Mursidah Nurhikmah Nurhikmah Nurwandah Muftadah Oktavia Triwanti Pramesthi, Asri Dwi Endah Dewi Pratika, Rika Putri Hawa Syaifie Rabiatul Demiati Ramadhan, Donny Rendra Kurniawan Rendri Arista Avimaro Rendri Arista Avimaro Ressandy, Sylvan Septian Rika Nur Junnah Rika Pratika Rimba Jagat Cahya Purnama Riska Aulia Rizka Humaira Rizki Ramdani Rofidatul Husna Romadhona Suci Adinda Ruly Emi Ruswanti Sabina Guseynova Safitri, Annisa Nurul Salsa Hermadhiyaa Jauzaa Sarah, Aulia Shella Carlina Tasya Sinta Ratna Dewi Siregar, Khalis Arsy Al Khairy Siregar, Khalish Arsy Al Khairy Siska Siska Siti Rahma Siti Sulayha Suwandi, Ahmad Syahbana, Muhammad Ali Syahrul R, Syahrul Syahrul Ramadhan Syaifie, Putri Hawa Sylvan Septian Ressandy Taghfirul Azhima Yoga Siswa Tiara Halidah Ratnasari Tri Purwoningsih Veggy Nadia Yuliawan Veggy Nadya Yuliawan Vera Anitra Vera Herliana Pratiwi Vera Herliana Pratiwi Yanti, Evita Novi Yogi Pratama Yuliawan, Veggy Nadia Yuliawan, Veggy Nadya