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All Journal HAYATI Journal of Biosciences MANAJEMEN HUTAN TROPIKA Journal of Tropical Forest Management Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Primatologi Indonesia Jurnal Sain Veteriner Buletin Peternakan Jurnal Veteriner BIOTROPIA - The Southeast Asian Journal of Tropical Biology Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Penelitian Hutan dan Konservasi Alam Jurnal Sumberdaya Hayati Journal of Tropical Biodiversity and Biotechnology ZOO INDONESIA Biosaintifika: Journal of Biology & Biology Education AL-HAYAT: Journal of Biology and Applied Biology Konservasi Hayati Zoo Indonesia Proceeding Biology Education Conference Makara Journal of Science
DYAH PERWITASARI -FARAJALLAH
Departemen Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Kampus IPB Darmaga, Bogor 16680 Pusat Studi Satwa Primata Institut Pertanian Bogor, Jl. Lodaya II/5, Bogor 16151
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Journal : Jurnal Veteriner

 1 
Variasi Molekuler Gen Reseptor Melanokortin-4 pada Monyet Ekor Panjang I Gusti Agung Arta Putra; Dondin Sajuthi; Dedy Duryadi Solihin; Raden Roro Dyah Perwitasari
Jurnal Veteriner Vol 11 No 3 (2010)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Melanocortin-4 receptor (MC4R) is one of G protein-coupled receptors that plays an important role inregulation of energy homeostasis. MC4R mutations constitute the most common cause of human obesity.The study was conducted in order to investigate the variation of MC4R gene in Macaca fascicularis and itsassociation with obesity as a model of human obesity. Forty eight adult male macaques from Bali (Ubudand Uluwatu), East Java (Alas Purwo and Baluran), and Sumatera island (Palembang) were used in thisresearch. The animals had been anaesthetized using ketamine (10 mg/kg body weight) and xylazine (2mg/kg body weight) before collecting blood samples and phenotypic data (weight, crown rump length. Bloodsamples were used as source of DNA. To determine MC4R variation, coding region of this gene wasamplified and sequenced. The results showed that 20 variations sites were identified and 13 of them werenon-synonymous. Among the non-synonymous mutations, five mutations were only found in obese macaque;two mutations were found both in obese and non-obese macaque; and six mutations were only found in nonobesemacaque .
Co-Authors ACHMAD FARAJALLAH Achmad, Alfiyan Alexander Kurniawan Sariyanto Putera Alexander Nater ALFIYAN, ACHMAD Andi Hiroyuki Andre Pasetha Annawaty Annawaty, Annawaty Annisa Devi Rachmawati Antje Engelhardt Arismayanti Eka Aron Batubara Asri Febriana Auliaputri, Tazkiah Azhari Purbatrapsila Baiq Farhatul Wahidah Bambang Suryobroto Behling, Hermann Chairunas Adha Putra Daisy Wowor, Daisy Dela Putri Amalia DEWI APRI ASTUTI Dondin Sajuthi Ellis Dwi Ayuningsih Entang Iskandar Entang Iskandar Entang Iskandar Entang Iskandar Entang Iskandar Entang Iskandar Entang Iskandar Erni Sulistiawati Fadla, Ilma Nadya Farida, Hilda Fery Dwi Riptianingsih Gholib Hana Intishar Sawitri Hana Intishar Sawitri Hélène Birot Helmi Romdhoni Hilda Farida Huda S. Darusman Huda Shalahudin Darusman Husni Mubarok I Gusti Agung Arta Putra Ibnu Maryanto Iffi Rizkiya Indra Purnama Irmanida Batubara Iskandar , Entang ISLAMUL HADI Jahnk, Svea Lina K.A.I Nekaris Kania Dewi Rafa Katherine Hedger Lhota, Stanislav LILIK BUDIPRASETYO Lisa Michelle Danish Lora purnamasari, Lora Marco Campera Maria Ulfah Mawardha, Fahrun Sahara Michael Krützen Muhamad Ilham MUHAMMAD AGIL Nabila Dhiya Ulhaq Nina Ratna Djuita Nirmala Fitria Firdhausi Novi Mayasari Novita Amalia Novita Anggraeni Nur Rachman Pamungkas, Ilham Hanaan Taqiuddin Pamungkas, Joko PASETHA, ANDRE Pradekso, Nur Aisyah Pratiwi, Intan Ratu Puji Rianti Qomariah, Indira Nurul Ramadhanti, Hanny Ribut, Amat Ridhatul Zuhra RIKA RAFFIUDIN Riki Herliansyah Rini Widayanti Riptianingsih, Fery Dwi Rissa Herawati Ginting Rizaldi Sari, Ruhama Maya Sayusti, Tiara Sese, Moh. Reza Silvy Thiyana Siti Lutvaniyah Sitompul, Rahmadi Sitti Aisyah May Wulandari Sodikin Sodikin Sri Suci Utami Atmoko Sri Sudarmiyati Tjitrosoedirdjo Stanislav Lhota TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN Tommy Langgeng Abimanyu Tommy Langgeng Abimanyu Toulec, Tadeas UUS SAEPULOH Vallen Sakti Maulana Waterman, James O. WIDYASTUTI, SALMAH Winarti, Indah WINDRA PRIAWANDIPUTRA, WINDRA Wira, Dwi Wahyuda Yeni Aryati Mulyani Yuniarti Dwi Astuti