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All Journal JURNAL PENGABDIAN KEPADA MASYARAKAT Universa Medicina JURNAL IBNU SINA BIOMEDIKA Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Abdimas Universal JURNAL ILMIAH MAKSITEK Journal SAGO Gizi dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Cancer Jurnal Kedokteran STM (Sains dan Teknologi Medik)
Delyuzar, Delyuzar
Universitas Sumatera Utara
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Journal : Universa Medicina

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Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats Sunarti Sunarti; Edy Fachrial; Urip Harahap; Delyuzar Delyuzar; Tri Widyawati; Lokot Donna Lubis
Universa Medicina Vol. 36 No. 3 (2017)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.228-235

Abstract

BACKGROUNDNon-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with increased free fatty acids, trans fatty acids and free radical compounds due to the consumption of deep frying oil (DFO). Ginger has hypolipidemic and antioxidant properties, and acts as an insulin sensitizer. The present study was conducted to evaluate the hepatoprotective effect of an ethanol extract of Zingiber officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.METHODSA study of experimental design was conducted involving 24 non-alcoholic steatohepatitis (NASH) male Wistar rats that were randomly divided into 4 groups. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10 ìl/g BW/day. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. The histopathology examination assessed fatty degeneration, and degree of fibrosis. The data were analyzed with the Kruskal-Wallis and Mann-whitney test.RESULTS    The Kruskal-Wallis test showed that fatty degeneration (steatosis, lobular inflammation, hepatocyte ballooning and NASH) were significantly different among the four groups (p<0.05). Mann-Whitney test proved that fatty degeneration was not significantly different between control and treatment groups (p>0.05).CONCLUSIONDeep frying oil increased fatty degeneration and NASH, and none of red ginger rhizome extract doses was able to inhibit fatty degeneration significantly. For the future research it is intended to prolong the induction time and the administration of red ginger rhizome extract.
Co-Authors Alamanda, Intan Nefia Alferraly, Ibnu Alferraly, T. Ibnu Basrul, Mohd. Yuwanda betty betty Chairani, Rizki Chrestela, Jessy Chrestella, Jessy CINDY CLARA AWE Dahlan, Nadjib Dedy Suryadi DITA ANNISA DIARA NASUTION Edi Kerina Sembiring, Edy Fachrial Eka Airlangga Emita Sabri Endang Sjamsudin Erjan Fikri Feby Yanti Harahap Fiandani, Fatma Fitri Dewi Ismida fitriani Lumongga Harahap, Rini Syahrani Hasibuan, Arie Widiansyah HENDRA SUTYSNA Hidayat Hidayat Hidayat Hilda Fitriyani Humairah Medina Liza Lubis Ibnu Alferally Indri Mahrani Indriani Saragih, Septina Intan, T. Kemala Jessy Chrestella Joko S. Lukito Kadri, Sayed Muhammad Kharismawaty, Dina Laksmi, Lidya Imelda Lidya Imelda Laksmi Lita Feriyawati Lokot Donna Lubis Lubis, Fahrurrozi Lubis, Nenni Dwi Aprianti Lukito, Joko S Lukito, Joko S. M. Nadjib D. Lubis Mariedina, Causa Trisna Masriana Masriana, Masriana Muhammad Nadjib D Lubis Muhammad Ramli Nadjib Dahlan Lubis Nasution, Annio Indah Lestari Nugraha, Anshari Dwi Nurcahaya Sinaga Nurlela Nurlela P. Poida B. Gurning Ren Astrid Allail Siregar Reza Aditya Digambiro Rita Juliana Pohan Riza, Ahyar Rizki, Diana Roza Rita S Lukito, Joko S. Lukito, Joko Sihotang, Marisi Cintya Debby sinambela, Roy Herbon Siregar, Ren Astrid Allail Soekimin Soekimin Soekimin Soekimin Soekimin, Soekimin Sri Amelia, Sri Sufitni Sunarti Sunarti Syafruddin Ilyas T Kemala Intan T. Ibnu Alferally T. Ibnu Alferally T. Ibnu Alferraly tengku ibnu alferraly Tri Widyawati Urip Harahap Utami, Tania Mulia