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All Journal Jurnal Dunia Farmasi Best Journal (Biology Education, Sains and Technology) Jurnal Aisyah : Jurnal Ilmu Kesehatan JUKESHUM: Jurnal Pengabdian Masyarakat International Journal of Health and Pharmaceutical (IJHP) Journal of Pharmaceutical and Sciences. Jurnal Sains dan Kesehatan
Rambe, Robiatun
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Examined study of the impact of ethanol extract from Sirih China (Peperomia pellucida L.) ointment on the histological appearance of the epidermis and the duration of burn healing in mice (Mus musculus) Harahap, Armansyah Maulana; Salamah, Salamah; Rambe, Robiatun; Elanda, Yurike; Khairunnisa, Nur Aini; Priawan, Indra
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10460

Abstract

Burns are a condition where there is damage to the epidermis layer down to the dermis layer. The skin structure sustains damage from the epithelium to the basal layer of the dermis. You can use the herbal Chinese pepper (Peperomia pellucida L.) for burn treatment. This study aims to evaluate the impact of administering Chinese betel leaf ointment, with variations in concentration and formula, on the duration of burn wound healing and the diameter of wound closure. Methods There were 30 Mus musculus mice in this study. Divided them into five groups: a regular group without burns, a positive control group that received gentamicin, treatment group 1 that received a low concentration 5% ethanol extract of Chinese betel leaf (EECB) ointment, a treatment group 2 that received a low concentration 10% EECB ointment, and a treatment group 3 that received a high concentration 15% EECB ointment. Results demonstrate wound closure activity by measuring the diameter of burn wounds treated with a 15% concentration of Chinese pepper ointment on the 18th day and a 15% concentration closed the burn wound. Histopathological differences were seen in the K3 group, where collagen density scored +3 (±0.06). We found a very weak positive correlation (0.000) between histopathology (collagen) and wound diameter and a strong negative correlation (-0.0527) between the histopathological parameter (collagen) and the duration of burn wound healing. Conclusion. The research concludes that the effectiveness of administering Chinese betel leaf ointment with a concentration of 15% was obtained
Co-Authors Affan Silalahi, Ali Aini Khairunnisa, Nur Andi Syahputra, Ricky ASWAN PANGONDIAN Athaillah, Athaillah Chandra, Putra Elanda, Yurike Fithri Pulungan, Ainil Gabena Indrayani Dalimunthe Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Harahap, Armansyah Maulana Hura, Arlitus Khairunnisa, Nur Aini Lestari, Amanda Putri Lusia Simatupang, Lenny Maulida Lubis, Roqayyah Monalisa, Anggi Muhammad Taufik Daniel Hasibuan Priawan, Indra Rahma Dona, Rahma Ridwanto Ridwanto Saddam Husein, Saddam Sakira, Dila salamah salamah Sartika Daulay, Anny Sugito - Virnoldi, Ukti Yahya Gulo, Trifani Ziza Putri Aisyia Fauzi Zulmai Rani