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Eneng Elda Ernawati
Universitas Mathla'ul Anwar
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Aphrodisiac Effects of Ethanolic Extract from White Ginger Rhizome (Zingiber officinale Rosc. var. officinarum) on Male Wistar Rats Oktavia, Swastika; Ernawati, Eneng Elda; Putra, Anca Suryadi
JST (Jurnal Sains dan Teknologi) Vol. 13 No. 3 (2024): Oktober
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jstundiksha.v13i3.84670

Abstract

Erectile dysfunction (ED) is a common condition marked by difficulty maintaining a penile erection, often linked to reduced nitric oxide (NO) production. This study investigates the aphrodisiac properties of ethanolic white ginger extract (Z. officinale Rosc. var. officinarum) in male Wistar rats. Sixteen male and sixteen female rats were divided into four groups: two groups received 25% and 50% ginger extract, one served as a negative control, and the other as a positive control using sildenafil. Ginger rhizomes were dried, powdered, and extracted with ethanol. Phytochemical analysis revealed alkaloids, flavonoids, tannins, saponins, and terpenoids. Behavioral parameters, including introduction (approach to females), climbing, and coitus, were observed to evaluate sexual activity. The group treated with 50% ginger extract showed the highest frequency of introduction and climbing, while the sildenafil group exhibited the highest coitus frequency. Statistical analysis using the Kruskal-Wallis test indicated significant differences in sexual behavior across the groups. The study suggests that white ginger extract, especially at higher concentrations, may have aphrodisiac effects by enhancing sexual behavior in male rats. This could be due to its bioactive compounds affecting hormone levels or the nervous system. The findings propose white ginger as a potential natural treatment for ED, with further research required to explore its implications in humans.
SERUM ANTIAGING KOMBINASI EKSTRAK BUAH CEREMAI (Phyllanthus acidus L. SKEELS) DAN KULIT BUAH SEMANGKA (Citrullus lanatus THUNB.) Ernawati, Eneng Elda; Suryani, Nani; Nuramalia, Sifa; Rudiana, Tarso
Pharmacoscript Vol. 7 No. 1 (2024): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v7i1.1530

Abstract

Kulit dapat mengalami penuaan atau aging yang didefinisikan sebagai hilangnya keseimbangan homeostatik suatu organisme secara progresif. Indikator aging diantaranya keberadaan hyperpigmentasi yang disebabkan oleh enzim tyrosinase. Banyak Cara yang dapat dilakukan untuk  mencegah aging adalah dengan melakukan perawatan kulit menggunakan serum antiaging. Senyawa bioaktif dari tanaman berkembang dan populer untuk digunakan sebagai bahan kosmetik dalam formulasi karena banyak dilaporkan mengandung vitamin, antioksidan, minyak essensial, protein, senyawa fenolik, dan zat aktif lainnya. Buah Ceremai (Phyllantus acidus) diidentifikasi mengandung senyawa asam glikolat dan asam sitrat, sedangkan kulit buah semangka (Citrullus lanatus) mengandung saponin, tanin, alkaloid dan flavonoid. Tujuan penelitian ini adalah untuk membuat formulasi serum  antiaging  dari kombinasi buah ceremai (Phyllantus acidus) dan ekstrak kulit buah semangka (Citrullus lanatus) sebagai inhibisi enzim tirosinase. Penelitian ini  meliputi pengujian aktivitas ekstrak dan sediaan serum terhadap inhibisi enzim tirosinase dengan metode in vitro menggunakan ELISA. Hasil penelitian aktivitas inhibisi enzim tirosinase ekstrak buah ceremai menunjukan nilai IC50 sebesar 9.551 µg/mL dan ekstrak kulit buah semangka 3.304 µg/mL. Inhibisi enzim tirosinase serum F1 mendapatkan nilai IC50  1.137 µg/mL sedangkan F2 sebesar 1.025 µg/mL.  Hasil yang dapat disimpulkan bahwa ekstrak kulit buah semangka lebih aktif sebagai inhibisi enzim tirosinase daripada ekstrak buah ceremai tetapi hasil sediaan serum menunjukan hasil yang memiliki potensi sebagai inhibisi enzim tyrosinase.
Telepharmacy Education As A Step To Strengthen The National Health System In Pandeglang Regency: Edukasi Telefarmasi Kepada Masyarakat Kabupaten Pandeglang Sebagai Langkah Memperkuat Sistem Kesehatan Nasional Yusransyah, Yusransyah; Stiani, Sofi Nurmay; Ismiyati, Renditya; Udin, Baha; Pratiwi, Linda Rani; Maharani, Sylvianti; US, Sumarlin; Ernawati, Eneng Elda
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 2 (2024): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v8i2.18816

Abstract

A health sector that uses information and communication technology (ICT) can offer a new perspective on health service delivery and help overcome the problem of insufficient availability of health workers. The form of implementation can be telepharmacy services, but only a few people understand telepharmacy. This service aims to provide telepharmacy education to the people of Pandeglang Regency as a first step to strengthening the National Health System. Health education is delivered through visualization using the community relations method. As part of the Community Service program, this activity aims to provide telepharmacy education to the people of Pandeglang Regency, which is part of improving the National Health System.
Effectiveness and Safety Test of Antiaging Serum Combination of Ceremai Fruit (Phyllantus acidus) and Watermelon Rind (Citrullus lanatus) In Vivo Elda Ernawati, Eneng; Suryani, Nani; Sodik, Akmal; Maulana, Farhan Hidayat; Khaerunisa, Arini; Jayantie, Dhyneu Dwi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.111-118.2025

Abstract

Antiaging serum is a cosmetic to prevent skin damage due to aging factors. The antiaging serum from the combination of ceremai fruit extract (Phylanthus acidus) and watermelon peel (Citrullus lanatus) has been tested ad an antioxidant, antihyperpigmentation and anti-wrinkle activities. However, its efficacy, safety, and toxicity had not yet been tested in vivo. This study aimed to evaluate these parameters using four groups of rats over four weeks. Two formulations (F1 and F2) contained the combination of ceremai fruit extract and watermelon peel, while the negative control (NC) used only the base serum, and the positive control (PC) contained a known antiaging compound. Results showed that all formulations affected moisture content, pigmentation, collagen, and skin elasticity. Notably, F2 demonstrated the most effective outcomes: it increased skin moisture by 11.2%, improved elasticity by 10.6%, enhanced collagen levels by 14.7%, and reduced pigmentation by 21.1%, without stimulating excess sebum. These results were significantly different from the negative control (p < 0.05). In addition, the results of the F2 serum toxicity test showed no toxic symptoms to the test animals because there was no irritation
Co-Authors Adini, Syilvi Agus Setiawan Agus Setiawan Anisah Arini Khaerunnisa Arini Khaerunnisa Arini Khaerunnisa Baha Udin Candra Junaedi Chairani, Farahdina Cory Novi Dhyneu Dwi Jayantie Dimas Danang Indriatmoko Dwi Marwati Juli Siswanti Eka Yulli Kartika Fajrin Noviyanto, Fajrin Gina Siti Nurhayati Hadi Susilo Indriatmoko, Dimas Danang Ismiyati, Renditya Jayantie, Dhyneu Dwi Junaedi, Candra Kartika, Eka Yulli Khaerunisa, Arini Komalasari Komalasari Maharani, Sylvianti Maulana, Farhan Hidayat Nani Suryani Nani Suryani Nani Suryani Nuramalia, Sifa Nurhayati, Ghina Siti Parwaz Setaviani Pratiwi, Linda Rani Putra, Anca Suryadi Renditya Ismiyati Sifa Nuramalia Siswanti, Dwi Marwati Juli Siti Amaliya Sodik, Akmal Stiani, Sofi Nurmay Sulistriyani, Sulistriyani Sumarlin US Swastika Oktavia Sylvianti Maharani Tarso Rudiana Tarso Rudiana Tarso Rudiana, Tarso Taurhesia, Shelly US, Sumarlin Yunahara Farida Yusransyah, Yusransyah Yustika, Rd. Widya Zahra Khaerul Kamila