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All Journal Journal of Multidisciplinary Science: MIKAILALSYS Asian Journal of Science, Technology, Engineering, and Art International Journal of Education, Culture, and Society International Journal of Humanities, Education, and Social Sciences African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset Kwaghe International Journal of Arts, Humanities and Religious Studies African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Umaru, Isaac John
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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IBS: Pathophysiology and Management Challenges Akram, Muhammad; Umaru, Isaac John; Mahmood, Abid; Hasan, Mohammed Khudhair; Abdulghafoor, Hind A.; Khan, Fahad Said; Ozdemir, Fethi Ahmet; Sołowski, Gaweł; Ali, Jaouher Ben; Jehan Mohammed Al-Musawi, Jehan Mohammed
African Journal of Sciences and Traditional Medicine Vol 2 No 2 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i2.5641

Abstract

Irritable Bowel Syndrome (IBS) is a widespread functional gastrointestinal ailment with chronic abdominal pain, change in bowel movements, and reduced quality of life as hallmarks. Unlike organic diseases, IBS is idiopathic—diagnosed in the absence of structural or biochemical disturbances, which makes disease management more difficult. The causes of IBS are heterogeneous: dysregulation of gut-brain axis, visceral hypersensitivity, motility disorders, changes in microbiome, and psychosocial aspects contribute to it. This article explains causes of IBS, symptomatology, diagnostic criteria, and treatment options multidisciplinary with a focus on tailored dietary intervention, medication, psychotherapy, as well as alternative methods.
Preserving Biodiversity: The Vital Role of Flora and Fauna in Global Sustainability Akram, Muhammad; Umaru, Isaac John; Mahmood, Abid; Hasan, Mohammed Khudhair; Abdulghafoor, Hind A.; Khan, Fahad Said; Ozdemi, Fethi Ahmet; Sołowski, Gaweł; Ali, Jaouher Ben; Al-Musawi, Jehan Mohammed
African Journal of Sciences and Traditional Medicine Vol 2 No 2 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i2.5814

Abstract

The ecological balance of the planet, human well-being, and the vitality of natural systems are inextricably linked to the diversity of flora and fauna—biological resources that sustain life through myriad ecosystem services. Flora, comprising the world’s plant life, is fundamental to oxygen production, carbon sequestration, and photosynthetic energy transfer, forming the base of nearly all food webs. Fauna, encompassing animal life, plays critical roles in pollination, seed dispersal, pest regulation, and nutrient cycling. The vast biodiversity encapsulated in global flora and fauna represents the outcome of millions of years of evolution and adaptation. However, unprecedented anthropogenic pressures—including deforestation, habitat destruction, pollution, climate change, overexploitation, and biological invasions—have precipitated significant biodiversity loss in the twenty-first century. This decline jeopardizes not only ecological stability but also the essential services that underpin human health, agriculture, and economic development. In response, disciplines such as environmental science, conservation biology, and sustainable development have mobilized to advocate for the protection of biodiversity through international frameworks like the Convention on Biological Diversity (CBD), targeted species and habitat conservation programs, and enhanced biodiversity monitoring systems. This paper underscores both the intrinsic and utilitarian value of biodiversity, highlighting the urgent need for coordinated global action. Ensuring the persistence of biological diversity demands reinforced environmental governance, expanded protected area networks, ecological restoration, and the integration of sustainability principles into development agendas. The survival of flora and fauna is not only an environmental imperative but a foundation for human resilience and planetary sustainability.
Effects of Methanol Stem Bark Extract of Annona senegalensis on Kidney Function and Lipid Profile in Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Rats Umaru, Isaac John; Abbas, Khalid Yahuza; Omolara, Mosugu Ovayoza; Ekunyi, Agbo Chibuike; Ikira, Usman; Okang, Ogar Fonne; Akem, Ingwu Joseph; Tansaba, Akafa Andes; Frank, Otashu Kenneth; Philip, Shadrach
African Journal of Sciences and Traditional Medicine Vol 2 No 3 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i3.7358

Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, with high morbidity and mortality. This study evaluated the anticancer properties of Annona senegalensis stem bark extract in N-diethylnitrosamine (DEN)-induced hepatocellular carcinoma in Wistar rats. Liver carcinogenesis was induced in groups II–VI by intraperitoneal injection of DEN (50 mg/kg body weight in DMSO) once weekly for three weeks. Group II served as the negative control, while group III was the positive control (treated with silymarin, 100 mg/kg b.w.). Groups IV, V, and VI received ethanol extracts of A. senegalensis at 200, 400, and 600 mg/kg b.w., respectively, administered orally for 14 days. Treatment with the extract significantly (p < 0.05) reduced blood urea and creatinine levels, improved electrolyte balance, and enhanced liver histoarchitecture. The extract also favorably modulated lipid metabolism, lowering cholesterol levels from 368.57 ± 1.72 in the negative control to 251.31 ± 1.10 at 400 mg/kg, while increasing HDL levels from 96.21 ± 1.23 to 233.13 ± 0.86 at 600 mg/kg. These results suggest a cardioprotective role via improved lipid profiles. Additionally, kidney function was improved, as reflected by reduced urea (17.30 ± 0.85) and creatinine (2.67 ± 0.23) compared to negative controls (34.53 ± 0.70 and 3.72 ± 0.45, respectively). Overall, the ethanol extract of A. senegalensis demonstrated hepatoprotective, nephroprotective, and lipid-regulating effects, highlighting its potential as a therapeutic agent for mitigating DEN-induced HCC and its associated metabolic complications.
Evaluating Microbial Quality of Drinking Water from Wells and Boreholes in Michika LGA and Its Impact on Community Health Umaru, Isaac John; Asare, Solomon Ossom; Olayeni, Abimbola Gbenga; Johnson, Joanna Afariba; Amofa, Gift
African Journal of Sciences and Traditional Medicine Vol 2 No 3 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i3.8029

Abstract

Access to safe drinking water remains a critical public health challenge in rural Nigeria, particularly in Michika Local Government Area (LGA) of Adamawa State, where communities depend on wells and boreholes for their daily water needs. This study evaluates the microbial quality of these groundwater sources and examines their impact on community health. Microbiological analyses revealed widespread contamination, with elevated levels of Escherichia coli, total and fecal coliforms, and high turbidity, especially in wells located in districts such as Zah, Moda, and Minkisi. Physicochemical parameters, including acidic pH and elevated temperatures, further exacerbated microbial proliferation. Environmental assessments identified key contamination sources—proximity to latrines and refuse dumps, open well structures, poor drainage, and unrestricted animal activity—which correlated strongly with high incidences of waterborne diseases, notably diarrhea, typhoid, and cholera, predominantly affecting children under five, pregnant women, and the elderly. In contrast, boreholes in Diaka and Michika Town demonstrated safer profiles due to better infrastructure and maintenance. The findings underscore the urgent need for integrated water, sanitation, and hygiene (WASH) interventions, routine water quality monitoring, and community education to mitigate health risks and promote sustainable access to potable water in Michika LGA.
Co-Authors A, Ajala-Lawal R. A, Arowora K. A., Arowora K. Abah, Moses Adondua Abbas, Khalid Yahuza Abbas, Sabahat Abdulghafoor, Hind A. Abdulkadir, Nurudeen Umar Abdulrasheed, Lubabatu Abershi, Ajiduku Leyoa Absalom, Augustine Abu, Michael S. Abu, Michael Sunday Acha, Ozzioma Praise Adam, Habiba Idris Adam, Idris Habiba Adams, Idris Habiba Adamu, Usman Lukman Adebisi, Arowora Kayode Adeseye, Abdullahi Sa’adu Adi, Godwin Baaku Agaba, Eric Agim Agwu, James Eneji Ahmed, Fasihuddin Badruddin Ahmed, Maayam Usman Ahmed, Maryam Usman Ahmed, Misbah Aisami, Abubakar Akafa, Andes Tensaba Akafa, Tensaba Andes Akafa, Vika Tensaba Akam, Odok Endurance Akem, Ingwu Joseph Akem3, Ingwu Joseph Akpan, Usenobong Morgan Akumia, Prince Osei Al-Musawi, Jehan Mohammad Al-Musawi, Jehan Mohammed Ale, Ebenezer Morayo Ali, , Jaouher Ben Ali, Jaouher Ben Aliyu, Sulaiman Abubakar Alooma, Emmanuel Amen, Ananias Ametefe, Mathias Mawuli Amoah, Kwabena Owusu Amofa, Gift Amuda, A. J. Andeuka, Useni Ajiya Asare, Solomon O. Asare, Solomon Ossom Aslam, Muhammad Tayyab Aslam, Nosheen Asuelimen, Steve Osagie Audu, Anthony Mishara Audu, Jankada Patience Ayara, Charles Ayi, Atsu Ayo, Victoria Ifeoluwa Bafai, Favour Joel Baig, Muhammad Haris Bando, David Christopher Bappa, Lipana Dorcas Benjamin, Wisdom L. Bobie, Shelter Agbeko Brown, Samuel Tamunoiyowuna Cockeye C, Ugwuoke Kenneth Chikata, Ezugwu Hilary Chinedu, Imo Chinonso, Anih David Chishti, Abdul Wadood Chisom, Gabriel Favour Chuanu, Solomon Chukwudi, Eluu Emmanuel Chukwudi, Emmanuel Eluu Dambazau, Zainab Bello Daniel, Benjamin Nanisi Danjuma, Janya Danjuma, Tyem Lawal Dauda, Mai-anguwa Abdulrashid Dauda, Maianguwa Abdulrashid Dauda, Maianguwa Abdulrsashid David, Bando Christopher David, Izam Emmanuel Dooshima, Arowora Mercy Efongwa, Emmanuel Efoseh, Danlami Ejeh, Yakubu Ojochenemi Ekpo, Fidelis Okii Ekubnse, Nkiri Annasthesia Ekunyi, Agbo Chibuike Ekup, Ogholo Ogholo Emmanuel, Okoli Emochone, Roy Yohanna Enang, Kingsley Bassey Eno, Gomba Victoria Enyojo, Lawal Favour Esseyi, Chabunda Endashi Essien, Inemesit Samuel Ezeonu, Chukuma Stephen Frank, Otashu Kenneth Galam, Nanyak Zingfa Gbadebo, Adetoyi Moses Ghazwani, Eisa Yazeed Goje, Lazaru Joseph Grace, Onwubiko N. Gyasi, Prince Kwadwo Habibu, Bilyaminu Hasan, Mohammed Khudhair Hassan, George Okra Hassan, Okrah George Henry, Onwubiko A. Iba, Bemhemba Iftikhar, Momina Iheanacho, Chinedu Christian Ijeomah, Nkechi Gift Ikira, Usman Innocent, Nwofor Ipav, Selumun Solomon Iseko, Kingsley Iyoko Ismail, Muhammad Zuhairah Istifanus, Dafup Kadel Istifanus, Dafup Katdel Jabir, Abdulmumin Jack, Precious Chioma Jacob, Mathew Janya, Danjuma Javed, Amna Jehan Mohammed Al-Musawi, Jehan Mohammed Joel, Emmanuel Askeb-nde Joel, Emmanuel Askebnde John, Artu Ishishen John, Omachi Blessing John, Tongle Nanle Johnson, Joanna Afariba Joseph, Ikwebe Joseph, Iornenge Terungwa Kayode, Arowora Khan, Alam Afroz Urooj Khan, Fahad Said Kingsly, Iseko Iyoko Konka, Daniel Laila, Umme Madaki, Kanati Mafe, Alice Njolke Mahmood, Abid Maianguwa, dulrashid Dauda Makanjuola, Victor Malantso, Jackson Soyinka Manu, Sukyakma Maqbool, Tahmina Marvelous, Solomon Godiya Matilda, Manasseh Ilumunter Mchibuma, Jibaniya Grace Melvin, Ugwuala Chimaobi Mijinyawa, Aboki Nwunuji Mijinyawa, Ibrahim Jamilat Mohammed, Ikrimah Usman Mohammed, Rashida Ismail Mona, Etah Hope Morayo, Ale Ebenezer Morgan, Akpan Usenobong Morolake, Olabanji Martina Moses, Iyekekpolor Osamudiame Muhammad Abdullah Muhammad Akram Muhammad, Muhammad Bashir Mustapha, Musa Azegya Najeeb, Aliyu Olamilekan Namuma, Shitta Nasisi Nanmar, Chakfa Ngabea, Nasiru Audu Ngbede, Ocheifa Mathew Ngbede, Ocheifa Matthew O, Mosugu O. Odufa, Egbeadumah Maryanne Ogochukwu, Edom Favour Okang, Ogar Fonne Oko, John Odiba Okoli, Emmanuel Chikodiri Okwori, Ameh Godwin Oladele, Gloria Omonefe Oladimeji, Oluwasegun M. Olawale, Otitoju Olawale, Otitujo Olayemi, Abimbola Gbenga Olayeni, Abimbola Gbenga Oluwabunmi, Adeseye Helen Oluwabunmi, Helen Oluwale, Otitoju Omanchi, Emmanuel Omanchi, Emmanuel Olofu Omolara, Mosugu Ovayoza Onyindia, Agbo Christiana Onyinyechi, Nwachukwu Favour Oteng, Joseph Otitoju, Olawale Oyibo, Okpanachi Nuhu Ozdemi, Fethi Ahmet Ozdemir, Fethi Ahmet Peter, Danladi Mbosire Peter, Prosper Uneju Philemon, Panah Philip, Shadrach Rashid, Abid Rebecca, Tsokwa Punarimam Rehman, Urooj S, Ezeonu C. Sadia, Haleema Salman, Julius Ishaya Shadrach, Katchim Evelyn Shadrach, Katchin Evelyn Shadrach, Philip Shahid, Isbah Shaibu, Isaac Eleojo Sheneni, Victor Duniya Shenia, Zephaniah Hananiah Siddan, Ahmad Alhassan Sirina, Bakari Genevieve Sołowski, Gaweł Sule, Josephine Maina Sunday, Abu Michael Sunday, James Agbu Talent, Akoh Miracle Tansaba, Akafa Andes Tensaba, Akafa Andes Tersur, Kyugah Jacob Tiimob, Gideon Likida Timothy, Mgbede Tony-Enwin, Evelyn Ovenomo Tyem, Lawal Danjuma Uchechukwu, Ukoh Daniel Udoh, Mary Athanasius Uduak, Peter Ise Ugbedeojo, Sule John Ugoeze, Egeonu Stephen Ujah, Oche Williams Ujah, Williams Oche Umahi, David Umar, Kerenhappuch Isaac Umaru, Hauwa A. Umaru, Kerenhappuch Isaac Umaru, Kerenhapucch Isaac Umogbai, Debora Akinola Utioukpan, Ashaka Fidelis Williams, Queen Uyo Wilson, Ubur Terzulum Yahaya, Musbau Adekunle Yakubu, Kaka Garpiya Yakubu, Ojochenemi E. Yakubu, Ojochenemi Ejeh Yeboah, Genevieve A. Yeboah, Genevieve Akpah Yemisi, Adeyanju Kate Yuguda, Ismail Yunusa Yusuf, Obadiah Saveni Yusufu, Dawoye Zinas, Simon Teza