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All Journal Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi Journal of the Indonesian Mathematical Society AGRIVITA, Journal of Agricultural Science EMITTER International Journal of Engineering Technology JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Teknologi Informasi MURA JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pendidikan dan Pembelajaran Sains Indonesia (JPPSI) Al-Ard: Jurnal Teknik Lingkungan Medical and Health Science Journal Jurnal Pendidikan dan Pembelajaran Sains Indonesia (JPPSI) Jurnal Ilmiah Akuntansi Peradaban Jurnal Kewarganegaraan Ilomata International Journal of Social Science Narra J Journal of Rural and Urban Community Empowerment Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Jurnal AGRISEP: Kajian Masalah Sosial Ekonomi Pertanian dan Agribisnis Masip: Jurnal Manajemen Administrasi Bisnis dan Publik Terapan Jurnal Teknologi Informasi Mura Asian Journal of Science, Technology, Engineering, and Art Jurnal Intelek Insan Cendikia African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset Kwaghe International Journal of Arts, Humanities and Religious Studies African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Muhammad Akram
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Narra J

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Aspirin-clopidogrel combination therapy for ischemic stroke patients: Clinical efficacy and cost-effectiveness analyses in low-resource setting Fitria, Najmiatul; Febiana, Dian; Akram, Muhammad; Yosmar, Rahmi
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.758

Abstract

Understanding the cost-effectiveness of aspirin-clopidogrel combination therapy is crucial in determining its influence on coagulation parameters, specifically prothrombin time (PT) and activated partial thromboplastin time (APTT). The aim of this study was to assess the cost-effectiveness and clinical impact of using the aspirin-clopidogrel combination compared to aspirin alone in managing ischemic stroke. Employing an observational research design, inpatient ischemic stroke cases receiving the aspirin-clopidogrel combination were compared to those treated with aspirin alone. Focusing on the hospital's perspective on costs, the research specifically analyzed medical expenses without discounting costs or effects. The analysis involved comparing the direct medical costs and coagulation parameters between the two treatment groups. Our data revealed that the aspirin-clopidogrel combination demonstrated superior cost-effectiveness over aspirin alone, indicated by the incremental cost-effectiveness ratio (ICER) values for PT (IDR -246,930/second) and APTT (IDR -119,270/second). This indicated that the combination therapy was associated with lower costs while yielding better clinical parameter values. The ICER analysis placed the aspirin-clopidogrel combination in the southeast quadrant, marking its dominance over aspirin monotherapy by demonstrating higher effectiveness at lower costs. These results suggest that combination therapy might be a favorable alternative for managing ischemic stroke, presenting a viable option for consideration in clinical practice. The findings underscore the potential economic and clinical advantages of employing the aspirin-clopidogrel combination in routine stroke management protocols.
Co-Authors Abbas, Sabahat Abdulghafoor, Hind A. Addilah, M. Fikri Agussabti Agussabti Ahmed, Misbah Al-Musawi, Jehan Mohammad Al-Musawi, Jehan Mohammed Ali, , Jaouher Ben Ali, Jaouher Ben Andi Tenri Famauri Anggriani, Rara Dewi Anshar Saud Anwar, Hina Arie Arma Arsyad Aslam, Muhammad Tayyab Aslam, Nosheen Burhanuddin Burhanuddin Bustanul Arifin Chairul Amsal Chalirafi, Chalirafi Chishti, Abdul Wadood Dmitriy Kulikov Dyah Nur Sasanti Elly Susanti Erna Erna Fadhlullah M, Muhammad farendi, Arya Fathul, Muh. Fatihaturrahma, Annisya Faza, Farzana Fakhira Febiana, Dian Ghazwani, Eisa Yazeed Gustina Gustina Hansen Nasif Hasan, Mohammed Khudhair Henni Syawal Ibnu Sina Chandranegara Iftikhar, Momina Ikramuddin, Ikramuddin Indra Indra Javed, Amna Jehan Mohammed Al-Musawi, Jehan Mohammed K, Narayana Kamaruzzaman, Suraiya Khalil, Muhammad Talha Khan, Alam Afroz Urooj Khan, Fahad Said Khan, Muhammad Naeem Ahmed Khan, Usman Habib Kholik Prasojo Kurnianingtyas, Erlina Laila, Umme M, Shilpa Magsi, Irfan Ahmed Mahmood, Abid Maqbool, Tahmina Mardatillah Mardatillah Mariska, Refi Marlina Achmad Marzolina ' Matilda, Manasseh Ilumunter Mirza, Aamir Mehmood Mohammad Ali Shariati Mohiuddin, Ghulam Muchsin Muchsin Mufti, Aulia Annas Muh Tawil, Muh Muhammad Abdullah Muhammad Amjad Muhammad Imran Muhammad Nadeem Muhammad Nouman Tariq Muhammad Sajjad Mujiburrahmad Mujiburrahmad Murod, Ma’mun Mutawakkil, M. Mufid Al Muttiarni Muttiarni Nadezhda Kenijz Najmiatul Fitria novita sari, dian Nur Amsal, A.Muh Ihsan Ozdemi, Fethi Ahmet Ozdemir, Fethi Ahmet RA, Sayyidina Abdul Qabidhi Rahman, Dhaffa Mulya Rahmi Yosmar Ramadhanita, Ramadhanita Rashid, Abid Rehman, Urooj Sabir Alwy Sadia, Haleema Saputra, Anugerah Sarini Vita Dewi Shahid, Isbah Shariqa Fakhar Shumaila Hussain Sitara, Muzzamal Sołowski, Gaweł Suteji Anwar, Andika Syahruni Cangara, Arie Syed, Sadat Ali Tanjung, Yuliza Virliansyah Tanweer Aslam Gondal Taufiqurokhman Umaru, Isaac John Umaru, Kerenhappuch Isaac Wagan, Raja Asif Wibisono, Dany Kunto Yuni Lisafitri, Yuni Zafar, Sadia Zainab, Rida Zainuddin, Zainuddin Zazna Syaputri, Yolanda Zikri, Irfan