Article Per Year (5 Year)
p-Index From 2021 - 2026
2.282
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Microbiology Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Biotechnology Sari Pediatri Paediatrica Indonesiana Belitung Nursing Journal Indonesian Journal of Chemistry Biota Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR) Makara Journal of Science
Amarila Malik
Faculty Of Pharmacy, Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 29 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : biota

 1 
Karakteristik Sel Punca Mesenkim yang Berasal dari Tali Pusat (Umbilical Cord Derived Mesenchymal Stem Cell/UCMSC) dari Macaca fascicularis dan Sekretomnya dalam Kondisi Hipoksia Dumingan, Alvian; Malik, Amarila; Rinendyaputri, Ratih; Utama, Hieronimus Adiyoga Nareswara; Sunarno, Sunarno; Purwaningtyas, Yoggi Ramadhani; Idrus, Hasta Handayani; Noverina, Rachmawati; Huda, Fathul; Faried, Ahmad
Biota Vol 17 No 1 (2024)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v17i1.492

Abstract

Mesenchymal Stem Cell (MSC) secretome has potential as a neuroprotective and neuroregenerative agent. It can have effects due to its paracrine factors, such as Brain Derived Neurotrophic Factor (BDNF) and Stromal-Cell Derived Factor-1 (SDF-1) which can be induced with hypoxia preconditioning. This compound may play a role in the treatment of neurological diseases. Stroke has become a neurological disease that contributes to high rates of mortality and morbidity worldwide. There have been several pre-clinical trials on animal stroke models using MSC secretomes from rats and humans, but no studies have been conducted on Non-Human Primate, such as Macaca fascicularis. This species has been widely used in biomedical research and part of it can be utilized for such studies which will reduce the cost of using human MSC. The results of this study, Umbilical Cord (UC)-MSCs of Macaca fascicularis have been successfully cultured and characterized in terms of phenotypic and differentiation. Hypoxia precondition was able to induce BDNF secretion up to 264 pg/mL and SDF-1 up to 666 pg/mL in the UCMSC secretome. Hypoxic preconditioning with 3% oxygen can induce the most optimal BDNF and SDF-1 secretion, compared to 1% and 5% hypoxia.
Co-Authors 'Alawiyyah, Raden Zulfa Achmad Fariz Ahmad Baikuni Ahmad Baikuni Ahmad Faried Ajitya Kurnia Hermawati Amin Soebandrio Anandayu Nurfachtiyani ANDI YEHUDA Andiani Wanda Putri Anis Karuniawati Antonius Suwanto Arry Yanuar Asmarinah Astutiati Nurhasanah ASTUTIATI NURHASANAH Atiek Soemiati Aulia Rizki Azminah Azminah Berna Elya CESILIA ANITA Deli Marteka Dewi Puspita Donna M. Ariestanti Dumingan, Alvian Endang Saepudin Endang W Bachtiar ESTI PUSPITASARI Fairuz Andini Fatiningtyas Fathan Luthfi Hawari Fathan Luthfi Hawari Fatiningtyas, Fairuz Andini HANIFAH RAHMI Hanita Omar HANS-JOACHIM FREISLEBEN HARALD HUBER Harry Ardiansyah Hermawati, Ajitya Kurnia Hestiningtyas, Mahardhika Huda, Fathul IMAN SANTOSO INDRIANI INDRIANI Ingrid Faustine Is Helianti IS HELIANTI Islamudin Ahmad Kambang Sariadji Kino-Oka, Masahiro Kusmiati . Kusmiati Kusmiati Kusmiati Kusmiati Larashintya Rulita LILIANA SARAGIH Mahardhika Hestiningtyas Maimunah Maimunah Maksum Radji Meidy Richky Wanyodiharjo Mohamad Sadikin Muhammad Hanafi MUHAMMAD IQBAL Murti Andriastuti, Murti Nadia Farhanah Syafhan Napitupulu, Riswanto Neneng Siti Silfi Ambarwati Nilam Sartika Noverina, Rachmawati NUNUK WIDHYASTUTI Nusaiba, Putri Oktaviyani, Devi Purwaningtyas, Yoggi Ramadhani Putri, Ratih Rinendya Radhian Amandito Radhian Amandito RAFIKA SARI RAMADON, DELLY Ratih Rinendyaputri Retnaningsih, Agustina Rina Mutiara Rinawati Rohsiswatmo Riswanto Napitupulu RIZKI AYU AMALIA Rosari Saleh S.Pd. M Kes I Ketut Sudiana . SAHLAN, MUHAMAD SELA SEPTIMA MARIYA Septelia I. Wanandi Septelia Inawati W SERUNI K.U. FREISLEBEN Sheilla Sheilla SISWA SETYAHADI Sri Wulandah Fitriani Stella Vania Sukma Nuswantara Sukma Nuswantara Sunarno Sunarno Sunarno Sunarno Susan Rahayu Sutriyo Syafrida Siregar Syafrida Siregar, Syafrida Tiodinar Theresia Tri Handayani Trismilah Margono Trismilah Trismilah TRISMILAH TRISMILAH Trismilah, Utama, Hieronimus Adiyoga Nareswara Utami, Emilia Rahmadaniah Wahono Sumaryono WALTER ERDELEN Wangi Firdausi Yamamoto, Riku Yuditya Artha YUKI DESIANDINI ZESSINDA LUTHFA