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All Journal Journal of Engineering and Technological Sciences Jurnal Farmasi Klinik Indonesia Biology, Medicine, & Natural Product Chemistry Pharmacon PROSIDING SEMINAR KIMIA JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Acta Pharmaceutica Indonesia Jurnal Fitofarmaka Indonesia Jurnal Keperawatan Padjadjaran JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JSKK (Jurnal Sains Keolahragaan dan Kesehatan) JPSCR : Journal of Pharmaceutical Science and Clinical Research Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Farmako Bahari Narra J Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Kesehatan Bakti Tunas Husada Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Kusnandar Anggadiredja
Institut Teknologi Bandung
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Kajian Efektivitas, Toksisitas, dan Cost-Effectiveness Obat-Obatan Penyakit Alzheimer Salsabila Andiyanti Putri; Kusnandar Anggadiredja
Acta Pharmaceutica Indonesia Vol. 48 No. 1 (2023)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i1.22224

Abstract

Alzheimer is a neurological disease characterized by loss of cognitive and non-cognitive functions. Drugs that can be used to treat Alzheimer’s disease include donepezil, galantamine, rivastigmine, and memantine. This literature review covers the effectiveness, toxicity, and cost-effectiveness of these four drugs as Alzheimer's therapy options. Review of the pertinent literatures from the databases Google Scholar, Pubmed, and Science Direct showed that galantamine has the best effectiveness compared to other drugs because it can improve all aspects of Alzheimer’s disease. The four drugs do not have a fixed toxic dose, but the effects they cause are not much different from one drug to another. Donepezil, galantamine, and memantine were cost-effective, whereas rivastigmine was not. Key words: Alzheimer’s disease, Alzheimer's drugs
Kajian Aktivitas Neurofarmakologi Acorus calamus Linn Rafika Thahirani Safira; Kusnandar Anggadiredja
Acta Pharmaceutica Indonesia Vol. 48 No. 1 (2023)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i1.22227

Abstract

ABSTRACT Jeringau (Acorus calamus Linn) is one of the plants often used in traditional Indian medicine, practiced to treat various disorders, including nervous, digestive, respiratory, metabolic, renal and hepatic. This study provides an overview of Acorus calamus Linn in terms of morphology, active constituents and neuropharmacological activity. A review of related literature from the Google Scholar, Pubmed, Reserch Gate, and Science Direct. databases showed the of neuroprotective, antiamnestic, anticholinesterase, antidepressant and anticonvulsant activities. Key words: Acorus calamus Linn, jeringau, chemical contents, neuropharmacological activites
Computer-Assisted Histopathological Calculation Analysis of the Sciatic Nerve of Diabetic Neuropathy Rat Model Indah Tri Lestari; Kusnandar Anggadiredja; Afrillia Nuryanti Garmana; Sevi Nurafni
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6590

Abstract

Histopathology is the science that studies the signs of disease by studying the structural and functional changes that occur in cells using certain types of dyes such as hematoxylin and eosin (H&E). Traditionally histopathological testing is carried out using semi-quantitative methods. A more advanced method is done by taking photos digitally, and then digital photos are quantified with the help of software such as ImageJ using plug-in tools. Recent advances in digital pathology require the development of more efficient computerized image analysis such as the Gaussian adaptive threshold method. This research aims to compare the calculation results of computer-assisted digitalization of histopathology using the ImageJ plugin manual method with automatic calculations using Gaussian adaptive threshold to quantify the amount of sciatic nerve cell damage in the Diabetic peripheral neuropathy (DPN) rat model. In this study, two image analysis methods were used to test their ability to measure the amount of cell damage in the sciatic nerve of normal rats using a model of diabetic neuropathy. The first method uses the ImageJ plugin manual. The second method is the Gaussian adaptive threshold method. The ImageJ plugin manual method obtained a cell abnormality value of 213 cells. Meanwhile, with the Gaussian adaptive threshold method, a value of 204 cells was obtained. The calculation results of the two methods show an insignificant difference between the methods p >0.05. This study presents a computerized morphometric image analysis method with the potential for pathology digitalization applications.
The Comparison of Long-term Effect Between Intermittent Fasting and Calorie Restriction on Neurological Parameters of Mice Ni'ma, Neli Syahida; Anggadiredja, Kusnandar
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.199-204

Abstract

Intermittent fasting (IF) and calorie restriction (CR) were purported to have health benefits. This research aimed to determine the long-term effect of IF and CR on selected neurological parameters in mice. Swiss Webster male mice were divided into 3 groups: ad libitum feeding (AL), IF, and CR. Mice in each group received the treatment for 16 weeks. They were then tested for anhedonia, depression, aggressiveness, and social approach. They were also subjected to contextual fear conditioning tests to model PTSD. Compared to AL, sucrose intake in the IF group was lower, while the CR group showed higher intake (p<0.01). This anhedonia characteristic shown in the IF group was confirmed not related to depression, as shown by significantly lower immobility time in the forced swimming test compared to AL (p<0.05). In the resident-intruder test, attack numbers in the IF group were fewer than in the AL group (p<0.05). As demonstrated by the results of the three-chamber test, the reduced aggressiveness in IF mice was unrelated to a deficit in sociability. In the fear extinction test (PTSD model), mice in the IF group showed lower freezing compared to those in AL (p<0.001). Although both IF and CR caused a reduction in total food intake, in the mice model tested, IF was shown to have favorable impacts on neurological parameters.
Toxicity assessment and bioimaging potential of carbon dots synthesized from banana peel in zebrafish model Wijayanti, Ni PAD.; Permatasari, Fitri A.; Damayanti, Sophi; Anggadiredja, Kusnandar; Iskandar, Fery; Wibowo, Indra; Rachmawati, Heni
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1228

Abstract

Zebrafish serve as a pivotal model for bioimaging and toxicity assessments; however, the toxicity of banana peel-derived carbon dots in zebrafish has not been previously reported. The aim of this study was to assess the toxicity of carbon dots derived from banana peel in zebrafish, focusing on two types prepared through hydrothermal and pyrolysis methods. Banana peels were synthesized using hydrothermal and pyrolysis techniques and then compared for characteristics, bioimaging ability, and toxicity in zebrafish as an animal model. Pyrolysis-derived banana peel and hydrothermal-derived banana peel showed blue emission under ultraviolet light, indicating excitation-dependent behavior. To test their potential application for bioimaging, a soaking method was used using zebrafish that showed fluorescence intensity in the eyes, abdomen, and tail of zebrafish. Toxicity comparison showed that pyrolysis-derived banana peel had lower toxicity with 50% lethal concentrations (LC50) of 1707.3 ppm than hydrothermal-derived banana peel (LC50 993 ppm) in zebrafish. Both types of carbon dots showed significant differences (p<0.05) in hatching rates at 96 and 120 hours of exposure. Of the two methods for carbon dot synthesis from banana peel, the pyrolysis method had a higher toxicity threshold than the hydrothermal method, as indicated by the LC50 value and the number of zebrafish embryos that died, hatched delayed, and experienced malformation during their development.
INVOLVEMENT ARACHIDONIC ACID CASCADE IN MEMORY DEFICIT BY KRATOM (Mitragyna speciosa) IN MALE WISTAR RATS Ramadhani, Chelsea Aulia; Anggadiredja, Kusnandar
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v49i01.23562

Abstract

Kratom (Mitragyna speciosa) is a plant that is widely found in Southeast Asia particularly, in Indonesia. Mitragynine, which was the main alkaloid of kratom, has been reported associated with addictiveness and memory impairment in animal studies. However, the mechanism of memory impairment is still unclear. In the present study, we investigated the involvement of the arachidonic acid cascade in memory impairment caused by kratom. Male Wistar rats were divided into seven groups, namely vehicle (CMC Na 0.5%; oral), kratom ethanolic extract (50, 100 and 200 mg/Kg; oral (p.o)), and the group given Diclofenac Sodium (5 mg /Kg; Intraperitonial (i.p)) 30 mins before administration of kratom ethanolic extract (50, 100 and 200 mg/Kg; oral) for 14 days. Memory impairment was carried out using a spatial memory test on days 10-16 using the Morris Water Maze and a working memory test using the Y Maze on the 17th day. Kratom administration was shown to impair spatial memory and working memory when compared with the vehicle group (P<0.05). Diclofenac sodium prevents spatial memory and working memory impairment due to Kratom when compared to the group administered by kratom monotherapy at the equivalent dose (P<0.05). In this study, it was found that there was involvement of the arachidonic acid cascade in memory impairment by kratom.
Moringa oil-based nanocarrier system containing curcumin formulation as anti- breast cancer agent: Efficacy and safety study Widodo, Ferri; Anggadiredja, Kusnandar; Amalia, Riezki; Rachmawati, Heni
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2101

Abstract

Current anti-breast cancer drugs have limited efficacy and often cause severe side effects, highlighting the need for bioactive agents that could overcome these limitations. Curcumin, a phenolic compound from Curcuma domestica, has antineoplastic activity but has low solubility in physiological media, while moringa oil is a key component of the oil-phase nanocarrier and also possesses anticancer properties. The aim of this study was to develop a moringa oil-based nanocarrier system containing curcumin and to analyze its anticancer effects on MDA-MB-231 cell lines, focusing on the underlying mechanisms involving B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X (Bax) proteins. Additionally, the study investigated the side effects of the nanocarrier system following acute administration in animals. The anticancer effects were evaluated in vitro using MDA-MB-231 cell lines, while the acute toxicity assessment was conducted in healthy female Wistar rats. The nanocarrier system was formulated using moringa oil, Cremophor RH40, and PEG 400. Its cytotoxicity against MDA-MB-231 cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. DNA fragmentation, apoptosis, and the expression of Bax and Bcl-2 proteins were analyzed via terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assays, flow cytometry, and western blotting. Acute toxicity was further evaluated in female Wistar rats. The results demonstrated that the moringa oil-based nanocarrier system containing curcumin inhibited cell proliferation and induced apoptosis in MDA-MB-231 cells. Curcumin suppressed tumorigenesis by modulating Bcl-2 and Bax protein expression. Our data indicated that the combination of curcumin and moringa oil in a nanocarrier system had greater anticancer potential than either component alone. Moreover, administration of the nanocarrier system did not result in any clinically significant changes in body weight, behavior, or organ weight indicative of toxicological effects. No treatment-related histopathological abnormalities were observed at terminal necropsy. In conclusion, this novel combination of curcumin and moringa in nanocarrier system has better anticancer potential; nevertheless, further studies are needed to confirm this in cancer animal models.
EVALUASI TINGKAT PENGETAHUAN TENTANG SEDIAAN, CARA PAKAI DAN EFEK SAMPING KONTRASEPSI SUNTIK AKSEPTOR KELUARGA BERENCANA (KB) DI KOTA BANDUNG Nuari, Doni Anshar; Anggadiredja, Kusnandar
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

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Abstract

Kontrasepsi suntik adalah sediaan injeksi yang mengandung hormon untuk pencegahan kehamilan pada wanita. Kepatuhan dalam penggunaan kontrasepsi menjadi penentu keberhasilan dalam penggunaannya termasuk penggunaan pada kontrasepsi suntik ini. Salah satu yang mempengaruhi kepatuhan adalah tingkat kepatuhan pasien terhadap suatu terapi. Tujuan penelitian ini adalah untuk mengukur tingkat pengetahuan akseptor tentang bentuk sediaan cara pakai dan efek samping kontrasepsi suntik sebelum dan setelah pemberian informasi dari konselor. Penelitian ini dilakukan dengan mengukur pemahaman akseptor terhadap bentuk sediaan, cara pakai dan efek samping pasien sebelum dan setelah mendapatkan informasi dari konselor, pengujian menggunakan kuesioner yang dibuat dengan skala Guttman, data yang diperoleh dianalisis secara deskriptif dan kuantitatif menggunakan uji Wilcoxon. Tingkat pengetahuan bentuk sediaan telah baik sementara pengetahuan tentang efek samping dan cara pakai menunjukan nilai cukup.
Future Prospects for Pharmacogenomics of Immune Checkpoint Inhibitors Cardiotoxicity Aryantha, Hasna Firdaus; Wisasani, Amiiratu Muthiia; Anggadiredja, Kusnandar; Zazuli, Zulfan
Indonesian Journal of Clinical Pharmacy Vol 13, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.1.34

Abstract

Immune checkpoint inhibitors (ICIs), including PD-1, PD-L1, and CTLA-4 inhibitors, have revolutionized cancer therapy but are associated with immune-related adverse events (IRAEs). Among these, ICI-associated cardiotoxicity is an uncommon yet serious complication, often resistant to glucocorticoid therapy, which effectively manages most IRAEs. A pharmacogenomic approach might be useful in prescribing ICIs and screening for relevant clinically measurable phenotypes such as the history of autoimmune diseases and cardiovascular disorders. This review explores the impact of genetic variations on ICI-associated cardiotoxicity, the mechanistic basis behind it, potential clinical applications, and directions of the future on how pharmacogenomics can assist oncologists in reducing the risk of cardiotoxicity. Evidence-based hypotheses on how ICI-associated cardiotoxicity occurs suggest that genetic differences might play a role in ICI response, especially regarding cardiotoxic IRAEs. Pharmacogenomic studies and multi-omics profiling might provide valuable insight regarding ICI-induced cardiotoxicity. They could be implemented to make fine-tuned clinical decisions for individual patients in the future.
LITERATUR REVIEW: PENGARUH INJEKSI INTRACEREBROVENTRIKULAR STREPTOZOTOCIN PADA OTAK MENCIT SEBAGAI KANDIDAT HEWAN MODEL ALZHEIMER Daryanti, Edhita Putri; Anggadiredja, Kusnandar; Wibowo, Agung Eru; Santoso, Koekoeh
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Background: Animal models of Alzheimer's have now been developed in various studies to become potential animal models suitable for clinical conditions. Alzheimer's in clinical conditions is characterized by Amyloid βeta (Aβ) plaques and intracellular tangles of neurofibrillary tangles as well as disorders of the acetylcholinesterase enzyme in the hippocampus. Rodents used include rats and mice. Mice are used because they are efficient and parts of the brain can be penetrated with a needle without requiring surgery. Objectives: Appropriate toxicant induction is needed so that the process of developing Alzheimer's pathology is known, namely the use of Streptozotocin. Intracerebroventricular induction of strepzotocin in mice needs to be further understood. Material and Methods: The research method uses literature review with identification, screening, evaluation and interpretation of all research results collected through online search engines such as; Sciencedirect, Pubmed, GoogleScholar with keywords and meet the inclusion criteria Results: The results of the synthesis obtained selected data from 8 articles. ICV-STZ has been proven from various studies to induce Alzheimer's pathology in both young and old male mice through neuroinflammatory pathways, oxidative stress, increasing Aβ expression and hyperphosphorylation of Tau as Alzheimer's markers which are similar to clinical patients. Keywords : Alzheimer, Hewan model, Literatur review, Mencit, Streptozotocin.
Co-Authors A.R. Ryadin Afifah B. Suciatmo Afrillia Nuryanti Garmana Agung Eru Wibowo Ainina Al Shadrina Amalia, Riezki Andreanusi A Soemardj Anggraini Barlian Aryantha, Hasna Firdaus Cindra Tri Yuniar Daryanti, Edhita Putri Dian Anggraeny Dudi Dudi Dudi, Dudi Eva Kusumahati Gusdinar, Tutus Hamidah Rahman Hegar Pramastya HENI RACHMAWATI I Ketut Adnyana Ikhwan Yuda Kusuma Indah Tri Lestari Iskandar, Fery Johnner P Sitompul Johnner Sitompul koekoeh santoso Kusumahati, Eva Lia Amalia Lia Amalia Lia Amalia Linda Amalia Lisna Anisa Fitriana, Lisna Anisa Lucy Lustiani Lustiani, Lucy Nazhifa Ufamy Ni'ma, Neli Syahida Nuari, Doni Anshar Permatasari, Fitri A. Raden Retno Ariani Rafika Thahirani Safira Ramadhani, Chelsea Aulia Rizka Zu Fadhilah Salsabila Andiyanti Putri Setiawan . Setiawan Setiawan Sevi Nurafni Sitompul, Johnner Sophi Damayanti Sophi Damayanti Suciatmo, Afifah B. Sukrasno Sukrasno Sukrasno, Sukrasno Suryani Gunadharma Tiara - Berliani Triantri Kartika Putri Tursino, Tursino Tutus Gusdinar Tutus Gusdinar Ufamy, Nazhifa Wibowo, Indra Widodo, Ferri Wijayanti, Ni PAD. Wisasani, Amiiratu Muthiia Yedy Purwandi Sukmawan Zazuli, Zulfan