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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kesehatan Lingkungan indonesia Jurnal Kedokteran Brawijaya Jurnal Kebijakan Kesehatan Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Indonesian Journal of Urology The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia Indonesian Journal of Biotechnology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika INDONESIAN JOURNAL OF PHARMACY Padjadjaran Journal of Dentistry Oto Rhino Laryngologica Indonesiana INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Biologi
Indwiani Astuti
Universitas Gadjah Mada
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Epidemiologic profile of oral squamous cell carcinoma in Yogyakarta, Indonesia Gracia, Isadora; Utoro, Totok; S., Supriatno; Astuti, Indwiani; Heriyanto, Didik Setyo; Pramono, Dibyo
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March 2017
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.633 KB) | DOI: 10.24198/pjd.vol29no1.11614

Abstract

ABSTRACTIntroduction: Oral cancer is a major health problem in the world, indicated by a high incidence of recurrence. In Southeast Asia, oral cancer ranks sixth from all cancers on the human body. The incidence of oral cancer, especially squamous cell carcinoma types, increases every year, but the prognosis and patients life expectancy are still unsatisfying enough and the reports about the profile of oral cancer is still limited.The objective of this research was to get the epidemiological profile of oral squamous cell carcinoma (OSCC) in Yogyakarta, Indonesia. Methods: The research method was observational analytic with cross-sectional design. All new OSCC cases in three anatomic pathology laboratory installations in Yogyakarta (January 2011-December 2015) were included in this study. Data collected were gender, age, anatomical location, and histology. All data were analyzed using statistical analysis program. Results: OSCC new cases amount increasing each year: 6 cases (6.6%) in 2011, and increased to 24 cases (26.4%) in 2015. Fifty-two of the 91 cases (57.1%) were found on male. The age group with the most cases was found in group of 41-60 years (49.5%). There is no difference in the case distribution by age between male and female. Forty-eight cases were found in the lingual part (52.7%). Histological examination showed 68 cases (74.7%) were well-differentiated carcinoma. Conclusion: OSCC profile in Yogyakarta mostly found in men with anatomical location in the lingual part in the age group above 40 years of age and were having well-differentiated histology.Keywords: Oral squamous cell carcinoma (OSCC), Epidemiologic profile, Yogyakarta 
MALONDIALDEHIDE (MDA) URINE AS AN EARLY MARKER OF DEVELOPMENTAL DISORDERS OF CHILDREN LIVING AROUND GOLD MINES Ernawati; Adi Heru Sutomo; Indwiani Astuti; Enda Silvia Putri; Marniati; Itza Mulyani; Sufyan Anwar; Eva Flourentina Kusumawardani; Suci Eka Putri; Hasanuddin Husin
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 4 No. 2 (2024): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/morfai.v4i2.1664

Abstract

Children born to mothers living around gold mines are at risk of mercury exposure (Hg) and can cause developmental disorders. These developmental disorders can be detected early through stress oxidation mechanisms based on Hg toxicity that directly harm brain cells. It can be detected early on from the level of DNA damage, which is malondialdehyde (MDA) in the urine. Examining children's MDA urine levels near gold mines is the aim of this study. The Observational Research Method performs measurement of MDA of baby urine with TBARS examination of 16 babies in the age range of 2-14 weeks babies who live around the gold mining village Kalirejo Prefecture Kokap district of Kulon Progo Yogyakarta. The result was a rate of 3.23 μmol/L of MDA in baby urine, which is above the normal level of 1.03 μMol/L. So it can be concluded that the high level of MDI in the baby's urine is an early indication of a child's developmental disorder living around the gold mining.
EXPRESSION OF HSA-MIR-22-3P IN THE URINE OF PROSTATE CARCINOMA PATIENTS AS A NON-INVASIVE BIOMARKER Prasetyo, Angga Dwi; Danarto, R.; Haryana, Sofia Mubarika; Astuti, Indwiani
Berita Biologi Vol 24 No 3 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.11311

Abstract

Prostate carcinoma is one of the prostate diseases with the highest prevalence in men. Many factors cause the disease; some are androgen receptor disorder, mutation of genes, age, epigenetics, and environment. Currently, the detection of the disease is done by Prostate-Specific Antigen (PSA), Transurethral Resection of Prostate (TURP), and Digital Rectal Examination (DRE) tests; all of which are invasive to the patients. The microRNA that exists in urine exosomes can be used to detect non-invasive prostate carcinoma.  Hsa-miR-22-3p with Gleason Score. This study aimed to examine the expression potential of Hsa-miR-22-3p in urine samples of prostate carcinoma exosomes as a non-invasive biomarker to determine the correlation between the expression of Hsa-miR-22-3p and the value of the Gleason Score. This study is of cross-sectional observational analysis. Urine samples were obtained from RSUP dr. Sardjito Yogyakarta dan RSUP dr. Soeradji Tirtonegoro. The exosome isolation was then carried out, followed by RNA isolation, cDNA synthesis, and quantification using qRT-PCR. Based on the result of the study, there was a decrease in the expression of Hsa-miR-22-3p by 6.6 times in prostate carcinoma; there was a significant difference between the samples of prostate carcinoma and healthy individuals (P = 0,031), and there was a correlation between the expression level of Hsa-miR-22-3p and the value of Gleason Score. Therefore, Hsa-miR-22-3p has the potential to be used as a biomarker for prostate carcinoma patients.
MiR-141-3p Relative Expression Level from FFPE Samples as Biomarker of Prostate Adenocarcinoma Carcinogenesis in Yogyakarta, Indonesia Sari Eka Pratiwi; Sri Nuryani Wahyuningrum; Rachmagreta Perdana Putri; Danarto Danarto; Didik Setyo Heriyanto; Nur Arfian; Sofia Mubarika Haryana; Indwiani Astuti
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 1 (2022): The future of diagnostic laboratory testing
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i1.2355

Abstract

Globally, prostate cancer (PCA) is the second leading cause of male cancer-associated mortality. Micro-RNAs (miRNAs) are small non-coding RNAs considered promising biomarkers for diagnosis, prognosis, and treatment options. A miR-141 expression is frequently dysregulated and influences the development and progression of PCA. This study aimed to identify miR-141 expression level as a marker to differentiate PCA from another prostate anomaly, especially in Yogyakarta. Formalin-fixed paraffin-embedded (FFPE) tissues for each three groups: benign prostatic hyperplasia/BPH, high-grade prostatic intraepithelial neoplasia/HGPIN, and PCA (n=7/group) were stored in a commercial clinical laboratory in Yogyakarta. The total RNA was extracted from FFPE sections using miRNeasy FFPE kit, followed by the quantification of miR-141-3p expression level by RT-PCR. The result showed that miR-141 relative expression level on PCA was higher than other groups and significantly different (P<0.05, Kruskal Wallis test). The mean of the miR-141 relative expression level of BPH, HGPIN, and PCA were 1.04±0.87, 6.44±7.8, and 7.06±8.83, respectively. The relative expression level of miR-141 can potentially be a prognostic biomarker in PCA and could differentiate aggressiveness in prostate anomaly, especially BPH, HGPIN, and PCA.
Co-Authors Adi Heru Husodo Adi Heru Husodo Adi Heru Sutomo Agus, Zaenal Arifin Nang Ahmad Hamim Sadewa Alma Linggar Jonarta Angga Dwi Prasetyo Anwar, Sufyan Arief Budiyanto Asdie, Ahmad Husain Bambang Hariwiyanto Brilliana Nur Rohima, Brilliana Nur Danarto Danarto Devi Usdiana Rosyidah Dibyo Pramono Didik Setyo Heriyanto Em Sutrisna Enda Silvia Putri Eni Mahawati Erna Kristin Ernawati Ernawati Eva Flourentina Kusumawardani Hajid Rahmadianto Mardihusodo, Hajid Rahmadianto Hari Kusnanto Hermawan, Dessy Husin, Hasanuddin Isadora Gracia, Isadora Itza Mulyani Iwan Dwiprahasto Kadarsih, Sri Laksono Trisnantoro Lorettha Wijaya Lutfan Lazuardi Mae Sri Hartati Wahyuningsih Marniati Muhammad Ghufron Munakhir Mudjosemedi Mustofa Mustofa Nur Arfian Pratiwi, Woro Rukmi Purwoko, Akhmad Edy Putri, Rachma Greta Perdana R. Danarto, R. Raden Danarto Regina TC Tandelilin Rurie Ratna Shantiningsih Sagung Rai Indrasari Sari Eka Pratiwi Sarto Sitarina Widyarini Soenarto Sastrowijoto, Soenarto Sofia Mubarika Haryana Sri Kadarsih Soejono Sri Nuryani Wahyuningrum Suci Eka Putri Sugiyanto, Sugiyanto Sunarti . Sunarti, ' Supriatno Sutjipto Sutjipto Suwaldi . Totok Utoro Waode Astria Sahrani Widya Asmara Yolanda Dyah Kartika Yuliani Setyaningsih Yuni Wijayanti Zainal Arifin Nang Agus