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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kesehatan Lingkungan indonesia Jurnal Kedokteran Brawijaya Jurnal Kebijakan Kesehatan Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Indonesian Journal of Urology The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia Indonesian Journal of Biotechnology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika INDONESIAN JOURNAL OF PHARMACY Padjadjaran Journal of Dentistry Oto Rhino Laryngologica Indonesiana INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Journal of Nutrition Science JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Biologi

Indwiani Astuti

Universitas Gadjah Mada

Author-ID : 235973

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Descriptions of Child Developmental Disorders Living Around Gold Mining Ernawati, Ernawati; Sutomo, Adi Heru; Astuti, Indwiani; Putri, Enda Silvia; Putri, Suci Eka; Marniati, Marniati; Mulyani, Itza
Journal of Nutrition Science Vol 5, No 1 (2024): May, 2024
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/jns.v5i1.9945

Living around the gold mining area, at risk of exposure to mercury (Hg). Pregnant women exposed to Hg alkyl can cause fetal brain damage so that the baby is born with d efects. This is due to the target toxicity of Hg, especially the organic metal compounds are the nervous system. Based on a child development screening questionnaire, ±100 children were questioned about their development, motor development, language and social interaction. This research was to see a picture of the development of children living around the Gold Mining village of Kalirejo, Kokap district, Kulon Progo District, Yogyakarta. The Longitudinal Observational Research Method with serial measurement measured the level of child development in five domains: cognitive, linguistic, motor, social, emotional and behavioral (adaptive behavior) with the Bayley Scale of Infant and Toddler Development Third Edition (BSID III) against 16 infants in the age range of 2-14 weeks (stage I) and 14-26 weeks. (tahap II). The baby's development observations resulted in an average composite development score of 85. Stage I obtained composite scores of cognitive domain; 102.81, language; 107.38, motor: 98.94, social emotional: 100,63 and behavioral: 90.00, while Stage II of each domain had the same scores as 105.94 : cognitive, 105.38: language, 104.81: motor, social-emotional: 98,69 and behavioural: 92.44. The conclusion that the composite child development score was in the average range of 90 - 109 for all domains, means that the child development composite score was still within the normal range (85-115), indicating that there is no developmental impediment. It is recommended to reduce Hg exposure, provide optimal nutrition to the baby and enhance developmental interventions with stimulation to stimulate auditorium, visual, tactile and kinesthetic, thereby improving the quantity and quality of brain cell synapses, to optimize brain function.

β-Carotene gingival mucoadhesive patch on Cx-43 and 8-Oxo-dg expression to prevent micronucleus formation due to panoramic radiography exposure Shantiningsih, Rurie Ratna; Suwaldi, Suwaldi; Astuti, Indwiani; Mudjosemedi, Munakhir
Padjadjaran Journal of Dentistry Vol 31, No 1 (2019): March 2019
Publisher : Universitas Padjadjaran

Introduction: β-carotene as a lipid-soluble antioxidant substance, expected to prevents the oxidative reaction and to improve the junctional communication detected by Cx-43. Micronucleus is known as one of the early markers of DNA damage which might be related to carcinogenesis mechanism that increased by panoramic radiography radiation exposure. The objective of this research was to analyse the effect of the β-carotene gingival mucoadhesive patch on Cx-43 expression and 8-oxo-dG to prevent micronucleus formation at the gingival mucosa of New Zealand rabbit due to panoramic radiography radiation exposure. Methods: β-carotene gingival mucoadhesive patch was applied to gingival mucosa of the experimental rabbits. In Group I, the rabbits without patch was a control group. Group II has applied the patch before radiography exposures, Group III during the radiography exposures, and Group IV after radiography exposures. Micronucleus samples were taken from the rabbit’s swabbed gingival mucosa, then stained using modified Feulgen-Rossenbeck. The 8-oxo-dG and Cx-43 expressions were detected using immunohistochemistry technique. The results were then analysed using two-way ANOVA. Results: The increasing number of micronucleus in Group I had a different mean (p < 0.05) with Group III and IV. The expression of 8-oxo-dG and Cx-43 had significant differences (p < 0.05) between Group I and III. This results indicated that β-carotene gingival mucoadhesive patch prevents the increasing number of micronucleus especially when it applied before and during panoramic radiography radiation exposure by the increasing Cx-43 and decreasing 8-oxo-dG expression. Conclusion: The β-carotene gingival mucoadhesive patch can be utilised to prevent the panoramic radiography radiation exposure’s effect. Keywords: β-carotene, gingival-mucoadhesive patch, micronucleus, radiation exposure

Epidemiologic profile of oral squamous cell carcinoma in Yogyakarta, Indonesia Gracia, Isadora; Utoro, Totok; S., Supriatno; Astuti, Indwiani; Heriyanto, Didik Setyo; Pramono, Dibyo
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March 2017
Publisher : Universitas Padjadjaran

ABSTRACTIntroduction: Oral cancer is a major health problem in the world, indicated by a high incidence of recurrence. In Southeast Asia, oral cancer ranks sixth from all cancers on the human body. The incidence of oral cancer, especially squamous cell carcinoma types, increases every year, but the prognosis and patients life expectancy are still unsatisfying enough and the reports about the profile of oral cancer is still limited.The objective of this research was to get the epidemiological profile of oral squamous cell carcinoma (OSCC) in Yogyakarta, Indonesia. Methods: The research method was observational analytic with cross-sectional design. All new OSCC cases in three anatomic pathology laboratory installations in Yogyakarta (January 2011-December 2015) were included in this study. Data collected were gender, age, anatomical location, and histology. All data were analyzed using statistical analysis program. Results: OSCC new cases amount increasing each year: 6 cases (6.6%) in 2011, and increased to 24 cases (26.4%) in 2015. Fifty-two of the 91 cases (57.1%) were found on male. The age group with the most cases was found in group of 41-60 years (49.5%). There is no difference in the case distribution by age between male and female. Forty-eight cases were found in the lingual part (52.7%). Histological examination showed 68 cases (74.7%) were well-differentiated carcinoma. Conclusion: OSCC profile in Yogyakarta mostly found in men with anatomical location in the lingual part in the age group above 40 years of age and were having well-differentiated histology.Keywords: Oral squamous cell carcinoma (OSCC), Epidemiologic profile, Yogyakarta

MALONDIALDEHIDE (MDA) URINE AS AN EARLY MARKER OF DEVELOPMENTAL DISORDERS OF CHILDREN LIVING AROUND GOLD MINES Ernawati; Adi Heru Sutomo; Indwiani Astuti; Enda Silvia Putri; Marniati; Itza Mulyani; Sufyan Anwar; Eva Flourentina Kusumawardani; Suci Eka Putri; Hasanuddin Husin
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 4 No. 2 (2024): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/morfai.v4i2.1664

Children born to mothers living around gold mines are at risk of mercury exposure (Hg) and can cause developmental disorders. These developmental disorders can be detected early through stress oxidation mechanisms based on Hg toxicity that directly harm brain cells. It can be detected early on from the level of DNA damage, which is malondialdehyde (MDA) in the urine. Examining children's MDA urine levels near gold mines is the aim of this study. The Observational Research Method performs measurement of MDA of baby urine with TBARS examination of 16 babies in the age range of 2-14 weeks babies who live around the gold mining village Kalirejo Prefecture Kokap district of Kulon Progo Yogyakarta. The result was a rate of 3.23 μmol/L of MDA in baby urine, which is above the normal level of 1.03 μMol/L. So it can be concluded that the high level of MDI in the baby's urine is an early indication of a child's developmental disorder living around the gold mining.

EXPRESSION OF HSA-MIR-22-3P IN THE URINE OF PROSTATE CARCINOMA PATIENTS AS A NON-INVASIVE BIOMARKER Prasetyo, Angga Dwi; Danarto, R.; Haryana, Sofia Mubarika; Astuti, Indwiani
Berita Biologi Vol 24 No 3 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.11311

Prostate carcinoma is one of the prostate diseases with the highest prevalence in men. Many factors cause the disease; some are androgen receptor disorder, mutation of genes, age, epigenetics, and environment. Currently, the detection of the disease is done by Prostate-Specific Antigen (PSA), Transurethral Resection of Prostate (TURP), and Digital Rectal Examination (DRE) tests; all of which are invasive to the patients. The microRNA that exists in urine exosomes can be used to detect non-invasive prostate carcinoma. Hsa-miR-22-3p with Gleason Score. This study aimed to examine the expression potential of Hsa-miR-22-3p in urine samples of prostate carcinoma exosomes as a non-invasive biomarker to determine the correlation between the expression of Hsa-miR-22-3p and the value of the Gleason Score. This study is of cross-sectional observational analysis. Urine samples were obtained from RSUP dr. Sardjito Yogyakarta dan RSUP dr. Soeradji Tirtonegoro. The exosome isolation was then carried out, followed by RNA isolation, cDNA synthesis, and quantification using qRT-PCR. Based on the result of the study, there was a decrease in the expression of Hsa-miR-22-3p by 6.6 times in prostate carcinoma; there was a significant difference between the samples of prostate carcinoma and healthy individuals (P = 0,031), and there was a correlation between the expression level of Hsa-miR-22-3p and the value of Gleason Score. Therefore, Hsa-miR-22-3p has the potential to be used as a biomarker for prostate carcinoma patients.

Co-Authors Adi Heru Husodo Adi Heru Husodo Adi Heru Sutomo Agus, Zaenal Arifin Nang Ahmad Hamim Sadewa Alma Linggar Jonarta Angga Dwi Prasetyo Anwar, Sufyan Arief Budiyanto Asdie, Ahmad Husain Bambang Hariwiyanto Brilliana Nur Rohima, Brilliana Nur Danarto Danarto Devi Usdiana Rosyidah Dibyo Pramono Didik Setyo Heriyanto Em Sutrisna Enda Silvia Putri Eni Mahawati Erna Kristin Ernawati Ernawati Eva Flourentina Kusumawardani Hajid Rahmadianto Mardihusodo, Hajid Rahmadianto Hari Kusnanto Hermawan, Dessy Husin, Hasanuddin Isadora Gracia, Isadora Itza Mulyani Iwan Dwiprahasto Kadarsih, Sri Laksono Trisnantoro Lorettha Wijaya Lutfan Lazuardi Mae Sri Hartati Wahyuningsih Marniati Marniati Marniati, Marniati Muhammad Ghufron Mulyani, Itza Munakhir Mudjosemedi Mustofa Mustofa Nur Arfian Pratiwi, Woro Rukmi Purwoko, Akhmad Edy Putri, Enda Silvia Putri, Suci Eka R. Danarto, R. Rachma Greta Perdana Putri Raden Danarto Regina TC Tandelilin Rurie Ratna Shantiningsih Sagung Rai Indrasari Sari Eka Pratiwi Sarto Sitarina Widyarini Soenarto Sastrowijoto, Soenarto Sofia Mubarika Haryana Sri Kadarsih Soejono Sri Nuryani Wahyuningrum Suci Eka Putri Sugiyanto, Sugiyanto Sunarti . Sunarti, ' Supriatno Sutjipto Sutjipto Suwaldi . Totok Utoro Waode Astria Sahrani Widya Asmara Yolanda Dyah Kartika Yuliani Setyaningsih Yuni Wijayanti Zainal Arifin Nang Agus

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