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All Journal Medical Journal of Indonesia Indonesian Journal of Urology Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Griya Widya: Journal of Sexual and Reproductive Health Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Ponco Birowo
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Comprehensive Histopathological Properties of Dartos Tissue Associated with Hypospadias Severity and Chordee: A Prospective Study Raharja, Putu Angga Risky; Birowo, Ponco; Rachmadi, Lisnawati; Wibowo, Heri; Kekalih, Aria; Duarsa, Gede Wirya Kusuma; Wahyudi, Irfan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.243

Abstract

Background: The cause of chordee in hypospadias is not fully understood. Dartos fascia resection has been shown to correct penile curvature, suggesting its potential involvement. This study aimed to evaluate the histopathological properties of dartos tissue and their association with hypospadias severity and chordee.Methods and Materials: Dartos tissue samples were collected from 37 children with hypospadias and ten controls undergoing circumcision between March and October 2024. Histopathological analysis using hematoxylin-eosin and Masson’s trichrome staining assessed for collagen, smooth muscle, and vascular density. Assessment and quantification of all histopathological components were blinded. Results: The hypospadias group showed lower collagen density (60.85±6.75% vs. 67.31±4.61%; p=0.003) and higher smooth muscle density (7.34±4.92% vs. 2.51±2.24%; p<0.001) compared to controls, with no significant difference in vessel density. Sub-analysis showed severe chordee was linked to lower collagen density compared to mild (Mean Difference [MD] -6.24±2.41%; p=0.014) and moderate chordee (MD -5.73±2.54%; p=0.031). Conclusions: The dartos tissue in hypospadias patients exhibited lower collagen density and higher smooth muscle density, with chordee severity specifically linked to decreased collagen density.
Co-Authors Achmadsyah, Armand Adianti Khadijah, Adianti Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Akmal Taher Andon Hestiantoro Ari Astram, Ari Ari Basukarno, Ari Aria Kekalih Ariyati, Ira Arry Rodjani Asmarinah Biddulth Sujana, Biddulth Brodjonegoro, Sakti R Budi Wiweko C Susilo, C Chaidir A. Mochtar CHAIDIR MOCHTAR, CHAIDIR charles johanes, charles Danarto, Raden Dedi Afandi Djoko Rahardjo donny eka putra, donny eka Dyandra Parikesit, Dyandra Endrika Noviandrini, Endrika Fadilah Fadilah, Fadilah Fajriani, Rosalina Fakhri Rahman, Fakhri Febriyani Ferry Safriadi Fiastuti Witjaksono Gede Wirya Kusuma Duarsa Gerhard Reinaldi Situmorang, Gerhard Reinaldi Gunawan, I Putu Gde Fredy Hakim, Rizky Lukman Harahap, Alida Roswita Hariwibowo, Rinto Hendri, Ahmad Z Heri Wibowo Hernawan Rahmat Muharia, Bayu Hery Tiera I Putu Gde Sanjaya, I Putu Ikhlas A. Bramono, Ikhlas A. Indah S. Widyahening Indrawarman Soeroharjo Irfan Wahyudi Isaac A. Deswanto, Isaac A. Iswara, Raja AFW. Iswara, Raja AW. Ivan Rizal Sini, Ivan Rizal Joedo Prihartono Levina S. Pakasi Lisnawati Rachmadi Meilinda, Astrid Mewahyu Dewi, Mewahyu Michelle Eva Mohammad Sulchan Namira Kesuma Jelita Nur Rasyid Nur Rasyid P Pryambodho, P Pakpahan, Karimul Abdi Pande Made Wisnu Tirtayasa Prahara Yuri Prasetyo, Dimas Tri Pudji Sari Puji Sari Purba, Herdiman Bernard Puspita E. Wuyung Putra, Donny E. Raharja, Putu Angga Risky Rahmad Mulyadi, Rahmad Retno A. Werdhani Retno Asti Werdhani Savira, Missy Savitri, Ary Indriana Selanno, Fradelino Esau Siti Setiati Siti T.K. Gardian Surya Putra, Abdul Hafiidh Suryoadji, Kemal Akbar Sutisna Himawan Tommie Prasetyo Tommie Prasetyo, Tommie Tri Indah Winarni Tri Prasetyo, Dimas Uiterwaal, Cuno Vinny Verdini Widi Atmoko Widyasmara, Her Bayu Wistara, Sevita Sathya Yopie Tjandradiguna Satyawan Yuli Budiningsih Zulfikar Ali Zulfikar Ali, Zulfikar