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Desain Primer Secara In Silico untuk Amplifikasi Gen Pre-S2 Virus Hepatitis B Tirtawati, Ni Putu Ayu; Yowani, Sagung Chandra
Innovative: Journal Of Social Science Research Vol. 5 No. 4 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i4.20964

Abstract

Hepatitis B is a serious infectious disease caused by the Hepatitis B virus (HBV), which can progress to cirrhosis and hepatocellular carcinoma. Early detection of HBV infection is crucial to prevent disease progression, but the Pre-S2 gene region as a diagnostic target remains understudied. This gene plays a crucial role in viral infectivity, replication, and immune response, and its mutations are known to contribute to latent infection and the pathogenesis of liver cancer. This study aimed to design in silico primer pairs specific to the HBV Pre-S2 gene using a bioinformatics approach. The design was performed using Primer3Plus based on the HBV genome sequence from GenBank (Accession Number AB246345.1), and evaluated through physicochemical parameters such as length, melting temperature (Tm), GC content, and potential for secondary structure formation. The best candidates were then tested for specificity using Primer-BLAST against various HBV isolates. The results showed that the forward primer pair 5’-TTCCTCTTCATCCTGCTGCT-3’ and reverse primer pair 5’-AGTTTCCGTCCGAAGGTTTT-3’ were able to amplify the Pre-S2 gene with a PCR product length of 193 bp and exhibited high specificity for the HBV genome. These findings demonstrate the effectiveness of the in silico approach in designing primers for molecular detection of the HBV Pre-S2 gene and its potential applications in diagnosis, mutation research, and the development of prevention strategies.
Eksplorasi Potensi Bahan Alam Sebagai Tabir Surya Sari Dewi, Kadek Ratna; Chandra Yowani, Sagung
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 3 No. 08 (2023): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v3i08.1105

Abstract

Kulit manusia memiliki perlindungan tersendiri terhadap bahaya sinar UV, tetapi radiasi ultraviolet yang berlebih dapat mengakibatkan perlindungan ini berkurang. Radiasi ultraviolet seringkali menyebabkan kerusakan jaringan tubuh seperti eritema, edema, sunburn, tanning, hyperplasia, photoaging bahkan kanker kulit. Tabir surya merupakan salah satu produk yang dapat digunakan untuk membantu melindungi kulit. Tabir surya dari bahan alam berpotensi digunakan sebagai perlindungan kulit dari radiasi ultraviolet. Tujuan penelitian ini untuk mengetahui potensi dari bahan alami yang dapat dimanfaatkan sebagai tabir surya. Metode yang digunakan adalah literatur review pada database jurnal penelitian dari tahun 2018 sampai 2023. Hasil penelitian menunjukkan adanya potensi dari berbagai bahan alam baik dalam bentuk ekstrak maupun sediaan dengan pengujian secara in vitro. Tanaman yang dapat dimanfaatkan sebagai tabir surya seperti daun stroberi, pegagan, buah sirsak, buah pare, daun kelor, ganggang hijau, daun keledang dan biji buah alpukat. Tanaman tersebut banyak ditemukan mengandung senyawa fenolik terutama flavonoid yang terbukti mampu menyerap paparan sinar UV.
Developing tuberculosis drug information system using a throwaway prototype: Udayana Hospital case study Rini Noviyani; Luh Arida Ayu Rahning Putri; I Nyoman Gede Budiana; Luh Gede Astuti; I Made Oka Widyantara; Ida Ayu Alit Widhiartini; Ida Bagus Nyoman Maharjana; Sagung Chandra Yowani; I Gusti Ngurah Anom Cahyadi Putra
TELKOMNIKA (Telecommunication Computing Electronics and Control) Vol 24, No 1: February 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/telkomnika.v24i1.27073

Abstract

Tuberculosis (TB) remains a major health problem in Indonesia, and efficient drug management is essential to ensure continuous treatment and prevent resistance. At Udayana University Hospital, manual recording and reporting often caused delays and errors, while integration with the National Tuberculosis Information System (SITB) was limited. This study developed a TB drug information system using the throwaway prototype model to address these challenges and enhance hospital workflow efficiency. The system implementation demonstrated measurable improvements in operational performance, with data entry errors reduced by 83% and the average recording time per patient shortened by 35% compared to the previous manual process. User feedback confirmed improved usability, accuracy, and reliability in supporting hospital workflows and timely reporting. In conclusion, the proposed system effectively improved the accuracy and efficiency of TB drug management while addressing hospital level operational challenges. This study demonstrates the applicability of the throwaway prototype model in healthcare information-system development and provides insights for scaling and integration with national TB programs.
Co-Authors A. W. Dwiputri Ade Ari Sundari Ade Ari Sundari Amelia Putri, Ni Luh Dian Saptari Arifani Siswidiasari Asmara A. A. R. Astuti, M.A.P. Ayu Nyoman Chandra Yustiana Cista Dewi, Ni Putu Fiona Dek Pueteri Dewi Suryani Deniariasih, N.W. Devi, Ni Wayan Antika Sri Devita Kusdianingrum Dewa Ayu Swastini Dewi Andayani Farmawati Dwicandra, N.M.O. Dyah Subadrika Warma Dewi Endang Kumolosasi Heni Pujiastuti I Gede Ketut Sajinadiyasa I Gusti A. A. Santhi Rahmaryani I Gusti Ayu Agung Septiari I Gusti Ngurah Anom Cahyadi Putra I Ketut Juniarta I Ketut Tunas I Made Dira Swantara I Made Oka Widyantara I Nengah Wirajana I Nyoman Gede Budiana I Nyoman Gede Budiana I Wayan Kasa Ida Ayu Alit Widhiartini Ida Ayu Gendari Ida Ayu Ratih Dwi Nugraha Putri Ida Bagus Nyoman Maharjana Ida Bagus Nyoman Putra Dwija Indra Juana Adikara Jennifer Tamara Jennifer Tamara Kadek Ratna Sari Dewi Kadek Widya Yuli Hartati Ketut Ratnayani Ketut Widyani Astuti Liangky Syane S Luh Arida Ayu Rahning Putri Luh Gede Astuti Luh Vida Sasmitha Luk Ketut Budi Maitriani M. A. Pratiwi Made Dharmesti Wijaya Made Rai Dwitya Wiradiputra Marlia Singgih Wibowo Mirawati N.K.W. Ni Kadek Ari Cipta Pratiwi Ni Kadek Ariani Ni Ketut Sri Anggreni Ni Komang Sasi Ani Ni Made Febrianti Ni Made Yustikarini Ni Nyoman Pradnya Utari Ni Putu Ariantari Ni Putu Intan Satya Dewi Ni Putu Monica Rosdiana Dewi Paramitha Ni Wayan Sukma Pramitha Sari1 Nurul Marfu’ah Osamu Iitsuka Pradnyaniti, D.G Putri, Ni Kadek Sri Adnyani Alit Putu Ayu Indrayathi Putu Lita Astriani Rasmaya Niruri Rini Noviyani Rini Noviyani Sang Ayu Putu Chika Iswari Anjani Saputra, Gusti Nyoman Oka Sari Dewi, Kadek Ratna Sudarma, I Wayan Ari Syamsul Arifin Tasya Pramiswari Tirtawati, Ni Putu Ayu Wijayakusuma, I Gusti Ngurah Lanang Yayanasri Yustiantara, Putu Sanna