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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Media Farmasi UMI Medical Journal Green Medical Journal Indian Journal of Forensic Medicine & Toxicology Wal'afiat Hospital Journal INDONESIAN JOURNAL OF HEALTH eJournal Kedokteran Indonesia jpki WAL'AFIAT HOSPITAL JOURNAL Jurnal Farmasi Indonesia
Zulfahmidah
Departemen Biokimia, Fakultas Kedokteran, Universitas Muslim Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Mekanisme Molekuler Muscle Disuse Atrophy Zulfahmidah Zulfahmidah; Imran Safei
Wal'afiat Hospital Journal Vol. 4 No. 1 (2023): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v4i1.102

Abstract

Kehilangan massa otot rangka sering terjadi sebagai respons terhadap imobilisasi sendi dan tirah baring, serta diinduksi oleh ketidak aktifan dari otot tersebut. Atrofi yang diinduksi oleh kurangnya aktivitas akan mempengaruhi setiap individu dalam hidupnya, dan dapat melemahkan terutama pada orang tua. Saat ini tidak ada terapi yang baik untuk mengobati disuse atrofi otot dapat disebabkan karena kurangnya pemahaman tentang mekanisme seluler dan molekuler yang bertanggung jawab untuk induksi dan pemeliharaan atrofi otot. Di dalam review ini akan dibahas mekanisme molekuler yang terlibat pada atropi otot disuse
Rehabilitation in Juvenile Myasthenia Gravis: Strategies and Challenges in Enhancing Pediatric Patient Quality of Life zulfahmidah zulfahmidah; Nila Mayasari
eJournal Kedokteran Indonesia Vol. 14 No. 1 (2026): Vol 14, No. 1 - April 2026
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.14.1140.1

Abstract

Juvenile Myasthenia Gravis (JMG) is a rare autoimmune disorder characterized by impaired neuromuscular transmission, resulting in fatigable weakness and significant functional limitations in pediatric patients. Despite growing recognition of rehabilitation's importance in JMG management, there remains a critical need to synthesize current evidence and establish standardized approaches. This comprehensive review examines the pathophysiology of JMG, focusing on autoantibody-mediated disruption of acetylcholine receptors (AChR) and muscle-specific kinase (MuSK) at the neuromuscular junction. We evaluate evidence-based rehabilitation strategies including (1) tailored exercise programs combining resistance (30-50% 1RM) and aerobic training; (2) targeted bulbar and respiratory interventions; and (3) integrated psychosocial support. The analysis highlights emerging technologies such as telerehabilitation and robotic exoskeletons while identifying persistent challenges in care accessibility and disease variability. Current evidence demonstrates rehabilitation's crucial role in optimizing functional outcomes for JMG patients, though significant knowledge gaps remain. The review underscores the urgent need for JMG-specific clinical trials, precision rehabilitation approaches, and standardized care protocols. Future research should prioritize biomarker-guided interventions and technology-enhanced therapies to advance pediatric JMG management globally.
The Role of Reactive Oxygen Species in Muscle: Beneficial/Harmful Zulfahmidah Zulfahmidah; Imran Safei
Green Medical Journal Vol 4 No 3 (2022): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v4i3.129

Abstract

Introduction: Skeletal muscle produces moderate quantities of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), due to its contractile action, high oxygen consumption, and metabolic rate (RNS). Under normal physiological circumstances, the generation and removal of ROS/RNS are in dynamic equilibrium. Content: The body reaches a condition of oxidative stress, however, when the oxidation products surpass the antioxidant defense capability. Increased oxidative stress has significant ramifications for the molecular, structural, and functional integrity of muscle. The release of reactive oxygen species (ROS) under pathological circumstances leads to cellular dysfunction and the progression of muscle disorders. Conclusion: The antioxidants can put ROS in optimal concentrations to perform physiological signals in muscle. At appropriate concentrations, ROS and RNS can regulate intracellular signal transduction. Thus, moderate quantities of radicals are advantageous to muscle, but high doses of ROS are harmful. The aim of this review is to know about the role of ROS in muscle.
Co-Authors Abdul Mubdi Ardiansar Arifuddin Karim Achmad Harun Muchsin Afrina F.Bustan Agung Dirgantara Aisyah, Windy Nurul Andi Dhedie Prasatia Sam Andi paluseri Andi Sitti Fahirah Andry Pratama Anna Sari Dewi Annisa Tri Srilistiany Arina Fathiyyah Arina Fathiyyah Arifin Armanto Makmun Arni Isnaini Arfah Asrini Safitri Asrini Safitri Dahlia Dahlia Dian Amelia Abdi Dzulfachri Kurniawan Eny Arlini Wello Erlin Syahril Erwin Rachman Fajriansyah Fajriansyah Febie Irsandy Fendy Dwimartyono Hardjo, Marhaen Haslinda Haslinda Imran Safei Imran Safei Imran Safei Imran Safei, Imran Irna Diyana Kartika Kasmawati Kasmawati Lisa Yuniaty M. Hamsah Meilinda Aji Syahputri Mufia Muin Muhamad Ilhamsyah Dandung Muhammad Mursyid Nasrudin Andi Mappaware Nila Mayasari Nurelly Noro Waspodo Nurfardiansyah Burhanuddin Rahmawati Rahmawati Rasfayanah Rasfayanah Resky Asfiani Rahman Rezky Putri Indarwati Abdullah Rika Oktaviani Risna Sri Wahyuni. M Santriani Hadi Shofiyah Latief Sri Rahayu Jamaluddin Sri Wahyu Sri Wahyuni Gayatri Surya Sumantri Abdullah Syahrijuita Kadir Syamsu Rijal Wialda Dwi Rodya Wiriansya, Edward Pandu Yusriani Mangarengi Zulfitriani Murfat Zulfiyah Surdam