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All Journal MEDIA MEDIKA INDONESIANA The Indonesian Journal of Public Health Sari Pediatri Paediatrica Indonesiana Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Keperawatan Muhammadiyah Holistik Jurnal Kesehatan Manuju : Malahayati Nursing Journal Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Kesehatan Ibu dan Anak Jurnal SMART Kebidanan Golden Age: Jurnal Ilmiah Tumbuh Kembang Anak Usia Dini JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JURNAL KESEHATAN MERCUSUAR World Nutrition Journal Psychiatry Nursing Journal (Jurnal Keperawatan Jiwa) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL PROFESSIONAL HEALTH JOURNAL Indonesian Journal on Medical Science (IJMS) MEDICINUS Jurnal Sosial dan Sains Journal of Public Health and Pharmacy Jurnal Vokasi Keperawatan (JVK) Folia Medica Indonesiana
Ahmad Suryawan
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Airlangga, RSU Dr. Soetomo, Surabaya.
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : World Nutrition Journal

 1 
Partially Hydrolyzed Whey Protein: A Review of Current Evidence, Implementation, and Further Directions Badriul Hegar; Zakiudin Munasir; Ahmad Suryawan; I gusti Lanang Sidhiarta; Ketut Dewi Kumara Wati; Erfi Prafiantini; Irene Irene; Yvan Vandenplas
World Nutrition Journal Vol. 5 No. 1 (2021)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.i1.0008

Abstract

Background: Human milk is known to be the best nutrition for infants as it provides many health benefits. For non-breastfed infants, cow's milk based infant formula is the most optimal option to provide the needed nutrition. However, approximately 2-5% of all formula-fed infants experience cow’s milk allergy during their first year of life. Partially hydrolyzed whey formula (pHF-W) have been widely recommended to prevent the development of allergic disease in infants. However, according to epidemiological data, approximately half of the infants developing allergy are not part of the at-risk group.Objectives and Methods: This article aims to review the effects of pHF-W in preventing allergy, especially atopic disease, in all non-breastfed infants, as well as the safety aspect of pHF-W if used as routine formula. The role of pHF-W in the management of functional gastro-intestinal (GI) disorders is also reviewed.Results: Several clinical studies showed that pHF-W decrease the number of infants with eczema. The strongest evidence is provided by the 15-year follow up of the German Infant Nutritional Intervention study which showed reduction in the cumulative incidence of eczema and allergic rhinitis in pHF-W (OR 0.75, 95% CI 0.59-0.96 for eczema; OR 0.67, 95% CI 0.47-0.95 for allergic rhinitis) and casein extensively hydrolysed formula  group (OR 0.60, 95% CI 0.46-0.77 for eczema; OR 0.59, 95% CI 0.41-0.84 for allergic rhinitis), compared to CMF as a control, after 15 years of follow-up. pHF-W was also found to be beneficial in the management of functional GI disorders such as regurgitation, constipation and colic.Conclusions: The use of pHF-W in allergic infants has been recommended in various guidelines across the countries, as a primary prevention of allergic disease. One pHF-W has been approved by the US FDA and the European Commission's European Food Safety Authority (EFSA) for its safety and suitability as a routine infant formula for all healthy infants. According to the data obtained in the management of functional GI disorders, pHF-W is better tolerated than formula with intact protein. Further studies assessing the effect of routine use of pHF-W in a larger population of non-breastfed infants should also be conducted, in order to observe any potential harm and to determine the benefit and cost-effectiveness ratio.
Co-Authors Afiliany, Amelia Anang Endaryanto Andri Kurnia Wahyudhi Anggrahini, Simplicia Maria Arinaa Manasika Farida Ariyanto Harsono Atika Atika Aulia Septyani, Reta Azwin Mengindra Putera Badriul Hegar Bambang Permono Budi Utomo Budi Utomo BUDI UTOMO Darto Saharso Desi Fitriani Dewi Astasari Diah Retno Sari Dian Dwi Sari Dian Fitria Kurniawati Dinda Anes Tunjungsari Dinda Chandra Yuliantari Dominicus Husada Dwi ariningtyas, Ninuk Eka Marta Puspita Rini Elok Widjianingsih Endang Retnowati Erfi Prafiantini Fachry Abda El Rahman Fardana, Nur Ainy Fatimah Indarso Fatimah Indarso Fatimah lndarso Febriyana, Nining Felisita Maritza Abidanovanty Firinda, Seif Fitri Erna Erfiany Hapsari Widya Ningtiar Hari Basuki Notobroto Helen Lucky Maharani Hendy Hendarto I Dewa Ayu Agung Sridharaswari I Dewa Gede Ugrasena I Gusti Ayu Indah Ardani I gusti Lanang Sidhiarta Ichromy, Ulfi Rifki Irene Irene Irwadi, Irfiansyah IRWANTO Irwanto Irwanto Irwanto Irwanto Irwanto, Irwanto Isha Akastia Ivon Diah Wittiarika Jonathan, Elizabeth Beatrice Juniastuti Juniastuti Katharina Laurentia Monika Nago Adja Ketut Dewi Kumara Wati Komang Ayu Witarini Kurniasari, Anggun Febry Laili Nur Rosyidah Laili Primasari Lilik Djuari Linda Dewanti Lisa Pangemanan Lolita Lestari Margarita Maramis, Margarita Mira Irmawati Moersintowarti B Narendra Moersintowarti B. Narendra Moersintowarti BN Moersintowati B. Narendra Muhammad Faizi Neni Asmawati Putri Ningrum, Astika Gita Ningtiar, Hapsari Widya Ninuk Dwi Ariningtyas Nur Rochmah Nyilo Purnami Pingkan Fredelia Lontoh Pudji Lestari Purwanti, Zamrotu Iva Putri, Oky Arnanda Antonia Rahma Furi Sagita Rahmadhanti, Diah Caesaria Garindra Reta Aulia Septyani Retno Asih Setyoningrum Rika Hapsari Rini Sekartini Risa Etika, Risa Rize Budi Amalia Romdhoni Romdhoni Romdhoni, Achmad Chusnu Rusli, Vinia Sensusiati, Anggraini Dwi Setiawati, Yunias Shalma Alya Fadilla Shella Permata Sari Siti Nurul Fajariyah Siti Wahyu Windarti Sri Utami Sulistiawati Sulistiawati Sulistiawati, S Sylviati M. Damanik Tutfah Razzak Fitriari Wahyul Anis Widati Fatmaningrum Widya Tresna Kusuma Windarti, Siti Wahyu Woro Setia Ningtyas Yusigania, Dinna Yvan Vandenplas Zahrah Hikmah, Zahrah Zakiudin Munasir Zamrotu Iva Purwanti Zamrotu Iva Purwanti