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Journal : Universa Medicina

Aloe vera extract reduces 8-oxo-2-deoxyguanosine levels and improves total antioxidants in streptozotocin-induced diabetic rats Christijanti, Wulan; Marianti, Aditya; Isnaeni, Wiwi
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.34-41

Abstract

BackgroundDiabetes mellitus is a chronic disease caused by lack of insulin production in the pancreas or by insulin resistance, the disease being characterized by elevated blood glucose levels. Hyperglycemia in diabetes could lead to oxidative stress due to the rise in 8-oxo-2-deoxyguanosine (8-oxo-dG) levels and the decrease in levels of total antioxidant status (TAS). The purpose of this study was to assess the effect Aloe vera extract on 8-oxo-dG level and total antioxidant status in diabetic rat testis. MethodsThis was an experimental laboratory study with 20 rat samples which were divided into 4 groups (1 control group and 3 treatment groups). Diabetes was induced in the rats by streptozotocin (STZ) at 65 mg/kgBW. The diabetic rats were then treated for 28 days with Aloe vera extract at 0 mg (P0), 200 mg rind (P1), 200 mg pulp (P2), respectively. The level of 8 -oxo-dG was measured by ELISA and total antioxidant status with 2,2 -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Data were analyzed with ANOVA and Least Significant Difference Advanced Test at P<0.05. Results8-Oxo-dG levels were significantly different between the control group and both P0 and P2, but not between the control group and P1. Among the treatment groups the 8-oxo-dG levels were significantly different. Mean total antioxidant status was significantly different between control and treatment groups, and also between treatment groups (p<0.05). ConclusionsAloe vera extract reduced free radicals (level of 8-oxo-dG) and increased the total antioxidant status in diabetic rat testis. 
Co-Authors - Suprihatin, - Aditya Marianti Alfiatun N, Alfiatun Amanatul Munawaroh, Amanatul Andreas Priyono Budi Prasetyo Anggoro, Naufal Sebastian Anisa Dewi Sri Puspitasari Ari Yuniastuti Arya Iswara Arya Iswara Aulia, Maliqa Ayu Etna Ningtyas, Ayu Etna Azkiyah, Nimas Catur Badingatus Sholihah Bagus Hammam Falah Cahya Buana Damar Galih Dewi Mustikaningtyas Dimarti, Safira Chaerani Dimarti, Safira Chairani Edward Louis Krey Eling Purwantoyo Ely Rudyatmi, Ely Endah Peniati Falistina, Amna Fifti Istiklaili, Fifti Fitri Arum Sasi, Fitri Arum Fonda, Sarah Shabrina Hammam, Bagus Ibnul Mubarok Jabar, Muhammad Abdul Kartika Widyaningrum Kikie Septiyana, Kikie Kusuma, Putri Patria Kusuma, Zeni Herawati Laraswati, Vivi Anggraeni Lina Herlina Lisdiana Lisdiana M.A. Sunny Maridah Nurjanah, Maridah Martien Herna Susanti Maulana, Silvia Faori Mighfar Khamida, Mighfar Mirtaati Na’ima Mohamed, Mohd Salim Bin Mu’afy, Faizal Daffa Na’ima, Mirtaati Nana Kariada Trimartuti Ning Setiati Nisa', Lailatun Nisa' Nissa, Ma’isyatun Noor Aini Habibah Nugrahaningsih WH Nugrahaningsih, WH Nur Rahayu Utami Nur Rahayu Utami Nuryanti, Novi Pauline, Maretha Putri Pramesti Dewi Priyanto, Yudi Purnamaningrum, Sisilia Prita Dewi Putri, Komala Amelia R Susanti R. Susanti R. Susanti R. Susanti Rakainsa, Senda Kartika Ramadhanti, Shifa Ramasamy, Sujatha Rismanika Anggraeni, Rismanika Rizki Raharyu Noviami, Rizki Raharyu Rizki Raharyu, Rizki Sasabila Mumtaz Sekar Dwi Ardianti Senda Kartika Rakainsa Sholihah, Badingatus Sigit Saptono Siti Harnina Bintari Siti Qomariah, Siti Sriyadi , Sriyadi Sriyadi Sriyadi, Sriyadi Stephani Diah Pamelasari, Stephani Diah Sumad Sumad Sumad Sumad, Sumad Supriyanto - Suryonegoro, Bayu Murti Talitha Widiatningrum Tsaniyah, Nurotun Najmatus Udin Ahmad Syahri, Udin Ahmad Wardani, Agata Iswiana Diah Widiyaningrum, Kartika Widyaningrum, Kartika Wijaya, Ifan Badra Wiwi Isnaeni Woro Sumarni Yudi Priyanto Zaenafree, Intan