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All Journal Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Industri Pertanian Jurnal Hortikultura Indonesia (JHI) ACTA VETERINARIA INDONESIANA Jurnal Penyuluhan Media Gizi dan Keluarga Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Media Kesehatan Masyarakat Indonesia Jurnal Online Mahasiswa (JOM) Bidang Perikanan dan Ilmu Kelautan Medical Laboratory Technology Journal AcTion: Aceh Nutrition Journal Journal of Tropical Crop Science AGROSAINSTEK: Jurnal Ilmu dan Teknologi Pertanian Journal of Agribusiness and Local Wisdom Journal of International Conference Proceedings Jurnal Kedokteran Hewan
Muhamad Rizal Martua Damanik
Departemen Gizi Masyarakat, Fakultas Ekologi Manusia (FEMA), Institut Pertanian Bogor, Bogor 16680
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Medical Laboratory Technology Journal

 1 
Anti-hyperglycemic Effect of Torbangun (Coleus amboinicus Lour) Leaves Extract Through Liver and Muscle Glycogen Deposits in Streptozotocin-induced Hyperglycmic Sprague-Dawley Rats Model Meilla Dwi Andrestian; Rizal Damanik; Faisal Anwar; Nancy Dewi Yuliana
Medical Laboratory Technology Journal Vol. 5 No. 2 (2019): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.547 KB) | DOI: 10.31964/mltj.v5i2.227

Abstract

The association of liver and muscle glycogen deposits with serum insulin levels, β-cells pancreas, and fasting blood glucose (FBG) of streptozotocin (STZ)-induced hyperglycemic rats receiving Torbangun leaves extract (TE) investigated. The intervention performed on 25 8-week-old Sprague-Dawley rats divided into four groups. Seven rats separated as a normal group (N), and other rats injected with streptozotocin (STZ). Confirmation of hyperglycemic was characterized by fasting blood glucose >126 mg/dl. Treatment group which is NG (hyperglycemic rats); N (normal rats); H-IM (62.5 mg/kg BW metformin); and H-IT (620 mg/kg BW TE) for 14 days. This study revealed that TE significantly decreased FBG levels, increased insulin production, and the amount of liver glycogen deposits (a=0.01). However, the intervention did not significantly increase the amount of muscle glycogen deposits. TE administration improves β-cells, increases the liver and muscle glycogen deposits. TE was shown to have antihyperglycemic activity by improving the β-cell, increasing blood serum insulin levels, decreasing blood glucose levels, and increasing the liver glycogen deposits.
Co-Authors . Triyani A.A. Ketut Agung Cahyawan W Abidah Nur Ade Chandra Iwansyah Ade Chandra Iwansyah Adhitya Aji Candra Adi, Fajar Ahmad Sulaeman Alfiah, Elma Amalia, Niken Rizki Anna Fatchiya Anwas, E. Oos M. Ardi Adji Aripin Ahmad Armina Puji Utari Arum Fitria Asri Sulistyawati Astri Ayu Novaria Aziz, Sandra A Budi Setiawan Budi Setiawan Budi Setiawan Clara M. Kusharto Clara M. Kusharto Dede Kusmana Devita Annisa Dewi Sukma Dian Ekawati Dias Indrasti Didik Hariyadi Dodik Briawan E. Oos M. Anwas, E. Oos Endang Warsiki Endang Warsiki dan Citra Dewi Wahyono Putri (E-Jurnal Agro-Industri Indonesia) Eny Rolenti Togatorop Eva Fitriyaningsih Evy Damayanthy Faisal Anwar Fitrah Reynaldi Hamidah, Hamidah Hardinsyah Hendrik Hendrik Hidayat Syarief Hidayat Syarief Husnah Husnah Iflan Naufal Ikeu Ekayanti Ikeu Tanziha Ilyatun Niswah Ita Djuwita ITA DJUWITA Izna Nurdianty Muhdar Junaidi Junaidi Karina Rahmadia Ekawidyani Katrin Roosita Kusai Kusai Leily Amalia Lilik Kustiyah Lilik N Yuliati Mahani Mahani Marisa Marisa Marissa Indreswari Marthin, Yodi Meilla Dwi Andrestian, Meilla Dwi Mokhamad Fahrudin Muhammad Hanafi Muhammad Hanafi Mulyana, Erik Mustafa Kamal Nancy Dewi Yuliana Nelly Marissa Nining Tyas Triatmaja Oktavianus Para Endro Ploeger, Angelika Pramadya Alfitra Pudji Muljono Renny Fridieyanti Rimbawan , Rimbawan R Risti Rosmiati Rusmiyati, Henny Sari, Dia Novita Sri Anna Marliyati Sri Yuliani Sukma, Dewi Sumali M Atmojo Syarifah Iis Aisyah Syuja' Rafiqi Tetty Herta Doloksaribu Teuku Muliadi Tiurma Sinaga Tjahja Muhamdri Utama, Lalu Juntra Vera Uripi Wahidin Wahidin Waras Nurcholis Wiwit Estuti