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All Journal Journal of Degraded and Mining Lands Management AGRIVITA, Journal of Agricultural Science agriTECH Jurnal Riset Industri Hasil Hutan Jurnal Kimia Mulawarman The Indonesian Biomedical Journal Jurnal Kreativitas PKM Gorontalo Journal of Forestry Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Inovasi ULIN: Jurnal Hutan Tropis Jurnal Riset Teknologi Industri Wood Research Journal : Journal of Indonesian Wood Research Society Wood Research Journal : Journal of Indonesian Wood Research Society Bivalen: Chemical Studies Journal International Journal of Multidisciplinary: Applied Business and Education Research Prosiding Konferensi Nasional PKM-CSR Journal Of Medicine And Health Sciences (Medisci) Journal of Tropical Pharmacy and Chemistry Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Enos Tangke Arung, Enos Tangke
Faculty Of Forestry, Mulawarman University Samarinda
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : The Indonesian Biomedical Journal

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Brucea javanica Leaf Extract Induced Apoptosis in Human Oral Squamous Cell Carcinoma (HSC2) Cells by Attenuation of Mitochondrial Membrane Permeability Britanto Dani Wicaksono; Enos Tangkearung; Ferry Sandra
The Indonesian Biomedical Journal Vol 7, No 2 (2015)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v7i2.76

Abstract

BACKGROUND: Brucea javanica extract has been reported to have anti-proliferative and cell death induction activities. B. javanica extract was reported to induce apoptosis through caspase cascade. Most of investigated B. javanica extracts were derived from seeds and fruits, or commercially available oil emulsion. Therefore we conducted a study on B. javanica leaf extract (BJLE) in oral cancer cells.METHODS: B. javanica leaves were collected, identified, minced, dried, extracted with distilled ethanol at room temperature for 24 hours, filtered and evaporated. Resulted BJLE was stored at 4°C. Human oral squamous cell carcinoma (HSC)-2 cells were fasted for 12 hours and treated with BJLE in various concentrations for 24 hours. Cells were then quantified with 3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide (MTT) assay, demonstrated with 4',6'-diamidino-2-phenylindole (DAPI) staining. To find out mitochondrial membrane permeability (MMP), mitochondrial membrane potential (ΔΨM) was analyzed.RESULTS: BJLE reduced percentage of viable HSC-2 cells in a concentration dependent manner. BJLE induced apoptosis in HSC-2 cells. With treatment of 50 μg/ml BJLE, fragmented nuclei were seen. ΔΨM of HSC-2 cells treated with 50 μg/ml BJLE were shifted to the left, meaning that BJLE induced reduction of ΔΨM and attenuation of MMP.CONCLUSION: Our results suggested that BJLE could induce apoptosis by attenuating MMP.KEYWORDS: Brucea javanica, leaf, apoptosis, HSC-2, MTT, DAPI, mitochondria, permeability
Evaluations of Antibacterial Properties of Zingiber purpureum Essential Oil Against 13 Different Gram-positive and Gram-negative Bacteria Nataniel Tandirogang; Silvia Anitasari; Enos Tangke Arung; Swandari Paramita; Yung Kang Shen
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.1967

Abstract

BACKGROUND: Indonesia's tropical forest is home to around 80% of the world's medicinal plants. One of these is Zingiber purpureum, which have traditionally been used to treat joint discomfort, the common cold, and jaundice. The rhizomes of this plant have been suggested to possess antibacterial action in the treatment of infections. In this study, Z. purpureum was screened for antibacterial activity against 13 bacteria (Gram-positive and Gram-negative).METHODS: Z. purpureum rhizomes were obtained and the distillated extracts were made to generate essential oil. The minimum inhibitory concentration (MIC) and Kirby Bauer disk diffusion methods were used to determine the antibacterial activity.RESULTS: All bacteria activity were inhibited by the essential oil of Z. purpureum at concentrations ranging from 2.5 vol% to 10 vol%. However, several bacterias (Escherichia coli, Pseudomonas aeruginosa, and Enterobacter cloacae) were inhibited at the lowest concentration (0.63 vol %), with the inhibition zones ranging from 6.7 mm to 8.0 mm. Meanwhile, the widest inhibition zone (13.3 mm) was reported on E. cloacae at 10 vol% concentration.CONCLUSION: A 10 vol% Z. purpureum rhizome extract inhibits Gram-positive and Gram-negative bacteria, particularly those that are resistant to a variety of antibiotics.KEYWORDS: Zingiber purpureum, antibacterial agents, susceptibility test, infection
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Rasyid Zarta Abdul Rasyid Zarta Amalia Riska Setyani Amirta, Rudianto Ananda, Bayu Susetya Ardy, Ari Binti Khairunnisa Britanto Dani Wicaksono Dewi Listyaningrum, Dyah Ayu Dewi, Januartha Kisari Dikarulin, Sarah Azzara Dungani, Rudi Edy Budiarso Edy Budiarso Edy Budiarso Enih Rosamah Ernita Obeth Eva Nurmarini Farida Ariani Farida Aryani Ferry Sandra Forestryana, Dyera Hamka Nurkaya Harlinda Kuspradini Heriad Daud Salusu Heriad Daud Salusu Heriad Daud Salusu Herliani Herliani Irawan Wijaya Kusuma, Irawan Wijaya Kadis Mujiono, Kadis Khairunnisa, Binti Kuniyoshi Shimizu KUNIYOSHI SHIMIZU Kusuma, Irawan W Lismana Sari, Ratih Afrida Manullang, Julinda Romauli Mardian, Yessi Maulida Mark Rayment Miftakhur Rohmah, Miftakhur Nataniel Tandirogang Netty Maria Naibaho Nor Hikmah Nugroho, Dimas Fajar Nurul Puspita Palupi Putri, Tasya Ananda Rahmayanti Fitriah Reny Marliadi Rico Ramadhan, Rico Ritson Purba Ritson Purba, Ritson Romadhon, Muhammad Rizky Roro Kesumaningwati Rosamah, Enih Rosamah, Enih Rosamah, Enih Ryuichiro Kondo Saat Egra Sari, Ayu Mitha Sari, Ayu Mitha Sari, Eadvin Rosrinda Awang Silvia Anitasari Sofian Sofian Subeki Subeki Sukemi Sukemi Sukemi Sukemi Sunardi Sunardi Suwinarti, Wiwin Swandari Paramita Swandari Paramita Syafrizal Syafrizal Teddy Tranoto Teddy Tranoto, Teddy Toruan, Vera Madonna Lumban Usman Usman Wicaksono, Dian Anggoro Wijaya Kusuma, Irawan Wiwin Tyas Istikowati Yani, Sinar Yanti Puspita Sari Yuliansyah Yuliansyah Yundari, Yundari Yung Kang Shen