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A Review of Di-(2-ethylhexyl) Phthalate (DEHP) Exposure and Metabolic Syndrome in Adults Daramusseng, Andi; Sulistiyani; Suhartono; Darundiati, Yusniar Hanani
Poltekita: Jurnal Ilmu Kesehatan Vol. 19 No. 2 (2025)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v19i2.4019

Abstract

The sources of DEHP exposure are very wide because it is used as a plasticizer and additive in cosmetics and personal care products. Epidemiological studies have shown that DEHP and its metabolites can increase the risk of metabolic syndrome. However, this observation is still debated. Therefore, we conducted a systematic review aimed to investigate the relationship between DEHP exposure and metabolic syndrome in adults. This study used three databases, namely Pubmed, Scopus, and ScienceDirect, with English-language publications from 2019 to 2024. Seven cross-sectional and cohort studies from South Korea, the United States, Mexico, and Taiwan met the inclusion criteria selected through the PRISMA stages They were assessed for quality using the JBI Critical Appraisal Tool. The findings showed that only studies conducted in the United States and South Korea showed a significant association between DEHP and its metabolites (MEHP, MECPP, MCMHP, MEHHP, and MEOHP) with metabolic syndrome. However, these findings were limited to men, white men, premenopausal women, and postmenopausal women. In conclusion, DEHP and its metabolites showed inconsistent results on metabolic syndrome in adults. Recommendations are that further studies are needed with more robust designs in the future in various countries to clearly describe the relationship between DEHP and metabolic syndrome and strong regulation of phthalate use to minimize exposure.
Impact of Brain Gym® on health outcomes of toddlers born with low birth weight: a randomized trial Setiawan, Cahyo; Kartini, Apoina; Winarni, Sri; Darundiati, Yusniar Hanani
Paediatrica Indonesiana Vol. 65 No. 5 (2025): September 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Low birth weight (LBW) children are at risk of developmental delay, including impaired motor skills, cognitive function, and stress regulation. Brain Gym® activities have been shown to improve motor coordination, attention span, and fine motor skills in preschool and primary school-aged children. Evidence for the use of Brain Gym® is limited for infants and toddlers with medical vulnerabilities such as low birth weight (LBW), who are at increased risk of developmental delay and heightened stress sensitivity. Objective To evaluate the impact of Brain Gym® exercises on cognitive function, motor skills (fine and gross motor), and cortisol levels in children aged 12–23 months with a history of LBW compared to a control group. Methods  A randomized controlled trial (RCT) was conducted in Sragen, Indonesia, involving 80 low birth weight (LBW) children aged 12 to 23 months. Participants were randomly allocated into two groups: an experimental group receiving Brain Gym® intervention and a control group.The experimental group received Brain Gym® exercises combined with routine baby massage, while the control group received only baby massage. Cognitive and motor development were assessed using the Denver Developmental Screening Test (DDST), while stress biomarkers were measured through salivary cortisol levels using enzyme-linked immunosorbent assay (ELISA). Assessments were conducted at baseline (pre-intervention) and after the 8-week intervention period. The evaluators who administered the DDST and laboratory staff analyzing cortisol were blinded to group allocation. Results The primary outcomes of this study were motor skills, cortisol levels, and cognitive function. At baseline, there were no significant differences between the Brain Gym® group and the control group in fine motor, gross motor, or cognitive function scores, as assessed by the DDST. After the intervention, between-group comparisons revealed no statistically significant differences in gross motor, fine motor, cortisol, or cognitive function outcomes. Within-group analysis showed that gross motor scores in the Brain Gym® group significantly increased after the intervention (P = 0.038), while fine motor scores demonstrated a non-significant trend toward improvement (P = 0.110). Cortisol levels in the Brain Gym® group significantly decreased (P = 0.009), whereas the control group exhibited no significant changes in gross motor (P = 0.548), fine motor, or cortisol levels (P = 0.118). Cognitive function scores remained statistically unchanged in both groups. Conclusion Our findings suggest that Brain Gym® exercises can improve gross motor function and reduce stress in LBW children. These findings highlight the potential of early interventions in enhancing development, but should be interpreted cautiously due to the modest sample size and short intervention period. Future studies should focus on the long-term effects and the mechanisms underlying these improvements.
Analisis Pajanan Debu dengan Gejala Gangguan Pernafasan pada Pekerja Industri Bata: Literature Review : Analysis of Dust Exposure with Symptoms of Respiratory Disorders in Brick Industry Workers: A Literature Review Yudi Akbar, Faris; Onny Setiani; Yusniar Hanani Darundiati
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 7 No. 1: JANUARY 2024 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v7i1.4633

Abstract

Latar Belakang: Industri Batu bata merupakan salah satu industri yang menghasilkan polutan di udara. Polutan yang dihasilkan dari industri tambang kapur adalah partikel debu dan gas. Debu yang dihasilkan dapat mengganggu kesehatan pekerjaannya. ISPA adalah salah satu penyakit gangguan saluran pernapasan yang menyerang pekerja tambang kapur. ISPA tidak hanya terjadi akibat pajanan debu kapur, terdapat beberapa faktor risiko pekerja yang dapat menyebabkan terjadinya ISPA. Tujuan: Penelitian ini bertujuan untuk mengetahui pajanan debu dari batu bata dan faktor risiko pekerja dengan kejadian ISPA. Metode: Penelitian ini dilakukan menggunakan metode literature review dengan besar sampel sebanyak 16 jurnal. Hasil: Penelitian ini menunjukkan variabel yang bermakna atau memiliki hubungan dengan kejadian ISPA diperoleh sekitar 80% dari beberapa variabel yang di teliti. Dari tinjauan artikel diketahui ada masa kerja, penggunaan alat pelindung diri (masker), usia, riwayat penyakit dan kebiasaan merokok. Faktor risiko yang paling dominan memiliki hubungan yang bermakna dengan kejadian ISPA adalah variabel masa kerja dan variabel penggunaan alat pelindung diri (masker).
Literature Review: Faktor Risiko yang Berhubungan dengan Gangguan Fungsi Paru Pekerja Industri Mebel di Indonesia Anissah, Neli; Setiani, Onny; Darundiati, Yusniar Hanani
Jurnal Ilmu Kesehatan Masyarakat Vol. 14 No. 03 (2025): Jurnal Ilmu Kesehatan Masyarakat
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikm.v14i03.3918

Abstract

Paparan debu di lingkungan kerja industri mebel bisa menyebabkan gangguan fungsi paru, baik restriktif, obstruktif, maupun kombinasi keduanya (mixed). Penurunan fungsi paru terjadi secara bertahap dan kronis. Kajian sistematis ini bertujuan untuk mengidentifikasi dan menganalisis faktor risiko yang ada hubungannya dengan gangguan fungsi paru pada pekerja industri mebel di Indonesia. Penelitian ini adalah tinjauan sistematis terhadap artikel ilmiah dengan desain studi cross-sectional yang dipublikasikan antara tahun 2016 hingga 2025. Pencarian dilakukan melalui tiga basis data yakni Google Scholar, ScienceDirect, dan Scopus. Kriteria inklusi meliputi artikel berbahasa Indonesia atau Inggris, membahas pekerja mebel di Indonesia, dan faktor risiko yang berkaitan dengan gangguan fungsi paru. Dari hasil tinjauan terhadap 19 artikel, ditemukan bahwa paparan debu kayu, lama masa kerja, durasi kerja harian, serta kebiasaan merokok merupakan faktor utama yang paling konsisten terkait dengan gangguan fungsi paru pada pekerja industri mebel. Sementara itu, pengaruh penggunaan alat pelindung diri (APD) serta usia menunjukkan hasil yang tidak konsisten antar studi. Oleh karena itu, diperlukan upaya pengendalian paparan debu yang lebih optimal, serta peningkatan edukasi dan kepatuhan dalam penggunaan APD secara tepat guna, untuk meminimalkan risiko gangguan pernapasan pada pekerja.
Mosquito control activities associated with dengue hemorrhagic fever in Indonesia: A literature review Puspita, Yashinta Dwi; Sulistiyani, Sulistiyani; Darundiati, Yusniar Hanani; Dewanti, Nikie Astorina Yunita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art13

Abstract

Dengue Hemorrhagic Fever (DHF) is an endemic disease. It has become a public health concern. Mosquito control activities are needed to control vectors and prevent DHF. Therefore, we conduct a literature review of mosquito control activities associated with DHF in Indonesia. This study applies the selected articles using PRISMA (Preferred reporting items for systematic reviews and meta-analyses), and they are sourced from Science Direct, Google Scholar, Scopus, ProQuest, Ebscohost, and Portal Garuda. The criteria for the selected articles are full-text articles, published in 2015-2020, and those which are published in national journals SINTA 2 or international journals. This study reviewed 683 articles, out of which were selected for further examination. The key variables, such as draining water containers, covering water containers, burying and recycling used containers, using mosquito repellent, using larvacide , keeping larva-eating fish, having mosquito repellent plants, installing wire mesh on ventilation, showed significant correlation with Dengue Hemorrhagic Fever (DHF) incidence. Among the selected articles, 38.89% employed cross-sectional design, and the rest belonged to case-control studies. Most articles have variable draining water containers (55.56%), 50% covers water containers, 80% have a significant association between draining water containers and DHF incidence, and 66.67% have a significant association between covering water containers and DHF incidence. Most articles show that not implementing PSN (Pemberantasan sarang nyamuk) or PSN 3M (Pemberantasan sarang nyamuk, menguras, menutup, mengubur plus) is associated with the incidence of DHF and is a risk factor for the occurrence of DHF. On the other hand, the implementation of PSN or PSN 3M Plus will be a protective factor.
Co-Authors Abd. Rasyid Syamsuri Ahmad Farid Ali Djamhuri Amalia Jamil Angelina, Maria Sylvia Anggraeni, Siti Hafidzhah Dyah Ayu Anissah, Neli Annisa Amaliana Annisa Rachmawati Apoina Kartini Ardias Ardias Arumsari, Fina Astri Wulandari Ayu Larasati Az Zahro, Putri Rahmawati Az-zahro, Putri Rahmawati Azhari, Achmad Rizki Azhari, Achmad Rizki Azzahra Pratadina Bariyadi Rifai Benedikta Familia Santcawarti Budiyono Budiyono Budiyono Budiyono Cahyo Setiawan Charles foeh Foeh Chesaria Candra Cahyani Chintya Pangestika Choirul Luluk Fatimah Cresti Dwitiya Murti Daramusseng, Andi Diah Ayu Pusparini, Diah Ayu Dian Indriyani Diana Islamawati Eka Wahyuni Fatikha Firdausi Fitria Andriani Fitrisya Lucki Dwiyanti Fransiska Vony Wicheisa Galuh Candra Dewi Hanan Lanang Dangiran Hanan Lanang Dangiran, Hanan Lanang Hapsari, Titi Hari Ismanto Hasim, Jamal Hisham Ika Fitriati, Ika Ilham Pradana Sulistiyono Putra intan permata sari Karunia Dwi HPS Kunti Wijiarti Laila Fitria Lailya Indha Pramastuti Lina Yulianti Linda Devega Masyithah, Wulan Maulida, Devina Alya Maysaroh Nur Istikomah Mayvika Farah Fadhila Munawaroh, Dinni Asmini Mursid Rahardjo Mursid Raharjo Nasution, Lailatussyifah Niki Astorina Yunita Darundiati Niki Astorina Yunita Dewanti Niki Astorina Yunita Dewanti, Niki Astorina Yunita Nikie Astorina Yunita Dewanti Nuha, Nabila Ulin Nur Endah Wahyunigsih Nur Endah Wahyuningsih Nur Latifah, Endah Nurjazuli Nurjazuli Nurjazuli Nurul Qodariyah Oktavia Suci Setyoningsih, Oktavia Suci Okti Iswari Triswindyaningrum Onni Setiani Onny Setiani Onny Setiani Poppi Nastasia Dewi Pudjaningrum Pudjaningrum Puspita, Yashinta Dwi Rahmadayanti Rahmadayanti Rahmah, Syifa Rifqa Ainur Rainy Rifta Raisha Selviastuti Regita Damayanti Saputri Rifka Fuazia Bilqis Risa Kartika Putri Risma Dwi Yulianti Rizka Laila Rachmawati, Rizka Laila Solly Aryza Sri Winarni Suhartono Sukma Dewi Novianti Sulistiyani SULISTIYANI SULISTIYANI Sulistiyono Putra, Ilham Pradana Sulistyani Sulistyani Tika Adelia Nurkholis Puteri Tri Joko Ufairoh, Azum Ulfa, Elok Fadila Utami, Desi Putri Vitasari, Marliana Wahida Inayatun Nikmah Wahyu Sekar Harjanti Widya Kristiani Dory Purba, Widya Kristiani Dory Winnoto Winnoto Yudi Akbar, Faris Yuliani Setyaningsih Zahra, Nabilah