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All Journal Jurnal Berkala Epidemiologi Jurnal Media Gizi Indonesia (MGI) The Indonesian Journal of Public Health Sari Pediatri Paediatrica Indonesiana Health Notions Jurnal Medik Veteriner Amerta Nutrition Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Media Gizi Kesmas Indian Journal of Forensic Medicine & Toxicology MEDICINUS Berita Kedokteran Masyarakat Folia Medica Indonesiana
Roedi Irawan
Child Health Department, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Serum Level of 25-Hydroxyvitamin D in Children with Epilepsy Receiving Long-Term Antiepileptic Treatment Ismail, Chasan; Irawan, Roedi; Saharso, Darto
MEDICINUS Vol. 33 No. 2 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.621 KB) | DOI: 10.56951/medicinus.v33i2.59

Abstract

Background: Long-term treatment with antiepileptic drugs (AED) requires monitoring of potential side effects, one of them is the decreasing in serum vitamin D level. Low serum vitamin D level is also a global health problem in healthy children. There are conflicting results regarding the low serum vitamin D level in epileptic children due to treatment with AED. Purpose: This study aimed to compare serum vitamin D level between healthy children and children with epilepsy receiving long-term AED treatment in Soetomo General Hospital. Methods: This was a cross-sectional study conducted in the pediatric neurology clinic of Soetomo general academic hospital from August 2018 to July 2019. Subjects are children ages 2-18 years with epilepsy receiving AED treatment for over 6 months (n=22), with healthy children as control (n=22). Peripheral serum 25-hydroxyvitamin D level were measured using enzyme-linked fluorescence assay (ELFA) method. The differences of those groups were analyzed by comparing the mean of 25-hydroxyvitamin D level of both groups using Anova and T-test (95% CI). Results: Low serum vitamin D level were identified in 27% children with epilepsy and 13% healthy children. The mean of serum 25-hydroxyvitamin D level in children with epilepsy and healthy children was 21.5 ng/ml (SD 8.41) and 34.3 ng/ml (SD 10.09), respectively. There was a significant difference between groups (p<0.05). Conclusion: Children with epilepsy receiving long-term AED treatment have lower level of serum 25-hydroxyvitamin D than healthy children.
Co-Authors Alexander Leonard Caesar Josediputra Alexander, Yoppi Yeremia Alifah Fajriyyatul Izzah Ardianah, Eva Ariandi Setiawan Arief Wibowo Ayuning Tetirah Ramadhani Bahmid, Moh Bahmid, Moh. Boerhan Hidayat Boerhan Hidayat Boerhan Hidayat, Boerhan Budi Prasety Christine Florens Christine Florens Darto Saharso Diah Indriani Dina Angelika Dwi Lestari Avianti Eddy Bagus Wasito Esthy Poespitaningtyas Febriyana, Nining Frieska Piesesha Gibrata, Aisyah Alhaura Hafiza Amadhin Rusti Hanindita, Meta Herdiana Hanindita, Meta Herdiana Hardiani, Kartika Hardiyani, Kartika Hardiyani, Kartika Hari Basuki Notobroto Hartojo Hartojo HERMANTO, EDI Hidajat, Boerhan Hidayatunnikmah, Nina I Dewa Gede Ugrasena I Gusti Ayu Putu Eka Pratiwi Iitdrie Iitdrie, Iitdrie Indri Safitri Mukono, Indri Safitri Ismail, Chasan Jusak Nugraha Keya , Rino Tryanto Keya, Rino Tryanto Khadijah Rizky Sumitro Khadijah Rizky Sumitro KUNTORO Mahrus A Rahman, Mahrus A Masayu Ramadhani Polanunu Meity Ardiana Miriawati Miriawati Mochammad Bagus Qomaruddin Muhammad Faizi Muthmainnah Muthmainnah Nanda Hudawarrahmah Ninik Asmaningsih Soemyarso Noviyanti, Tausiyah Rohmah Noviyanti, Tausyiah Rohmah Nur Aisiyah Widjaja, Nur Aisiyah Nur Aisiyah Widjaya Nur Aisiyah Wijaya Nur Aisyah Widjaja Nurfidaus, Yasmine Pebriaini, Prisma Andita Piesesha, Frieska Putri, Melvanda Gisela Qonitatillah, Ana Rachmah Indawati Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Ria Puspitasari Rina Elizabeth Risa Etika, Risa Rizky Arisanti Maharani Royke Tony Kalalo Rusti, Hafiza Amadhin Santoso, Febrina Mustika Setiawan, Ariandi Sigit Ari Saputro SITI NURUL HIDAYATI Soenarnatalina Melaniani Taufiq Hidayat Widati Fatmaningrum Widjaja, Nur Aisyah Widjaja, Nur Aisyah Wigati, Kristanti Wanito Windhu Purnomo