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All Journal Journal of Mathematical and Fundamental Sciences Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Padjadjaran Journal of Dental Researchers and Students MDJ (Makassar Dental Journal) Denta: Jurnal Kedokteran Gigi Odonto dental journal

Nanan Nur’aeny

Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran Bandung, Indonesia

Author-ID : 2541182

Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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THE IMPORTANT ROLE OF ORAL MEDICINE SPECIALIST IN MANAGEMENT OF STEVENS-JOHNSON SYNDROME PATIENT Nuri Fitriasari; Eko Rotary Nurtito; Nanan Nur’aeny; Indah Suasani Wahyuni
Dentino : Jurnal Kedokteran Gigi Vol 5, No 2 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i2.8969

ABSTRACTIntroduction: Stevens-Johnson Syndrome (SJS) is an acute hypersensitivity reaction that manifests on the skin, oral mucosa, ocular, gastrointestinal, genital and anal area. It is also potentially life-threatening in concern of dehydration and infection. Oral mucosal lesions due to SJS resulted in a significant decrease of patient’s quality of life. When the oral mucosa involved, the intake of nutrients and fluids is disrupted contributing to electrolyte imbalance that aggravates dehydration. Moreover, oral mucosal lesions have become an entry point for infection. Purpose: This case report describes the important role of oral medicine specialists in the management of oral mucosal lesions in SJS patient. Review: A 26-year-old female patient was referred from the Department of Dermatology and Venereology with a diagnosis of SJS et causa suspected paracetamol and/or amoxycillin. The complaints comprised of pain on the lips and oral cavity, difficulty in mouth opening, and pain when swallowing. The management for oral lesions included: history taking, external and intra oral examinations, dexamethasone mouthwash, nystatin oral suspension, and sodium chloride (NaCl) 0.9% solution. The patient showed improvement in oral mucosal lesions within 3 weeks of treatment that was provided by oral medicine specialist and medical team collaboration. Conclusion: Based on this case report, the role of oral medicine specialist is very important as part of the management team for SJS patient. Oral medicine specialist can reduce morbidity that results from oral mucosal involvement. Collaboration with oral medicine specialist since the beginning of treatment is the key to success in SJS management. Keywords: Oral medicine specialist, Oral mucosal lesion, Stevens-Johnson Syndrome.

IDENTIFICATION OF CANDIDA SPECIES IN DIABETIC PATIENTS WITH COATED TONGUE Hilda Hindasah; Yuti Malinda; Riani Setiadhi; Indah Suasani Wahyuni; Wahyu Hidayat; Nanan Nur’aeny
Dentino : Jurnal Kedokteran Gigi Vol 4, No 2 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i2.7068

Background: Coated tongue is a condition in which the dorsum of the tongue is covered by a white layer containing food debris or microorganisms such as Candida species (Candida spp). Factor that can influence coated tongue including a condition such as Diabetes mellitus which often reduce the production of saliva and initiate the increase of Candida spp in number. Objective: to determine various species of Candida spp. in the saliva of Diabetes mellitus patients with coated tongue as a preliminary condition to detect oral candidiasis. Methods: Coated tongue examination was performed by evaluating the lesion visually or using tongue scraper. Salivary collection was performed using oral rinse concentrate method. Saliva samples were inoculated in Chromogenic Agar to identify Candida spp. by examining the colour and the form of colony. Results: Eight samples (88.8%) were identified as C. albicans while C. parapsilosis was presented in 5 samples (66.6%) and C. tropicalis in 2 samples (22.2%). Overall, C. albicans is the most common Candida spp. that found in oral cavity. Candida spp. as normal flora in the oral cavity could be pathogen if the body's immune system decreases. In this study, there was a slight difference between Candida spp. found in the saliva of Diabetes mellitus patients compared to the control group. Conclusions: Candida spp. that identified in Diabetes mellitus patients with coated tongue are C.albicans, C. glabrata, and C. tropicalis.

Challenges in the management of oral ulceration in elderly patients Nanan Nur'aeny
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 4 (2015): December 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Oral ulceration can be experienced by anyone, including those who are elderly. Various trigger factors can occur in elderly patient, but the main thing to consider is the degenerative factors that affect the occurrence of some medical problems. Handling oral ulceration in elderly patients should be done carefully and holistically otherwise the improvement is only temporary and can reappear or even be worse. Purpose: In this paper we will discuss two different case reports of elderly female patients and both having some oral ulceration. Cases: First case of recurrent oral ulceration experienced by 58 years old patient, and second case is concerning a 77 years old patient with chronic oral ulceration and also having some medical problems. Aphthous like ulcers (ALU) is a diagnosis for recurrent oral ulceration associated with systemic condition, and usually started after adolescent age. Elderly or geriatric condition itself is a special condition that contribute to the degree of a disease. Cases management: Both patients given non pharmacology and pharmacology therapies. The non pharmacology therapy includes communication, information, and education, also oral hygiene instruction. Steroid as anti-inflammatory drugs had an important role in healing process, beside other medication. Conclusion: Oral ulceration in elderly patients with or without a medical problems becomes a challenging thing to handle due to the complexity of their condition. As a dentist we have more careful to arrange the treatment plans for elderly patients when combine with some therapy related systemic disease.

Correlation between reactive oxygen species and oral conditions in elderly individuals with hypertension: a preliminary study Nanan Nur'aeny; Wahyu Hidayat; Indah Suasani Wahyuni
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 3 (2017): September 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: The increased number of elderly people in Indonesia can be a positive phenomenon if their health is well-preserved. The elderly are influenced by physiological changes, environmental factors, and personal habits making them susceptible to chronic diseases. The oral cavity is also subject to change, one of the causes being reduced salivary flow that is manifested in dental caries and other oral health concerns. This disease is stimulated by oxidative stress in the body due to an imbalance between reactive oxygen species (ROS) and the antioxidant defense system. Purpose: This preliminary study aimed to investigate ROS-related hypertension and the state of oral health of elderly patients. Methods: The study constitutes a combination of cross-sectional observation and consecutive sampling. Twelve subjects, selected on the basis of inclusive and exclusive criteria, consisted of two males and ten females. Physical examinations and blood sampling were performed on all subjects. R version 3.4.1 for Windows operating system was used to perform statistical tests. Results: The 12 patients shared a history of hypertension, the lowest ROS level was 0.87 IU/ml, while the highest was one of 7.20 IU/ml. The correlation between ROS and oral conditions showed only ROS and tooth loss as having a significant positive correlation. An independent t test showed there to be a mean difference between ROS with Miyazaki index 1 and 2 but it was statistically insignificant. Conclusion: There was no correlation between the ROS level in the bloodstream and general oral health, except in the relationship between the ROS level in the bloodstream and tooth loss which had a positive correlation.

Faktor risiko dan tatalaksana kandidiasis oral pada pasien dengan drug reaction with eosinophilia and systemic symptoms (DRESS)Risk factors and management of oral candidiasis in drug reaction with eosinophilia and systemic symptoms (DRESS) patients Embun Manja Sari; Nuri Fitriasari; Nanan Nur'aeny
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 1 (2022): April 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v34i1.33531

Pendahuluan: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) adalah reaksi obat yang jarang terjadi, tetapi menimbulkan reaksi klinis yang berat, berupa demam, erupsi kulit, dan keterlibatan organ internal. Terapi medikasi untuk pasien DRESS berupa pemberian kortikosteroid high potent memiliki faktor risiko terjadinya kandidiasis oral selain faktor gangguan imunitas secara sistemik akibat DRESS. Penulisan laporan kasus bertujuan untuk memaparkan faktor risiko dan tatalaksana kandidiasis oral pada pasien DRESS. Laporan kasus: Seorang laki-laki berusia 51 tahun dirawat selama 14 hari dengan diagnosis DRESS oleh bagian Dermatologi dan Venereologi Rumah Sakit Hasan Sadikin Bandung. Terapi intravena yang diberikan adalah Deksametason 20 gram/hari, Vitamin K 3x1 ampul/hari, Omeprazole 1x40 gram/hari, dan Siprofloksasin 2x400 gram/hari. Terapi per oral yang diberikan adalah: Cetirizine 1x10 gram/hari, Curcuma 3x1 kapsul/hari, Asam folat 1x1 tab/hari, Asetilsistein 2x2 mg/hari, serta Callos 1x500 mg/hari. Pasien kemudian dikonsulkan ke bagian Ilmu Penyakit Mulut karena memiliki keluhan sakit pada rongga mulut, tenggorokan, dan bibir sejak 3 hari di RS. Riwayat sariawan berulang disangkal. Pasien tidak pernah menyikat gigi selama rawat inap. Tatalaksana kandidiasis oral diberikan Nystatin in oral suspension 4x200.000 IU/hari, Chlorhexidine digluconate 0,12%, asam hialuronat, NaCl 0,9%, serta Mikonazol krim 2% dan racikan deksametason salep 0,002% diberikan terkait lesi pada bibir dan dioleskan pada sudut mulut. Simpulan: Faktor risiko kandidiasis oral pada pasien DRESS adalah penggunaan kortikosteroid secara sistemik, gangguan imun terkait DRESS, dan kebersihan rongga mulut yang buruk. Tatalaksana kandidiasis oral diberikan adalah antifungal dan antiseptik.Kata kunci: drug reaction with eosinophilia and systemic symptoms; faktor risiko; kandidiasis oral ABSTRACTIntroduction: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare drug reaction but causes severe clinical reactions in the form of fever, skin eruptions, and involvement of internal organs. Medical therapy for DRESS patients in the form of high potent corticosteroids has a risk factor for oral candidiasis and systemic immune disorders. This case report aimed to describe the risk factors and management of oral candidiasis in DRESS patients. Case report: A 51-year-old male was treated for 14 days with a diagnosis of DRESS by the Department of Dermatology and Venereology of Hasan Sadikin Hospital, Bandung. Intravenous therapy administered was 20 grams/day of Dexamethasone, 3x1 ampoules/day of Vitamin K, 1x40 grams/day of Omeprazole, and 2x400 grams/day of Ciprofloxacin. Oral therapy was 1x10 grams/day of Cetirizine, 3x1 capsules/day of Curcuma, 1x1 tab/day of folic acid, 2x2 mg/day of Acetylcysteine, and 1x500 mg/day of Callos. The patient was then referred to the Department of Oral Medicine because of complaints of pain in the oral cavity, throat, and lips after hospitalisation for three days. History of recurrent thrush was denied. The patient never brushed his teeth during hospitalisation. The management of oral candidiasis was the administration of Nystatin in oral suspension with the dose of 4x200,000 IU/day, 0.12% Chlorhexidine digluconate, hyaluronic acid, 0.9% NaCl, and 2% topical Miconazole, and a mixture of 0.002% dexamethasone ointment, which was given related to lesions on the lips, and topically administered in the corner of the lips. Conclusion: The risk factors for oral candidiasis in DRESS patients are systemic use of corticosteroids, DRESS-related immune disorders, and poor oral hygiene. The management of oral candidiasis is antifungal and antiseptic.Keywords: drug reaction with eosinophilia and systemic symptoms; oral candidiasis, risk factors

Manajemen pendarahan gingiva akibat pansitopenia pada pasien dengan suspek anemia aplastikManagement of pancytopenia gingival bleeding in patients with suspected aplastic anaemia Fika Faradillah Drakel; Dewi Zakiawati; Nanan Nur'aeny
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 1 (2022): April 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v34i1.33530

Pendahuluan: Pansitopenia merupakan suatu keadaan yang ditandai oleh adanya anemia, leukopenia serta trombositopenia akibat gangguan pada sumsum tulang yang menyebabkan proses produksi sel hematopoietik menjadi tidak normal. Salah satu manifestasi rongga mulut pada pansitopenia adalah pendarahan gingiva. Perawatan pendarahan gingiva telah banyak dilakukan dengan pemberian obat kumur feracrylum 1%, atau dengan cara mengompres lokasi pendarahan menggunakan kain kasa yang ditetes dengan lidokain. Laporan kasus ini bertujuan untuk memaparkan manajemen perawatan pendarahan gingiva pada pasien pansitopenia dengan suspek anemia aplastik. Laporan kasus: Seorang pria berusia 50 tahun dengan keluhan lemah badan, demam, melena dan gingiva berdarah sejak dua tahun yang lalu, tidak disertai rasa sakit pada gingiva dan area lainnya dalam rongga mulut. Pasien ini dirawat bersama oleh bagian Ilmu Penyakit Dalam dan Ilmu Penyakit Mulut. Pemeriksaan rongga mulut menunjukkan adanya pendarahan pada gingiva regio rahang atas kiri dan bawah kiri. Hasil pemeriksaan penunjang menunjukkan hemoglobin: 7,1g/dL, hematokrit: 18%, eritrosit 1,46x104/μL, leukosit 2,5x103/μL, trombosit 7,2x104/μL. Hasil pemeriksaan sumsum tulang yang pertama sulit dinilai. Transfusi darah diberikan dua labu perhari selama enam hari, area pendarahan pada gingiva dilakukan kompres menggunakan asam traneksamat selama satu sampai tiga menit kemudian dilanjutkan kumur asam traneksamat selama satu menit. Hasil setelah terapi selama 6 hari, tidak ditemukan lagi pendarahan pada gingiva. Simpulan: Terapi lokal kompres dan kumur asam traneksamat dapat menjadi pilihan perawatan yang sangat efektif untuk menghentikan pendarahan gingiva pada pasien pansitopenia, selain terapi transfusi darah tetap dilakukan untuk mengembalikan kadar normal komponen dalam darah.Kata kunci: anemia aplastik; asam traneksamat; pansitopenia; pendarahan gingiva ABSTRACTIntroduction: Pancytopenia is a condition characterised by anaemia, leukopenia and thrombocytopenia due to disorders of the bone marrow that cause the production process of hematopoietic cells to become abnormal. One of the oral manifestations of pancytopenia is gingival bleeding. Gingival bleeding treatment has been mainly carried out by administering 1% Feracrylum mouthwash or compressing the bleeding site using gauze dripped with lidocaine. This case report aimed to describe the management of pancytopenia gingival bleeding in patients with suspected aplastic anaemia. Case report: A 50-year-old male with the chief complaint of weakness, fever, melena, and gingival bleeding two years prior, without gingival pain and other oral cavity areas. This patient was treated simultaneously by the Department of Internal Medicine and Oral Medicine. Examination of the oral cavity revealed bleeding in the left maxillary and left mandibular gingiva. Investigation results showed haemoglobin level was 7.1g/dL, hematocrit 18%, erythrocytes 1.46x104/μL, leukocytes 2.5x103/μL, and platelets 7.2x10⁴/μL. However, the first bone marrow examination result was still challenging to assess. Therefore, two flasks of blood transfusions were given per day for six days. The bleeding gingival area was compressed using tranexamic acid for one to three minutes, followed by tranexamic acid gargling for one minute. After six days of therapy, no more gingival bleeding was detected. Conclusion: Local compress therapy and tranexamic acid gargling can be effective treatment options to stop gingival bleeding in pancytopenia patients; blood transfusion therapy needs to remain carried out to restore normal levels of blood components.Keywords: aplastic anaemia; tranexamic acid; pancytopenia; gingival bleeding

Suplementasi mikronutrien pada pasien eritema multiforme dengan penurunan kualitas eritrositMicronutrient supplementation in erythema multiforme patients with decreased erythrocyte quality I Nyoman Gede Juwita Putra; Suniti Suniti; Nanan Nur'aeny; Indah Suasani Wahyuni
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 32, No 3 (2021): Februari 2021 (Suplemen 2)
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v32i3.31871

Pendahuluan: Eritema multiforme (EM) adalah penyakit peradangan akut yang merupakan reaksi hipersensitivitas pada mukokutan dan jarang ditemukan. Gambaran klinis EM berupa lesi erosi-ulseratif dan memiliki tendensi perdarahan. Kualitas eritrosit yang menurun dapat mempengaruhi proses penyembuhan penyakit ini, namun hal ini dapat diatasi dengan pemenuhan asupan mikronutrien. Tujuan laporan kasus ini untuk memaparkan hasil terapi suplementasi mikronutrien yang diberikan untuk tatalaksana EM pada pasien yang mengalami penurunan kualitas eritrosit. Laporan kasus: Seorang wanita berusia 21 tahun mengeluhkan perdarahan bibir dan sariawan dalam rongga mulut, terasa sakit sejak 3 minggu sebelumnya. Riwayat keluhan yang sama pernah dialami 7 tahun sebelumnya. Pemeriksaan ekstraoral memperlihatkan krusta hemoragik pada bibir, sedangkan hasil pemeriksaan intraoral menunjukkan ulserasi multipel pada hampir seluruh mukosa rongga mulut. Hasil pemeriksaan laboratorium menunjukkan adanya penurunan kualitas eritrosit berdasarkan parameter Mean Corpuscular Volume (MCV), Mean Cell Hemoglobin (MCH), dan Mean Cell Hemoglobin Concentration (MCHC); peningkatan jumlah eritrosit; dan eosinofil pada borderline atas, serta anti HSV-I IgG non-reaktif. Diagnosis pasien adalah eritema multiforme dengan riwayat stomatitis aftosa rekuren (SAR). Tatalaksana farmakologis diberikan asam folat dan vitamin B12 sebagai suplementasi mikronutrien. Diberikan pula chlorhexidine digluconate 0,12% mouthrinse sebagai antiseptik, dan petroleum jelly untuk pelembab bibir. Lesi oral pasien sembuh setelah 2 minggu terapi. Simpulan: Suplementasi mikronutrien berperan penting dalam mempercepat penyembuhan lesi mukosa oral pada pasien eritema multiforme yang mengalami penurunan kualitas eritrosit. Mikronutrien berupa asam folat dan vitamin B12 berperan penting dalam sintesis DNA eritrosit, pembelahan sel, dan perbaikan jaringan. Kata kunci: Mikronutrien, eritema multiforme, kualitas eritrosit. ABSTRACTIntroduction: Erythema multiforme (EM) is an acute inflammatory disease as a hypersensitivity reaction to mucocutaneous and is rarely found. The clinical feature of EM is an erosive-ulcerative lesion with a tendency of bleeding. Decreasing erythrocyte quality can affect its healing process, although able to be overcome by fulfilling the micronutrient intake. The purpose of this case report was to describe the results of micronutrient supplementation therapy given in the management of EM patients with decreasing erythrocyte quality. Case report: A 21-year-old woman complained of lip bleeding and oral thrush, which felt pain three weeks prior. A similar complaint history had been experienced in the previous seven years. Extraoral examination revealed haemorrhagic crusting on the lips, whereas intraoral examination showed multiple ulcerations of almost the entire oral mucosa. Laboratory examination results showed a decreasing erythrocyte quality based on the parameters of Mean Corpuscular Volume (MCV), Mean Cell Haemoglobin (MCH), and Mean Cell Haemoglobin Concentration (MCHC); an increasing number of erythrocytes and eosinophils in the upper borderline, as well as non-reactive anti-HSV-I IgG. The patient was diagnosed with erythema multiforme with a history of recurrent aphthous stomatitis (RAS). Pharmacological management was performed by given folic acid and vitamin B12 as micronutrient supplementation. Also, given a 0.12% chlorhexidine digluconate mouth rinse as an antiseptic and petroleum jelly for lip balm. The patient’s oral lesions resolved after two weeks of therapy. Conclusion: Micronutrient supplementation plays an essential role in accelerating the oral mucosal lesions healing in erythema multiforme patients with decreasing erythrocyte quality. Micronutrients in folic acid and vitamin B12 play an important role in erythrocyte DNA synthesis, cell division, and tissue repair.Keywords: Micronutrient, erythema multiforme, erythrocyte quality.

Tatalaksana infeksi herpes simpleks virus tipe-1 dan necrotizing ulcerative stomatitis pada anak dengan anemia aplastikManagement of type-1 herpes simplex virus infection and necrotising ulcerative stomatitis in children with aplastic anaemia Yannie Febby Martina Lefaan; Wahyu Hidayat; Nanan Nur'aeny
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 33, No 3 (2022): Maret 2022 (Suplemen 3)
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v33i3.30642

ABSTRAKPendahuluan: Necrotizing ulcerative stomatitis (NUS) merupakan penyakit inflamasi pada rongga mulut, ditandai oleh ulser nekrosis akut, berkembang cepat serta menyebabkan kerusakan masif pada jaringan. NUS dapat berkembang dari kondisi necrotizing ulcerative gingivitis (NUG) dan necrotizing ulcerative periodontitis (NUP). NUS dapat disertai infeksi lain, salah satunya infeksi herpes simplex tipe 1 (HSV-1). Infeksi HSV-1 dan NUS pada anak dengan anemia aplastik jarang ditemukan. Anemia aplastik merupakan kelainan hematologi, ditandai dengan hipoplastik/aplasia sumsum tulang dan pansitopenia, sehingga menurunkan resistensi host terhadap infeksi. Gingivostomatitis herpetik primer memudahkan perkembangan bakteri komensal seperti bakteri Fusiform, Spirochetes dan Pseudomonas aeruginosa menjadi patogen pada kondisi imunosupresif sehingga meningkatkan progresivitas penyakit periodontal menjadi NUS. Tujuan laporan kasus ini adalah menjelaskan tatalaksana infeksi HSV-1 dan NUS pada anak dengan anemia aplastik. Laporan kasus: Seorang anak perempuan usia 3 tahun dengan diagnosis anemia aplastik dan febrile neutropenia, dirujuk oleh divisi Hematologi-onkologi anak Rumah Sakit Dr. Hasan sadikin (RSHS) Bandung dengan keluhan pembengkakan pada bibir dan stomatitis. Hasil pemeriksaan darah menunjukan adanya pansitopenia dan pemeriksaan anti HSV-1 IgG reaktif. Diagnosis terkait kondisi bibir dan mulut pasien adalah Infeksi HSV-1 dan NUS. Tatalaksana yang dilakukan adalah debridement dengan Hidrogen peroksida 1,5% (H2O2 1,5%), kontrol plak dengan chlorhexidine digluconate 0,12% dan multivitamin. Pembengkakan mulai membaik setelah 3 hari debridement serta memberikan hasil yang signifikan setelah 1 bulan perawatan. Simpulan: Tatalaksana berupa peningkatan oral hygiene dan terapi antiseptik dapat memperbaiki kondisi infeksi HSV-1 dan NUS, khususnya pada pasien dengan kondisi imunosupresif seperti anemia aplastik.Kata kunci: febrile neutropenia; stomatitis; herpes simpleks; anemia; spirochetes ABSTRACTIntroduction: Necrotising ulcerative stomatitis (NUS) is an inflammatory disease of the oral cavity, characterised by acute necrotising ulcers, proliferating, and causing massive tissue damage. NUS can be developed from necrotising ulcerative gingivitis (NUG) and necrotising ulcerative periodontitis (NUP). NUS can be accompanied by other infections, such as herpes simplex type 1 (HSV-1) infection. However, HSV-1 and NUS infections in children with aplastic anaemia are rare. Aplastic anemia is a haematological disorder characterised by hypoplastic/bone marrow aplasia and pancytopenia, reducing the host's resistance to infection. Primary herpetic gingivostomatitis facilitates the development of commensal bacteria such as Fusiform bacteria, Spirochetes and Pseudomonas aeruginosa to become pathogens under immunosuppressive conditions, thereby increasing the progression of periodontal disease to NUS. This case report aims to describe the management of HSV-1 and NUS infections in children with aplastic anemia. Case report: A 3-year-old female child diagnosed with aplastic anaemia and febrile neutropenia was referred by the paediatric haematology-oncology division of Dr Hasan Sadikin Hospital (RSHS) Bandung with complaints of swelling of the lips and stomatitis. Blood test results showed pancytopenia and reactive anti-HSV-1 IgG examination. The diagnosis related to the patient's lips and mouth condition was HSV-1 and NUS infection. The treatment is debridement with 1.5% hydrogen peroxide (H2O2 1.5%), plaque control with 0.12% chlorhexidine digluconate and multivitamins. After three days of debridement, the swelling started to improve and gave significant results after one month of treatment. Conclusion: Management of improving oral hygiene and antiseptic therapy can improve the condition of HSV-1 and NUS infections, especially in patients with immunosuppressive conditions such as aplastic anemia.Keywords: febrile neutropenia; stomatitis; herpes simplex; anaemia; spirochetes

Serum Level of IL-6, Reactive Oxygen Species and Cortisol in Patients with Recurrent Aphthous Stomatitis related Imbalance Nutrition Intake and Atopy Nanan Nur'aeny; Dida Akhmad Gurnida; Oki Suwarsa; Irna Sufiawati
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 3 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.3.3

One of the most common oral ulcerations is recurrent aphthous stomatitis (RAS), affecting approximately 20% of the general population worldwide. The etiology of RAS is still unclear but it is considered to be multifactorial, including imbalanced nutrition intake and allergic conditions such as atopy. The purpose of this study was to investigate the differences and correlation between the serum level of IL-6, reactive oxygen species (ROS), and cortisol in RAS patients. Our study was cross-sectional and used a consecutive sampling method. There were significant differences of IL-6 and ROS levels in all groups (p = 0.000, p = 0.049 respectively) and a significant correlation between cortisol and ROS in the RAS group without atopy (r = -0.985, p = 0.015). Serum IL-6 and ROS measurement may be used for detecting RAS caused by malnutrition or atopy but not cortisol for patients without psychological stress detected. This is consistent with the results of a very strong correlation with a negative value between cortisol and ROS in RAS without atopy.

Etiologi, Distribusi Lokasi, dan Terapi Ulser Traumatik pada Pasien di Rumah Sakit Gigi dan Mulut Universitas Padjadjaran Erna Herawati; Nanan Nur'aeny
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 3, Desember 2021
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i3.1022

Introduction: Oral mucosal ulceration can be caused by local or systemic factors. One of the local factors often expressed by patients is the result of being bitten. Research data on oral mucosal ulceration has not been widely published, especially in Indonesia, so the purpose of this study was to provide information on the etiology, site distribution and therapy of traumatic ulcers in patients at the Dental Hospital, Universitas Padjadjaran (RSGM Unpad). Methods: A descriptive study, with data obtained secondary from the medical records of patients at the RSGM. Data presentation is done by tabulation and percentage. Results: There were 44 patients consisting of 15 males (34.05%) and 29 females (65.95%), with an age range of 17 – 55 years. Trauma which is the most common cause of ulcers is due to accidentally biting, the most common site is the buccal mucosa, and the most widely used drug is a combination of vitamins and anti-inflammatory which was given to 10 patients with traumatic ulcers (22.7%). Conclusion: The most common cause of oral ulcers is trauma, and the most common trauma in adults is the result of accidentally biting.

Co-Authors Abraari, Mohammad Agiel Achmad Syawqie Alamsyah Piliang Aziza, Fidela Dwirahma Bakti, Fitrah Utari Desi Elvhira Rosa Dewi Marhaeni Diah Herawati Dewi Zakiawati Dida Akhmad Gurnida Dwiarie, Theodora Adhisty Dzulfikar Djalil Lukmanul Hakim Eko Rotary Nurtito Embun Manja Sari Erna Herawati Erna Herawati, Erna Fadhilah, Fania Fajar Fatriadi Fauziah, Hana Febryna, Chivita Wulandari Fidya Meditia Putri, Fidya Meditia Fika Faradillah Drakel Fitri Rahmadhanti Nurfajrina Fransisca Sri Susilaningsih Fransisca Sri Susilaningsih Gilang Yubiliana Hapid, Hasan Hilda Hindasah I Nyoman Gede Juwita Putra Iis Rosita Indah Suasani Wahyuni Indrati Soedjarwo Inesh Zuria Artika Irna Sufiawati Izzatul Syafiqah, Izzatul Kamilah Winda Kartika Indah Sari Lulu Eva Rakhmilla Marcella bt Mohamad Azlin Murnisari Darjan Nelly Nainggolan Nita Septiani Nuri Fitriasari Nuri Fitriasari Nurul Mukhliza Safely Oki Suwarsa Purnomo, Luthfiyyah Andini Rajasa, Adrianus Surya Wira Revi Nelonda Riani Setiadhi Ridho, Faiznur Rio Guntur Maharsi Risti Saptarini Rosiliwati Wihardja Sekar SAFITRI Shafuria, Amira Suniti Suniti Tenny Setiana Dewi Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Yannie Febby Martina Lefaan Yuliana Yuliana Yuti Malinda

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