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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Amerta Nutrition Cendekia Journal of Pharmacy JURNAL GIZI DAN KESEHATAN Lumbung Farmasi : Jurnal Ilmu Kefarmasian Community Empowerment Journal of Holistics and Health Sciences (JHHS) Journal of Fundamental and Applied Pharmaceutical Science JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Abdi Masyarakat Indonesia Media Farmasi Indonesia Kreasi: Jurnal Inovasi dan Pengabdian Kepada Masyaraka Mestaka: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmacy and Natural Product Indonesian Journal of Community Empowerment (IJCE) Usadha Journal of Pharmacy Journal of Community Empowerment
Dian Oktianti
Universitas Ngudi Waluyo
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Aplikasi SEDEKA ( Sistem Dokumentasi Kesehatan Masyarakat ) Dalam Rangka Mendukung Gerakan Masyarakat Hidup Sehat (GERMAS) Sunnah, Istianatus; Oktianti, Dian; Dianingati, Ragil Setia
Journal of Community Engagement and Empowerment Vol 3, No 2 (2021)
Publisher : Institut Ilmu Kesehatah Bhakti Wiyata Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang : Upaya peningkatan  kesehatan dapat dilaksanakan melalui Gerakan Masyarakat Hidup Sehat(GERMAS) dengan pemeriksaan kesehatan secara berkala terutama pada usia lanjut yang rentan terhadap penyakit menular maupun tidak menular. Tujuan : Untuk meningkatkan upaya promotif dan preventif  serta pemantauan kesehatan  pada lansia di Desa Lerep, Ungaran Kabupaten Semarang dengan melaksanakan pemeriksaan rutin serta monitoring kesehatan sehingga tercipta peningkatan  kualitas hidup sehat lansia menggunakan aplikasi SEDEKA. Metode :  Sosialisasi materi tentang penyakit degeneratif dan aplikasi SEDEKA serta pretes postes pada  44 peserta posyandu lansia. Selain itu juga dilaksanakan pengukuran tekanan darah dan kadar gula darah peserta. Nilai pretes dan postes dianalisis untuk mengevaluasi prosentase  tingkat pemahaman lansia terhadap materi. Hasil:  Pengamatan  yang dilakukan  sebelum kegiatan,  monitoring dan dokumentasi kesehatan oleh penderita  belum dilakukan secara baik, sehingga perlu adanya sistem dokumentasi yang dapat membantu lansia untuk memonitor kesehatannya.  Berdasarkan hasil evaluasi pretes dan postes,  peserta posyandu lansia memiliki peningkatan pemahaman menjadi “BAIK bahkan “SANGAT BAIK” diikuti peningkatan prosentase nilai pemahaman materi pada materi hipertensi sebanyak 100%, materi diabetes mellitus 27,88%  dan hiperkolesterolemia 80,60%. Kesimpulan : Kegiatan sosialisasi ini mampu memberikan efek positif terhadap pemahaman penyakit degeneratif peserta posyandu lansia
KEEFEKTIFAN PENGGUNAAN ANTIBIOTIK PROFILAKSIS PADA PASIEN BEDAH SESAR (SECTIO CAESAREA) Sikni Retno Karminingtyas; Dian Oktianti; Nova Hasani Furdiyanti
Cendekia Journal of Pharmacy Vol 2, No 1 ( Mei 2018) : Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (884.684 KB) | DOI: 10.31596/cjp.v2i1.14

Abstract

Bedah sesar (Sectio Caesarea) adalah melahirkan janin melalui suatu insisi pada dinding rahim dengan syarat rahim dalam keadaan utuh serta berat janin di atas 500 gram. Wanita yang melakukan persalinan secara bedah sesar memiliki risiko infeksi lebih besar 5-20 kali lipat dibandingkan persalinan normal. Di Indonesia prevalensi bedah sesar meningkat setiap tahunnya, semakin banyak biaya yang dikeluarkan oleh pasien bedah sesar di rumah sakit yang berhubungan dengan biaya medik langsung. Mengetahui gambaran penggunaan antibiotik profilaksis, keefektifan antibiotik profilaksis dan biaya medik langsung pada pasien bedah sesar di Rumah Sakit Islam Sultan Agung Semarang tahun 2016. Penelitian dilakukan secara non eksperimental (observasional), menggunakan metode deskriptif dan data diperoleh dari rekam medik secara retrospektif. Data yang digunakan sebagai sampel dalam penelitian ini sebanyak 87 pasien dengan metode pengambilan data secara purposive sampling. Analisis data meliputi karakteristik pasien berdasarkan umur, lama perawatan, kondisi keluar rumah sakit, gambaran penggunaan antibiotik profilaksis, keefektifan antibiotik profilaksis yang dinilai dari nilai leukosit, dan suhu tubuh pasien pasca operasi serta biaya medik langsung. Hasil penelitian menunjukkan dari 87 pasien yang diteliti paling banyak terjadi pada umur 20-35 tahun (75,86%), lama perawatan 5 hari (67,82%), dan kondisi keluar rumah sakit dengan status perbaikan (100%). Antibiotik profilaksis yang digunakan adalah Sefotaksim (66,67%), Sefuroksim (32,18%), dan Sefazolin (1,15%). Keefektifan penggunaan antibiotik profilaksis di Rumah Sakit Islam Sultan Agung Semarang tahun 2016 yakni 100% efektif. Rata-rata biaya medik langsung pada perawatan kelas I sebesar Rp.10.425.014,00, kelas II sebesar Rp. 8.806.403,00 dan kelas III sebesar Rp. 8.733.429,00. Berdasarkan penelitian penggunaan antibiotik profilaksis pada pasien bedah sesar di Rumah Sakit Islam Sultan Agung Semarang tahun 2016 adalah 100% efektif. Rata-rata biaya medik langsung pada perawatan kelas I, II dan III berbeda. Kata kunci      : antibiotik profilaksis, bedah sesar, keefektifan, analisis biaya
PERBANDINGAN RESPON AWAL PEMBERIAN WARFARIN PADA PASIEN OBESITAS DENGAN NON-OBESITAS Dian Oktianti; I Dewa Putu Pramantara; Djoko Wahyono
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 4, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.278

Abstract

Pendosisan dan respon terapi warfarin bervariasi antara setiap pasien tergantung dari umur, tingkat keparahan penyakit, status nutrisi, berat badan, pengobatan lain, dan ada tidaknya polimorfisme genetik dari CYP2C9 atau VKORC1.. Sesuai atau tidaknya dosis warfarin dapat dilihat dari pemeriksaan nilai international normalized ratio (INR). Penelitian bertujuan untuk membandingkan respon awal pemberian warfarin pada pasien obesitas dan non obesitas. Penelitian ini adalah penelitian retrospektif yang bersifat deskriptif dan observasional. Subyek penelitian adalah pasien rawat jalan yang menerima terapi warfarin pertama kali di RSUP dr Sardjito Yogyakarta disertai dengan pemeriksaan nilai INR. Analisis nonparametrik dengan uji Kaplan-Meier dilakukan untuk melihat lama hari yang diperlukan untuk mencapai target nilai INR. Hasil penelitian menunjukkan bahwa dari 92 pasien yang memenuhi kriteria inklusi, terdapat pasien obesitas sebanyak 44 orang dan pasien nonobesitas sebanyak 48 orang. Berdasarkan uji Kaplan-Meier diperoleh median dari waktu untuk mencapai target nilai INR pada kelompok obesitas adalah 56 hari dan untuk kelompok nonobesitas adalah 57 hari tidak ada perbedaan bermakna antara kelompok pasien dengan berat badan normal dan kelompok pasien obesitas untuk mencapai target nilai INR. Kata kunci: warfarin, respon awal, obesitas, nilai INR
Evaluation of Antihypertension Drugs on Patients Diabetes Mellitus in RSI Sultan Agung Semarang 2016 Dian Oktianti; Nurul Fitria Dewi; Meiji Pujiawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.33342

Abstract

More than 50% of patients with type 2 diabetes mellitus are associated with hypertension. Uncontrolled blood pressure in patients with type 2 diabetes mellitus correlated with the onset of cardiovascular and cerebrovascular complications. Therefore, proper blood pressure management is needed to delay and prevent complications. Selection of appropriate antihypertensive drugs along with appropriate doses is one way to inhibit the possibility of complications. The purpose of this study is to know about the accuracy of the use of antihypertensive drugs and doses used. This research is a descriptive and observational retrospective research. The subjects of the study were 88 patients with diabetes mellitus with accompanying hypertension. Data taken include antihypertensive, antidiabetes mellitus, laboratory data. The data obtained are then analyzed descriptively using JNC edition 8 and DIH 2015. The results showed that there were 88 samples meeting the inclusion and exclusion criteria. The commonly used single antihypertensive group is Angiotensin Receptor Blocker (ARB) of 56.09%, and antihypertensive combination is Angiotensin Receptor Blocker (ARB) - Calsium Chanel Blocker (CCB) of 65.95%. Based on the results of analysis, the results obtained for the right drug and the patient is 98.86% and for the accuracy of the dose obtained 97.72%.
Yellow Pumpkin (Cucurbita maxima D.) Extract As Anti-Hypercholesterolemia Istianatus Sunnah; Erna Kustiyaningsih; Dian Oktianti
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 2 (2021): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v1i2.10819

Abstract

Hyperlipidemia is a risk factor for various diseases, which is still a big problem in Indonesia. Yellow pumpkin (Cucurbita maxima D.) is a plant containing flavonoids and terpenoids, which can be used as an anti-hypercholesterolemic agent. This study aims to analyze the activity and dosage of yellow pumpkin extract, which can be used as an anti-hypercholesterolemic agent to reduce total cholesterol levels comparable to simvastatin by 1.8mg/kg BW/day. This research is pure experimental research with a pre and post-test group design approach. The number of samples was 25 male Wistar rats induced by high-fat feed, quail egg yolk: pork oil (2:1) by 5 ml/200 gramBW/day for 7 days. The extract dosage range was 200, 400, 600 mg/kg BW/ day  for 7 days. Data were analyzed using One Way ANOVA. The results showed that the administration of yellow pumpkin extract could reduce rats' total blood cholesterol levels with a dose of 600 mg/kg BW/day, comparable to simvastatin 1.8 mg/kg BW/day. The secondary metabolites of the extract were flavonoids and terpenoids. Extract of yellow pumpkin (Cucurbita maxima D.) could reduce total blood cholesterol levels of rats. The dose of 600 mg/kg BW/day could reduce blood cholesterol levels in rats comparable to simvastatin 1.8 mg/kg BW/ day.
Indeks glikemik dan beban glikemik bolu kukus dan cookies labu kuning (Cucurbita moschata Durch) berbahan formula modisco: Indeks Glikemik dan Beban Glikemik Bolu Kukus dan Kukis Labu Kuning (Cucurbita moschata Durch) Berbahan Formula Modisco Sugeng Maryanto; Windy Harly; Dian Oktianti
Amerta Nutrition Vol. 6 No. 1SP (2022): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 2nd Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v6i1SP.2022.206-213

Abstract

Background: Modisco (modified dried milk and coconut oil) is a processed food in liquid form that contains high energy and protein. Provision of high-calorie, high-protein supplementary food is necessary for nutritionally vulnerable age groups who have problems with digestion. The development of the modisco formulation made from pumpkin into processed steamed cakes and cookies based on the modisco formulation aims to improve taste and increase the length of time of storage before consumption. The addition of pumpkin as a source of fiber in processed steamed cakes and cookies is a choice of low glycemic index and glycemic load snacks. Objectives: This study conducted to describe the glycemic index and glycemic load of processed steamed cakes and cookies using the ingredients of the modified pumpkin (Cucurbita moschata Durch) formulation. Methods: The design of this study was an experimental in vitro vivo design. The in vitro study was carried out by making steamed cakes and cookies with the main ingredients of the modisco III formula with several formulations, then the best formula was selected to be given as an in vivo treatment. The respondent in this study were 10 Ngudi Waluyo students aged 17-25 years, who had a normal Body Mass Index (18.5 to 22.9 kg/m2), normal pre-prandial blood sugar (70-100 mg/dl), and never suffered from diabetes mellitus. The respondents were previously  fast at night for 10 hours at least, and do not strenuous activities during preparation for blood collection. The first blood collection was taken at 0 minutes, carried out at 7 am through the fingertips (peripheral blood) carried out by the nurse, then the respondents were given steamed cakes to one group and cookies to the other group, each of 50 grams. Blood collection was continued at 30, 60, 90, and 120 minutes. Blood sugar levels were measured using a gluco-test. The blood glucose data obtained was then analyzed to determine the glycemic index and glycemic load of processed steamed cakes and cookies.. Results: The value of glycemic index and glycemic load of processed steamed cake products were 23.00% and 5.75, respectively, while those of the cookie product were 38.9% and 9.75, respectively. Conclusions: The value of the glycemic index and glycemic load of processed products of steamed cake and yellow pumpkin pumpkin cookies formula are in the low category.
Training on the use of digital media for implementation digital pharmacy for pharmacist at Salatiga in supporting the industrial revolution 4.0 Dian Oktianti; Jaya Ramadey Bangsa; Anita Kumala Hati
Community Empowerment Vol 7 No 12 (2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.7939

Abstract

Today, the health sector has begun to adopt digital information technology, one of which is telemedicine. Utilization of digital media can be used for business interests and support pharmaceutical care activities. However, pharmacists in Salatiga city have not been able to make optimal use of digital media. This activity was carried out in the form of training on the use of digital media for the implementation of digital pharmacy for IAI PC Pharmacists in Salatiga City in facing the era of the industrial revolution 4.0. Activities carried out are training and providing information about digital pharmacy and medication therapy management. This program has proven successful in increasing pharmacist knowledge regarding digital pharmacy and medication therapy management with a p-value of 0.0000. Furthermore, 69 pharmacists experienced an increase in knowledge, 5 pharmacists experienced a decrease, and 7 pharmacists did not experience an increase in knowledge.
Kadar Apo-B dan Ketebalan Dinding Aorta Abdominalis Tikus Hiperkolesterolemia dengan Perlakuan Buah Jambu Biji Merah: Apo-B Levels and Abdominal Aortic Wall Thickness in Hypercholesterolemic Rats Treated with Red Guava Fruit Sugeng Maryanto; Dian Oktianti
Amerta Nutrition Vol. 7 No. 1 (2023): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v7i1.2023.112-119

Abstract

Background: Coronary heart disease (CHD) is mainly related to hypercholesterolemia. Sometimes CHD occurs in people with normal cholesterol. Therefore, it is necessary to study other factors that cause CHD: apolipoprotein B (apo-B). Atherosclerosis is a marker of CHD, characterized by the thickening of the walls of blood vessels and the narrowing of blood vessels. Non-pharmacologically, CHD can be managed by consuming foods with high fiber and antioxidants, such as red guava fruit.  Objectives: This research aimed to analyze the consequence of red guava fruit on the Apo-B levels and the thickness of the abdominal aortic wall in hypercholesterolemic rats.  Methods: The research design was a pre and post-test and a randomized control group. Fifty hypercholesterolemic adults male Sprague Dawley rats were given red guava fruit. The primary treatment used red guava fruit as a treatment group, referring to the fiber requirement of 38 g/day, and simvastatin as a positive control group based on a human dose of 10 mg/day, the conversion of human to mouse dose, according to Laurence-Bacarach is 0.018. The negative control group was hypercholesterolemic rats. The standard feed for the rats was based on AIN93. The Enzyme-linked Immunosorbent Assay method measures apo-B levels, Kit For apo-B Rattus norwegicus, Catalog No. E92003Ra, produced by Uscn Life Science Inc. The aorta was taken after going through general anesthesia and thoracotomy. Furthermore, the aorta was processed for making histological preparations with hematoxylin-eosin (HE) staining to observe histopathological changes.  Results: Observation of aortic wall thickness using a microscope with a magnification of 400X. Simvastatin and red guava fruit have reduced Apo-B by 7% and 6%, respectively.  Conclusions: The performance of red guava fruit in reducing Apo-B concentration and the thickness of the abdominal aortic wall was equal to the simvastatin. 
Pengaruh Pemberian Informasi Obat Dengan Media Video Terhadap Kepatuhan Minum Obat Pasien Hipertensi Di Ungaran Dian Oktianti; Nova Hasani Furdiyanti; Sikni Retno Karminingtyas
Indonesian Journal of Pharmacy and Natural Product Vol. 2 No. 2 (2019)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.642 KB) | DOI: 10.35473/ijpnp.v2i2.268

Abstract

Hipertensi merupakan salah satu penyakit kronis yang menjadi satu prioritas masalah  kesehatan  di  Indonesia  maupun  di  dunia. penyakit hipertensi dapat menyebabkan komplikasi seperti dapat menyebabkan oklusi arteri, cedera iskemik dan stroke sebagai komplikasi  jangka  panjang. Maka diperlukannya pemahaman oleh pasien tentang instruksi pengobatan dan peningkatan kepatuhan pasien melalui pemberian informasi obat dengan media video. Penelitian dilakukan secara prospektif dengan pretest-posttest design dan menggunakan rancangan cross sectional. Pengambilan sampel dilakukan secara purposive sampling dan didapatkan sampel sebanyak 40 orang. Data dianalisis menggunakan uji t-berpasangan. Hasil penelitian di Puskesmas Lerep menunjukkan kepatuhan sebelum intervensi kategori sedang 60%, kategori rendah 35% dan kategori tinggi 5%. Kepatuhan sesudah intervensi kategori sedang 20%, kategori rendah 0% dan kategori tinggi 80%. Nilai signifikansi uji t berpasangan yaitu 0,000 (<0,05). Hasil penelitian di Klinik Gracia kepatuhan pasien sebelum intervensi adalah rendah (20%), sedang (55%), dan tinggi (25%), setelah intervensi terjadi peningkatan kepatuhan yaitu rendah (5%), sedang (5%) dan tinggi (90%). Nilai signifikasi uji t-berpasangan dalam penelitian ini yaitu 0,000 < 0,05. Tingkat kepatuhan untuk uji pill count terdiri atas dua kategori yaitu patuh (kepatuhan≥80%) dan tidak patuh (kepatuhan<80%). Seluruh responden, baik pada Puskesmas Lerep maupun Klinik Gracia menunjukkan skor kepatuhan ≥80%, termasuk kategori patuh. Hasil penelitian menunjukan bahwa penyuluhan dengan media video dapat meningkatkan kepatuhan minum obat hipertensi di puskesmas Lerep dan Klinik Gracia.Kata Kunci : Hipertensi, Media Video, Kepatuhan Minum Obat, MMASHypertension is a chronic disease which is a priority health problem in Indonesia and in the world. Hypertension can cause complications such as can cause arterial occlusion, ischemic injury and stroke as long-term complications. Then there is a need to increase patient compliance by using video to provide drug information in order to increase patient’s understanding. The study was conducted prospectively with pretest-posttest design using cross sectional design. Forty sample was chosen by purposive sampling method. Data were analyzed using paired t-test. The results at Lerep Health Centre showed that the patient’s compliance before the intervention was categorized as moderate (60%), the low (35%) and high (5%). After the intervention, the moderate group was down to 20%, low was down to 0%, and the high group was increased to 80%. The significance value of paired t-test is 0,000 (<0.05). Research results at Gracia Clinic showed that patient’s compliance before intervention was low (20%), moderate (55%), and high (25%), and after intervention there was an increase in patient’s compliance that was low (5%), moderate (5%) and high (90 %). The significance value of paired t-test in this study is 0,000 <0.05. The level of adherence to the pill count test consists of two categories: adherence (80% adherence) and non-adherence (adherence <80%). All respondents, both at the Lerep Health Center and the Gracia Clinic showed a compliance score of ≥80%, including the compliance category. Counseling using video could improve compliance with taking hypertension medication at the Lerep health center and Gracia Clinic.Keywords: Hypertension, Video, Medication Compliance, MMAS
Penetapan Kadar Flavonoid Total Ekstrak Etanol Biji Pinang (Areca catechu L.) Menggunakan Metode AlCl3 Agitya Resti Erwiyani; Dina Sihot Rejeki Gultom; Dian Oktianti
Indonesian Journal of Pharmacy and Natural Product Vol. 4 No. 1 (2021)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.734 KB) | DOI: 10.35473/ijpnp.v4i1.888

Abstract

Pinang merupakan tanaman yang banyak tersedia di Indonesia dan memiliki berbagai manfaat. Pemanfaatan air rebusan biji pinang digunakan masyarakat dalam membersihkan dan menyembuhkan luka infeksi. Biji pinang mengandung senyawa fenolik seperti flavonoid, tannin, asam galat, katekin, beta-sitosterol, gum dan asam amino. Biji pinang dilakukan purifikasi untuk mengilangkan zat ballast yang tidak dibutuhkan. Penelitian ini bertujuan untuk menetapkan kadar flavonoid total ekstrak kasar dan ekstrak terpurifikasi. Metode yang digunakan dalam penetapan kadar adalah metode kolorimetri AlCl3. Penetapan kadar flavonoid dilakukan pada panjang gelombang 413,5 nm dengan standar baku pembanding kuersetin. Plot hubungan antara konsentrasi kuersetin versus absorbansi diperoleh persamaan kurva baku sebesar y = 0,0088x – 0,17 dengan nilai R2 sebesar 0,9998. Uji kualitatif menunjukkan ekstrak biji pinang tanpa purifikasi, dengan perlakuan purifikasi n-heksan dan etil asetat mengandung metabolit sekunder diantaranya flavonoid, saponin, tannin dan fenol. Purifikasi pelarut n-heksan didapatkan hasil rendemen lebih banyak dibandingkan ekstrak yang dipurifikasi dengan pelarut etil asetat. Kadar flavonoid ekstrak tanpa purifikasi, ekstrak purifikasi pelarut n-heksan dan etil asetat berturut – turut sebesar 69,13 ; 130,3 ; dan 94,73 mgQE/g. Hal tersebut sebanding dengan perolehan % rendemen tertinggi diperoleh dari ekstrak terpurifikasi n-heksan. Purifikasi pada ekstrak akan menyebabkan hilangnya zat ballast dalam ekstrak sehingga kandungan flavonoid pada ekstrak akan lebih tinggi.Kata kunci : flavonoid, metode AlCl3, ekstrak, purifikasiAreca nut is a plant that is widely available in Indonesia and has various benefits. Utilization of boiled betel nut water is used by the community to clean and heal infected wounds. Betel nuts contain phenolic compounds such as flavonoids, tannins, gallic acid, catechins, beta-sitosterol, gum, and amino acids. Areca seeds are purified to remove unnecessary ballast substances. This study aims to determine the total flavonoid levels of crude extract and purified extract. The method used in the assay is the AlCl3 colorimetric method. Determination of flavonoid levels was carried out at a wavelength of 413.5 nm with a quercetin standard. The plot of the relationship between quercetin concentration versus absorbance obtained a standard curve equation of y = 0.0088x - 0.17 with an R2 value of 0.9998. The qualitative test showed that betel nut extract without purification, with purification treatment of n-hexane and ethyl acetate, contained secondary metabolites including flavonoids, saponins, tannins, and phenols. The purification of the n-hexane solvent obtained more yields than the extract purified with ethyl acetate solvent. The flavonoid levels of the extract without purification, the purified extract of n-hexane and ethyl acetate were 69.13; 130.3; and 94.73 mg QE / g. This is comparable to the highest% yield obtained from purified extracts of n-hexane. Purification of the extract will cause the loss of ballast substances in the extract so that the flavonoid content in the extract will be higher.Keywords: flavonoids, AlCl3 method, extract, purification
Co-Authors Abririn, Martina Lestiana Ade Pratama admin, Yulistiawan Ardita Agitya Resti Erwiyani Al Hajar Fuadatus Zurroh Ambarsari, Utami Angelica, Dita Aprilliana R, Melati Azahra, Intan Cholisoh, Zakky Chotifah, Tila Noer Coreira, Lidya Coreira De Cruz Poety, Cresensia Apolonia Devia, Uci Asna Dewi, Nurul Fitria Dina Sihot Rejeki Gultom Dini Otavianingsih Dita Angelica Djoko Wahyono Djoko Wahyono Elvansi, M. Eningsari, Luh Putu Mahatrianti erika, nurlia Erna Kustiyaningsih Eunike Panjaitan Fajriani, Windha Novia Fiki Wijayanti Galih Y, Yunita Hasani Furdianti, Nova Hati, Anita Kumala Hidayah Karuniawati I Dewa Putu Pramantara I Dewa Putu Pramantara Istianatus Sunnah Jatmiko Rahmat Jatmiko Susilo Jaya Ramadey Bangsa Karina Febrianti Karminingtyas, Sikni Kusuma, Arinda Maya Lidya Coreira Coreira Luh Putu Indah Arviani Luhurningtyas, Fania Putri M. Elvansi Mahyuni, Ni Luh Ayu Mariatun, Mariatun Martina Lestiana Abririn Maulida Hayati Meiji Pujiawati Melati Aprilliana Ramadhani, Melati Aprilliana Muhammad Alim Nabila Ghassani Adani Nabila Hi Daud Nanda Ariyanto Putri Niken Dyah Ariesti Niken Dyaharesti Nova Hasani Furdiyanti Nova Hasani Furdiyanti Nova Hasani Furdiyanti Nova Hasani Furdiyanti, Nova Hasani Novanita Puspa Kencana Nur Hasanah Nurul Fitria Dewi Nurul Huda Setiawan Nurul Maulidya Otavianingsih, Dini Poety, Cresensia Apolonia Da Cruz Pujiawati, Meiji Putu Ayu Danung Ningrat Ragil Setia Dianingati Ragil Setia Dianingati Rahmadi, Romi Rahmadi Richa Yuswantina Rina Suryati Romi Rahmadi Rahmadi Rozalia Sandriana, Mira Sikni Retno Karminingtyas Sismawati Siswati Siswati Siti Haryani Sugeng Maryanto Thalia Dwi Septiyawati Utami Ambarsari Windha Novia Fajriani Windy Harly Yunita Galih Y Zaskia, Annisa Vera