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All Journal E-JUPEKhu Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) E-Dimas: Jurnal Pengabdian kepada Masyarakat AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal SOLMA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCPS (Journal of Current Pharmaceutical Sciences) JURNAL FARMASIMED (JFM) Majalah Farmasetika Jurnal ABDINUS : Jurnal Pengabdian Nusantara JATI (Jurnal Mahasiswa Teknik Informatika) BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Farmasi dan Herbal Jurnal Pengabdian Masyarakat (ABDIRA) Jurnal PkM (Pengabdian kepada Masyarakat) J-KIP (Jurnal Keguruan dan Ilmu Pendidikan) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Pendidikan Indonesia (Japendi) Jurnal Pengabdian Masyarakat Bangsa Indonesian Journal of Pharmacy and Natural Product Journal of Pharmaceutical and Sciences. JITAA : Journal Of International Taxation, Accounting And Auditing Jurnal Pengabdian Kepada Masyarakat Bangun Cipta, Rasa, & Karsa (Jurnal PKM BATASA) Kajian Ilmiah Mahasiswa Administrasi Publik (KIMAP)
Nining, Nining
Fakultas Farmasi Dan Sains Universitas Muhammadiyah Prof. DR. HAMKA
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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Optimization of Oral Thin Film Cetirizine HCI by Response Surface Methodology: Disintegration and Mechanical Properties Nining, Nining; Amalia, Anisa; Rahmatullah, Rizki
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.44098

Abstract

Starch is a natural biopolymer used as a film-forming polymer on oral thin film (OTF). Its solubility can increase by modifying enzymes to form maltodextrin (MDX). Sorghum is a potential plant because it contains relatively high starch, 72.3-75.1%. The concentration of film-forming and plasticizers in OTF will significantly affect its disintegration and mechanical properties. This study aimed to obtain the optimal formula for OTF cetirizine HCl based on MDX-sorghum as a film-forming and triethyl citrate as a plasticizer using the Response Surface Methodology (RSM). Sorghum starch was enzymatically modified and characterized physically and mechanically. The formula is optimized based on the disintegration and mechanical properties of the film on the contour plot using Central Composite Design (CCD) in RSM. The percentage error between the predicted and actual values in the response validates the suggested model. The results showed that the production of MDX-sorghum was successful with a characteristic value of dextrose equivalent (DE) 6,3±0,13; swelling power of 2.87; solubility of 52.9%; and a yield of 86.71%. Response data from the 14 formulas obtained include disintegration time of 85-172 seconds, elongation 64.86-109.32%, and tensile strength from 1.4 to 3.57 MPa. The optimal formula suggested a concentration of 4.56% MDX-sorghum and 10% triethyl citrate, with desirability of 0.87. The model validation results show an error percentage of <5%, so the suggested model can be accepted.
Formulasi Sabun Gel Ekstrak Biji Manjakani Menggunakan Tragakan dan Carbopol 934 sebagai Gelling Agent Amalia, Anisa; Nursal, Fith Khaira; Nining, Nining; Bariroh, Tahyatul; Laszairina, Andra Yunita; Dinaianti, Adelia
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.45499

Abstract

Biji manjakani (Quercus infectoria) dapat digunakan sebagai bahan aktif pada sediaan sabun pembersih kewanitaan karena mengandung senyawa tannin yang dapat menghambat pertumbuhan jamur Candida albicans. Tragakan dan carbopol 934 merupakan gelling agent yang dapat digunakan pada pembuatan sabun gel. Tujuan penelitian ini adalah untuk mengetahui pengaruh perbedaan jenis dan konsentrasi gelling agent terhadap stabilitas fisik sabun gel pembersih kewanitaan ekstrak etanol 96% biji manjakani. Formula 1 - 4 menggunakan tragakan pada konsentrasi 0,5% (F1), 1% (F2), 1,5% (F3), dan 2% (F4). Formula 5 - 8 menggunakan carbopol 934 pada konsentrasi 0,75% (F5), 1% (F6), 1,25% (F7), dan 1,5% (F8). Uji Stabilitas fisik dilakukan selama 6 minggu pada suhu 300C dan dilakukan pengamatan organoleptis, homogenitas, nilai pH dan viskositas yang dilanjutkan denganuji stabilitas tinggi busa dan uji cycling test. Penggunaan kedua jenis gelling agent menghasilkan sabun gel yang homogen dan stabil secara visual pada penyimpanan pada suhu kamar. Penggunaan tragakan menghasilkan sabun gel dengan viskositas yang lebih tinggi dibandingkan carbopol 934. Nilai pH sabun gel adalah 3,86 – 4,54 dan memenuhi kriteria sabun kewanitaan. Busa yang dihasilkan oleh tiap formula stabil selama masa pengamatan. F1 dan F5 mengalami pemisahan fase pada pengujian cycling test.  Penggunaan tragakan pada konsentrasi 1,5% (F3) dan carbopol pada konsentrasi 1,5% (F8) mampu mempertahankan (p > 0,05) nilai pH dan viskositas sediaan selama penyimpanan. F3 dan F8 memiliki respon daya hambat pertumbuhan C. albicans yang lemah.
Preliminary Study of Physical and Chemical Stability of Polyherbal Suspensions by UV-Vis Spectrophotometry Nining, Nining; Nursal, Fith Khaira
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.45338

Abstract

Allicin, the main bioactive compound in garlic, contributes to its pharmacological effects. Monitoring the physical and chemical stability of herbal preparations is essential for ensuring product quality. This study aimed to evaluate the stability of a polyherbal suspension containing garlic, lemon, red ginger, honey, and apple cider vinegar. The suspension was assessed for physical properties (pH, viscosity, specific gravity, and particle dispersion) and chemical stability, focusing on thiosulfinate (TS) content. Measurements were taken over a period of five weeks under three different storage temperatures. TS levels were analyzed spectrophotometrically. The suspension had a specific gravity of 1.114 ± 0.002 g/mL and a pH of 3.74 ± 0.03. Both storage time and temperature significantly influenced pH, viscosity, and TS content (p<0.05), though all remained within acceptable pharmaceutical limits. TS degradation followed second-order kinetics. The polyherbal suspension demonstrated good physical stability over a five-week period. However, TS levels declined over time at all storage temperatures, indicating a trend toward reduced chemical stability.
Co-Authors Abu Rijal Algifari Agustin Yumita Andriani, Kris anisa amalia Anisa Amalia Ari Sartinah, Ari Ari Widayanti Armadany, Fery Indradewi Aulia, Rizma Budi Setiawati Dania Athaya Putri Devi Puspita Sari Dinaianti, Adelia Ema Dewanti Etin Diah Permanasari Euis Erlin Faizal Ridwan Zamzany Febri Romansyah Fith Khaira Nursal Fujianti Fujianti Gantini, Sri Nevi Hapsari, Fadjriah Hariyanti Hariyanti Ilmiyati, Nur Inding Gusmayadi Kori Yati Larasati, Kinanti Dara Laszairina, Andra Yunita MAHMUDAH, RIFA'ATUL Maspupah, Meti Mega Iswari Mone, Ansyari Naniek Setiadji Radjab Nugrahaeni, Fitria Palensia, Fadhilah Poppy Mutiara Indah Pramulani Mulya Lestari Pramulani Mulya Lestari Putri Nabila Zulvianti Putri, Dania Athaya Putri, Riska Damayanti Rahmatullah, Rizki Rismawati Rismawati Ristianti Azharita Riyanto, Raditya Naufal Saleh Wikarsa Saleh Wikarsa, Saleh Sawitri, Feny Eka Seowandhi, Sundani Nurono Septia Handayani, Lidra Sri Hartati Sundani Nurono Seowandhi Supandi Tahyatul Bariroh Widati, Endah Winda Sulistiyaningrum Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Zeinora, Zeinora