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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY QUANTUM: Jurnal Inovasi Pendidikan Sains Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Media Bahasa, Sastra, dan Budaya Wahana JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Surya Enthusiastic : International Journal of Applied Statistics and Data Science Journal of Applied Nursing and Health Kolaborasi Jurnal Pengabdian Masyarakat Khazanah: Jurnal Mahasiswa Jurnal Riset Kebidanan Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Abdi Kesehatan dan Kedokteran SPIKESNAS Media Farmasi Borneo Journal of Pharmacy Jurnal Keperawatan Mandira Cendikia (JKMC)
Hayati, Farida
Prodi Farmasi, Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta Prodi Profesi Apoteker, Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta
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Farmakokinetika Rifampisin akibat Praperlakuan Jus Kulit Buah Manggis pada Tikus Wistar Jantan Pradana, Dimas Adhi; Hayati, Farida; Praptiwi, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 2 (2014)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Aim of this study was to determine the effect of pre-treatment of mangosteen rind juice on the pharmacokinetics of rifampicin on white male Wistar rats. Rats (10) devided into 2 groups, each group consisted of 5 rats. Group I rats were given a dose of rifampicin 50 mg/kg body weight as the control group. Group II rats were given pre-treatment  mangosteen rind juice 200 mg/kg for 7 days and then on day 8 were given rifampicin 50 mg/kg and ma ngosteen rind juice 200 mg/kg as the treatment group. On the hour of 0,25; 0,5; 1; 1,5; 2; 3; 4; 6; 8; 10; 12 and 24  blood sample was taken and then deter-mined the rifampicin plasma levels by HPLC. The results obtained produced curve rifampicin levels in the blood versus time and pharmacokinetic parame-ters of rifampicin such AUC0-∞ , AUMC0-∞, and MRT and MRT can be determined.The results showed that pre-treatment mangosteen rind juice did not have a signiϔicant effect on the pharmacokine tics of rifampicin based parameters AUC0-∞, AUMC0-∞, and MRT.Keywords: pharmacokinetics, mangosteen rind, rifampicin Penelitian ini bertujuan untuk mengetahui pengaruh praper-lakuan jus kulit manggis terhadap proϐil farmakokinetika rifampisin pada ti-kus Wistar jantan. Hewan uji terdiri dari 2 kelompok, tiap kelompok terdiri dari 5 ekor tikus. Kelompok I, tikus diberi rifampisin dengan dosis 50 mg/kg BB sebagai kelompok kontrol. Kelompok II tikus diberi praperlakuan jus kulit manggis 200 mg/kg BB selama 7 hari kemudian pada hari ke-8 diberi rifampisin 50 mg/kg BB sebagai kelompok perlakuan bersama jus kulit mang-gis 200 mg/kg BB. Pada jam ke 0,25; 0,5; 1; 1,5; 2; 3; 4; 6; 8; 10; 12; dan 24 di-ambil sampel darah kemudian ditetapkan kadar rifampisin dalam sampel da-rah dengan HPLC. Hasil yang diperoleh dibuat kurva kadar rifampisin dalam plasma terhadap waktu kemudian ditentukan nilai parameter farmakokinetik rifampisin seperti AUC0-∞, AUMC0-∞, dan MRT. Hasil penelitian menunjukkan bahwa pemberian praperlakuan jus kulit manggis tidak memberikan penga-ruh yang signiϐikan terhadap farmakokinetika rifampisin berdasarkan para-meter AUC0-∞, AUMC0-∞, dan MRT.Kata kunci: farmakokinetika, kulit manggis, rifampisin
Farmakokinetika Rifampisin akibat Praperlakuan Jus Kulit Buah Manggis pada Tikus Wistar Jantan Pradana, Dimas Adhi; Hayati, Farida; Praptiwi, .
Jurnal Farmasi Indonesia Vol 7, No 2 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v7i2.162

Abstract

Aim of this study was to determine the effect of pre-treatment of mangosteen rind juice on the pharmacokinetics of rifampicin on white male Wistar rats. Rats (10) devided into 2 groups, each group consisted of 5 rats. Group I rats were given a dose of rifampicin 50 mg/kg body weight as the control group. Group II rats were given pre-treatment  mangosteen rind juice 200 mg/kg for 7 days and then on day 8 were given rifampicin 50 mg/kg and ma ngosteen rind juice 200 mg/kg as the treatment group. On the hour of 0,25; 0,5; 1; 1,5; 2; 3; 4; 6; 8; 10; 12 and 24  blood sample was taken and then deter-mined the rifampicin plasma levels by HPLC. The results obtained produced curve rifampicin levels in the blood versus time and pharmacokinetic parame-ters of rifampicin such AUC0-â?? , AUMC0-â??, and MRT and MRT can be determined.The results showed that pre-treatment mangosteen rind juice did not have a signiÏ?icant effect on the pharmacokine tics of rifampicin based parameters AUC0-â??, AUMC0-â??, and MRT.Keywords: pharmacokinetics, mangosteen rind, rifampicin Penelitian ini bertujuan untuk mengetahui pengaruh praper-lakuan jus kulit manggis terhadap proϐil farmakokinetika rifampisin pada ti-kus Wistar jantan. Hewan uji terdiri dari 2 kelompok, tiap kelompok terdiri dari 5 ekor tikus. Kelompok I, tikus diberi rifampisin dengan dosis 50 mg/kg BB sebagai kelompok kontrol. Kelompok II tikus diberi praperlakuan jus kulit manggis 200 mg/kg BB selama 7 hari kemudian pada hari ke-8 diberi rifampisin 50 mg/kg BB sebagai kelompok perlakuan bersama jus kulit mang-gis 200 mg/kg BB. Pada jam ke 0,25; 0,5; 1; 1,5; 2; 3; 4; 6; 8; 10; 12; dan 24 di-ambil sampel darah kemudian ditetapkan kadar rifampisin dalam sampel da-rah dengan HPLC. Hasil yang diperoleh dibuat kurva kadar rifampisin dalam plasma terhadap waktu kemudian ditentukan nilai parameter farmakokinetik rifampisin seperti AUC0-â??, AUMC0-â??, dan MRT. Hasil penelitian menunjukkan bahwa pemberian praperlakuan jus kulit manggis tidak memberikan penga-ruh yang signiϐikan terhadap farmakokinetika rifampisin berdasarkan para-meter AUC0-â??, AUMC0-â??, dan MRT.Kata kunci: farmakokinetika, kulit manggis, rifampisin
Co-Authors . PRAPTIWI Agung Giri Samudra Amalinda Setya Kartika Arba Pramundita Ramadani Arde Toga Nugraha Ari Wibowo Arief Rahman Hakim Ariefaldy, Muhammad Ilhan Awaluddin, Rizki Cynthia Astiti Putri DAYAR ARBAIN Desyandri Desyandri Dhina Widayati Dhina Widayati, Dhina DIAN AMALIA Dian Sukma Dimas Adhi Pradana Dimas Adhi Pradhana Dina Zakiyyatul Fuadah, Dina Zakiyyatul Diny Lidya Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Brilyani Sandy Dwi Setyorini Elok Atiqoh Fajarotin, Dwi Rori Febrianti, Shabrina Adzhani Firnanda, Muhammad Erick Fitriani, Hannie Gina Nadia Hastarin Ginna Zabrina Girianto, Pria Wahyu Romadhon Hakim, Lukman Hasanah, Primadian Helmina Wati Herianto Pandapotan, Herianto Indriani Indriani Ishariani, Linda Islamiyah Neda Rahayu Khaerunnisa, Siti Laviana Nita Ludyanti Leny Leny, Leny Lian Widi Astutik Ludyanti, Laviana Lutfi Chabib, Lutfi M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mae Sri Hartati Wahyuningsih Maulaya, Ikvini Muh Iqbal Pangestu Muhammad Agus Firmansyah Ramadhani Muhammad Iqbal Pangestu Muhammad Sulaiman Zubair Mustaqim, Rafli Mulkan Mustarianti, Lila Nina Salamah Nurlaily, Diana Nurul Laili Parham Saadi, Parham Pinus Jumariyatno Pinus Jumaryatno Poluan, Jesica Carine Puspita, Arum Dwi Putri Widi Renditya Ismiyati Retno Murwanti Rilia Iriani Riptasari, Rhatna Dewi Rizki Awaluddin Rizsanti Meirina Satar Samad, Ayu Wandari Sandi, Dita Ayulia Dwi Sandi, Dita Ayulia Dwi Satrio, Rezky Metra Septian Pradana, Dimas Sitarina Widyarini Stiani, Sofi Nurmay Sugiyanto . Sugiyanto Sugiyanto Syahmani Syahmani Taukhid, Muhammad Tri Alfiana, Yolanda Velincia Tanriono, Levana Wahyu Utaminingrum Yandi Syukri Yogo Dwi Prasetyo Yundari, Yundari Yusmein Uyun