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All Journal HAYATI Journal of Biosciences VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Alchemy : Journal of Chemistry INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Chimica et Natura Acta Indonesian Journal of Chemistry Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Social Research Molekul: Jurnal Ilmiah Kimia Jurnal Sains Materi Indonesia Jurnal Kefarmasian Indonesia Annales Bogorienses
Sofa Fajriah
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Banten
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Toxicity and Lethality Evaluations of Koordersiodendron pinnatum Leaves Methanolic Extract in DDY Mice Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah Dwiatmi; Angelina, Marissa; Fajriah, Sofa
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.10

Abstract

The study of toxic features of Koordersiodendron pinnatum is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of K. pinnatum in DDY mice. Animals were grouped into five: Group 1 was given 1 mL solution of 2.5% Tween 80 in a single oral dose; the remaining groups were orally given a single dose of 2, 4, 8 and 16 g/kg of K. pinnatum, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 2% of the male group, and no mortality within the female group. The extract is practically non toxic for both male and female (LD50>15 g/kg).
Apigenin, an Anticancer Isolated from Macaranga gigantifolia Leaves Fajriah, Sofa; Megawati, Megawati; Darmawan, Akhmad
Journal of Tropical Life Science Vol 6, No 1 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.01.02

Abstract

Apigenin, a flavonoid compound has been isolated from the ethyl acetate fraction of methanol extract of Macaranga gigantifolia leaves. Isolation and purification of apigenin conducted using chromatographic method, and chemical structure characterized based on spectroscopic data. In vitro anticancer activity test against murine leukemia P-388 cell line showed potential activity with IC50 14.13 μg/mL.Key words: apigenin, flavones, Macaranga gigantifolia, anticancer, murine leukemia P-388 cell line.
Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah D; Angelina, Marissa; Megawati, Megawati; Fajriah, Sofa
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
Co-Authors . Megawati A Darmawan Abdi Wira Septama Ace Tatang Hidayat Akhmad Darmawan Alifia Agustina, Putri Antonius Herry Cahyana Azmi, Mohamad Nurul Darwati Darwati Desi Harneti Putri Huspa Dewa Gede Katja Dewijanti, Indah Dwiatmi Djami, Ratna Eka Prasasti Nur Rachmani Farabi, Kindi Febi Nurilmala Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Galuh Widiyarti Gunawan, Latifah Harizon Harizon Herdini Herdini , Herdini Hidayatullah, Sigit Hilmayanti, Erina Hutagaol, Ricson Pemimpin Indah D Dewijanti, Indah D Isramiharti Isramiharti Kautsari, Arsi Khalijah Awang Kusumiyati Leonardus B.S. Kardono Lia Meilawati Maira, Faizah Marissa Angelina Maulina Handayani Megawati - Meliana, Yenny Munfarikhatin, Atina Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Naini, Al Arofatus Narti Fitriana, Narti Nurfauziyah Nurlelasari Nurlelasari Ofa Suzanti Betha Prastya, Muhammad Eka Primahana, Gian PUJI LESTARI Putria, Devi Kasih RAHMAT, DENI Rani Maharani Rehana Romundza, Febbry Rurini Retnowati Sabrina Dahlizar Sandra Amalia Riyadi Saputra, Ziyan Saputri, Ariyanti Sari, Aprilia Permata Satyaningsih, Desy Septiyanti, Melati Shiono, Yoshihito Sinaga, Siska Elisahbet Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Soleh Kosela Supriadi, Edi suryani, nelly Swandiny, Greesty Finotory Tjandrawati Mozef Tri Mayanti Triana Dewi, Rizna Unang Supratman Utami, Usi Hikmah Wahyudi P. Suwarso, Wahyudi P. Wira Septama, Abdi Yuni Anggraeni Zilhadia Zilhadia Zilhadia