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All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Matematika & Sains Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Journal of Medicine and Health Jurnal Ilmu Kefarmasian Indonesia Current Research on Biosciences and Biotechnology Narra J

Irda Fidrianny

Departemen Farmasi, Institut Teknologi Bandung

Author-ID : 266077

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health

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Formulasi dan Evaluasi Efek Anti Kerut Mikroemulsi Ekstrak Beras Hitam (Oryza sativa L.) Ardian Baitariza; Sasanti Tarini Darijanto; Jessie Sofia Pamudji; Irda Fidrianny
Acta Pharmaceutica Indonesia Vol. 38 No. 4 (2013)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Telah dilakukan formulasi mikroemulsi ekstrak beras hitam (Oryza sativa L.) dan evaluasi efek anti kerutnya secara in vivo. Hasil menunjukkan bahwa formula mikroemulsi ekstrak beras hitam yang stabil memiliki komposisi ekstrak beras hitam 4%, VCO 28,8%, Croduret-50-SS 28,8%, gliserin 28,8%, dan dapar sitrat fosfat 9,6% pada pH 3,0. Efektivitas anti kerut ekstrak beras hitam dalam sediaan mikroemulsi lebih besar daripada dalam sediaan emulsi. Penurunan rata-rata level kerut oleh mikroemulsi ekstrak beras hitam adalah 44,46%±19,7%, sedangkan oleh emulsi ekstrak beras hitam adalah 36,6%±19,5%.Kata kunci: beras hitam, mikroemulsi, antikerutAbstractFormulation of black rice extract (Oryza sativa L.) microemulsion and evaluation of its anti-wrinkle effect in vivo have been investigated. The results showed that black rice extract microemulsion has composition as black rice extract of 4%, VCO of 28.8%, Croduret-50-SS of 28.8%, glycerol of 28.8%, and citrate-phosphate buffer pH 3.0 of 9.6%. The anti-wrinkle effectivity of black rice extract in microemulsion form was more than in emulsion form. The average decrease of wrinkle level by black rice extract microemulsion was 44.46%±19.7%, and by black rice extract emulsion was 36.6%±19.5%.Keywords: black rice, microemulsion, anti-wrinkle

Senyawa Antioksidan dari Ekstrak n-Heksana Daun Asam Jawa (Tamarindus indica L.) dari Banyuresmi, Garut - Indonesia Irda Fidrianny; Ellis Siti Zahidah; Rika Hartati
Acta Pharmaceutica Indonesia Vol. 39 No. 3 & 4 (2014)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Pada proses metabolisme tubuh radikal bebas terbentuk secara alami, dalam jumlah tertentu diperlukan tubuh karena merupakan bagian dari sistem pertahanan tubuh. Jika tubuh terpapar radikal bebas berlebihan dan terus menerus dapat menyebabkan kerusakan sel bahkan kematian sel. Antioksidan merupakan senyawa yang dapat menghambat reaksi oksidasi dengan mengikat radikal bebas dan molekul yang sangat reaktif. Berdasarkan beberapa penelitian, daun asam Jawa (Tamarindus indica L.) diketahui memilki efek antioksidan. Selain itu, daun asam Jawa telah banyak dimanfaatkan oleh masyarakat untuk mengobati berbagai macam penyakit. Penelitian ini bertujuan untuk menguji aktivitas antioksidan berbagai ekstrak daun asam Jawa dengan DPPH, menetapkan IC50 peredaman DPPH, menetapkan kadar fenol total, flavonoid total, karotenoid total dari masing-masing ekstrak, menganalisis korelasi fenol total, flavonoid total, dan karotenoid total terhadap aktivitas peredaman DPPH dan mengisolasi senyawa aktif antioksidan dari ekstrak daun asam Jawa. Simplisia daun asam Jawa diekstraksi dengan refluks menggunakan tiga pelarut dengan kepolaran meningkat yaitu n-heksana, etil asetat, dan etanol. Dilakukan pemantauan pada setiap ekstrak secara kromatografi lapis tipis (KLT). Uji aktivitas peredaman radikal bebas DPPH (2,2-difenil-1-pikrilhidrazil), IC50 peredaman DPPH, penentuan flavonoid total, fenol total, karotenoid total dilakukan dengan spektrofotometri ultraviolet-sinar tampak dan analisis korelasinya dengan aktivitas peredaman DPPH menggunakan metode Pearson. Ekstrak n-heksana difraksinasi secara kromatografi cair vakum (KCV). Fraksi ke-4-5 selanjutnya dilakukan subfraksinasi secara kromatografi kolom. Subfraksi 31 dimurnikan dengan KLT preparatif dan dilakukan uji kemurnian secara KLT. Simplisia daun asam Jawa (Tamarindus indica L.) mengandung flavonoid, fenol, terpenoid, steroid/triterpenoid. Ekstrak etanol daun asam Jawa (BJ ekstrak 1 % 0,81 g/mL) menunjukkan aktivitas peredaman DPPH tertinggi (66,74%) dengan IC50 peredaman DPPH 2,05 µg/mL, fenol total 6,17 g GAE/100 g, flavonoid total 3,22 g QE/100 g, karotenoid total 0,35% g BE/100 g. Satu senyawa antioksidan E diperoleh dari ekstrak n-heksana. Aktivitas peredaman DPPH ekstrak etanol daun asam Jawa berbeda bermakna terhadap ekstrak etil asetat dan ekstrak n-heksana (p<0.05). Golongan fenol merupakan kontributor utama pada aktivitas antioksidan ekstrak daun asam Jawa dengan metode DPPH. Senyawa antioksidan E merupakan senyawa aglikon flavonol yang mempunyai -OH bebas pada C-3 dan diduga mempunyai -OH bebas pada cincin A dan atau B.Kata kunci: antioksidan, DPPH, asam Jawa, daun, ekstrak n-heksana, isolat EAbstractIn metabolism process free radicals are formed naturally. The body needs a certain amount as a part of the body's defense system. If body is exposed by free radicals excessively and continuously can cause cell damage and even cell death. Antioxidant are compounds that can inhibit the oxidation reaction by binding to free radicals and highly reactive molecules. Based on several studies, tamarind (Tamarindus indica L.) leaves were known to have the effect of antioxidants. In addition, tamarind leaves have been used by people for treating various diseases. This research aimed to test the antioxidant activity of various extracts of tamarind leaves by DPPH method, determine IC50 DPPH scavenging activity, total phenolic, total flavonoids, total carotenoid of each extract, analyze their correlation with DPPH scavenging activity and isolation antioxidant compound of tamarind leaves extract. Crude drug of tamarind leaves was extracted by reflux aparatus using three solvents with increasing polarity, n-hexane, ethyl acetate and ethanol. Each extract were monitored by TLC, IC50 DPPH scavenging activity, total phenolic, total flavonoids, total carotenoid of each extracts by ultraviolet-visible spectrophotometry and their correlation with DPPH scavenging activity by Pearson method. N-hexane extract was fractionated by vacuum liquid chromatography. Then fractions 4-5 were subfractionated by column chromatography. Subfraction 31 was purified using preparative thin layer chromatography (TLC) and purity test was performed by TLC. Crude drug of tamarind (Tamarindus indica L.) leaves contained flavonoids, phenolic compound, terpenoids, steroids / triterpenoids. Ethanol extract of tamarind leaves (MW 1 % extract was 0.81 g / mL) showed the highest DPPH scavenging activity (66.74 % ) with IC50 of DPPH scavenging activity 2.05 µg/mL. Total phenolic, flavonoid, carotenoid content were 6.17 g GAE/100 g, 3.22 g QE/100 g and 0.35 g BE/100 g, respectively. An antioxidant compound E was obtained from n-hexane extract. The antioxidant activity of ethanol extract significantly different with n-hexane extract and ethyl acetate extract (p<0.05). Phenolic compounds were the major contributor in tamarind leaves extract using DPPH assay. Antioxidant compound E was flavonol aglycone that had free -OH group in C-3 and expected had free -OH in ring A and or ring B.Keywords: antioxidant, DPPH, tamarind, leaves, n-hexane extract, isolate E

Uji Aktivitas Antimikroba Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa Bilimbi L.) terhadap Propionibacterium acnes, Staphylococcus epidermidis, MRSA dan MRCNS Elin Yulinah Sukandar; Irda Fidrianny; Rizka Triani
Acta Pharmaceutica Indonesia Vol. 39 No. 3 & 4 (2014)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Belimbing wuluh adalah salah satu tanaman tropis yang hidup subur di Indonesia.Saat ini pemanfaatan buah belimbing wuluh masih terbatas dibandingkan dengan ketersediannya. Aktivitas antimikroba ditentukan terhadap empat bakteri uji meliputi penentuan konsentrasi hambat minimum, konsentrasi bakterisid minimum dan profil kurva pertumbuhan.Nilai KHM ekstrak etanol buah belimbing wuluh terhadap Staphylococcus epidermidis, Propionibacterium acnes, Methicillin-resistant Staphylococcus aureus (MRSA) dan Methicillin Resistant Coagulase-Negative Staphylococci (MRCNS) berturut-turut adalah 128,256, 256 dan 256 µg/mL. Nilai konsentrasi bakterisid minimum ekstrak etanol buah belimbing wuluh terhadap Staphylococcus epidermidis, Propionibacterium acnes, MRSA dan MRCNS berturut-turut adalah 512, 512, 1024 dan 512 µg/mL. Hasil pengujian kurva pertumbuhan menunjukkan ekstrak memiliki aktivitas bakteriostatik terhadap keempat bakteri pada 1 KHM, 4 KHM dan 8 KHM. Ekstrak etanol buah belimbing wuluh memiliki aktivitas bakteriostatik terhadap bakteri Staphylococcus epidermidis, Propionibacterium acnes, MRSA dan MRCNS.Kata kunci: antibakteri, ekstrak etanol, buah belimbing wuluh, mikrodilusi.AbstractCucumber tree is one of lush tropical plants that live in Indonesia. Currently, the use of cucumber fruit is still limited compared to availability. Antimicrobial activity was determined against four bacteria includes the determination of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and the profile of the growth curve. By using the microdilution method, the MIC value of the ethanol extract of cucumber tree fruit against Staphylococcus epidermidis, Propionibacterium acnes, Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin Resistant Coagulase-Negative Staphylococci (MRCNS) was 128, 256, 256 and 256 Î¼g/mL respectively. Value of the minimum bactericidal concentration of ethanol extract of cucumber fruit against Staphylococcus epidermidis, Propionibacterium acnes, MRSA and MRCNS was 512, 512, 1024 and 512 µg/mL respectively. Turbidimetry method showed the ethanol extract of the cucumber tree fruit had bacteriostatic activity against Staphylococcus epidermidis, Propionibacterium acnes, MRSA and MRCNS until 8 MIC.Keywords: antibacterial, Averrhoa bilimbi L., ethanolic extract, broth microdilution, MIC.

EFEK VASODILATASI DAN INHIBISI ANGIOTENSIN CONVERTING ENZYME DARI EKSTRAK ETANOL DAN FRAKSI DAUN BINAHONG (ANREDERA CORDIFOLIA (TEN). V. STEENIS) Afrillia Nuryanti Garmana; Elin Yulinah Sukandar; Irda Fidrianny
Acta Pharmaceutica Indonesia Vol. 42 No. 2 (2017)
Publisher : School of Pharmacy Institut Teknologi Bandung

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ABSTRAKEfek antihipertensi binahong pada model hewan hipertensi yang diinduksi dengan adrenalin dan deksametason telah dibuktikan pada penelitian sebelumnya. Pada penelitian ini, dikaji mekanisme kerja lebih lanjut dari efek antihipertensi ekstrak etanol daun binahong dan fraksinya. Pengujian secara ex vivo dilakukan dengan menggunakan aorta kelinci yang diinduksi dengan norepinefrin, metilen biru- norepinefrin, dan kalium klorida. Efek pemberian ekstrak etanol daun binahong (EEDB), fraksi n-heksana (FH), fraksi etil asetat (FE), dan fraksi air (FA) diamati pada kimograf lalu dihitung persen relaksasi dan waktu relaksasi. Pengujian secara in vitro dilakukan dengan menggunakan Hip-His-Leu sebagai substrat dan mengukur produk yang terbentuk secara spektrofotometri UV-sinar tampak pada panjang gelombang 228 nm. Dari data absorbansi, dihitung persen inhibisi angiotensin converting enzyme (ACE) dan ditentukan nilai IC50. Pada kontraksi yang diinduksi norepinefrin, EEDB, FH, FE, dan FA menunjukkan persen relaksasi berturut-turut sebesar 60,9; 39,2; 48,2; dan 52,5%. Waktu relaksasi pada semua kelompok uji menurun secara signifikan terhadap kelompok yang diinduksi norepinefrin (p<0,05). Pada kontraksi yang diinduksi norepinefrin dengan pretreatmen metilen biru, persen relaksasi yang terjadi akibat pemberian EEDB, FH, FE, dan FA berturut-turut sebesar 21,4; 30,7; 21,6; dan 23,8% serta tidak terjadi penurunan waktu relaksasi. Pada kontraksi yang diinduksi KCl, persen relaksasi yang terjadi akibat pemberian EEDB, FH, FE, dan FA berturut-turut sebesar 42,2; 20,4; 49,1; dan 35,8%, akan tetapi tidak terjadi penurunan waktu relaksasi. Nilai IC50 pada pemberian EEDB, FH, FE, dan FA berturut-turut sebesar 22,63; 242,60; 115,77; dan 97,53 Î¼g/mL. Ekstrak etanol daun binahong memiliki efek vasodilatasi melalui jalur NO, inhibisi kanal kalsium (lemah), dan inhibisi ACE (sedang). Fraksi n-heksana tidak menunjukkan efek inhibisi kanal kalsium dan inhibisi ACE, tetapi menunjukkan efek vasodilatasi melalui jalur NO. Fraksi etil asetat menunjukkan efek vasodilatasi melalui jalur NO, inhibisi kanal kalsium (lemah), serta inhibisi ACE (lemah). Fraksi air menunjukkan efek vasodilatasi melalui jalur NO serta inhibisi ACE (lemah), tetapi tidak menunjukkan efek inhibisi kanal kalsium.Kata kunci: Anredera cordifolia, binahong, vasodilatasi, nitrit oksida, inhibisi kanal kalsium, inhibisi angiotensin converting enzymeVASODILATATION AND ANGIOTENSIN CONVERTING ENZYME INHIBITION EFFECT OF ETHANOL EXTRACT AND FRACTION FROM MADEIRA VINE (ANREDERA CORDIFOLIA (TEN). V. STEENIS) LEAFABSTRACTThe antihypertensive effects of Anredera cordifolia (madeira vine) on adrenaline-induced and dexamethasone-induced hypertensive rat have been demonstrated in previous studies. In this study, mechanism of antihypertensive effect of ethanol extract of madeira vine leaves and its fraction studied further. Ex vivo experiment was performed using rabbit aortic rings induced with norepinephrine, methylene blue-norepinephrine, and potassium chloride. The respond of aortic rings to ethanol extract of madeira vine (EEMV), n-hexane fraction (HF), ethyl acetate fraction (EF), and water fraction (WF) were observed in the kymograph, then percentage of relaxation and relaxation time were calculated from the graph obtained. Angiotensin converting enzyme (ACE) inhibitor activity test was performed in vitro using Hip-His-Leu as the substrate. The product of enzymatic reaction measured using UV-visible spectrophotometry at wavelength 228 nm. From the absorbance data, percentage of enzyme inhibition was calculated and IC50 value was determined. In norepinephrine-induced contraction, EEMV, HF, EF, and WF showed percentage of relaxation 60.9; 39.2; 48.2; and 52.5%, respectively. Relaxation time of all groups were significantly decrease compared to norepinephrine group (p<0.05). In norepinephrine-induced contraction with methylene blue pretreatment, the percent of relaxation were 21.4; 30.7; 21.6; and 23.8%, respectively for EEMV, HF, EF, and WF, and there was no reduction in relaxation time. In KCl-induced contraction, the percentage of relaxation of EEMV, HF, EF, and WF were 42.2; 20.4; 49.1; and 35.8%, respectively, but no reduction in relaxation time. IC50 of EEMV, HF, EF, and WF were 20.76, 198.13, 115.77, and 88.41 Î¼g/mL, respectively. The ethanol extract of madeira vine leaves showed vasodilator effect through the endothelium-dependent pathway, inhibition of calcium channel (weak), and ACE inhibition (moderate). The n-hexane fraction showed no inhibitory effect of calcium channel and ACE, but showed vasodilation effect via endothelium-dependent pathway. Vasodilation effect of ethyl acetate fraction occurred through the endothelium-dependent pathway, inhibition of calcium channel (weak), and ACE inhibition (weak). The water fraction showed vasodilation effect through endothelium-dependent pathway and inhibition of ACE (weak), but did not show calcium channel inhibition effect.Keywords: Anredera cordifolia, madeira vine, vasodilatation, nitric oxide, calcium channel blocker, angiotensin converting enzyme inhibition

The Effect of Melinjo (Gnetum gnemon L.) Leaves and Melinjo Peel Extracts on Induced-Hyperuricemia Male Rats Model Nia K Sari; Andreanus A Soemardji; Irda Fidrianny
Journal of Medicine and Health Vol. 2 No. 4 (2019)
Publisher : Universitas Kristen Maranatha

Hyperuricemia is condition which blood uric acid levels increase, in men are greater than 7 mg/dL and in women over 6 mg/dL. In Indonesia the prevalence of hyperuricemia was 32% in people under 34 years and increases every year. Beside an emping from melinjo seed there is Indonesian meals made from mixture of seed, peel and leaves of melinjo, namely as sayur asem. Consumption a lot of emping can induced hyperuricemia. This study aims to assess the effect of melinjo leaves and peel extracts to reduce uric acid levels on melinjo seed hyperuricemia male rats model. Methods: Induction was performed by giving high purine diet, melinjo seed crude drug (emping) 4.5 g/kg bw. Ethanol extracts of melinjo leaves and melinjo peel were administered in 3 doses. Results: Ethanol leaves extract of melinjo (Gnetum gnemon L.) 36 mg/kg bw could decrease uric acid levels up to 61.04%, while ethanol peel extract of melinjo 13 mg/kg bw can decrease uric acid levels up to 31.25%. Conclusions: Melinjo seed crude drug (emping) could increase the bloods uric acid level in rats up to 4.65 mg/dL. Ethanol leaves and peel extracts of melinjo could decrease uric acid blood levels in hyperuricemia rats. Keywords : Gnetum gnemon L., seed, leaves, peel, antihyperuricemia

Phytochemistry and pharmacological activities of Annona genus: A review Siti Kusmardiyani; Yohanes Andika Suharli; Muhamad Insanu; Irda Fidrianny
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/KNIA7708

Plants have been significantly used in traditional medicine by a variety of societies since antiquity, and knowledge of their safety, efficacy, and quality value can be developed through further research. The Genus Annona consisting of 119 species has been extensively researched and proven to have a diverse range of pharmacological activities such as antioxidant, antiulcer, antidiarrheal, and antiparasitic. This is because the Annona plants possess a great number of phytochemicals found in almost every part of the plant, which can be isolated to be developed into herbal medicine. Phytochemicals are classified into several classes, such as Annonaceous acetogenin, alkaloids, flavonoids, and essential oils. This article was created by collecting 137 research articles which discuss phytochemical compounds from 38 species and the pharmacological activity from 13 species.

Ethnopharmacognosy study, antioxidant activity, and chemical content in chicken bile Slamet Tuty; Irda Fidrianny; Sukrasno
Current Research on Bioscences and Biotechnology Vol. 3 No. 2 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.3.2/UFG27H3H

The aim of this research was to study the ethnopharmacognosy, antioxidant activity, and chemical content of chicken bile. In addition, a bioactivity-guided isolation was also performed to identify compounds in chicken bile having antioxidant activity. Extraction was carried out by reflux method. Each extract was tested for its antioxidant activity using DPPH and CUPRAC methods. Fractionation was performed on selected extract, namely ethyl acetate extract, using vacuum liquid chromatography and subfraction using preparative TLC method and classical column chromatography (CCC). Compound 1 was characterized and identified by NMR, compound 2 was characterized and identified by LC-MS/MS and NMR, subfraction 7 was characterized by GC-MS. The result of the antioxidant activity of ethanol extract of chicken bile using the DPPH method (IC 50: 46.64 g/mL), ethyl acetate extract (IC 50: 69.99 g/mL), n-hexane extract (IC 50: 71.65 g/mL, fraction 15-17 (IC 50: 88.77 g/mL) showed strong antioxidant, whereas by CUPRAC method all extracts (EC 50: 69.90, EC 50: 80.28, EC 50: 70.40) and fraction (EC 50: 64.53) are strong antioxidants. The result of identification of compound 1 by NMR was identified as cholesterol, identification of compound 2 by LC-MS/MS was (E)-hexadecyl-ferulate and subfraction 7 which was identified by GC-MS produced dominant compounds, namely oleic acid, n-hexadecanoic acid, octadecanoic acid and palmitoleic acid. In conclusion, extract, fraction 15-17 and subfraction of chicken bile have antioxidant activity where the active antioxidant compound is a phenol group compound, namely (E)-hexadecyl-ferulate. The other chemical constituents found in chicken bile are, oleic acid, n-hexadecanoic acid, octadecanoic acid, and palmitoleic acid.

Optimasi Nanoemulsi A/M/A Ekstrak Etanol Daun Binahong dan Konjugat AG-Kitosan Menggunakan Desain Box-Behnken Malinda Prihantini; Irda Fidrianny; Tri Suciati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Skin premature aging which is characterized by fine wrinkles can be overcome by stimulating collagen production and inhibiting its degradation, and also reducing corneocyte buildup. Madeira vein has been shown to induce collagen production and inhibit its degradation, while glycolic acid increase desquamation. The aim of this research was to optimize W/O/W multiple nanoemulsion formula of Madeira vein-leaves extract in W1 phase and glycolic acid in W2 phase. Glycolic acid was added after conjugated with chitosan to reduce its stinging effect on skin. The W/O/W multiple nanoemulsion was prepared through two emulsification steps: W1/O primary emulsion using high speed homogenizer, and the secondary emulsion using magnetic stirrer. W1/O was optimized including the selection of co surfactant and extract concentration, followed by secondary emulsion optimization using response surface methodology consisted of 2-level factorial and Box-Behnken design. The W1/O consisted of extract, polysorbate 80 as surfactant, PEG 400 as co surfactant and isopropyl myristate as oil phase. The 2-level factorial gave the three significant factors: W1/O sonication time, W1/O concentration, and secondary emulsification stirring time. Box-Behnken optimization for globule size below 400 nm was obtained by 6-10 minutes W1/O sonication time, 12-16% W1/O concentration, and 32-42 minutes stirring time of secondary emulsification.

Antioxidant Activity, Sun Protection Factor and Phytochemical Properties of Different Parts Sawo Walanda (Pouteria Campechiana (Kunth.) B.) Extract Fitriansyah, Sani Nurlaela; Fadhilah, Syifa; Ruslan, Komar; Hartati, Rika; Fidrianny, Irda
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.50584

AbstractUV radiation can lead production of Reactive Oxygen Species (ROS) on the skin and can cause negative effects1. Sun protector and antioxidant ingredients are needed to protect the skin2. Phenolic compounds and flavonoids have been used as sun protectors and as antioxidants3. Pouteria campechiana is known for its high abundance of phenolic compounds4. This study reported the phytochemical group, total phenol and total flavonoid content, antioxidant activity, and sun protector factor of ethanol extracts of pulp, seed, leaves, and twigs of Pouteria campechiana. Determination of antioxidant activity, sun protection factor, and total phenol and total flavonoid content were carried out using UV-visible spectrophotometry. Crude drugs and extract of pulp, seed, twig, and leaves P.campechiana containing phenolic group, tannin, and flavonoid. The leaf extract had the highest total phenolic content, while the highest total flavonoid content was in the seed extract. All of the extracts tested had very strong antioxidant activity indicated by the Antioxidant Activity Index (AAI) to DPPH value, >2. At a concentration of 1000 µg/mL, the leaf extract showed the highest SPF value, 16.01 ± 0.38.The conclusion, the leaf extract had the potential to further as a natural antioxidant, and sun protector. AbstrakPaparan radiasi UV dapat meningkatkan produksi Reactive Oxygen Species (ROS) sebagai radikal bebas dan dapat menimbulkan efek negatif pada kulit. Dibutuhkan senayawa aktif sebagai fotoprotektor dan senyawa penangkal radikal bebas yang disebut antioksidan untuk melindungi kulit. Golongan senyawa fenol dan flavonoid dapat menyerap radiasi UV dan menangkal radikal bebas. Pouteria campechiana dilaporkan mengandung senyawa fenol. Penelitian ini melaporkan golongan senyawa kimia, kadar fenol dan flavonoid total, aktivitas antioksidan terhadap DPPH dan aktivitas fotoprotektor yang menggunakan parameter nilai Sun Protector Factor (SPF) dari ekstrak etanol daging buah, biji, ranting dan daun Poteria campechiana. Ativitas antioksidan, nilai SPF, kadar fenol total, dan flavonoid total diukur secara spektrofotometri UV-Sinar tampak. Hasil penelitin menunjukkan simplisia dan ekstrak etanol daging buah, biji, ranting dan daun P.campechiana mengandung golongan senyawa fenoli, tanin, dan flavonoid. Ekstrak etanol daun memiliki kadar fenol total tertinggi, sedangkan kadar flavonoid total tertinggi ada pada ekstrak etanol biji. Keempat ekstrak tergolong pada antioksidan sangat kuat, dengan parameter nilai AAI >2. Pada konsentrasi 1000 µg/mL, ekstrak daun menunjukkan nilai SPF tertinggi yaitu sebesar 16,01 ± 0,38. Kesimpulan, ekstrak etanol daun P.campechiana lebih berpotensi untuk dikembangkan sebagai bahan baku aktif antioksidan alami dan fotoprotektor.

Parang Romang (Boehmeria virgata (Frost.) Guill.): Correlation of Phytochemistry with Antioxidant and Xanthine Oxidase Inhibitory Activities Arsul, Muhammad Ikhlas; Fidrianny, Irda; Insanu, Muhamad
HAYATI Journal of Biosciences Vol. 31 No. 3 (2024): May 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.3.457-464

Secondary metabolites such as phenolic and flavonoid from the plant are essential in their activity, especially activities related to the prevention of oxidation and the inhibition of xanthine oxidase. One plant that is believed to have prevention of oxidation and XOI and correlates with secondary metabolites is parang romang. The purpose of this study is to assess the antioxidant capacity and xanthine oxidase inhibitory activities of parang romang, and to examine their relationship with the TPC and TFC. Total phenolic and flavonoid were measured for all parts, and the DPPH, FRAP, and CUPRAC methods determined antioxidant capacity. The activity of xanthine oxidase inhibition was also assessed. Flavonoids, alkaloids, and coumarin were found in parang romang. The steroid/triterpenoid was found in the stem, leaves, and flower; saponin was in the roots and flower; quinone and tannin were only in the roots. The root gave the highest of TPC, while the flower had the highest TFC. The highest antioxidant capacity was found in roots, leaves, flowers, and stems. The highest xanthine oxidase inhibitory was given by leaves (9.74±0.14 µg/ml), followed by flower, steam, and rood. The correlation was shown between the phenolic and flavonoid quantities and the actions of antioxidants and xanthine oxidase inhibitors.

Co-Authors - Satrialdi . Elfahmi Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Amanda, Patricia Andreanus A Soemardji Andreanus A Soemardji Annisa Rahman Ardian Baitariza Ardian Baitariza Ardian Baitariza, Ardian Arsul, Muhammad Ikhlas Baitariza, Ardian Choirunnisa, Atina Rizkiya Darijanto, Sasanti Tarini Dinda Prasetya Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Ellis Siti Zahidah Fadhilah, Syifa Fitria, Alfiyani Fitriansyah, Sani Nurlaela Hartanti, Rika Hartati, Rika HENI RACHMAWATI I Ketut Adnyana IGNA Supradja Iwo, Maria I. Jessie Sofia Pamudji Jessie Sofia Pamudjie Jessie Sofia Pamudjie, Jessie Sofia Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Kosasih Padmawinata Leonny Yulita Hartiadi Meutia Faradilla, Meutia Muhamad Insanu Muhamad Insanu Nia K Sari Pamudji, Jessie Sofia Patricia Amanda Pramastya, Hegar Prasetya, Dinda Prihantini, Malinda Raveendaran, Narmmatha Regiana, Zhafira Amalia Rika Hartati Rika Hartati Rika Hartati Rizaldy, Defri Rizka Triani Ruslan, Komar Sasanti Tarini Darijanto Sasanti Tarini Darijanto Sasanti Tarini Darijanto, Sasanti Tarini Satrialdi, - Shelvi E. Suherman Shelvi E. Suherman, Shelvi E. Sienny Wijaya Siti Kusmardiyani Slamet Tuty Soediro Soetarno Sukandar, Elin Yulinah Sukrasno Tri Suciati Triani, Rizka Wijaya, Sienny Yohanes Andika Suharli Yundari, Yundari Yuniarto, Ari Zahidah, Ellis Siti

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