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All Journal HAYATI Journal of Biosciences Jurnal Matematika & Sains Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Journal of Medicine and Health Jurnal Ilmu Kefarmasian Indonesia Current Research on Biosciences and Biotechnology Narra J
Irda Fidrianny
Departemen Farmasi, Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health

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Antioxidant and immunomodulatory activities of ethanol extracts from Syzygium cumini L. Skeels and Pogostemon cablin Benth Faradilla, Meutia; Fidrianny, Irda; Iwo, Maria I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.918

Abstract

Syzygium cumini and Pogostemon cablin are mostly cultivated in tropical climates for culinary and perfumery purposes, yet their potential medicinal properties remain underreported. The aim of this study was to examine the antioxidant and immunomodulatory activities of ethanol extracts from S. cumini (EESC) and P. cablin (EEPC). Reflux extraction was carried out using 96% ethanol on the collected plant specimens to produce EESC and EEPC. Secondary metabolites of each extract were identified using gas chromatography-mass spectrometry (GC-MS). The extracts were measured for total phenol and flavonoid levels and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The immunomodulatory activity test was carried out in vivo by assessing several parameters, including the phagocytic index via the carbon clearance method, organ indices, antibody titers, and delayed-type hypersensitivity (DTH) response, using sheep red blood cells (SRBC) as antigens. The extracts were also examined for their anti-inflammatory activity in acute and chronic inflammation models. In the DPPH antioxidant test, EESC and EEPC had IC50 values of 12.33 µg/mL and 182.17 µg/mL, respectively. Both extracts showed immunosuppressant activity, marked by a phagocytic index of <1. EESC yielded lower organ indices for the liver (p=0.025 at 200 mg/kg BW), spleen (p=0.028 at 100 mg/kg BW), and thymus (p=0.032 at 200 mg/kg BW) compared to the control group. For EEPC, lower organ indices were observed in the liver at 100 mg/kg BW (p=0.005) and 200 mg/kg BW (p=0.031). In the primary antibody titer and DTH tests, both EESC and EEPC showed immunosuppressant activity at 200 and 400 mg/kg BW (p<0.05). The extracts suppressed both the innate and adaptive immune systems. Both EEPC (p=0.004) and EESC at 100 mg/kg BW (p=0.03) significantly reduced serum TNF-α levels. In conclusion, EESC and EEPC have the potential as immunosuppressive and anti-inflammatory agents.
KARAKTERISASI DAN PENAPISAN FITOKIMIA SIMPLISIA WORTEL SERTA REVIEW KANDUNGAN KIMIA DAN AKTIVITAS FARMAKOLOGI WORTEL (DAUCUS CAROTA L.) Rika Hartati; Fidrianny, Irda; Fitria, Alfiyani
Acta Pharmaceutica Indonesia Vol. 48 No. 2
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i2.22428

Abstract

Carrot is an important source of nutrition for humans and a good source of dietary fiber. Carrot are rich in bioactive compounds such as phenolic compounds, carotenoids, polyacetylene, and ascorbic acid which has health effects. Carrot are known to have many health benefits such as antioxidants, antidiabetic, antiinflammatory, antihypertensive, antibacterial, and antifungal. This study aims to determine the characteristics and phytochemical screening of root, leaves and stem carrot (Daucus carota L) and prepare a review article about chemical compounds and pharmacological activities of carrot. Characterization performed of crude drug included macroscopic and microscopic, determination of total ash content, acid insoluble ash, water soluble ash, water content, water soluble extract, ethanol soluble extract, and loss on drying. Phytochemical screening was carried out to check the presence of secondary metabolite in crude drug. Root, leaves and stem of carrot extracted by reflux method with n-hexane, ethyl acetate, and 96% ethanol. Review article was prepared by considering and analyzing literatures. Water content of roots, leaves and stem of carrot were 5%, 4,17% and 6,67%, respectively. All crude drugs contained flavonoid, phenol, quinone and steroid/triterpenoid groups. Article review was done by collecting and analysing 82 literatures. The water of all crude drugs fulfilled the requirement. Wortel (Daucus carota L.) has many chemical compounds and pharmacological activities. Keywords: carrot, characterization, phytochemical screening, chemical compounds, pharmacological activities
Co-Authors - Satrialdi . Elfahmi Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Amanda, Patricia Andreanus A Soemardji Andreanus A Soemardji Annisa Rahman Ardian Baitariza Ardian Baitariza Ardian Baitariza, Ardian Baitariza, Ardian Dinda Prasetya Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Ellis Siti Zahidah Fadhilah, Syifa Fitria, Alfiyani Fitriansyah, Sani Nurlaela Hartanti, Rika HENI RACHMAWATI I Ketut Adnyana IGNA Supradja Iwo, Maria I. Jessie Sofia Pamudji Jessie Sofia Pamudjie Jessie Sofia Pamudjie, Jessie Sofia Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Kosasih Padmawinata Leonny Yulita Hartiadi Meutia Faradilla, Meutia Muh Ikhlas Arsul Muhamad Insanu Nia K Sari Pamudji, Jessie Sofia Patricia Amanda Prasetya, Dinda Prihantini, Malinda Raveendaran, Narmmatha Rika Hartati Rika Hartati Rizka Triani Ruslan, Komar Sasanti Tarini Darijono Satrialdi, - Shelvi E. Suherman Shelvi E. Suherman, Shelvi E. Sienny Wijaya Siti Kusmardiyani Slamet Tuty Soediro Soetarno Sukandar, Elin Yulinah Sukrasno Tri Suciati Triani, Rizka Wijaya, Sienny Yohanes Andika Suharli Yundari, Yundari Yuniarto, Ari Zahidah, Ellis Siti