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All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Matematika & Sains Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Journal of Medicine and Health Jurnal Ilmu Kefarmasian Indonesia Current Research on Biosciences and Biotechnology Narra J
Irda Fidrianny
Departemen Farmasi, Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health

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Antioxidant and immunomodulatory activities of ethanol extracts from Syzygium cumini L. Skeels and Pogostemon cablin Benth Faradilla, Meutia; Fidrianny, Irda; Iwo, Maria I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.918

Abstract

Syzygium cumini and Pogostemon cablin are mostly cultivated in tropical climates for culinary and perfumery purposes, yet their potential medicinal properties remain underreported. The aim of this study was to examine the antioxidant and immunomodulatory activities of ethanol extracts from S. cumini (EESC) and P. cablin (EEPC). Reflux extraction was carried out using 96% ethanol on the collected plant specimens to produce EESC and EEPC. Secondary metabolites of each extract were identified using gas chromatography-mass spectrometry (GC-MS). The extracts were measured for total phenol and flavonoid levels and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The immunomodulatory activity test was carried out in vivo by assessing several parameters, including the phagocytic index via the carbon clearance method, organ indices, antibody titers, and delayed-type hypersensitivity (DTH) response, using sheep red blood cells (SRBC) as antigens. The extracts were also examined for their anti-inflammatory activity in acute and chronic inflammation models. In the DPPH antioxidant test, EESC and EEPC had IC50 values of 12.33 µg/mL and 182.17 µg/mL, respectively. Both extracts showed immunosuppressant activity, marked by a phagocytic index of <1. EESC yielded lower organ indices for the liver (p=0.025 at 200 mg/kg BW), spleen (p=0.028 at 100 mg/kg BW), and thymus (p=0.032 at 200 mg/kg BW) compared to the control group. For EEPC, lower organ indices were observed in the liver at 100 mg/kg BW (p=0.005) and 200 mg/kg BW (p=0.031). In the primary antibody titer and DTH tests, both EESC and EEPC showed immunosuppressant activity at 200 and 400 mg/kg BW (p<0.05). The extracts suppressed both the innate and adaptive immune systems. Both EEPC (p=0.004) and EESC at 100 mg/kg BW (p=0.03) significantly reduced serum TNF-α levels. In conclusion, EESC and EEPC have the potential as immunosuppressive and anti-inflammatory agents.
Potential Antioxidant Activity of the Unused Part of Tamarillo (Solanum betaceum Cav.) Choirunnisa, Atina Rizkiya; Regiana, Zhafira Amalia; Insanu, Muhamad; Hartati, Rika; Pramastya, Hegar; Rizaldy, Defri; Fidrianny, Irda
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.336-344

Abstract

Tamarillo (Solanum betaceum Cav.) is a member of the Solanaceae family that contains phenolic and flavonoid compounds. The fruit of the tamarillo is commonly consumed. However, other parts that are rarely used also have many potential benefits, including antioxidant activity. This study aims to evaluate antioxidant activity of used part (flesh) and unused part (leaves and peel) extracts of tamarillo through ascorbic acid equivalent antioxidant capacity (AEAC), phenolic and flavonoids content, correlation the phenolic and flavonoid content on antioxidant activity, correlation the DPPH and CUPRAC methods and the levels of flavonoid compound in selected extract. Three organs (flesh, leaves, peel) were extracted using polarity solvents (n-hexane, ethyl acetate, ethanol). Antioxidant activity was conducted using DPPH and CUPRAC assays, and total phenolic acid and flavonoid acid were also investigated. The result showed that the highest antioxidant activity of tamarillo extracts using DPPH and CUPRAC methods was given by ethanol leaves, 94.917 ± 3.920 and 110.182 ± 7.987 mg AEAC/g sample. The highest TPC in the ethanol leaves extract 10.416 g GAE/100 g, while the highest TFC in the n-hexane leaves extract 8.367 g QE/100 g. Phenolic and flavonoid compounds were identified as significant contributors to the antioxidant activity, with both assessment methods showing a strong linear correlation. In conclusion, Tamarillo leaves had the potential to be a natural antioxidant source, with a rutin content of 0.088%, according to HPLC analysis.
KARAKTERISASI DAN PENAPISAN FITOKIMIA SIMPLISIA WORTEL SERTA REVIEW KANDUNGAN KIMIA DAN AKTIVITAS FARMAKOLOGI WORTEL (DAUCUS CAROTA L.) Rika Hartati; Fidrianny, Irda; Fitria, Alfiyani
Acta Pharmaceutica Indonesia Vol. 48 No. 2
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i2.22428

Abstract

Carrot is an important source of nutrition for humans and a good source of dietary fiber. Carrot are rich in bioactive compounds such as phenolic compounds, carotenoids, polyacetylene, and ascorbic acid which has health effects. Carrot are known to have many health benefits such as antioxidants, antidiabetic, antiinflammatory, antihypertensive, antibacterial, and antifungal. This study aims to determine the characteristics and phytochemical screening of root, leaves and stem carrot (Daucus carota L) and prepare a review article about chemical compounds and pharmacological activities of carrot. Characterization performed of crude drug included macroscopic and microscopic, determination of total ash content, acid insoluble ash, water soluble ash, water content, water soluble extract, ethanol soluble extract, and loss on drying. Phytochemical screening was carried out to check the presence of secondary metabolite in crude drug. Root, leaves and stem of carrot extracted by reflux method with n-hexane, ethyl acetate, and 96% ethanol. Review article was prepared by considering and analyzing literatures. Water content of roots, leaves and stem of carrot were 5%, 4,17% and 6,67%, respectively. All crude drugs contained flavonoid, phenol, quinone and steroid/triterpenoid groups. Article review was done by collecting and analysing 82 literatures. The water of all crude drugs fulfilled the requirement. Wortel (Daucus carota L.) has many chemical compounds and pharmacological activities. Keywords: carrot, characterization, phytochemical screening, chemical compounds, pharmacological activities
Co-Authors - Satrialdi . Elfahmi Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Afrillia Nuryanti Garmana Amanda, Patricia Andreanus A Soemardji Andreanus A Soemardji Annisa Rahman Ardian Baitariza Ardian Baitariza Ardian Baitariza, Ardian Arsul, Muhammad Ikhlas Baitariza, Ardian Choirunnisa, Atina Rizkiya Darijanto, Sasanti Tarini Dinda Prasetya Elin Yulinah Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Elin Yulinah Sukandar Ellis Siti Zahidah Fadhilah, Syifa Fitria, Alfiyani Fitriansyah, Sani Nurlaela Hartanti, Rika Hartati, Rika HENI RACHMAWATI I Ketut Adnyana IGNA Supradja Iwo, Maria I. Jessie Sofia Pamudji Jessie Sofia Pamudjie Jessie Sofia Pamudjie, Jessie Sofia Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Kosasih Padmawinata Leonny Yulita Hartiadi Meutia Faradilla, Meutia Muhamad Insanu Muhamad Insanu Nia K Sari Pamudji, Jessie Sofia Patricia Amanda Pramastya, Hegar Prasetya, Dinda Prihantini, Malinda Raveendaran, Narmmatha Regiana, Zhafira Amalia Rika Hartati Rika Hartati Rika Hartati Rizaldy, Defri Rizka Triani Ruslan, Komar Sasanti Tarini Darijanto Sasanti Tarini Darijanto Sasanti Tarini Darijanto, Sasanti Tarini Satrialdi, - Shelvi E. Suherman Shelvi E. Suherman, Shelvi E. Sienny Wijaya Siti Kusmardiyani Slamet Tuty Soediro Soetarno Sukandar, Elin Yulinah Sukrasno Tri Suciati Triani, Rizka Wijaya, Sienny Yohanes Andika Suharli Yundari, Yundari Yuniarto, Ari Zahidah, Ellis Siti