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SUPLEMENTASI BEKATUL BERAS HITAM UNTUK MENGHAMBAT PERKEMBANGAN KANKER KOLON MELALUI PENGHAMBATAN PROLIFERASI DAN PENINGKATAN APOPTOSIS PADA MENCIT BALB/C Yeni Kurniati; Slamet Budijanto; Lilis Nuraida; Fitriya Nur Annisa Dewi; Safrida Safrida
Media Bina Ilmiah Vol. 18 No. 10: Mei 2024
Publisher : LPSDI Bina Patria

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33758/mbi.v18i10.806

Abstract

Colon cancer is one of the degenerative diseases caused of death after lung and breast cancer. One of the food ingredients that potentially inhibites the occurrence of colon cancer is black rice bran. The aim of this study was to found the effect of black rice bran on apoptosis and cell proliferation on BALB/c mice. In this study, BALB/c mice were divided into three groups, they are normal group (K-), AOM/DSS induced tumor group (K+), and feeding black rice bran with induction of AOM/DSS (BRB). At the end of the study, all mice were terminated and the presence of nodule were analysed in colon tissue used imageJ application. The expression of caspase-3, caspase-8, and PCNA were analysed in colon tissue used q-RT PCR. The data obtained by analyzes of variance (ANOVA) and continued by Tukey HD different test at 5% level. Administration of BRB significantly decreased the expression of PCNA in comparison with that of control mice (K+) (0.58 ± 0.09 vs 5.22 ± 0.80). The expression of caspase 3 (0.91 ± 0.20) and caspase 8 (0.36 ± 0.15) of BRB significantly increased comparasion with control mice K+. Our results thus indicated that black rice bran performed to suppresed proliferation and induced apoptosis
Extra-hepatic biliary duct obstruction pada anjing ras Dachshund Kartjito, Nicolas Edward Christanto; Effendi, Siti Aisyah Rahmalia; Solinda, Gamelita Rizkawandi; Widodo, Setyo; Widhyari, Sus Derthi; Wulansari, Retno; Wijaya, Agus; Dewi, Fitriya Nur Annisa; Wibowo, Deny Setyo; Esfandiari, Anita
ARSHI Veterinary Letters Vol. 7 No. 2 (2023): ARSHI Veterinary Letters - Mei 2023
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.7.2.25-26

Abstract

Anjing jantan ras dachsund (Teckel) berwarna hitam, berusia 4 tahun dengan bobot badan 7,5 kg dibawa pemiliknya datang ke klinik hewan dengan keluhan muntah berulang. Hasil pemeriksaan hematologi menunjukkan polisitemia, leukositosis dan jumlah granulosit yang tinggi. Hasil uji biokimia darah menunjukkan peningkatan pada aktivitas SGPT/ALT, GAMA-GT, total bilirubin, total protein, albumin, rasio ALB/GLOB dan rasio BUN/CRE. Hasil radiografi menunjukkan adanya bentukan membulat radiolucent didekat organ hati. Diagnosa kasus klinis pada anjing ini yaitu extrahepatic biliary duct obstruction dan terapi simptomatik dilakukan dengan memberikan gastroprotektan, antiemetik, serta obat-obatan untuk membantu memperbaiki fungsi hati. Pengobatan dilakukan selama 2 minggu dan menunjukan perbaikan pada organ hati berdasarkan hasil pemeriksaan biokimia darah, diikuti dengan tidak ada dilatasi kantung empedu pada radiogram.
Symmetry dimethylarginine (SDMA) assay for diagnosis of kidney disease in dogs and cats: a mini review of case reports in Indonesia Dewi, Fitriya Nur Annisa; Widhyari, Sus Derthi; Mihardi, Arief Purwo; Widodo, Setyo; Esfandiari, Anita
ARSHI Veterinary Letters Vol. 8 No. 2 (2024): ARSHI Veterinary Letters - May 2024
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.8.2.35-36

Abstract

Symmetry Dimethylarginine (SDMA) is an important biomarker for early diagnosis of kidney disease. Studies suggest that SDMA is a more sensitive indicator of kidney function compared to traditional markers such as blood urea nitrogen (BUN) and creatinine. Since 2015, the International Renal Interest Society (IRIS) has established SDMA as one of the indicators for diagnosis and determining the stage of chronic kidney disease (CKD) in dogs and cats. SDMA assay use in veterinary clinics in Indonesia has empirically become more common. The aim of this study was to identify scientific reports on SDMA assay use in the diagnosis of kidney disease in dogs and cats in Indonesia. We performed a literature search in the Garuda portal and Google Scholar using the following keywords: “SDMA” or “Symmetry Dimethylarginine”, “dogs”, “cats” and “Indonesia”. The search strategy utilized English and Bahasa Indonesia, and the results were screened for relevance to the topic, and limited to studies conducted in Indonesia. Seven scientific articles in national and international journals reported the use of SDMA assay in cases of kidney disease in dogs or cats in Indonesia, published between 2021-2023. It is expected that SDMA assay use will continue to increase in veterinary practice settings in the country, and it is therefore critical to have a proper understanding of the advantages and limitations of SDMA use for kidney disease diagnosis.
Co-Authors . Permanawati Agus Wijaya Anita Esfandiari Dedi Fardiaz Deni Noviana Deny Setyo Wibowo Diah Iskandriati Diah Iskandriati DIAH ISKANDRIATI Diah Iskandriati Diah Iskandriati Diah Iskandriati Diny Agustini Sandrasari Dondin Sajuthi Dwi Ramadhani Effendi, Siti Aisyah Rahmalia Eric Hayes Eric Hayes ESTHER ARIFIN Farida Laila Firman Alamsyah Fitria Senja Murtiningrum FITRY TAFZI Gregory K. Wilkerson Harrold Halilintar MR Subu Taopan Hendra Wijaya Hidekazu Shigematsu Hidekazu SHIGEMATSU Huda S Darusman Huda Shalahudin Darusman I Nengah Budiarsa I Nengah Budiarsa Iin Indriawati Iin Kurnia Hasan Basri Irma H Suparto Irma Herawati Suparto Izzatun Niswah Ajrina J. Mark Cline Kartika Sari Kartjito, Nicolas Edward Christanto Lilis Nuraida MOSES AFFANDI Nancy Dewi Yuliana Nishigaki, Toshiaki Nuri Andarwulan NURI ANDARWULAN2 Pamungkas, Joko Permanawati Permanawati Permanawati Permanawati PUSPO EDI GIRIWONOB R.P Agus Lelana Ratni Ernita Retno Wulansari Safrida Safrida Sela S Mariya Sela S. Mariya Sela Septima Mariya Setyo Widodo Shigematsu, Hidekazu Silmi Mariya Silmi Mariya Silmi Mariya Silmi Mariya Silvia Arin Prabandari Slamet Budijanto Solinda, Gamelita Rizkawandi Sus Derthi Widhyari Tatang Mitra Setia Teja Kisnanto Toshiaki Nishigaki Toshiaki NISHIGAKI Uus Saepuloh Uus Saepuloh UUS SAEPULOH Villiandra Villiandra Villiandra Villiandra Villiandra Villiandra Warsito P. Taruno Widanti, Berlian Wijaya, Hendra Yasmina A Pramastri Yasmina A. Paramastri Yasmina Arditi Pramastri YASMINA PARAMASTRI Yeni Kurniati Yeni Kurniati