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All Journal The Journal of The Indonesian Medical Students´ Association Medical Journal of Indonesia Narra J
Harapan Harapan
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : The Journal of The Indonesian Medical Students

 1 
Antimicrobial Activity Test of Methanol Extract of Sygyzium cordatums Leaves on Eschericia coli and Staphylococcus aureus Using Kirby-Bauer Method Ardhuha, Fadhlan; Harapan, Harapan
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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A research for determining antimicrobial activity from leaf extract of Syzygium cordatum to E. coli dan S. aureus has been conducted. This research was based on Kirby-Bauer method by using BHIB media and MHA agar. Five hundred gram of sample was dried then extracted with 1 litre methanol. The methanol extract obtained was evaporated with water bath at 50oC. Furthermore, antimicrobial activity test for E. coli and S. aureus was done in different concentration: 60%, 30%, 15%, and 7,5%. Inhibition activity of leaf extract of S. cordatum to S. aureus in 60% concentration is 16,5 mm. In concentration of 30%, 15%, and 7,5%, the inhibition activity for S. aureus were 14.5 mm, 13,5 mm, and 11 mm. Inhibition activity for positive control (Chloramphenicol) is 24,5 mm for E. coli and S. aureus. No inhibition activity was shown in negative control (methanol) for E. coli and S. aureus. There was no inhibition activity of leaf extract of S. cordatum for E. coli. In conclusion, leaf extract of S. cordatum have antimicrobial activity for S. aureus but not for E. coli. Furthermore, a research to identify this component have to be conducted. Key words: Antimicrobial, Sygyzium cordatum, Staphylococcus aureus, Eschericia coli, Kirby-Bauer method
Role of Fasting on Enteroendokrin Cell Remodelling to Prevent Type 2 Diabetes Mellitus Harapan, Harapan; Fitri Jamil, Kurnia; Hayati, Zinatul; Muhammad, Iqbal
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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Hitherto, there was no study dedicated to analyze the effect of fasting associated enteroendocrine (EE) cell population remodelling on type 2 diabetes mellitus prevention. This article aimed at discussing the molecular and cellular mechanisms of fasting associated EE cell remodelling to type 2 diabetes mellitus prevention and estimating its effectiveness. It was shown that fasting could inhibit EE cell hyperplasia, thus decreased glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) production from K and L cells. Both hormones caused hyperinsulinemia -via enteroinsular axis- and obesity when they interacted with their respective receptors GIPR and GLP-1R in pancreatic beta cell and adipocyte. This would cause insulin resistance through PI-3 kinase and Cb1. Thus, the levels of GIP and GLP-1 are diabetic predisposition factors. Another study also revealed that EE cell remodelling due to fasting had effective target site on type 2 diabetes mellitus prevention - and was also more superior than GIP and GLP-1 analogs. Key words: type 2 diabetes mellitus, fasting, enteroendocrine cell, GIP, GLP-1
Co-Authors Abdeen, Ziad Acharya, Yogesh Agung Pranata Akel, Kaitlyn B. Aksa, Rahmad Anak Agung Dewi Megawati, Anak Agung Dewi Andri Frediansyah, Andri Ayulinda, Arianisah P. Bakhtiar Bakhtiar Bondarenko, Anastasia Chandran, Deepak Dhama, Kuldeep Diah, Muhammad Emran, Talha B. Fadhlan Ardhuha Fahriani, Marhami Fathima, Raisha Fauzi Yusuf, Fauzi Firzan Nainu Fredo Tamara, Fredo Ichsan Ichsan Ikram Ikram Ikram, Aamer Iqbal Muhammad Iqbal, Qanita Iqhrammullah, Muhammad Jayawarsa, A.A. Ketut Jonny K. Fajar Kamil, Qatrunnada Khader, Yousef Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Kurnia F. Jamil Kurnia Fitri Jamil Latief, Kamaluddin Lemu, Yohannes K. Maelani, Imelda Maimun Syukri, Maimun Mamada, Sukamto S. Maulana, Teuku Mellinia, Sania A. Memish, Ziad A. Mohammad B. Hossain Mohd. Andalas Mudatsir Mudatsir Mutiara, Suci Nalapraya, Widhy Y. Nanda, Cut M. Nirwana, Aura Nurjannah Nurjannah Prabowo, Nurhasan A. Putranto, Wachid Putri, Widia Rademaker, Marius Ramadhana, Ika F. Rudi Kurniawan Sallam, Dina E. Sallam, Malik Samsul Anwar Saputra, Irwan Sarifuddin Sarifuddin Sharun, Khan Smith, Lee Sofyan, Sarwo E. Syahraini, Aigia Syarifah Feramuhawan Torres-Roman, J. Smith Vento, Sandro Wagner, Abram Wagner, Abram L. Wendt, Guilherme W. Wira Winardi, Wira Wiwik Handayani Yesi Astri Yossadania, Asyriva Yufika, Amanda Yundari, Yundari Zinatul Hayati