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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Manajemen Bisnis Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Majalah Obat Tradisional STRATEGIC INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik YUME : Journal of Management Majalah Kesehatan Pharmamedika Jurnal Minfo Polgan (JMP) Indonesian Journal of Digital Business Jurnal Ilmiah Manajemen dan Bisnis (JIMBI) Journal of Artificial Intelligence and Digital Business Journal of Information Systems Management and Digital Business Journal of Management and Innovation Entrepreneurship (JMIE) Jurnal Kefarmasian Indonesia Indonesian Journal of Pharmacology and Therapy
Adam Hermawan
Departemen Kimia Farmasi, Fakultas Farmasi, Universitas Gadjah Mada, Sekip Utara II, Yogyakarta 55281, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Pengaruh Nilai Fungsional, Nilai Emosional, Dan Nilai Sosial Terhadap Niat Beli Barang Virtual Dalam Game Mobile Legends (Studi Kasus Pada Pemain Game Online Mobile Legends Di Jawa Barat Tamara, Agra Fadhilla; Hermawan, Adam; Purwaamijaya, Btari Mariska
Jurnal Minfo Polgan Vol. 13 No. 2 (2024): Artikel Penelitian
Publisher : Politeknik Ganesha Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33395/jmp.v13i2.14384

Abstract

Penelitian ini bertujuan untuk menganalisis pengaruh nilai fungsional, emosional, dan sosial terhadap niat beli barang virtual dalam game Mobile Legends. Game ini populer di kalangan pengguna smartphone dengan sistem mikrotransaksi yang memungkinkan pembelian barang virtual seperti skin dan item eksklusif. Topik ini menarik karena meskipun mikrotransaksi terus meningkat, terdapat keluhan pemain terkait kualitas produk yang menimbulkan penurunan niat beli. Penelitian ini dilatarbelakangi oleh fenomena penurunan pendapatan Mobile Legends sejak 2022, dengan fokus utama pada pengaruh nilai-nilai barang virtual terhadap keputusan pembelian. Data dikumpulkan dari 160 pemain Mobile Legends di Jawa Barat menggunakan kuesioner tertutup berbasis skala Likert dan dianalisis dengan regresi linier berganda. Hasil penelitian menunjukkan bahwa nilai fungsional dan emosional memiliki pengaruh signifikan terhadap niat beli barang virtual, sementara nilai sosial tidak memiliki pengaruh yang signifikan. Kesimpulannya, nilai fungsional dan emosional menjadi faktor penting yang perlu diperhatikan oleh pengembang game untuk meningkatkan niat beli. Implikasi praktisnya adalah pengembang disarankan untuk mengoptimalkan fitur barang virtual yang memberikan manfaat nyata serta menciptakan pengalaman emosional yang kuat bagi pemain melalui desain visual dan cerita yang menarik.
Strategi Pemasaran Untuk Meningkatkan Occupancy Kamar Hotel Melalui Online Travel Agent Di Indies Hotel Bandung Khairunnisa, Najla; Hermawan, Adam; Guntara, Rangga Gelar
Jurnal Minfo Polgan Vol. 13 No. 2 (2024): Artikel Penelitian
Publisher : Politeknik Ganesha Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33395/jmp.v13i2.14511

Abstract

Industri perhotelan di Indonesia menghadapi tantangan persaingan yang semakin ketat, terutama dengan munculnya teknologi digital dan platform Online Travel Agent (OTA). Penelitian ini bertujuan untuk menganalisis efektivitas strategi pemasaran melalui OTA dalam meningkatkan tingkat hunian (occupancy) kamar di Indies Hotel Bandung. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan studi kasus pada Indies Hotel Bandung, mencakup wawancara mendalam, observasi, dan analisis data sekunder. Hasil penelitian menunjukkan bahwa Traveloka menjadi mitra OTA paling dominan dengan kontribusi penjualan kamar tertinggi dibandingkan platform lainnya, seperti Tiket.com dan Agoda. Strategi pemasaran digital melalui OTA meningkatkan visibilitas hotel, mempermudah proses pemesanan, dan memberikan dampak positif terhadap tingkat okupansi kamar. Namun, terdapat tantangan seperti pengelolaan ulasan negatif pelanggan yang mempengaruhi peringkat hotel di platform OTA. Penelitian ini menyimpulkan bahwa pemanfaatan OTA secara strategis efektif dalam meningkatkan okupansi kamar hotel, dengan syarat didukung oleh pengelolaan hubungan pelanggan yang baik dan optimalisasi platform digital. Hasil penelitian ini diharapkan dapat memberikan kontribusi praktis bagi manajemen hotel dalam meningkatkan strategi pemasaran digital mereka.
Fingerroot (Boesenbergia pandurata) Extract Inhibits Proliferation and Migration of 4T1 Metastatic Breast Cancer Cells Nurrachma, Marsya Yonna; Maran, Gergorius Gena; Putri, Nindya Budiana; Esti, Yuni Fajar; Hermawan, Adam; Meiyanto, Edy; Jenie, Riris Istighfari
Indonesian Journal of Cancer Chemoprevention Vol 11, No 3 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss3pp103-114

Abstract

Fingerroot (Boesenbergia pandurata) is an Indonesian herb, with anti-proliferation and anti-migratory effects against several cancer cells. This study aims to investigate the anticancer property of Fingerroot Extract (FE) in combination with doxorubicin (Dox) against 4T1, a metastatic breast cancer cell lines. FE was prepared by 96% ethanol maceration and characterized by thin-layer chromatography analysis. FE was subjected to a cytotoxicity test with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay alone or in combination with 10 nM Dox against 4T1 cells. Cytotoxic effect was then confirmed by measure reactive oxygen species (ROS) intracellular level using 2’,7’-dichloroflourescin diacetate (DCFDA)-staining flow cytometry-based assay. The anti-migratory effect was observed using scratch wound healing assay and gelatin zymography to investigate matrix metalloproteinase (MMP)-9 expression. FE showed a cytotoxic effect with an inhibitory concentration 50 (IC50) value of 25.5±3.9 μg/mL and performed an improved effect in combination with 10 nM Dox. A single treatment of FE decreased ROS intracellular level, while in combination with Dox, FE increased the ROS intracellular level. Further, at 42 h observation, FE and its combination with Dox inhibited the migration of 4T1 cells with % closure of 82.6 and 82.5, respectively, correlates with a significant decrease of MMP-9 expression. Overall, FE performs a cytotoxic activity and anti-migration activity on 4T1 breast cancer cells.Keywords: Boesenbergia pandurata, cytotoxic, ROS, anti-migration, 4T1 
The Doxorubicin-Induced G2/M Arrest in Breast Cancer Cells Modulated by Natural Compounds Naringenin and Hesperidin Junedi, Sendy; Hermawan, Adam; Fitriasari, Aditya; Setiawati, Agustina; Susidarti, Ratna Asmah; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 12, No 2 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss2pp83-89

Abstract

Doxorubicin as the common drug for breast cancer has been widely proposed to use in combine with a natural compound in order to overcome its side effects such as cardiotoxicity and resistance. Previously, we reported that naringenin and hesperidin, the abundant flavanons in citrus fruit peel, increased cytotoxic and apoptosis activities of doxorubicin in doxorubicin resistant breast cancer cells (T47D and MCF-7 cells). Since doxorubicin arrests G2/M phase in most cancer cells, both flavanons are speculated to affect the similar phase in breast cancer cells. Cell cycle distributions were determined by flowcytometry using propidium iodide (PI) to stain DNA of the cells. Combination of naringenin or hesperidin with doxorubicin increased accumulation of T47D cells in G2/M phase, while in MCF-7 cells, accumulated cells in G2/M phase were decreased, accompanying with slightly increased in G1 phase. Naringenin itself had no effect on cell cycle of both cells. Whereas, hesperidin arrested G2/M and G1 phases in T47D and MCF-7 cells, respectively. The different effect of naringenin and hesperidin in T47D and MCF-7 cells is most likely caused by difference of p53 status. In p53 mutant, T47D cells, naringenin and hesperidin supported mechanism of doxorubicin to arrest at G2/M that to be considered via p53-independent pathway. Whereas, in p53 wild-type MCF-7 cells, naringenin and hesperidin decreased G2/M arrest, suggesting that both flavanons do not utilize cell cycle arrest for their anticancer activity with doxorucibin. This study revealed that potential co-chemoterapeutic agents, naringenin and hesperidin distinctly modulated cell cycle arrest induced by doxorubicin according to the characteristic of breast cancer cells.Keywords: naringenin, hesperidin, doxorubicin, cell cycle, breast cancer cells.
Chemopreventive Properties Curcuma heyneana Rhizome Ethanolic Extract on Hepatocellular Carcinoma Cells, JHH-4 Santoso, Christopher Filando; Rahmawati, Desty Restia; Nugraheni, Nadzifa; Adisusilo, Midori Rahmadhany Putri; Maharani, Dini; Hermawan, Adam; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 15, No 1 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss1pp40-49

Abstract

Hepatocellular carcinoma is the most common type of liver cancer. Curcuminoids are natural polyphenol compounds abundant in Curcuma heyneana ethanolic extract (CHE) and are known to inhibit breast and cervical cancer cell proliferation. Based on previous research, curcuminoid compounds have been studied to inhibit the growth of the liver cancer cell model, HepG2. This study aims to examine the potential of CHE as a chemopreventive agent in liver cancer using JHH-4 cell as a model. CHE was obtained by maceration method using ethanol which was then identified for its phytochemical profile using thin layer chromatography (TLC). Then TLC results were quantified to calculate the levels of compounds present in the CHE based on spot intensity with ImageJ software. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) antioxidant assay was conducted to determine the radical scavenging activity of CHE. Cytotoxic activity of CHE on JHH-4 liver cancer cells was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Extraction produces a yield of 10.2 %w/w. CHE contains 4.52 %w/w curcuminoid compound consisting of 0.49 %w/w curcumin, 3.21 %w/w demethoxycurcumin, and 0.82% w/w bisdemethoxycurcumin. CHE exhibited antioxidant activity with an IC50 value of 378.96 μg/mL, meanwhile ascorbic acid as a positive control has an IC50 value of 8.49 μg/mL. Cytotoxic activity of CHE on JHH-4 cells is characterized by an IC50 value of 16.62 μg/mL which is classified as having strong cytotoxic activity. This study concluded that CHE has the potential to be developed as a chemopreventive agent in liver cancer.Keywords: liver cancer, hepatocelullar carcinoma, Chemopreventive, antioxidant,Curcuma heyneana.
Pentagamaboronon-0-Sorbitol Induces Apoptosis through Elevation of Reactive Oxygen Species in Triple Negative Breast Cancer Cells Ramadani, Ratna Dwi; Utomo, Rohmad Yudi; Hermawan, Adam; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 12, No 1 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss1pp46-56

Abstract

Breast cancer is the most common type of cancer causing mortality for women due to metastasis. More than 50% of breast cancer patients are suffered lung metastases. One strategy to target the cancerous cell is Boron Neutron Captured Therapy (BNCT) which showed high affinity toward cancer cells and reported to have anti-proliferative as well as anti-metastatic activities. Pentagamaboronon-0 (PGB-0) is a curcumin analogue substance which had reported to exert anticancer activities against Her-2 expressing as well as triple negative breast cancer cells. Despite its great potency as BNCT agent candidate, this compound also exerted several anticancer properties. Complex formation of this substance with sorbitol was achieved to improve the solubility and maximize compound’s delivery to the target cells. This study aimed to investigate the ability of Pentagamaboronon-0-Sorbitol (PGB-0-So) to modulate cell cycle and induce apoptosis especially through the mechanisms of reactive oxygen species (ROS) modulation. The 3-(4,5-dimethylthiazzol-2yl)-2,5-diphenyltetrazolium (MTT) cytotoxicity assay of PGB-0-So against 4T1 breast cancer cell line were found to exert potential effect in dose-dependent manner with lethal concentration (IC50) values of 39 μM. The cytotoxicity of PGB-0-So complex was found to be increased considerably compared with that of PGB-0. Cell cycle modulation identified using propidium iodide (PI) staining showed cell accumulation in S phase following treatment with PGB-0-So. Apoptosis induction assay analyzed using flowcytometer with Annexin V and PI staining on its IC50 dose was found to induce programmed cell death (apoptosis). The sub-IC50 treatment of this compound was also improved the cellular ROS level which also took role in apoptosis induction. These findings suggest that PGB-0-So is potential as an anticancer agent.Keywords: Curcumin analogue, PGB-0-So, Anticancer, 4T1 cell line, ROS modulation.
Analog Curcumin, Pentagamavunon-0 (PGV-0), Induces Senescence and Increases Cytotoxic Effect of Doxorubicin on HCC 1954 Cells Angraini, Sonia Meta; Nugraheni, Nadzifa; Meiyanto, Edy; Hermawan, Adam
Indonesian Journal of Cancer Chemoprevention Vol 10, No 3 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss3pp114-121

Abstract

Senescence defined as an irreversible cell cycle arrest. Senescence can inhibit cancer growth and suppress the progression of cancer. Some anticancer compounds are known to have the potential to induce senescence. Senescence defence against tumor development by preventing proliferation of cells with DNA damage. The study aimed to determine the cytotoxic effects and senescence induction of Pentagamavunon-0 (PGV-0) on Human Epidermal Growth Factor Receptor 2-positive (HER2-positive) breast cancer cells, HCC 1954. Cytotoxic tests carried out with 3- (4.5-dimethylthiazzol-2yl) -2.5-tidiphenyltetrazolium (MTT) assay showed that PGV-0 exhibited a strong cytotoxic effect with a the half maximal inhibitory concentration (IC50) value of 39 μM. Treatment with IC50 in sub-doses combined with doxorubicin showed cytotoxic enhancement effects. The senescence assay using SA-β-Galactosidase showed that the PGV-0 in a single treatment was able to induce senescence with a percentage of cell senescent of 15%. The combination treatment of PGV-0 at the half dose of IC50 with doxorubicin 100 nM was able to induce senescence with the percentage of senescent cells of 25%. Moreover, PGV-0 also increased intracellular reactive oxygen species (ROS). The results of this study indicate that PGV-0 exhibits cytotoxic effect, increases cytotoxic effect of doxorubicin and induces senescence that may correlate to the increasing of intracellular ROS in 1954 HCC cells.Keywords: Pentagamavunon (PGV-0), HCC 1954, Cytotoxic, Senescence
The role of angiotensin I - converting enzyme (ACE) insertion/deletion gene polymorphism in hypertension and ACE inhibitor therapy: a narrative review Handani, Dewa Ayu Sri; Zullies Ikawati; Hermawan, Adam
Indonesian Journal of Pharmacology and Therapy Vol 4 No 3 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.8281

Abstract

Primary hypertension is the most prevalent type of hypertension, which is primarily attributed to genetic factors. The angiotensin-converting enzyme (ACE) gene has emerged as a prominent candidate among the genetic factors influencing blood pressure regulation. The ACE gene encodes the ACE, which plays a crucial role in the renin-angiotensin system. The ACE gene insertion/deletion (I/D) polymorphism is a variation of the ACE gene that affects blood pressure regulation. Individuals with II, ID, and DD genotypes may exhibit distinct ACE plasma concentrations, potentially contributing to variations in blood pressure levels and response to ACE inhibitor therapy. This article aimed to provide a comprehensive overview of the relationship between the ACE I/D gene with hypertension and angiotensin-converting enzym inhibitor (ACEI) effectiveness. This article presents a narrative review encompassing relevant studies published between 2013 and 2023. A systematic search was conducted using reputable databases such as PubMed, Science Direct, and Scopus. Inclusion criteria were applied, resulting in the selection of 25 articles that met the predefined criteria. The analysis included 25 studies, comprising 5 articles that investigated the impact of ACEI therapy and 20 articles that examined the ACE I/D gene polymorphism in hypertensive populations without ACEI therapy. It can be concluded that compared to the I allele, the D allele of the ACE I/D gene is associated with a higher level of essential hypertension and a reduced ACEI response.
Co-Authors . Anindyajati . Larasati Adisusilo, Midori Rahmadhany Putri Aditya Fitriasari Aditya Fitriasari Agusta Fauzi, Ilham Agustina Setiawati Al-Qorin, Fadillah Amaliyatul, Mita Ameilinda Monikawati Andita Pra Darma Angraini, Sonia Meta Anindyajati Anindyajati Anindyajati Anindyajati Arya Nugraha, Reyhan Asep Nuryadin Astrid Ayu Maruti Astrid Ayu Maruti Azmi Rahmadani Bambang Sulistiyo Ari Sudarmanto Bani Adlina Shabrina Cyndwika Ayu Dewi Pratiwi Dewi Pratiwi Dhania Novitasari Dini Maharani Dyaningtyas D. P. Putri Dyaningtyas D.P. Putri Dyaningtyas Dewi Putri Pamungkas Ediati Sasmito Ediati Sasmito Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Erlina Rivanti Esti, Yuni Fajar Fauziyah Darwis, Rattu Syahada Fazri, Rezi Muhammad Fikri Amalia Guntara, Rangga Gelar Handani, Dewa Ayu Sri Heny Hendrayati Herwandhani Putri Ibrahim Arifin Ika Nurzijah Ikawati, Muthi' Ilham Agusta Fauzi Ilham Augusta F Ilham Augusta F. Indah Hairunisa Indri Kusharyanti Inna Armandari Jenie, Riris Istighfari Juni Ekowati Kartika Dyah Palupi Kartika Dyah Palupi Khairunnisa, Najla Laeli Muntafiah Lailatul Qodria Lailatul Qodria Larasati Larasati Luthfia Indriyani Luthfia Indriyani Maesaroh, Syti Sarah Maran, Gergorius Gena Marcellino Rudyanto Maulid, Zaki Nuraziz Meiyanto, Edy Mokh Adib Sultan, Mokh Adib Muhammad Novrizal Abdi Sahid Musyaffa, Fakhrizal Labib Muthi Ikawati Nanda Resa Pratama Nanda Resa Pratama Naufa Hanif Niken Nur W Niken Nur W, Niken Novi Hastuti Novi Hastuti, Novi Nugraha, Muhammad Rizki Nugraheni, Nadzifa Nur Fitra Sari Nurhaliza, Jelita Nurma Sabila Nurrachma, Marsya Yonna Perdana Adhi Nugroho Pratama, Dimo Purwaamijaya, Btari Mariska Putri, Nindya Budiana Rahmawati, Desty Restia Rahmi Khamsita Rahmi Khamsita Ramadani, Ratna Dwi Ratih Hurriyati Ratna Asmah Susidarti Ratna Asmah Susidarti Ratna Dwi Ramadani Retno Murwanti Ridlo, Muhammad Dzikri Ar Riris Istighfari Jenie Riris Istighfari Jenie Riris Istighfari Jenie Rita Riata Rita Riata Ritmaleni, Ritmaleni Rohmad Yudi Utomo Rosana Anna Ashari, Rosana Anna Rumiyati Rumiyati Sahid, Muhammad Novrizal Abdi Santoso, Christopher Filando Sari Haryanti Sari Haryanti Sarmoko Sarmoko Sendy Junedi Shigeru Sasaki Shigeru Sasaki Sofa Farida Sofa Farida Sukardiman Susi Ari Kristina Susi Ari Kristina Susi Ari Kristina Susi Ari Kristina Tamara, Agra Fadhilla Tutuk Budiati Yanti, Septi Dwi Yullia Febrianti, Sheilla Yurista Gilang Yurista Gilang Zahra, Nasywa