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All Journal Health Science Journal of Indonesia The Indonesian Biomedical Journal Jurnal Sinaps Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Majalah Kedokteran Neurosains The Indonesian Journal of Community and Occupational Medicine Jurnal Locus Penelitian dan Pengabdian Jurnal Penyakit Dalam Indonesia Journal of General Procedural Dermatology and Venereology Indonesia Occupational and Environmental Medicine Journal of Indonesia
Herqutanto -
Department Of Community Medicine, Faculty Of Medicine, Universitas Indonesia
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Total and Intratumoral CD8+ T Cell Expressions are Correlated with Miller Payne Grading and WHO Clinical Response of Neoadjuvant Chemotherapy Sonar Soni Panigoro; Sinta Chaira Maulanisa; Ahmad Kurnia; Denni Joko Purwanto; Primariadewi Rustamadji; Herqutanto Herqutanto; Ferry Sandra
The Indonesian Biomedical Journal Vol 15, No 2 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i2.2110

Abstract

BACKGROUND: Chemotherapy has reported to stimulate immune system through direct activation of cluster of differentiation (CD)8+ T cells. Neoadjuvant chemotherapy (NAC) is known to improve the clinical response of locally advanced breast cancer (LABC) patients. However, the immune response-related factor evaluation of NAC in LABC patients has not been routinely performed. Therefore, current study was conducted to evaluate the correlation of NAC-induced CD8+ T cell with chemotherapy response based on Miller Payne grading and World Health Organization (WHO) criteria.METHODS: LABC patients were recruited and data regarding age, gender, tumor, nodal stages, histopathological grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki67 were obtained. Biopsy and mastectomy tissues were collected and processed for hematoxylin-eosin and CD8 immunohistochemical staining. CD8+ T cell expression in peritumoral and intratumoral areas were documented and measured. Clinical responses based on Miller Payne grading and WHO were analyzed and correlated with CD8+ T cell expression.RESULTS: There were more subjects with high expression of total (80%), intratumoral (82.5%) and peritumoral (65%) CD8+ T cell expressions. The total (p=0.013) and intratumoral (p=0.015) CD8+ T cell expression, but not peritumoral CD8+ T cell expression, were significantly correlated with Miller Payne Grading. The total (p=0.009) and intratumoral (p=0.001) CD8+ T cell expressions were also significantly correlated with WHO clinical response.CONCLUSION: Total and intratumoral CD8+ T cell expressions are correlated with Miller Payne grading and WHO clinical response of NAC. Therefore, total and intratumoral CD8+ T cell expressions could be suggested as a predictive marker for clinical response of NAC.KEYWORDS: breast cancer, neoadjuvant chemotherapy, CD8, clinical response, Miller Payne, intratumoral, peritumoral 
Amino Acid Profile of Luminal A and B Subtypes Breast Cancer Sonar Soni Panigoro; Arif Kurniawan; Ramadhan Ramadhan; Ninik Sukartini; Herqutanto Herqutanto; Rafika Indah Paramita; Ferry Sandra
The Indonesian Biomedical Journal Vol 15, No 3 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i3.2109

Abstract

BACKGROUND: Amino acids are important for proliferation and maintenance of tumor cells. Breast cancer patients were found to have significant changes in the number of amino acids, which are assumed to be correlated with the molecular subtypes of breast cancer. Therefore, current study was conducted to analyze plasma amino acids in breast cancer patients with luminal A and B subtypes.METHODS: Breast cancer and control subjects were recruited, and venous blood was collected for the measurement of plasma amino acids. Total 19 plasma amino acids were measured using reverse-phase high-performance liquid chromatography with C18 column. Mean comparison for normally distributed and homogeneous data was further analzyed using independent sample T-test, with p<0.05 was considered as significant.RESULTS: From total 19 amino acids, only 7 amino acids; cysteine, glutamic acid, histidine, ornithine, threonine, tyrosine, valine, were statistically different between the healthy control and breast cancer subjects. Eventhough no amino acids was found to be statistically different between breast cancer subjects with luminal A and B subtypes, but some amino acids were found to be significantly different when correlated to various breast cancer risk factors.CONCLUSION: Amino acid profile of patients with Luminal A and B subtypes of breast cancer differs compared to healthy controls and is also correlated with breast cancer risk factors. Increase in cysteine level in Luminal A subtype patients and decrease of alanine and leucine in Luminal B subtype patients can be used as a biomarker.KEYWORDS: amino acid, plasma, breast cancer, risk factor, biomarker
Validity and reliability of the Indonesian version of Expanded Nursing Stress Scale (ENSS) as a job-stress assessment tool for nurses Harsono, Hasto; Herqutanto, Herqutanto; Wibowo, Suryo; Kekalih, Aria; Sulistomo, Astrid
Occupational and Environmental Medicine Journal of Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

ABSTRACT Background: Job stress is a serious health problem in the 21st century because of its high incidence and impact. Nurses are known as a profession that has high risks of stress, has distinctive characteristics, and hence requires a work stress assessment instrument that suits its peculiarities. The Expanded Nursing Stress Scale (ENSS) is a nurse-specific stress assessment instrument that has high validity and reliability (Cronbach's alpha = 0.96) and is widely used in many countries but is not yet available in Indonesian. This study aims to obtain the Indonesian version of ENSS and evaluate its reliability and validity. Method: We applied the 10 steps of ISPOR's (International Society for Pharmacoeconomics and Outcomes Research) transcultural adaptation method, followed by validity and reliability tests on 104 nurses at a private hospital in Jakarta. Result: The Indonesian version of the ENSS questionnaire, consisting of 57 items, was obtained. All of the items were valid, with r values ranging from 0.362 to 0.793. Cronbach's alpha was 0.956, and the reliability test value using test-retest was 0.939. Conclusion: The Indonesian version of the ENSS has proven to be valid and reliable and has excellent internal consistency. The instrument can be used to assess job stress among Indonesian nurses. Keywords: ENSS; Indonesian; work stress; nurse
The Effectiveness of Education through Web-Based Seminar in Increasing Knowledge about the Early Detection and Reporting of Occupational Diseases Monintja, Keyne Christa; Soemarko, Dewi Sumaryani; Fitriani, Dewi Yunia; Herqutanto, Herqutanto; Wibowo, Suryo
Occupational and Environmental Medicine Journal of Indonesia Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: In 2022, the Indonesian Occupational Medicine Association (IOMA) collaborated with oil and gas companies and conducted a web-based seminar (webinar) to enable participants to recognize occupational disease earlier and enhance reporting in companies. We aimed to investigate the effectiveness of the webinar in increasing the intended knowledge. Method: The webinar was separated into three batches, with different participants per batch. Using a one-group pretest-posttest design, we utilized secondary data from IOMA. The effectiveness of the webinar was determined by participants' satisfaction and knowledge as measured by pre-test and post-test. After performing item analysis, we removed poor discriminating items in pre-test and post-test ( Results: Data was gathered from 147 subjects (23.8%, 34%, and 42.2% of the three batches, respectively). Except for company status in the second batch (P = 0.045), there was no significant difference in initial knowledge based on the individual factors studied. Significant knowledge improvement was observed post-webinar in each batch compared to the initial. (P < 0.05). The correlation between satisfaction and post-test scores was negligible (r < 0.3; P > 0.05). Conclusion: The initial knowledge of oil and gas company workers in early detection and reporting of OD was low (
Item generation in the development of a questionnaire for predicting multidrug therapy compliance in leprosy Siskawati, Yulia; Asih, Sali Rahadi; Kekalih, Aria; Menaldi, Sri Linuwih; Herqutanto, Herqutanto; Bramono, Kusmarinah
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 7, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Lengthy therapeutic regimens in leprosy are prone to defaults, contributing to more antibiotic-resistant Mycobacterium. Intervening patients’ medical habits midway would be more complicated than understanding their perception of undergoing such regimens in advance. We study the factors considered relevant to leprosy patients’ compliance to construct a novel self-reporting questionnaire that can predict the patients’ adherence before initiating multidrug therapy. Methods: According to the Delphi methods, we conducted three rounds of interviews with twenty-three respondents from various backgrounds, including dermatologists, government officials, healthcare workers, and patients with leprosy, to infer the associated factors of the included items. Each item was scored using the Likert scale, and accepted items (scores above 75%) were classified into six-dimensional categories based on the health belief model theory. Result: The initial 236 items were simplified to 72 items. Then, a panel discussion was conducted to score each item. Finally, 48 items were accepted and categorized into 12 indicators from 6 dimensions. The 12 indicators encompass knowledge about leprosy, its severity, therapeutical options, stigma, challenges in the treatment maintenance, availability of medical facilities and workers, therapeutic impact, drug regulation, health personnel, personal beliefs, attitude, and motivation. (p Conclusion: The study identified 12 critical factors influencing adherence to leprosy treatment, contributing to the prevention of antibiotic-resistant mycobacterium and providing valuable insights through the predictive self-reporting questionnaire.
Gejala Neuropsikiatri Pasien HIV Setelah Menjalani Transisi Antiretrovirus Nevirapin ke Dolutegravir di Rumah Sakit Cipto Mangunkusumo, Jakarta Pratama, Metra Adi; Putranto, Rudi; Herqutanto, Herqutanto; Syahrani, Aisyah; Hapsari, Aljira Fitya; Natali, Veritea; Pane, Meivina Ramadhani; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 12, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Dolutegravir (DTG) is one of the effective antiretroviral therapies (ART) for suppressing HIV replication and has a favorable safety profile. However, reports regarding neuropsychiatric side effects, especially in patients transitioning from a nevirapine (NVP) regimen to dolutegravir, have started to emerge. This study aimed to describe the changes in neuropsychiatric symptoms before and after the transition from a NVP-based ARV regimen to DTG in HIV patients at Cipto Mangunkusumo Hospital (RSCM), Jakarta. Methods. This study employed a prospective cohort design involving 292 HIV patients at Cipto Mangunkusumo Hospital who were transitioning from NVP to DTG regimen. Participants were monitored for six months, and neuropsychiatric symptoms were assessed using a modified HIV symptom index (mHSI). Data collection was conducted at the beginning of the transition (baseline) and during follow-up through interviews regarding HIV-related symptoms and ART. Results. At the start of the study, 70.2% of participants reported at least one neuropsychiatric symptom, which increased to 80.1% after 6 months of transitioning to TLD. The most commonly reported symptoms were insomnia, headaches, and anxiety, with women reporting more symptoms than men. Statistical analysis showed a significant increase in symptoms of sadness, headaches, and irritability (p < 0.01) after the transition to dtg. Conclusions. Although DTG shows good viral suppression capabilities, significant neuropsychiatric side effects still arose, especially in patients with a history of mental disorders. Close monitoring of neuropsychiatric symptoms and adjustments to the ART regimen need to be carried out to improve the quality of life for HIV patients undergoing DTG therapy.
Comparison of ABI, TBI, TOE Pressure, and Ankle Pressure Examinations in PAD Patients, Before and After Angioplasty with and without Type 2 DM at RSCM Rizki, Mohammad Nazril; Suhartono, Raden; Herqutanto , Herqutanto
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 8 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i8.4753

Abstract

Diabetes Mellitus (DM) exacerbates peripheral artery disease (PAD) and can affect the diagnostic accuracy of the ankle-brachial index (ABI) due to arterial calcification. Alternative examinations such as toe-brachial index (TBI), toe pressure (TP), and ankle pressure (AP) require evaluation to compare their effectiveness post-angioplasty in PAD patients with and without DM. This study aims to compare the changes in the values of these four parameters before and after angioplasty in both groups of patients. Method. This retrospective cohort study involved 78 PAD patients (39 with DM, 39 without DM) at Cipto Mangunkusumo Hospital. Hemodynamic parameters (ABI, TBI, AP, TP) were measured 24 hours before and after angioplasty. Bivariate analysis and linear regression are used to assess changes and their predictive factors. Post-angioplasty, all parameters showed significant improvement in both groups. However, the delta differences between groups were only significant in ABI and AP, not in TBI and TP. Preangioplasty parameter values were the main predictors of the magnitude of post-operative changes (p<0.001), while age had only a significant effect on delta TBI and TP. Conclusion. Angioplasty significantly improved ABI, TBI, TP, and AP values in PAD patients with and without type 2 DM. There was a significant difference between the delta parameters of ABI and AP in both groups after angioplasty. The value of the clinical parameters of preangioplasty had an effect on the delta value of each parameter, while age only affected the change in TBI and TP. The finding that TBI and TP did not show  significant delta differences  between the DM and non-DM groups implied that these two parameters were more robust and less affected by the condition of diabetes, making them worthy of consideration as a more reliable assessment tool, particularly in diabetic populations at risk of arterial calcification.
The Relationship Between Workplace Bullying and Job Stress in Female Blue Collar Workers in Indonesia Anitasari Kusumawati; Endang Parahyanti; Aria Kekalih; Herqutanto; Dewi Sumaryani Soemarko
The Indonesian Journal of Community and Occupational Medicine Vol. 4 No. 1 (2024): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v4i1.132.10-16

Abstract

Introduction: Among the many risk factors for stress in the workplace, bullying is a factor that is rarely discussed. As many as 19% of people in America experience bullying at work, followed by other European countries. Bullying is a strong link to worker stress, especially in blue-collar workers. Gender differences, especially in women, also have an important prevalence in workplace bullying. In Indonesia itself, there is no data regarding bullying in the workplace, especially among women and blue-collar workers. Objective: This study aims to find the relationship between bullying and stress in the workplace among female blue-collar workers. Method: This research is a cross-sectional analytical study using a negative act questionnaire-revised (NAQ-R) questionnaire on work stress in female blue collar workers in garment factories, in Bekasi city, Indonesia. Job stress assessment uses the Perceived Stress Scale-10 (PSS-10) questionnaire. Other variables assessed are age, salary, marital status, and subjective questions related to workload and work communication. Results: A total of 379 female blue collar workers in garment factories, in the city of Bekasi, Indonesia took part in this research. Workplace bullying is associated with job stress in female blue-collar workers. Workers who are often bullied tend to have medium-high levels of work stress. Bullying is the type of bullying with the highest scale. Conclusion: Workplace bullying is the factor that has the most influence on work stress in female blue-collar workers. Then, high workloads, poor communication, and lower salaries are related to bullying and stress in the workplace.
Analysis of The Relationship Between Manual Handling and Individual Factors with De Quervain Syndrome In Workers of Heavy Equipment Manufacturing Company PT. K Finna Fitriana; Dewi Sumaryani Soemarko; Nuri Purwito Adi; Herqutanto -; Pukovisa Prawiroharjo
The Indonesian Journal of Community and Occupational Medicine Vol. 4 No. 2 (2024): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v4i2.137.45-51

Abstract

Introduction: According to the European Occupational Disease Statistics in 2016, as much as 38.1% of Occupational Diseases are Musculoskeletal Disorders. Research in 2013 on the electrical assembly industry in Thailand showed that the most common cause of upper extremity MDS is De Quervain syndrome (DQS) with a prevalence of 13.03%. Previous studies showed that occupational factors are very important as risk factors for DQS, in addition to individual factors. Caused by excessive use of the muscles around the fingers to the wrist, sustained repetitive movements, forceful manual exertion and prolonged static position. In manufacturing industry, the production process need to use tools, machines, and still requires workers for manual work activities and work processes that cannot be replaced by machines. Because manual handling is one of the occupational risk factors for DQS, it is necessary to study DQS in manufacturing industry. This study aims to determine the prevalence of DQS, identify, and analyze the relationship between manual handling and individual factors related to DQS.Method: This research method is a cross sectional using secondary data of PT K employees’ Medical Check-Up (MCU) in 2021. The samples used was all employee’s MCU data with total of 1244 samples. Independent variables include manual handling work factors and individual factors, include age, gender, and years of service. The dependent variable is the De Quervain Syndrome. The DQS was diagnosed with Finkelstein test.Results: A total of 1244 respondents were obtained, with the DQS prevalence 9%. In the analysis of the relationship between manual handling work factor and individual factors (age, sex, and years of service) showed that no significant relationship with suspected DQS in PT K workers. Whereas the multivariate analysis showed that there were no factors that most dominantly influenced DQS, with p>0.05. Conclusion: There is no significant relationship between manual handling work factor and individual factors on suspected DQS.
N-ACETYL-S-(N-METHYLCARBAMOYL)-CYSTEINE (AMCC) as Cumulative Biomonitoring of Dimethylformamide Exposure among Industrial Workers Arifianto, Angga; Ilyas, Muhammad; ., Herqutanto
Occupational and Environmental Medicine Journal of Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: N,N-Dimethylformamide (DMF) is an aliphatic amide which is miscible with water and a majority of organic liquids. Due to its amphiphilic properties, it is a widely used industrial solvent, especially for polymers. DMF has been consistently hepatotoxic, inducing effects on the liver at lowest concentrations or doses. N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC) which is one major metabolites of DMF, found in urine after DMF exposure of the whole workweek. Objective: To determine the way of AMCC can be use as biomarker of DMF exposure and the best possible sampling time. Method: This study conducted a literature search using evidence-based databases focusing on clinical questions using the “PICO” method. The author searched the relevant articles using the following databases: “PubMed”, “Scopus”, and “Embase”. The keywords used included “Dimethylformamide”, “Workes,” “AMCC” (MESH Term), “N-Acetyl-S-(N-Methylcarbamoyl)cysteine,” along with their synonyms combined with Boolean operators. Inclusion criteria comprised studies involving workers populations, cohort, cross sectional, systematic reviews/meta-analyses, written in English, and with full-text availability. Exclusion criteria included case report, RCT, and articles with incomplete data or inaccessible full text. Results: Based on the analysis of five reviewed literature, the author obtained insights into the effectiveness of AMCC use as biomarker of DMF exposure. It can be use after several workdays exposure of DMF (3-5 days). The best of time sampling is at morning or afternoon of last day on the workweek. AMCC result is described as cumulative DMF exposure of a whole week, and more relevant associated with the hepatotoxicity of DMF than the other DMF metabolite, N-methylformamide (NMF). Conclusion: AMCC can be considered as a cumulative exposure of DMF of a whole week and more relevant associated with DMF induced hepatotoxicity. Keywords: Dimethylformamide, Worker, AMCC
Co-Authors Agus Purwadianto Ahmad Fuady Albert Wijaya Ambar W. Roestam Anitasari Kusumawati Aria Kekalih Arif Kurniawan Arifianto, Angga Astrid B. Sulistomo Ayu Munawaroh Boy Subirosa Sabarguna Budi Sampurna Denni Joko Purwanto Dewi Sumaryani Soemarko Dewi Yunia Fitriani Diantha Soemantri Elsa P. Setiawati Endang Parahyanti Evy Yunihastuti Ferdi Afian Ferry Sandra Finna Fitriana Hansen Angkasa Hapsari, Aljira Fitya Harsono, Hasto Hasto Harsono herlinah herlinah Hikmah Muktamiroh Hirzi Zulkarnain Imron Khazim Irwan Suhadi Junanta, Herlando Karolina Margareta Kurnia, Ahmad Kurniawan, Mohammad Kusmarinah Bramono Levina Chandra Khoe Malik, Khamelia Manaor F.L. Napitupulu Maulanisa, Sinta C. Meita Damayanti Monintja, Keyne Christa Muhammad Ilyas Natali, Veritea Ninik Sukartini Nuri Purwito Adi Nuri Purwito Adi Pane, Meivina Ramadhani Paramita, Rafika Indah Pramastuty, Ajeng Pratama, Metra Adi Primariadewi Rustamadji Pukovisa Prawiroharjo Ramadhan Ramadhan Retno A. Werdhani Retno Asti Werdhani Rizki, Mohammad Nazril Rudi Putranto Saleha Sungkar Sali Rahadi Asih Siskawati, Yulia Sonar Panigoro Sri L. Menaldi Suhartono, Raden Sulistomo, Astrid Syahrani, Aisyah Tanama, Fery Alfaro Tiara Anindhita Tiara Aninditha Titis Mariyamah Triana Agustin Victor Santawi Wibowo, Suryo William Jayadi Iskandar