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All Journal Pharmaciana: Jurnal Kefarmasian Current Biochemistry BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Indonesian Journal of Chemistry Jurnal Aplikasi Teknologi Pangan MATRIK : Jurnal Manajemen, Teknik Informatika, dan Rekayasa Komputer Chemistry Education Practice Jurnal Kolaboratif Sains Jurnal Pijar MIPA Jurnal Pengabdian Masyarakat Bhinneka Jurnal Ilmiah Pengabdian dan Inovasi BIOCITY: Journal of Pharmacy Bioscience and Clinical Community Asian Journal of Environmental Research
Eka Nurul Qomaliyah
Department Of Pharmacy, Bumigora University, Jl. Ismail Marzuki No.22, Mataram 83127, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Phytochemical Screening, Total Flavonoids and Antioxidants of Kalanchoe Pinnata Linn. Leaves Qomaliyah, Eka Nurul; Indriani, Nurul; Rohma, Atika; Islamiyati, Ricka
Current Biochemistry Vol. 10 No. 1 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.1.1

Abstract

Kalanchoe pinnata Linn. or in Indonesia known as cocor bebek, this plants grow well in temperate and tropical regions. Cocor bebek is used to treat several diseases including skin diseases, wound healing, kidney stones, gallstones, diabetes. The pharmacological activities of cocor bebek leaves have been reported as anti-inflammatory, anti-oxidant and anti-microbial. The objective of this study is to determine the metabolite content of cocor bebek leaves, total flavonoid levels and antioxidant activity. Observations of secondary metabolites of cocor bebek leaves were carried out through qualitative secondary metabolite screening, while total flavonoid levels were carried out quantitatively UV-VIS with quercetin as a comparison, atioksidan activity through DPPH molecular inhibition testing. The results of this study indicate that cocor bebek leaves contain alkaloids, flavonoids, saponins, triterpenoids, tannins and phenols. 200gr of cocor bebek leaves obtained % yield extract is 14.63%. The total favonoid content obtained was 8.77% of quercetin, while the antioxidant inhibition of DPPH molecules obtained IC50 of 97.42 ppm.
Optimasi Ekstrak Daun Pecut Kuda Menggunakan Simplex Centroid Design: Kajian Sitotoksisitas : Optimization of horse leaf extraction using simplex centroid desaign: cytotoxicity study Sri Winarni Sofya; Eka Nurul Qomaliyah; Aji Kresnapati, Bagus; I Made Kawi Widana; I Gusti Nyoman Hari Satwika
Jurnal Kolaboratif Sains Vol. 7 No. 3: MARET 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v7i3.4963

Abstract

Abstrak: Tanaman pecut kuda dapat mengurangi radang tenggorokan, amandel, batuk, pilek. Adapun potensi bioaktivitas tanaman pecut kuda diantaranya sebagai antioksidan, antibakteri, antiinflamasi. Senyawa kimia yang terdapat pada pecut kuda antara lain flavonoid, fenol, saponin, glikosida, tanin dan steroid. Senyawa tersebut memiliki karakteristik semipolar-polar sehingga untuk pemisahan senyawa menggunakan pelarut semipolar-polar. Metode pemisahan senyawa pada penelitian ini menggunakan metode maserasi. Pelarut yang digunakan berupa etanol,n-heksan dan etil asetat dan proses optimasi pelarut tersebut dapat dilakukan dengan salah satu teknik pada response surface mixture yaitu Simplex centroid design. Hasil optimasi dianalisis berdasarkan yield ekstraksi yang akan dilanjutkan dengan menentukan nilai konsentrasi bunuh minimum (LC50) sitotoksisitas yang diperoleh dari pengujian sitotoksisitas akut pada larva Artemia salina Leach setelah diberi perlakukan dan didiamkan selama 24 jam. Uji sitotoksisitas dilakukan pada ekstrak dengan nilai %yield ekstrak tertinggi yakni ekstrak etanol (kode EE). Nilai LC50 dari semua ekstrak menunjukan potensi toksik. LC50 yang diperoleh pada ekstrak etanol sebesar 343,094 g/mL. sehingga diperoleh informasi bahwa ekstrak etanol daun pecut kuda memiliki sitoksisitas aktif dan potensi bioaktivitas yang tinggi. Nilai LC50 < 1000 ?g/ml berbanding lurus dengan potensi antiproliferasi dan antibakteri begitupun juga dengan inhibisi enzimatis alpha-Glukosidase dan alpha-amilase dalam penelitian antidiabetes secara In Vitro, sehingga pengujian lanjutan terkait potensi ekstrak etanol daun pecut kuda sebagai antiproliferasi, antibakteri, uji inhibisi enzimatis alpha-Glukosidase dan alpha-amilase menjadi target penelitian lanjutan. Abstract: Horsewhip can reduce sore throats, tonsils, coughs and colds. The potential bioactivity of the horsewhip plant includes antioxidant, antibacterial and anti-inflammatory properties. Chemical compounds found in horse whip include flavonoids, phenols, saponins, glycosides, tannins and steroids. This compound has semipolar-polar characteristics so that the separation of the compound uses a semipolar-polar solvent. The method for separating compounds in this research uses the maceration method. The solvents used are ethanol, n-hexane and ethyl acetate and the solvent optimization process can be carried out using one of the response surface mixture techniques, namely Simplex centroid design. The optimization results were analyzed based on the extraction yield which will be followed by determining the minimum kill concentration (LC50) cytotoxicity value obtained from acute cytotoxicity testing on Artemia salina Leach larvae after being treated and left for 24 hours.Cytotoxicity test was carried out on the extract with the highest extract yield value, namely the ethanol extract (code EE). The LC50 value of all extracts showed toxic potential. The LC50 obtained from the ethanol extract was 343.094 g/mL. Thus, information was obtained that the ethanol extract of horse whip leaves has active cytotoxicity and high bioactivity potential. The LC50 value < 1000 ?g/ml is directly proportional to the antiproliferative and antibacterial potential as well as the enzymatic inhibition of alpha-glucosidase and alpha-amylase in in vitro antidiabetic research, so further testing is related to the potential of horsewhip leaf ethanol extract as antiproliferative, antibacterial, inhibition test Enzymatic alpha-Glucosidase and alpha-amylase are the targets of further research.
Development of Case-Based Electronic Student Worksheets (E-LKPD) on Carbohydrate Metabolism Disorders for Science Education Students Qomaliyah, Eka Nurul; Habiddin, Habiddin
Chemistry Education Practice Vol. 8 No. 2 (2025): Edisi November
Publisher : FKIP University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/cep.v8i2.10128

Abstract

 Biochemistry is one of the courses that encompasses broad and complex material, including metabolism. Students’ understanding of carbohydrate metabolism is often limited to theoretical and memorization aspects. Therefore, it is necessary to develop learning media that support interactive and more meaningful learning. This study aims to develop a case-based Electronic Student Worksheet (E-LKPD) on carbohydrate metabolism disorders for students in the Science Education Program. The research employed the Research and Development (R&D) method with the development stages of Define, Design, and Develop. Data were obtained from expert validation as well as user response questionnaires involving 25 science education students. The results of material validation, language validation, and output validation showed “high validity and feasibility,” while user questionnaires indicated an average 90% “very good” response and agreement to use the E-LKPD in Biochemistry learning. Thus, the case-based E-LKPD on carbohydrate metabolism disorders is considered feasible to be used as a learning medium in Biochemistry courses, particularly in supporting case-based and student-centered learning.
Co-Authors Abraham Tiandno Witjaksono Afandi, Frendy Ahmad Agus Setyono Ainul Yaqin Aji Kresnapati, Bagus Arifin, Achmad Saiful Asyaun Niqris, Adelliana Aulia Azahra, Rahmania Ayu, Fatma Aisyah Baiq Yulia Hasni Pratiwi Bambang Pontjo Priosoeryanto Chairani Fatimah, Nina Damayanti, Lisa Kurnia Anggraeni Dian Nugraheni Fardani, Indra Fardhani, Indra Habiddin Hanandya Rahma Dinda Destriani Hasim - Hasim Hasim Hasim Hasim I Gusti Nyoman Hari Satwika I Made Kawi Widana I Nyoman loka Islamiyati, Ricka Kresnapati, I Nyoman Bagus Aji Kurniawati, Nika Fitri Lisnawati Tumanggor Maudina, Rahma Ursula Mira Takene Moh Asroriy Nuris Muchsin, Lalu Busyairi Mudawil Qulub Muhamad Azwar Muhamad Azwar, Muhamad Muhammad Eka Putra Ramandha Muhammad Maftuchin Sholeh Muhsin, Lalu Busyairi Mukti, Nuril Chasanah Murti, Aisyah Andhina Nadia, Intan Naila Zulfa Nina Chairani Fatimah Nisa, Hafidzah Ra'iyatun Nurul Indriani Nyoman Bagus Aji K Prabowo, Himawan Ganjar Praptawati, Atika Ramadhani, Muhammad Wisda Pradja Ratna Puspita Relia Fitrah, Aura Rini Anggi Arista Riyanto, Obaja Eden Santosa Rohma, Atika Rosita Assyifa Purba Royana, Dhita Fitri Santosa, Khalis Nadhira Setyoningrum, Nadia Shofi, Fifi Maziyatus Sofya, Sri Winarni Sri Winarni Sofya Sri Winarni Sofya Sukib Sukib Surya Pangidoan Nasution Syamsuddin, Imam Waras Nurcholis Widowati, Tamara Rahma