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All Journal KAPAL Jurnal Ilmu Pengetahuan dan Teknologi Kelautan SIGMA: Jurnal Pendidikan Matematika PYTHAGORAS: Jurnal Program Studi Pendidikan Matematika JURNAL INTEGRASI JMPM: Jurnal Matematika dan Pendidikan Matematika Jurnal Bidang Pendidikan Dasar Pi: Mathematics Education Journal Pendas : Jurnah Ilmiah Pendidikan Dasar JTAM (Jurnal Teori dan Aplikasi Matematika) Jurnal Basicedu EDUPEDIA Wave: Jurnal Ilmiah Teknologi Maritim J-ADIMAS (Jurnal Pengabdian kepada Masyarakat) Rainstek : Jurnal Terapan Sains dan Teknologi Edumatika MEDICINUS Makara Journal of Technology Jurnal Basicedu Pi: Mathematics Education Journal Journal Focus Action of Research Mathematic (Factor M) Jurnal Pengabdian kepada Masyarakat (Ngabdimas) Journal of Global Pharma Technology Sewagati Jurnal Pengabdian Masyarakat Bangsa JME (Journal of Mathematics Education) Educare : Jurnal Penelitian Pendidikan dan Pembelajaran Mindset : Jurnal Pemikiran Pendidikan dan Pembelajaran Jurnal Tadris Matematika Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
I. K. Suastika
Department Of Naval Architecture, Faculty Of Marine Technology, Institut Teknologi Sepuluh Nopember (ITS), Surabaya, 60111, Indonesia
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Journal : MEDICINUS

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Obesity as a Risk Factor of Cancer Theodore Dharma Tedjamartono; Ketut Suastika
MEDICINUS Vol. 39 No. 1 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/xjymmp28

Abstract

The prevalence of overweight and obesity continues to increase globally. These conditions are considered a serious public health concern due to its correlation with other diseases, such as type 2 diabetes mellitus, cardiovascular disease, andcancer. Obesity is defined as the accumulation of abnormal or excessive body fat that can impair health. Although obesity is not considered a major risk factor for cancer, it is associated with several types of cancer. One of the key mechanismsunderlying the relationship between obesity and cancer is chronic inflammation. In individuals with obesity, hypoxia can occur in adipose tissue, triggering alterations in leptin levels, dysregulation of adiponectin, macrophage infiltration, mitochondrial dysfunction, and an increased endoplasmic reticulum (ER) stress response. These changes collectively contribute to a state of chronic inflammation. Chronic inflammation is a mediator of cancer cell development, primarily by inducing changes in the tumor microenvironment and promoting the formation of cancer phenotypes (tumorigenesis). Other factors that explain the relationship between obesity and cancer in general will be explained in this literature review.
Co-Authors Affandi, Ahmad Rizal Ahmad Firdhaus Ambarwati, Adna Arum Anak Agung Gede Budhiarta Andriani, Tifaniar Angga Yustiawan Aries Sulisetyono Budianto Budianto Dyah Triwahyuningtyas Fara Zulfa Kurnia Ferdiani, Rosita Dwi Firstdhitama, Wisnu Hafis, Hafis Hanum, Abdila Ayu Hanna Mulya Harfin Lanya, Harfin Harianto, Wahyudi Hasanudin Hasanudin Herawati Sudoyo I Gusti Ngurah Kade Mahardika I Ketut Aria Pria Utama I Made Pande Dwipayana I Made Siswadi Semadi Ida Bagus Aditya Nugraha Kiryanto Kiryanto Komang Agus Wira Nugraha Lidiawati, Artaning Ma'ruf, Buana MADE RATNA SARASWATI . Meida Perwira Antartika Muhamad Ari Mulyanto, Bayu Hadi Nabila, Dewi Nafi'ah, Muti'atun Nasirudin, Ahmad Ningrum, Siska Widyana Nugroho, Ardi Nur Farida Nurita Primasatya NURUL AZIZAH Pramiswari, Elok Dara Rahaju, Rahaju Ratnasari, Yuliana Retno Marsitin Rosa, Andrea Grech La Safarina G. Malik Samuel Samuel Sarman, Afriano Andri Sesanti, Nyamik Rahayu Setyawan, Dony Sri Hariyani Sri Rejeki Wahyu Pribadi Suistiani, Suistiani Sukma Oktavianthi Suwanti, Vivi Tatik Retno Murniasih Tebiary, An Apriyani Theodore Dharma Tedjamartono Umi Hanik Utomoh, Karnadi Virliantarto, Noor Wibowo Nugroho Wildaniyah, Khoirani Wira Gotera Yovita Puspasari Yudiono, Udik Yuwono, Timbul