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All Journal Jurnal Bios Logos JBIO: jurnal biosains (the journal of biosciences) Prosiding Seminar Biologi Elkawnie Padjadjaran Journal of Dentistry Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Buletin Farmatera BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains IJOEP : International Journal of Ecophysiology Bioscientist : Jurnal Ilmiah Biologi Archives of The Medicine and Case Reports Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik)
Syafruddin Ilyas
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Sumatera Utara
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Pengaruh Pemberian Ekstrak Buah Gandaria terhadap Profil Darah Tikus yang Diinduksi Karbon Tetraklorida Muhammad zaharul ichsan; syafruddin Ilyas; Masitta Tanjung
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 9 No. 4 (2026): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/pb7cvp76

Abstract

This study aims to analyze the antioxidant potential of gandaria fruit extract against carbon tetrachloride-induced free radicals based on complete blood profile analysis in experimental animals. The method used was a completely randomized design with 30 rats divided into six treatment groups, namely normal, negative, positive, and three gandaria fruit extract treatment groups at doses of 200, 400, and 600 mg/kg BW. The results showed that gandaria fruit extract had a significant effect in improving blood profile damage after CCl4 induction, contained alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins, had total phenolic content of 6133 mg/kg, antioxidant inhibition activity of 81%, and an IC50 value of 90 ppm. In conclusion, gandaria fruit extract at a dose of 600 mg/kg BW was the best dose and showed potential as a hematoprotective agent. Keywords: Blood Profile, Bouea Macrophylla, Carbon Tetrachloride, Plum Mango.
Uji Aktivitas Hepatoprotektor pada Tikus Model Kanker Payudara yang Diinduksi Benzo(A)Piren Setelah Pemberian Ekstrak Metanol Daun Biwa (Eriobotrya japonica Lindl) Hasibuan, Fitri Elizabrth; Syahfitri, Widya; Hutahaean, Salomo; Ilyas, Syafruddin; Hasibuan, Febry Rahmadani
JURNAL BIOS LOGOS Vol. 15 No. 1 (2025): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v15i1.63461

Abstract

This study aimed to evaluate the hepatoprotective activity of methanolic extract of loquat (Eriobotrya japonica Lindl) leaves in breast cancer model rats induced by benzo(α)pyrene. This study used a completely randomized design with five groups: Group I as the negative control, Group II as the positive control (administered BaP 50mg/KgBW), and three treatment groups receiving methanolic extract of loquat leaves at doses of 200 mg/kg BW, 300 mg/kg BW, and 400 mg/kg BW for 30 days. Blood serum samples from the breast cancer model rats were analyzed to determine SGPT and SGOT levels using the IFCC method. Data were statistically analyzed using Analysis of Variance (ANOVA) followed by Tukey’s HSD post-hoc test. The results showed no significant differences between the treatment and control groups for SGOT (F(4,20) = 0.7123, P = 0.593) and SGPT (F(4,20) = 0.4460, P = 0.774) levels. Based on these findings, it can be concluded that administration of methanolic extract of loquat leaves did not cause liver function impairment in the breast cancer model rats. These results support the potential of loquat leaf extract as a hepatoprotective agent, particularly in maintaining stable SGPT and SGOT levels in breast cancer conditions.
Co-Authors Anggraini, Dwi Rita Antika, Maya Anjelir Ashfira Asmarinah Budianto Siregar Datten Bangun Dearni Damanik Dharma Lindarto Dian Handayani Dina R. Purba Endy Juli Anto Evi Irianti fatchiyah . Fauzi Yusuf, Fauzi Hadyanto L Halimatussakdiah Halimatussakdiah Harry Agusnar Harun Al Rasyid Hasibuan, Febry Rahmadani Hasibuan, Fitri Elizabrth Ira Cinta Lestari Kesuma Wardani Lestari, Chandra Marpaung, Okto P.E Masitta Tanjung Mesrawati Purba Mieke Hemiawati Satari Muhammad zaharul ichsan Nukman Moeloek Nurjati C. Siregar Nursal Olivia Avriyanti Hanafiah Polem, Wardah Sawitri Ramlan Silaban Ria Lumbantoruan Rina Marintan Sitorus Rosidah, Rosidah Salomo Hutahaean Salomo Hutahaen Sari, Mutiara Indah Siahaan, Jekson Martiar Silvia W Lestari Sinaga, Ade Putra Fratama Siregar C Siregar, Siregar C Suryani Eka Mustika Syahfitri, Widya Teguh Firdaus Ternala Alexander Barus Tisna Harmawan Tisna Hermawan Tri Widyawati Utmi Arma, Utmi Vivi Mardina Vivi Mardina Yasmeini Yazir