Article Per Year (5 Year)
p-Index From 2021 - 2026
1.325
P-Index
This Author published in this journals
All Journal JBIO: jurnal biosains (the journal of biosciences) Prosiding Seminar Biologi Elkawnie Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Buletin Farmatera Indonesian Journal of Medicine IJOEP : International Journal of Ecophysiology Bioscientist : Jurnal Ilmiah Biologi Archives of The Medicine and Case Reports Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik)
Syafruddin Ilyas
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 21 Documents
Search

 1   2   3 
Anticancer Activity of N-Hexane Extract from Sphagneticola trilobata (L.) J.F Pruski Against MCF-7 Breast Cancer Cell Vivi Mardina; Tisna Harmawan; Halimatussakdiah Halimatussakdiah; Syafruddin Ilyas; Masitta Tanjung
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6183

Abstract

Abstract : Sphagneticola trilobata (L.) J.F. Pruski is one of the perennial herbs that is widely used by the national and international community to treat various diseases including cancer. The objective of this study was to assessment the anticancer activity of n-hexane extract of S. trilobata leaves for inhibiting the growth of MCF-7 breast cancer cells in vitro by MTT (microculture tetrazolium salt) method. The n-hexane extract of sernai leaves was obtained from the maceration process of samples that were collected from the Langsa city, Aceh. The cytotoxicity test was carried out by incubating MCF-7 cells which had been exposed to several series of sample levels, viz. 1000; 500; 100; 50; 25; 10; 5 and 1 µg/mL. LC50 values are calculated using probit analysis. The results revealed that the n-hexane extract of S. trilobata leaves was cytotoxic against breast cancer cells (MCF-7) with an LC50 value of  0.037 μg /mL.Abstrak : Sphagneticola trilobata (L.) J.F. Pruski merupakan salah satu tanaman herbal yang digunakan secara luas oleh masyarakat nasional dan internasional untuk mengobati berbagai penyakit termasuk kanker. Penelitian ini bertujuan untuk mengetahui aktivitas antikanker ekstrak n-heksana daun S. trilobata dalam menghambat pertumbuhan sel kanker payudara MCF-7 secara in vitro dengan metode MTT (microculture tetrazolium salt). Ekstrak n-heksana daun sernai diperoleh dari proses maserasi sampel yang dikoleksi dari kota Langsa, Aceh. Uji sitotoksisitas dilakukan dengan menginkubasi sel MCF-7 yang telah dipaparkan beberapa seri  kadar sampel yaitu 1000, 500, 100, 50, 25, 10, 5 dan 1 µg/mL. Nilai LC50 dihitung dengan menggunakan analisa probit. Hasil penelitian menunjukkan bahwa ekstrak n-heksana daun S. trilobata bersifat sitotoksik terhadap sel kanker payudara (MCF-7) dengan harga LC50 sebesar 0,037 µg/mL. 
Co-Authors Ameta Primasari Anggraini, Dwi Rita Antika, Maya Anjelir ashfira Asmarinah Asmarinah Budianto Siregar Datten Bangun Dharma Lindarto Dian Handayani Ervina Sofyanti Evi Irianti fatchiyah . Fauzi Yusuf, Fauzi Halimatussakdiah Halimatussakdiah Harry Agusnar Harun Al Rasyid Hery Widijanto Indra Ira Cinta Lestari Kesuma Wardani Lestari, Chandra Marpaung, Okto P.E Masitta Tanjung Mesrawati Purba Mieke Hemiawati Satari Narmada , Ida Bagus Nukman Moeloek Nurjati C. Siregar Nursal Olivia Avriyanti Hanafiah Polem, Wardah Sawitri Ramlan Silaban Ria Lumbantoruan Rina Marintan Sitorus Rosidah, Rosidah Salomo Hutahaean Salomo Hutahaen Sari, Mutiara Indah Silvia W Lestari Sinaga, Ade Putra Fratama Siregar C Siregar, Siregar C Siti Bahirrah Suryani Eka Mustika Teguh Firdaus Ternala Alexander Barus Tisna Harmawan Tisna Hermawan Tri Widyawati Utmi Arma, Utmi Vivi Mardina Vivi Mardina Yasmeini Yazir