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All Journal HAYATI Journal of Biosciences Jurnal Farmasi Klinik Indonesia JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Eduvest - Journal of Universal Studies Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Mahdi Jufri
Department Of Pharmaceutics And Pharmaceutical Technology, Faculty Of Pharmacy, University Of Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Uji Aktivitas Penghambatan Tirosinase dan Antioksidan Ekstrak Akar Murbei (Morus alba) dengan Metode Ekstraksi Hijau NADES Sebagai Agen Pencerah Kulit Alishlah, Tanfidz; Mun’im, Abdul; Jufri, Mahdi
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4699

Abstract

Morus alba (mulberry) root contains a secondary metabolite of oxyresveratrol with its potential skin-brightening activity. The application of the green extraction method using Ultrasonic-Assisted Extraction with Natural Deep Eutectic Solution (NADES-UAE) was developed because of its advantages, namely it can increase extract yields, low toxicity profile, reduce extraction time, shorter extraction stages without evaporation, and can be applied directly in topical preparations for cosmetic products. To ensure the potential for skin-brightening activity, some activity tests on mulberry root extract are needed. The purpose of this study was to determine the in vitro skin-brightening activity of mulberry root extract using NADES-UAE method. The method used was an in vitro tyrosinase enzyme inhibition test using a microplate reader and an antioxidant activity test using the DPPH method. The IC50 value of the best mulberry root extract (glycerin: urea 1:3 for 15 minutes) showed tyrosinase inhibition activity was 178.43 μg/mL. While the IC50 value in the best antioxidant activity test was 1392.14 μg/mL. Tyrosinase inhibitory and antioxidant activities in three samples showed the best results having the highest oxyresveratrol content. NADES-UAE mulberry root extract has the potential as a cosmetic preparation for skin lightening and has antioxidant effects for skin health.
Analisis Pelayanan Kefarmasian Berdasarkan Indikator Pelayanan Pasien WHO pada Puskesmas Kecamatan yang Belum dan Sudah Terakreditasi di Kota Depok Makhdalena, Makhdalena; Jufri, Mahdi; Andrajati, Retnosari
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.355

Abstract

Pharmaceutical care based on WHO patient care indicators in various developing countries, including Indonesia, have not met the requirements. Puskesmas accreditation is expected to improve pharmaceutical care that has an impact on rational drug use. The purpose of the study was to analyze pharmacy care based on WHO patient care indicators in all sub-district health centers (9 health centers not yet accredited and 2 health centers already accredited) in Depok City. This study used a cross-sectional design and was carried out in December 2016-February 2017. The sample was adult patients from general poly and accompanying patients from integrated management of sick toddlers who met the inclusion criteria, as well as all prescription drugs taken. There were 30 respondents and 30 prescriptions for each sub-district health center. Data collection was done through interviews and observation of respondents and analysis of the recipe sheets. Data analysis used Mann-Whitney and Chi-square tests. The results show that the sub-district health centers have not been accredited which meets WHO recommendations for preparation time and delivery of drugs (> 3 minutes) of 77.8% and those who are 100% accredited. None of the sub-district health centers in Depok City meet WHO recommendations for the suitability of drug delivery, adequate drug labeling and patients with correct drug knowledge (= 100%). The time of preparation and delivery of drugs at the subdistrict health centers has been accredited significantly longer than those not yet accredited (p
Formulasi dan Uji Penetrasi Sediaan Gel Transfersom yang Mengandung Kojyl 3 Amino Propil Fosfat sebagai Pencerah Kulit Andini, Septia; Jufri, Mahdi; Djajadisastra, Joshita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2948

Abstract

Kojyl 3 APPA is a compound used for skin lightening. Kojyl 3 APPA has a good solubility in water. This causes the hydrophilic nature kojyl 3 APPA difficult to penetrate through the skin. Transfersom is a carrier system that can improve the effectiveness of drug penetration. This study aims to formulate, characterize and evaluate transfersom preparations containing kojyl 3 APPA. Further more transfersom formulated in a gel formulation. Preparation gel was tested its physical stability and in vitro penetration test against non transfersom kojyl 3 APPA. Transfersom gel formulation is physically proven stable at room temperature, low temperature and high temperature storage. In vitro penetration tests showed that kojyl 3 APPA penetration loaded in transfersom gel was 11,16% while for non transfersom gel 8,02%
Stabilitas Kimia Nanoemulsi Gel Kombinasi Eugenol dan Sitronellal: Chemical Stability of Gel Nano Emulsion Combination of Eugenol and Sitronellal Wahda Fitria; Fadlina Chany Saputri; Mahdi Jufri
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2355

Abstract

Clove oil and lemongrass essential oil can be formulated into Nanoemulsion Gel preparations as topical preparations for the skin. This Nanoemulsion Gel preparation is formulated by first making a nanoemulsion preparation, which is then made into a Nanoemulsion Gel preparation by dispersing the nanoemulsion into a gel that has been made with active ingredients from clove oil and lemongrass essential oil. The gel nanoemulsion preparation was then analyzed for the stability of its chemical components using GC-MS. The results of analysis using GC-MS obtained that a Nanoemulsion Gel preparation formulated from clove oil and lemongrass oil was chemically stable.   Keywords:          Nanoemulsion gel preparation, Chemical stability, GC-MS   Abstrak Minyak atsiri cengkeh dan minyak atsiri sereh dapat diformulasikan menjadi sediaan nanoemulsi gel sebagai sediaan topikal pada kulit. Sediaan nanoemulsi gel ini diformulasikan dengan terlebih dahulu membuat sediaan nanoemulsi, yang selanjutnya dibuat menjadi sediaan nanoemulsi gel dengan mendispersikan nanoemulsi ke dalam gel yang telah dibuat dengan bahan aktif dari minyak atsiri cengkeh dan minyak atsiri sereh. Sediaan nanoemulsi gel kemudian dianalisis stabilitas komponen kimianya dengan menggunakan GC-MS. Hasil analisis menggunakan GC-MS diperoleh sediaan nanoemulsi gel yang diformulasikan dari minyak cengkeh dan minyak sereh cukup stabil secara kimia.   Kata Kunci:         sediaan Nanoemulsi Gel, stabilitas Kimia, GC-MS
Total Phenolic Content in Black Rice (Oryza sativa L. indica) Bran Ethanolic Extract from Two Different Regions in Java, Indonesia Vardhani, Afifah; Anggraini, Nadia Bunga; Jufri, Mahdi; Purwaningsih, Erni; Perdanastuti, Hidayah Sunar
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.293

Abstract

Rice bran, a rice by-product yielded by the milling process, has recently been recognized as a potential source of natural active constituents. Black rice bran has the highest antioxidant capacity compared to white and brown rice bran. It is correlated with the contribution of phenolic compounds in rice bran. The purpose of this study was to determine the total phenolic content in black rice (Oryza sativa L. indica) bran ethanolic extract from two different regions in Java, Indonesia, using Folin-Ciocalteu Reagent (FCR). Black rice bran samples used in this study were planted in Ciletuh Geopark Sukabumi, West Java (BRBE1), and Karanganyar Regency, Central Java (BRBE2). The parameters observed were total phenolic content, and the result was statistically tested with an unpaired t-test by GraphPad Prism 8.3.0 application. The samples contained 175.48 mg GAE/g extract in BRBE1 and 174.39 mg GAE/g extract in BRBE2. There was no significant difference based on these results. It can be concluded that both samples contained phenolic compounds and statistically, there was no significant difference.
Perbandingan Ekstrak Jahe Merah (Zingiber Officinale Roscoe. Var. Rubrum), Gingerol dan Shogaol sebagai Anti-Toksoplasma terhadap Parasit Toxoplasma Gondii Secara In-Vitro Siti Sa’diah; Effionora Anwar; Mahdi Jufri; Umi Cahyaningsih
Jurnal Jamu Indonesia Vol. 4 No. 3 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i3.160

Abstract

Metode ekstraksi dan jenis pelarut yang digunakan akan berdampak pada proses penarikan komponen aktif sehingga akan berpengaruh juga pada aktivitasnya. Jahe merah (Zingiber officinale var. Rubrum) merupakan salah satu bahan rempah yang juga berpotensi sebagai tanaman obat. Salah satu khasiat ekstrak jahe merah adalah sebagai anti toksoplasma. Pada penelitian ini telah dilakukan pembuatan ekstrak jahe merah dengan dua jenis metode yaitu maserasi dan sokhletasi masing-masing menggunakan tiga jenis pelarut (etanol 30%, etanol 70% dan etanol 96%) sehingga diperoleh enam jenis ekstrak. Kemudian masing-masing ekstrak ditentukan kadar senyawa pencirinya meliputi 6-gingerol, 8-gingerol, 10-gingerol dan 6-shogaol dengan Kromatografi Cair Kinerja Tinggi (KCKT). Selanjutnya ekstrak diuji aktivitas antitoksoplasma secara in vitro terhadap parasit Toksoplasma gondii pada fase takhizoit yang ditumbuhkan pada sel vero. Penentuan aktivitas antitoksoplasma juga dilakukan pada senyawa murni 6, 8, 10-gingerol dan 6-shogaol serta kontrol positif antibiotik spiramisin. Hasilnya menunjukkan bahwa ekstrak etanol 96% dengan metode maserasi adalah yang paling baik aktivitasnya dan 6-gingerol adalah senyawa penciri yang paling berperan sebagai anti-toksoplasma.
Total Phenolic Content in Black Rice (Oryza sativa L. indica) Bran Ethanolic Extract from Two Different Regions in Java, Indonesia Afifah Vardhani; Nadia Bunga Anggraini; Mahdi Jufri; Erni Purwaningsih; Hidayah Sunar Perdanastuti
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.293

Abstract

Rice bran, a rice by-product yielded by the milling process, has recently been recognized as a potential source of natural active constituents. Black rice bran has the highest antioxidant capacity compared to white and brown rice bran. It is correlated with the contribution of phenolic compounds in rice bran. The purpose of this study was to determine the total phenolic content in black rice (Oryza sativa L. indica) bran ethanolic extract from two different regions in Java, Indonesia, using Folin-Ciocalteu Reagent (FCR). Black rice bran samples used in this study were planted in Ciletuh Geopark Sukabumi, West Java (BRBE1), and Karanganyar Regency, Central Java (BRBE2). The parameters observed were total phenolic content, and the result was statistically tested with an unpaired t-test by GraphPad Prism 8.3.0 application. The samples contained 175.48 mg GAE/g extract in BRBE1 and 174.39 mg GAE/g extract in BRBE2. There was no significant difference based on these results. It can be concluded that both samples contained phenolic compounds and statistically, there was no significant difference.
Pharmaceutical Formulation Strategy Approach from Red Palm Oil (Elaeis guineensis Jacq) Azhari, Andre Alwi; Jufri, Mahdi; Setiawan, Heri
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.49970

Abstract

Red palm oil (RPO) comes from the mesocarp of the palm fruit (Elaeis guineensis Jacq.) which is rich in carotenoids, vitamin E, and fatty acids. The use of RPO in pharmaceutical formulations poses challenges related to stability, oxidation susceptibility, and consumer acceptance due to its distinctive aroma and taste. To address these limitations, a variety of innovative formulation strategies, including emulsification, nanoemulsification, microencapsulation, and lipid-based systems have been researched. The RPO formulation aims to improve stability, bioavailability, and enhance therapeutic effects. Manufacturing techniques such as high-pressure homogenization, spray drying, and encapsulation of supercritical fluids have stabilized the bioactive components of RPO, minimizing oxidation, and controlling continuous release. Nanoemulsions and lipid nanoparticles have shown results in a wide range of applications from topical antioxidants to systemic drug delivery, by utilizing the synergistic effects of the lipophilic properties of RPO with other active ingredients. In addition, encapsulation technology has improved the stability of RPO storage, thereby expanding its usefulness in nutraceuticals and multivitamin supplements. This article also aims to bridge the research gap related to RPO formulation and provide insights into optimizing RPO formulations for broader benefits in health and disease management. The use of RPO in the future perspective is focused on nanotechnology formulations to improve solubility, stability, bioavailability, and support targeted and controlled drug delivery.
Co-Authors Abdul Munim Abiyoga Pradata Afifah Vardhani Ahmad Fauzantoro Andre Fahriz Perdana Harahap Andri Pramesyanti Pramono Anggraeni, Yosita Anggraini, Nadia Bunga Anisa Amalia Anna U. H. Rochjana Asnimar Binu Asnimar Binu, Asnimar Ayup Milladi Azhari, Andre Alwi Basra Ahmad Amru Berna Elya Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Erni Purwaningsih Fadlina Chany Saputri Fajriati Zulfa Febriani, Amelia Firli, Akhmad Ridwan Halimah Anggi Rahmani Henry . Henry, Henry Heri setiawan Hidayah Sunar Perdanastuti Ika Maruya Kusuma Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra JOSHITA DJAJADISASTRA Joshita Djajadisastra, Joshita Julia Rahmawati Julia Rahmawati, Julia Kori Yati Kori Yati Ledy Maya Ledy Maya, Ledy Lusi Dwita Lusi Putri Dwita Makhdalena Makhdalena Makhdalena Makhdalena, Makhdalena Mardiastuti Mardiastuti Mardiastuti Wahid Meiskha Bahar Misri Gozan Muhammad Yusuf Arya Ramadhan Mun’im, Abdul Nadia Bunga Anggraini Nasihin Saud Irsyad Oktania Sandra Puspita Perdanastuti, Hidayah Sunar Purnasari, Santi Purwaningsih, Erni Putri Margaining Utami Putri Margaining Utami, Putri Margaining Raditya Iswandana Ratu A. D. Sartika Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Rosmala Dewi Rosmala Dewi Akhmad Ridwan Firli SANDRA AULIA MARDIKASARI Sari, Dini Permata Septia Andini Sheila Azelya Fernanda Siti Sa’diah Suci Syafitri Utami Tanfidz Alishlah, Tanfidz Umi Cahyaningsih Vardhani, Afifah Wahda Fitria Yohanna Aristanti Yudhi Nugraha