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All Journal HAYATI Journal of Biosciences Jurnal Farmasi Klinik Indonesia JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Eduvest - Journal of Universal Studies Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Indonesian Journal of Jamu
Mahdi Jufri
Department Of Pharmaceutics And Pharmaceutical Technology, Faculty Of Pharmacy, University Of Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Perbandingan Ekstrak Jahe Merah (Zingiber Officinale Roscoe. Var. Rubrum), Gingerol dan Shogaol sebagai Anti-Toksoplasma terhadap Parasit Toxoplasma Gondii Secara In-Vitro Siti Sa’diah; Effionora Anwar; Mahdi Jufri; Umi Cahyaningsih
Jurnal Jamu Indonesia Vol. 4 No. 3 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1473.786 KB) | DOI: 10.29244/jji.v4i3.160

Abstract

Metode ekstraksi dan jenis pelarut yang digunakan akan berdampak pada proses penarikan komponen aktif sehingga akan berpengaruh juga pada aktivitasnya. Jahe merah (Zingiber officinale var. Rubrum) merupakan salah satu bahan rempah yang juga berpotensi sebagai tanaman obat. Salah satu khasiat ekstrak jahe merah adalah sebagai anti toksoplasma. Pada penelitian ini telah dilakukan pembuatan ekstrak jahe merah dengan dua jenis metode yaitu maserasi dan sokhletasi masing-masing menggunakan tiga jenis pelarut (etanol 30%, etanol 70% dan etanol 96%) sehingga diperoleh enam jenis ekstrak. Kemudian masing-masing ekstrak ditentukan kadar senyawa pencirinya meliputi 6-gingerol, 8-gingerol, 10-gingerol dan 6-shogaol dengan Kromatografi Cair Kinerja Tinggi (KCKT). Selanjutnya ekstrak diuji aktivitas antitoksoplasma secara in vitro terhadap parasit Toksoplasma gondii pada fase takhizoit yang ditumbuhkan pada sel vero. Penentuan aktivitas antitoksoplasma juga dilakukan pada senyawa murni 6, 8, 10-gingerol dan 6-shogaol serta kontrol positif antibiotik spiramisin. Hasilnya menunjukkan bahwa ekstrak etanol 96% dengan metode maserasi adalah yang paling baik aktivitasnya dan 6-gingerol adalah senyawa penciri yang paling berperan sebagai anti-toksoplasma.
Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (DE 35–40) Sebagai Stabilizer Jufri, Mahdi; Anwar, Effionora; Utami, Putri Margaining
Majalah Ilmu Kefarmasian Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.
Studi Kemampuan Pati Biji Durian Sebagai Bahan Pengikat Dalam Tablet Ketoprofen Secara Granulasi Basah Jufri, Mahdi; Dewi, Rosmala; Firli, Akhmad Ridwan
Majalah Ilmu Kefarmasian Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Many type of starch from various plants can be exploited as an alternative for additional materials in tablet formulation. One of the source that have been developed as a pharmaceutical excipient is durian seed starch, which relatively easy to find in tropic area such as Indonesia. The objective of this research was to observe the ability of durio seed starch as binder in wet granulation of ketoprofen tablet formulation. Durio seed starch obtained by extraction and drying methode. Starch as a paste used in wet granulation as a binder. Tablet made by wet granulation with ketoprofen (25%) as a drug model; calcium phosphate dihidrate as a diluent; Avicel® PH 102 as a disintegrant; magnesium stearat (1%) and talc (2%) as a lubricant. Placebo formula with various durio seed starch concentration (5%, 6%, 8%, 10%) in tablet compared to other binder that is cassava starch. Placebo tablet formula with better hardness and friability used in ketoprofen tablet formula and compared to cassava starch as a binder with the same concentration. Formula with durio seed starch as binder have smaller hardness and more friable than cassava starch as a binder. Thereby tablet with durio seed starch as binder have faster disintegration time than tablet with cassava starch as a binder. The dissolution test for both ketoprofen formula did not meet the pharmacopeial requirements.
Pembuatan Mikroemulsi Dari Minyak Buah Merah Jufri, Mahdi; Djajadisastra, Joshita; Maya, Ledy
Majalah Ilmu Kefarmasian Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Red fruit oil (Pandanus conoideus) is a natural product typicaly from Papua used as a medication for some disease, as a food supplement, and for beauty skin care. But this advantages are not supported by an appropriate dosage form. Oils are difficult to dissolve in GIT and difficult to penetrate the human skin, slower the absorption then. Microemulsion is a dispersion system which can help to solve the problems by enhanc-ing the oil solubility in GIT and the oil penetration through the skin. The objective of this study is to formulate a clear and stabile microemulsion. Microemulsion will be physically evaluated for 2 months. The material composition is 5% glycerin and 15% sorbitol as the cosolvent, and 20% , 30%, and 40% tween -20 as the surfactants. The result showed that formula of 40% tween-20 gave a good microemulsion which is physically stable as long as 2 months stored at room temperature.
Uji Stabilitas Fisik Losio Yang Mengandung Fraksi Diklorometana Ekstrak Metanol Kulit Buah Manggis (Garcinia mangostana L.) Apriyanti, Elis; Jufri, Mahdi; Elya, Berna
Majalah Ilmu Kefarmasian Vol. 9, No. 3
Publisher : UI Scholars Hub

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Abstract

Mangosteen pericarp (Garcinia mangostana L.) contains some of xanthones derivates which have antioxidant activity.Those compounds prevent formation of free radicals that cause premature aging. Dichloromethane fraction from methanol extract of mangosteen pericarp has very strong antioxidant activity. Dicholomethane fraction of mangosteen pericarp was formulated into lotion dosage form with different concentration 0.01; 0.05; and 0.25%.. Physical stability of lotion was evaluated by cycling test, centrifugal test, and stored the lotions at low temperature (4±2˚C), room temperature (27±2˚C), dan high temperature (40±2˚C). The result showed that the lotions stable at each strorage condition and cycling test. However, the result of centrifugal test showed separation phase of lotions.
Pembuatan Niosom Berbasis Maltodekstrin DE 5-10 Dari Pati Singkong (Manihot utilissima) Jufri, Mahdi; Anwar, Effionora; Djajadisastra, Joshita
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Niosomes are non ionic surfactant vesicles that have potential application in the delivery of hydrophobic or amphilic drugs. We developed proniosomes, a dry formulation using a maltodextrin as a carrier coated with non ionic surfactant, which can be used to produce niosomes within a minutes by addition of hot water followed by agitation. A novel method is reported here for rapid preparation of proniosomes with wide range of surfactant loading. Maltodextrin DE 5-10 was hidrolyzed from tapioca starch using Thermamyl L 120 da Novo at 85ºC. The result from SEM analyses shown that proniosomes appear very similar to the maltodextrin, but the surface was more smooth. Niosome suspensions which was observed under the optical microscopy and particle size analyzer were evaluated as drug carrier using ibuprofen as a model. The result provide an indication of maltodextrin DE 5-10 from tapioca starch are potentialy carrier in the proniosome preparation which can be used for producing niosomes.
Arah dan Perkembangan Liposome Drugs Delivery Systems Jufri, Mahdi
Majalah Ilmu Kefarmasian Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Since the dicovery of liposome or lipid vesicles derived from self limiting enclosed lipid bilayer upon hydration, liposome drug delivery systems have played a significant role in formulation of potent drugs to improve therapeutics. Currenlty most of these liposome formulation are designed to reduced toxicity and to some extent increase accumulation at the target site(s) in a the number of clinical application. The current pharmaceutical preparations of liposome based therapeutics stem from our understanding of lipid drug interactions and the liposome disposition mechanism including the inhibition of rapid clearance of liposome by controlling size , charge and surface hydration.
Formulasi Gameksan Dalam Bentuk Mikroemulsi Jufri, Mahdi; Binu, Asnimar; Rahmawati, Julia
Majalah Ilmu Kefarmasian Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

The clinical use of the poorly water-soluble drug substance become inefficient by means of low level penetration of such kind drug in the body. Microemulsion is a dispersion system like an emulsion which could help to increase the solubility of poorly water-soluble drug. In this research, poorly water-soluble drug is made in a dosage form of microemulsion with Gamexan as a model. An experiment has been conduct by using benzyl benzoate as an oil phase, Tween 20 with variety concentra- tion (35%;40%;45%) and sodium lauryl ether sulphate as surfactant components. The evaluation are consist of determining the amount of Gamexan in the microemulsion and stability test both physic and chemically. The result shows that all three of the microemulsion formula dosage form indicate good stability during two months of storing.
Pengaruh Variasi Konsentrasi Hidroxy Propyl Methyl Cellulose (HPMC) terhadap Stabilitas Fisik Gel Ekstrak Tembakau (Nicotiana tabaccum L.) dan Aktivitasnya terhadap Streptococcus mutans Yati, Kori; Jufri, Mahdi; Gozan, Misri; Mardiastuti, Mardiastuti; Dwita, Lusi Putri
Pharmaceutical Sciences and Research Vol. 5, No. 3
Publisher : UI Scholars Hub

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Abstract

Tobacco extract had been proven to have antimicrobial activity against Streptococcus mutans. To maximize the use of tobacco extract on topical use as an antibacterial, it could be formulated into a pharmaceutical preparation. This study aimed to formulate tobacco extract in gel preparation by using Hidroxy Propyl Methyl Cellulose (HPMC) as a gelling agent and to test its activity on S. mutans. The tobacco extract gel was prepared in 3 formulas with variations of HPMC concentration of 1.5% (F1), 2% (F2) and 2.5% (F3). The research began with tobacco extraction, then continued with characteristics evaluation. The extract was formulated in gel form and evaluated for 12 weeks of physical stability. Antibacterial activity was tested using the diffusion method. The evaluation results of tobacco extract gel showed that all formulas were stable during 12 weeks storage. Antimicrobial activity against S.mutans showed inhibitory diameter of F1, F2 and F3, were 9,07 mm, 19,53 mm, and 11,57 mm respectively. The test was continued by determining the relative potential of F2 compared to erythromycin. The test results showed 1.2 x 10-2 relative potential compare to erythromycin. Based on the results of this study, it can be concluded that HPMC concentration difference did not give significant difference to the physical stability of tobacco gel, with the best antibacterial activity on S. mutans obtained from F2.
STUDI KEMAMPUAN NIOSOM YANG MENGGUNAKAN MALTODEKSTRIN PATI GARUT (Maranta arundinaceae Linn.) SEBAGAI PEMBAWA KLORFENIRAMIN MALEA Anwar, Effionora; Henry, Henry; Jufri, Mahdi
Makara Journal of Science Vol. 8, No. 2
Publisher : UI Scholars Hub

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Abstract

Study of the Capability of Niosomes that Used Maltodextrin from Garut Starch (Maranta arundinaceae Linn.) as a Chlorpheniramine Maleate Carrier. The aim of this research was to study the entrapment ability of ampiphylic drug, chlorpheniramine maleate (CTM), by niosome. Like liposomes, niosomes is an encapsulated drug carrier that has important role in a drug release system. Niosomes and liposomes are unstable, but niosomes could be handled by proniosomes. Proniosomes in this research was prepared using the combination of maltodextrin DE 5-10 from arrowroot starch (Maranta arundinaceae Linn.), Span 60 and Cholesterol as non ionic surfactant in six formulas. The entrapment level of CTM depends on combination of surfactant in proniosomes, drug substance concentration and proniosomes quantity, temperature, and hydration times. Niosomes (10mM) that was prepared by proniosomes in formula 3 has been hydrated at 80 oC for 2 minutes using demineralized water could entrapped 94,04%, of 1 mM CTM. The proniosomes in formula 3 was increased up to 30 mM surfactant and 10 mM CTM in niosomes, could increase the entrapment of CTM.
Co-Authors Abdul Munim Abiyoga Pradata Ahmad Fauzantoro Andre Fahriz Perdana Harahap Andri Pramesyanti Pramono Anggraeni, Yosita Anggraini, Nadia Bunga Anisa Amalia Anna U. H. Rochjana Asnimar Binu Asnimar Binu, Asnimar Ayup Milladi Azhari, Andre Alwi Basra Ahmad Amru Berna Elya Effionora Anwar Elis Apriyanti Elis Apriyanti, Elis Fadlina Chany Saputri Fajriati Zulfa Febriani, Amelia Firli, Akhmad Ridwan Fitria, Wahda Halimah Anggi Rahmani Henry . Henry, Henry Ika Maruya Kusuma JOSHITA DJAJADISASTRA Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra, Joshita Julia Rahmawati Julia Rahmawati, Julia Kori Yati Kori Yati Ledy Maya Ledy Maya, Ledy Lusi Dwita Lusi Putri Dwita Makhdalena Makhdalena Makhdalena Makhdalena, Makhdalena Mardiastuti Mardiastuti Mardiastuti Wahid Meiskha Bahar Misri Gozan Muhammad Yusuf Arya Ramadhan Mun’im, Abdul Nasihin Saud Irsyad Nurwijayanti Oktania Sandra Puspita Perdanastuti, Hidayah Sunar Purnasari, Santi Purwaningsih, Erni Putri Margaining Utami Putri Margaining Utami, Putri Margaining Raditya Iswandana Ratu A. D. Sartika Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Rosmala Dewi Rosmala Dewi Akhmad Ridwan Firli SANDRA AULIA MARDIKASARI Sari, Dini Permata Sa’diah , Siti Septia Andini Sheila Azelya Fernanda Siti Sa’diah Suci Syafitri Utami Tanfidz Alishlah, Tanfidz Umi Cahyaningsih Vardhani, Afifah Wahda Fitria Yohanna Aristanti Yudhi Nugraha