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All Journal E-Jurnal Medika Udayana Jurnal Veteriner The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Global Pharma Technology
Sianny Herawati
Departemen Patologi Klinik Fakultas Kedokteran, Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health Veterinary

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PREANALITIC AND INTERPRETATION BLOOD GLUCOSE FOR DIAGNOSE DIABETIC MELITUS Ida Bagus Wayan Kardika; Sianny Herawati; I Wayan Putu Sutirta Yasa
E-Jurnal Medika Udayana vol 2 no 10 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Diabetes mellitus (DM) is a metabolic disorder disease which has been characterised by chronic hyperglycemia as well as abnormalities in the metabolism of carbohydrates, fats and proteins caused by abnormalities of insulin secretion, insulin resistance or both. The Diagnoses of diabetes mellitus in addition based on the clinical aspects of which include anamnesis, physical examination and diagnoses is required in the form of investigations the laboratory examination. The simplest laboratory examination is the examination of blood sugar. The stages of preanalitic and the interpretation of results examination of the blood sugar is worth noting in order to obtain meaningful results so that a diagnosis of diabetes mellitus can be enforced and for monitoring treatment outcomes.
HUBUNGAN ANTARA KADAR GULA DARAH PUASA DENGAN KADAR TRIGLISERIDA PADA PENDERITA DIABETES MELITUS TIPE 2 DI RUMAH SAKIT UMUM PUSAT SANGLAH BALI Kadek Pipin Rahina Soethama; Sianny Herawati; Ngurah Subawa
E-Jurnal Medika Udayana Vol 9 No 5 (2020): Vol 9 No 05(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2020.V09.i5.P10

Abstract

Diabetes Melitus (DM) adalah penyakit metabolik dengan hiperglikemi sebagai penanda khasnya dan dapat terjadi resistensi insulin pada DM Tipe 2 yang dikaitkan dengan kenaikan kadar Trigliserida (TG). Menjaga kadar gula darah menjadi dasar dari pengobatan DM Tipe 2. Menormalkan kadar gula darah biasanya disertai pula dengan turunnya kadar TG. Tujuan dari penelitian ini untuk mengetahui adakah hubungan kadar Gula Darah Puasa (GDP) dengan kadar TG pada penderita DM Tipe 2 di RSUP Sanglah Bali. Penelitian ini dilakukan pada 1 Maret-30 Juni 2016 menggunakan studi analitik cross-sectional terhadap 100 penderita DM Tipe 2 dengan menggunakan data sekunder. Sampel merupakan penderita DM Tipe 2 yang pada rekam medisnya menerangkan hasil pemeriksaan GDP dan TG pada hari yang sama dan berobat di RSUP Sanglah Bali pada periode 1 Januari-31 Desember 2015. Hasil penelitian menunjukkan bahwa terdapat korelasi positif antara kadar GDP dengan kadar TG (r= 0,772; p= 0,000).Melihat hasil yang ada, penderita DM Tipe 2 harus menjaga kadar gula darahnya dengan baik. Kata Kunci: Diabetes Melitus Tipe 2, Gula Darah Puasa, Trigliserida
UMUR DAN JENIS KELAMIN SEBAGAI FAKTOR RISIKO PENINGKATAN KADAR SERUM GLUTAMIK-PIRUVIC TRANSAMINASE (SGPT) PADA PASIEN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT UMUM PUSAT SANGLAH Made Yuliantari Dwi Astiti; Sianny Herawati; A.A. Ngurah Subawa
E-Jurnal Medika Udayana Vol 10 No 9 (2021): Vol 10 No 09(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i9.P13

Abstract

Latar Belakang: Diabetes Melitus (DM) adalah suatu merupakan penyakit kronis yang membutuhkan perawatan medis serta manajemen pasien untuk mencegah adanya komplikasi yang bersifat akut dan mengurangi risiko komplikasi jangka panjang. Hiperglikemia kronis yang terjadi berhubungan dengan kerusakan, disfungsi, dan kegagalan berbagai organ, salah satunya organ hepar. Peningkatan aktivitas enzimserum glutamik-piruvik transaminase (SGPT) sering terjadi pada penderita DM. Tujuan: Mengetahui umur dan jenis kelamin sebagai faktor resiko peningkatan kadar SGPT pada pasien DM Tipe 2 di Rumah Sakit Umum Pusat (RSUP) Sanglah Periode Juni 2015-Desember 2015. Metode: Jenis penelitian ini adalah observasional analitik dengan desain penelitian cross sectional. Data menggunakan seluruh penderita DM tipe 2 yang dirawat inap di RSUP Sanglah Denpasar pada Juni 2015 – Desember 2015 yang melakukan pemeriksaan SGPT. Metode total sampling digunakkan untuk menentukan jumlah sampel. Data dianalisis dengan menggunakan program SPSS. Hasil: Terdapat 60 subyek DM. Mayoritas pasien berumur >55 tahun dan berjenis kelamin laki-laki. Hasil Penelitian didapatkan kadar SGPT mayoritas <33 IU/L. Berdasarkan analisis bivariat, kadar SGPT berdasarkan jenis kelamin menunjukkan hasil RR 2,864 (1,066-7,691) dan berdasarkan umur menunjukkan hasil 1,733 (0,710-4,233). Simpulan: Jenis kelamin sebagai faktor risiko peningkatan kadar SGPT dan umur belum tentu sebagai faktor risiko peningkatan kadar SGPT pada pasien diabetes melitus tipe 2 di RSUP Sanglah Kata Kunci:DM Tipe 2, Kadar SGPT, Umur, Jenis Kelamin
PERBEDAAN KADAR HEMOGLOBIN SEBELUM DAN SESUDAH HEMODIALISIS PADA PASIEN PENYAKIT GINJAL KRONIS DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR BALI Ni Made Evitasari Dwitarini; Sianny Herawati; A.A. Ngurah Subawa
E-Jurnal Medika Udayana Vol 6 No 4 (2017): E-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Penyakit ginjal kronis (PGK) merupakan penyakit penurunan fungsi ginjal untuk ekskresi sisa metabolisme dan menyeimbangkan cairan tubuh. Anemia sering ditemukan pada pasien PGK dengan prevalensi dan keparahan sebanding dengan keparahan PGK. Anemia pada PGK berkaitan dengan peningkatan morbiditas dan penurunan kualitas hidup. Hemodialisis rutin dilakukan sebagai terapi pengganti fungsi ginjal pada penderita gagal ginjal. Penelitian ini bertujuan untuk mengetahui perbedaan kadar hemoglobin sebelum dan sesudah hemodialisis pada pasien PGK di RSUP Sanglah Bali. Penelitian ini menggunakan metode penelitian analitik cross-sectional dengan menggunakan data sekunder dan teknik consecutive sampling. Sampel yang digunakan berjumlah 76 pasien yang memenuhi kriteria inklusi. Data diambil dan dicatat dari rekam medis pasien PGK di RSUP Sanglah Bali periode 1 Januari 2014-31 Desember 2016. Uji statistik dengan menggunakan uji Kolmogorov-Smirnov didapatkan data berdistribusi normal, dimana nilai p sebelum hemodialisis adalah 0,752 dan nilai p sesudah hemodialisis adalah 0,498. Uji t berpasangan didapatkan nilai p=0,018 (p<0,05), dengan rerata sebelum hemodialisis adalah 9,0195 sedangkan rerata sesudah hemodialisis adalah 9,4141. Hasil penelitian ini menunjukkan bahwa terdapat perbedaan bermakna kadar hemoglobin sebelum dan sesudah hemodialisis pada pasien PGK, dimana kadar hemoglobin sesudah hemodialisis lebih tinggi daripada kadar hemoglobin sebelum hemodialisis.
KARAKTERISTIK PENDERITA KETOASIDOSIS DIABETIK PADA PASIEN DENGAN DIABETES MELLITUS TIPE 2 DI RUMAH SAKIT UMUM DAERAH WANGAYA PERIODE?1 JANUARI 2017 – 31 DESEMBER 2019 Komang Vika Nariswari Ratna Kinasih; Anak Agung Ngurah Subawa; Sianny Herawati
E-Jurnal Medika Udayana Vol 10 No 5 (2021): Vol 10 No 05(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i5.P05

Abstract

menjadi target untuk ditangani dengan segera. Ketoasidosis Diabetik adalah komplikasi dari Diabetes Mellitus tipe 2 akibat penurunan kadar insulin dalam darah karena meningkatnya kadar glukosa. Penelitian bertujuan untuk mengetahui karakteristik penderita Ketoasidosis Diabetik pada Pasien dengan Diabetes Mellitus Tipe 2 di Rumah Sakit Umum Daerah Wangaya periode 1 Januari 2017 – 31 Desember 2019. Metode : Metoda deskriptif studi potong lintang digunakan pada penelitian ini. Sampel dikumpulkan dengan menggunakan data sekunder dari rekam medik RSUD Wangaya dengan sampel penelitian sebanyak 33 orang dengan teknik total sampling dan mempertimbangkan kriteria inklusi dan eksklusi. Hasil : Sebagian besar kejadian kasus ditemukan pada perempuan dan pada kelompok usia 46 – 55 tahun. Pada sebagian besar kasus kadar gula darah sewaktu berkisar antara 451 mg/dL hingga 550 mg/dL. Kadar keton urin 1+, 2+, dan 3+ memiliki frekuensi yang sama. Kadar pH darah pada kasus sebagian besar berkisar antara 7 hingga 7,24 dan kadar serum bikarbonat (HCO3) pada kasus sebagian besar adalah kurang dari 10 mEq/L. Sebagian besar kasus memiliki derajat berat Ketoasidosis Diabetik. Kesimpulan : Sebagian besar kasus Diabetes Mellitus tipe 2 dengan Ketoasidosis Diabetik mengalami Ketoasidosis Diabetik derajat berat. Kata kunci : Ketoasidosis Diabetik, Diabetes Mellitus Tipe 2, Karakteristik
PERBEDAAN JUMLAH TROMBOSIT KONSENTRAT TROMBOSIT PADA PENYIMPANAN HARI I, III, V DI UNIT DONOR DARAH PMI PROVINSI BALI/RSUP SANGLAH DENPASAR Ni Kadek Lestariyani; Sianny Herawati
E-Jurnal Medika Udayana Vol 6 No 3 (2017): E-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Storage of platelet concentrate undergo some changes one of which is the count of platelet. The aim of study is to examine differences in the count of platelets concentrate on the day storage I, III, V. The study design was observational analytic which platelet concentrates obtain from volunteer donors who come to the unit donor darah PMI Provinsi Bali/RSUP Sanglah Denpasar. Platelet concentrate used as samples with the result HIV testing, Hapatitis B, Hepatitis C and VDRL are negative, without hemolysis and were prepared in June-August 2014. From 18 samples were used on the day I the mean value is 401.56±166.435, on the day III the mean value is 387.11±137.066 and on the day V the mean value is 338.00±106.536. Results of normality test p-value > 0,05. Which indicated hat Ho is accepted and normally distributed data. Results homegenitas test p-value 0,420 (p>0,05) indicating that Ho is accepted and data is homogeneous. ANOVA test showed p-value of 0, 362 so that significant difference in the average count of platelets in storage I, III, V. From this study it can be concluded that there is difference in platelet count is not significant. Some of the factors that caused are the presence of dextrose in anticoagulant were added to platelet concentrates, fragmentation on the platelet conncrates and good agitation during storage. Need for further research on the differences in the count of platelet concentrates with more sample.  
EXAMINATION OF THE IMMUNOGLOBULIN M ANTI SALMONELLA IN DIAGNOSIS OF THYPOID FEVER I Kadek Septiawan; Sianny Herawati; I Wayan Putu Sutirta Yasa
E-Jurnal Medika Udayana vol 2 no6(2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Typhoid fever is an acute systemic infectious disease caused by Salmonella typhi, that can be found all over the world. According to the world health organization ( WHO ) 2003, is predicted there are about 17 million cases of typhoid fever in the entire world with incidence 600,000 cases of deaths every year. The diagnosis of typhoid fever is done clinically and by laboratory examination. Laboratory examination can be an examination of the blood test, serological test, and culture. Examination of the IgM anti Salmonella (TUBEX® test) is one of the new serological test which more quickly and accurately in diagnose typhoid fever. This examination is competitive agglutination test, semi quantitative, simple, quick and very accurate in the diagnosis acute infection of typhoid fever as it only detects the antibodies IgM Anti-Salmonella in a few minutes.
PEMERIKSAAN MIKROSKOP DAN TES DIAGNOSTIK CEPAT DALAM MENEGAKKAN DIAGNOSIS MALARIA Wijaya Kusuma; A.A. Wiradewi Lestari; Sianny Herawati; I Wayan Putu Sutirta Yasa
E-Jurnal Medika Udayana vol 3 no 2 (2014):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Malaria is an infection disease caused by plasmodium parasite that transmitted to humanbody by female anopheles mosquito bites. World Health Organization (WHO) predictedthat 3,3 billion people around the world were at risk to infected by malaria in 2006 andalmost 1 million died because of this disease. Diagnosis of malaria according to clinicalmanifestation only is not specific; therefore it is less reliable and should be s upported bylaboratory examination result. Microscopic examination of blood smear and rapiddiagnostic test are most often used to diagnose malaria. Both of this test gave big chance tomake accurate diagnostic but still have their own limitations.
Perbedaan kadar kolesterol low density lipoprotein (LDL) pada diabetes mellitus tipe 2 dengan hipertensi serta tanpa hipertensi di RSUP Sanglah Denpasar, Bali Stephanie Inge Wijanarko; Sianny Herawati; Anak Agung Ngurah Subawa
E-Jurnal Medika Udayana Vol 7 No 3 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Diabetes Mellitus was a disease with high blood sugar levels that allows the patient to an increase in blood pressure. Increased blood pressure itself is suspected because of the increased levels of LDL. This study aims to prove whether there is a difference between the levels of LDL in patients of DM type 2 with hypertension and without hypertension. The study was cross sectional analytic to determine differences in levels of LDL cholesterol in DM type 2 with or without hypertension. . The mean levels of LDL in patients with DM type 2 with hypertension (n=28) is 127.72 ± 73.7 (41-435) while the mean LDL levels in patients with DM type 2 without hypertension (n=25) was 73.70 ± 27.47 (6.46 - 120) with p = 0.0001. From these results it can be concluded that, there were significant differences for average levels of LDL patients of DM type 2 with hypertension and patients with DM type 2 without hypertension. Keywords: Diabetes Mellitus, Hypertension, LDL, Sanglah Hospital
METHYLMALONIC ACID AND HOMOCYSTEIN SERUM IN DIAGNOSING MEGALOBLASTIC ANEMIA DUE TO COBALAMIN AND FOLATE DEFICIENCY IN TRAVEL MEDICINE Made Gian Indra Rahayuda; Sianny Herawati
E-Jurnal Medika Udayana vol 3 no 1 (2014):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Anemia is a major global health problem, especially in developing countries. Anemia is a condition where the red blood cell mass and / or hemoglobin mass that circulating in the body was decreased to below normal level so it can not function well in providing oxygen to the body tissues. One of the most common type is megaloblastic anemia. Megaloblastic anemia is mostly caused by vitamin B12 (cobalamin) and folate deficiency. One of the causes of cobalamin and folate deficiency anemia is tropical sprue. Cobalamin deficiency anemia and folate deficiency anemia gives a similar symptom, but in cobalamin deficiency there is neuropathy symptoms. Normal serum folate is between 3-15 ng/mL. Normal folate erythrocyte is 150-600 ng/mL. In cobalamin deficiency, serum cobalamin decreased below the cut off point 100pg/mL (normally 100 - 400pg/mL). Other examination such as elevated homocysteine??, methylmalonic acid, or formioglutamic acid (FIGLU) in the urine can confirm the diagnosis of cobalamin and folic acid deficiency. There is no consensus on the cut-off point of homocysteine ??and MMA. Homocysteine ??has been considered to increase when the levels are above 12-14 ?mol /L in women and in the 14-15 ?mol/L. According to research by Robert et al in the case of cobalamin deficiency, serum tHcy> 15.0 ?mol/L. Most research considers the increase of MMA in cobalamin deficiency is> 0:28 ?mol / L, but the cut off point in circulation varies between 0:21 to 0:48 ?mol/L. MMA level is increased in serum and urine in cobalamin deficiency, whereas MMA normal in folate deficiency.
Co-Authors Agus Roy Rusly Hariantana Hamid Agustinus I Wayan Harimawan Anak Agung Ayu Lydia Prawita Anak Agung Ayu Lydia Prawita Anak Agung Ayu Lydia Prawita Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Betti Bettavia Hartama Pardosi Cokorda Istri Dewiyani Pemayun Desak Gde Diah Dharma Santhi Desak Laksmi Dewa Ayu Putri Adnyani Dina Sophia Margina dinda Pradnya Paramitha Paturusi Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Fandy Wira Utama Gede Wira Mahadita Grace Inriani Rongre I Gde Raka Widiana I Gusti Putu Hendra Sanjaya I Gusti Putu Hendra Sanjaya I Kadek Septiawan I Made Kardana I Made Suka Adnyana I Made Tomik Nurya Wardana I Nyoman Hery Sumertayasa I Nyoman Wande I Putu Yuda Prabawa I Wayan Agus Surya Pradnyana I Wayan Niryana I Wayan Putu Sutirta Yasa I.A.A. Widhiartini Ida Ayu Putri Wirawati Ida Ayu Putri Wirawati Ida Ayu Trisna Wulandari Ida Bagus Wayan Kardika Ivan Master Worung J Nugraha Kadek Pipin Rahina Soethama Ketut Ariawati Ketut Suega Komang Satvika Yogiswara Komang Vika Nariswari Ratna Kinasih Luh Marina Wirahartari Luh Putu Rihayani Budi Luh Putu Sukma Diyanti M.Y. Probohoesodo Made Gian Indra Rahayuda Made Minarti Witarini Dewi Made Wulan Utami Dewi Made Yuliantari Dwi Astiti Michael Ferdinand N. K. Niti Susila, N. K. Ni Kadek Lestariyani Ni Kadek Mulyantari Ni Ketut Puspa Sari Ni Komang Krisnawati Ni Komang Krisnawati Ni Komang Krisnawati Ni Made Dharma Laksmi Ni Made Evitasari Dwitarini Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Yuliantini Nyoman Siska Ananda Prihatini . Putu Budhiastra Putu Purna Astika Utama Putu Putri Titamia Saraswati Putu Yudi Adnyani Stephanie Inge Wijanarko Teguh Triyono Tjokorda Gede Oka Usi Sukorini Wijaya Kusuma Yenny Kandarini Yuliana Yuliana