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All Journal E-Jurnal Medika Udayana Jurnal Veteriner The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Global Pharma Technology

Sianny Herawati

Departemen Patologi Klinik Fakultas Kedokteran, Universitas Udayana

Author-ID : 2936101

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health Veterinary

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KADAR IL-6 PLASMA PASIEN DIABETES MELITUS DENGAN DAN TANPA PENGIDAP RETINOPATI DIABETIKA (The Level of Interleukin-6 Plasma in Diabetes Mellitus Patients With and Without Diabetic Retinopathy) I Wayan Putu Sutirta Yasa; I Nyoman Wande; Ni Ketut Niti Susila; Putu Budhiastra; Cokorda Istri Dewiyani Pemayun; Sianny Herawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1249

Diabetic retinopathy is a complication of diabetes mellitus in the form of microvascular (aneurysma) which can cause blindness.Interleukin-6 is a pro - inflammatory cytokine produced by monocyte macrophage in the early inflammation. Chronic inflammationplays the role on artherosclerosis event, because it is directly correlated with all phases of it and cardiovascular disease as well. Theaim of this study is to know the difference in plasma IL-6 levels among patients suffering from diabetes mellitus together with diabeticretinopathy and without diabetic retinopathy. This study is an observational analytical research with cross sectional design. The sampleswere taken randomly as many as 16 patients, divided in each group suffering from or without retinopathy. The diabetic mellitus patientswere established through their related history and were examined randomly for blood glucose and their fundus or retinal abnormality.The level of IL-6 was examined by ELISA method with double antibody sandwich streptavidin - biotin. Based on this study it was foundthat the mean plasma levels of interleukin 6 (IL-6) of the diabetic mellitus patients with retinopathy was 1.165 ± 0.296 pg/mL andthe mean plasma levels of IL-6 with diabetes mellitus without retinopathy was 0.879 ± 0.230 pg/mL. Based on the normality test withShapiro-Wilk the data showed a normal distribution (p>0.05), while the Levene’s homogenity test obtained homogeneous with p= 0.369(p>0,05). The statistical analysis with two independent samples t-test showed that there were significant differences between the groupsof patients who suffered diabetes mellitus with retinopathy and without retinopathy (p=0.005). It can be concluded so far that the meanlevels of interleukin-6 (IL-6) plasma in diabetic mellitus patients with retinopathy is higher compared to patients with the same diseasebut without retinopathy.

POLA MIKROORGANISME PADA LIANG VAGINA WANITA HAMIL DI RSU DR. SOETOMO SURABAYA Sianny Herawati; M.Y. Probohoesodo; Prihatini .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.846

In pregnant women especially in the third trimester, it is seldom that attention is paid to microorganism in the vagina. Many studies have reported about microorganism in the vagina which possibly can infect the foetus. This is due to the migration of bacterial colonization in the vagina to the foetus during labour, causing infection or sepsis in the foetus after delivery. To study the microorganism pattern in the vagina of pregnant women, pathogenic as well as normal flora of the vagina. If the microorganism is known, prevention or treatment before and after delivery can be applied. Population was recruited from pregnant women in the third trimester who visited The Maternity Outpatient Clinic, Dr. Soetomo Hospital from September until October 2005. Specimens from ostium of the cervix and posterior fornix of the vagina were collected in Amies media and examined in the Department of Clinical Pathology, Airlangga University/ Dr. Soetomo Hospital to detect any bacteria, fungi and parasites using direct method and culture. The microorganism pattern from 30 pregnant women consisted of non-haemolytic Streptococcus 25%, Escherichia coli 25%, Lactobacillus 35%, Staphylococcus aureus 10%, and Staphylococcus coagulase negative 5%. The result of fungi examination showed 14 (47%) samples with negative result and 16 (53%) samples with positive result (Candida sp). The pattern of microorganism was dominated by Lactobacillus and Candida sp but no parasites in the vagina were found.

NEONATAL ACUTE MYELOID LEUKAEMIA Luh Putu Rihayani Budi; Ketut Ariawati; Sianny Herawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 3 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i3.417

Acute myeloid leukaemia (AML) is a. malignant, clonally disease that involves proliferation of blasts in bone marrow, blood, or other tissue. The blasts most often show myeloid or monocytic differentiation. The incidence of AML increases with age, but when neonatal leukaemia does occur, it is paradoxically AML rather than ALL. All the signs and symptoms that present on patient with AML are caused by the infiltration of the bone marrow with leukaemic cells and resulting failure of normal haematopoiesis. Without the normal haematopoietic elements, the patient is at risk for developing life-threatening complications of anaemia, infection due to functional neutropenia, and haemorrhage due to thrombocytopenia. Organomegaly is seen in approximately half of patient with AML due to hepatic and sphlanic infiltration with leukaemic blasts. Prognosis of neonatal leukaemia is poor with the 6-month survival rate is only one third despite aggressive chemotherapy. It has higher mortality rate than any other congenital cancer. The researchers reported two of AML diagnosed cases in neonatal period. The first case, a one-day-old male was referred with respiratory distress and suspect Down syndrome with spontaneous petechiae. The second case, a 17-day-old female presented with bloody diarrhoea and history of hypothyroid. Dysmorphic face and hepatosplenomegalia were found in both of the physical examination. Their complete blood count revealed leukocytosis and thrombocytopenia. Peripheral blood smear revealed myeloblast 30% on the first case and 23% on the second case. Both immunophenotyping revealed the population of blast expressing myeloid lineage (CD33 and CD34).

SUHU PENYIMPANAN KREATININ DAN ASAM URAT DALAM AIR KEMIH SELAMA 24 JAM AAN. Subawa; Sianny Herawati; I Nyoman Wande; I Wayan Putu Sutirta Yasa; Tjokorda Gede Oka
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1107

Creatinine and uric acid is a product that excreted in the urine by normal kidney functions. The examination of creatinine and uricacid in urine is done on 24-hour urine collection. During the storage of the urine, it is recommended to be stored in a refrigerator withthe grade temperatures ranging from 2–8°C and is not recommended to use any preservative for the examination of creatinine anduric acid in urine. To know the comparation of creatinine and uric acid concentrations in urine between the urine tested immediatelyafter the collection with urine that was stored at a temperature 2–8°C and those at room temperature for 24 hours. A total of 45 urinesamples from outpatient clinic that came to the laboratory, were collected in particular urine vacutainer. Each urine sample is divided intothree tubes. The first tube (P1) examined concentrations of creatinine and uric acid immediately after collection, was considered as thebaseline value. The second tube (P2) stored at 2–8°C and the third tube (P3) is stored at room temperature for 24 hours, then followedby the examination of creatinine and uric acid concentrations. The examination of creatinine in urine was using reagent CREP2 RocheDiagnostic and uric acid in urine was using reagent UA2 Roche diagnostics by Cobas Integra ® 400 plus ® instrument. The mean ofcreatinine in urine concentrations which immediately examined (P1) is (125.10±74.85 mg/dL), concentrations after storage at 2−8°C(P2) and at room temperature (P3) were (123.42±73.80 mg/dL) and (124.09±73.95 mg/dL) respectively. Based on the analysis ofone-way ANOVA, there were no significant differences between the concentrations of creatinine in urine immediately checked which werestored at 2–8°C and at room temperature (P>0.05). The mean of uric acid in urine concentrations which immediately examined (P1) is(52.61±35.48 mg/dL), where as after storage at 2–8°C (P2) and room temperature (P3) were (45.11±31.62 mg/dL) and (46.38±28.91mg/dL) respectively. Based on the analysis of one-way ANOVA, there were no significant differences between the concentrations of uricacid in urine immediately checked by those stored at 2–8°C and at room temperature (P>0.05). Based on this study, it can be concludedthat there were no effect of storage temperature on the concentrations of creatinine and uric acid in urine within 24 hours.

PARAS INTERLEUKIN-18 PENDERITA TUBERKULOSIS PARU DAN PERAWAT SEHAT BERISIKOTUBERKULOSIS Sianny Herawati; J Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.900

Tuberculosis is an infectious disease which is the second cause of death in the world. Indonesia belongs to the third ranks as themost prevalent tuberculosis country. However the eradication is programmed only to focus on finding the case and treatment of theactive tuberculosis patients. Health care workers are at risk to tuberculosis infection, but there is no examination yet for early detectionactivity of tuberculosis. In order to know the activity of tuberculosis, other examinations are needed such as IL-18 examination. Today, no research about IL-18 is performed yet in Indonesia; therefore this study is performed in order to know the difference of IL-18level in active tuberculosis patients and nurses at risk. This study is to know the difference between IL-18 plasma of active tuberculosispatients and nurses at risk by analysis. A cross sectional, observational analytical study of 8 nurses at risk of tuberculosis and 8 activetuberculosis patients, has been conducted from February up to April 2007, at the Dr. Soetomo General Hospital and Karang TembokHospital in Surabaya. The diagnosis of active tuberculosis patients was based on positive sputum bacteriological examination, positiveradiology examination and who never had received anti-tuberculosis drugs. Nurses at risk of tuberculosis consisted of those who had beenworking more than 2 years, and was examined by negative bacteriological and radiology examination, TB-dot and positive tuberculinskin test with a diameter – 10 mm. IL-18 examination was done by double antibody sandwich ELISA method (MBL/Medical & BiologicalLaboratories Co.Ltd). IL-18 level in active tuberculosis patients was 491.4–1215.3 pg/ml (mean 794.6 pg/ml, SD 222.6), in nursesat risk of tuberculosis was 88.9–429.0 pg/ml (mean 256.2 pg/ml, SD 137.6). There was a significant difference of IL-18 level amongactive tuberculosis patients and nurses at risk of tuberculosis (p < 0.001); the IL-18 level in active tuberculosis patients was significantlyhigher than in nurses at risk of tuberculosis.

PREVALENSI DAN KARAKTERISTIK REAKSI TRANSFUSI DARAH DI RUMAH SAKIT UMUM PUSAT SANGLAH I Wayan Agus Surya Pradnyana; Anak Agung Wiradewi Lestari; Sianny Herawati; AAN Subawa
E-Jurnal Medika Udayana Vol 11 No 6 (2022): Vol 11 No 06(2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Transfusi darah merupakan proses pemberian darah atau komponen darah dari donor ke penerima, transfusi darah yang sesuai memainkan peran penting dalam layanan kesehatan modern. Reaksi transfusi didefinisikan sebagai kejadian apa pun yang terjadi sebagai akibat dari pemberian produk darah, dapat selama atau setelah pemberian produk tersebut. Gambaran gejala reaksi transfusi adalah parameter penting dalam menentukan suatu kejadian reaksi transfusi. Penelitian ini dilakukan untuk mengetahui data prevalensi dari reaksi transfusi dan karakteristik penderita reaksi transfusi berdasarkan usia, jenis kelamin, produk darah dan tingkat keparahan dari gejala reaksi transfusi di RSUP Sanglah Denpasar Bulan Januari 2018 hingga Juni 2019. Penelitian ini bersifat retrospektif dengan menggunakan data sekunder formulir monitoring transfusi pasien reaksi transfusi berupa usia, jenis kelamin, produk darah yang ditransfusi, dan gejala reaksi transfusi di RSUP Sanglah Denpasar bulan Januari 2018 hingga Juni 2019. Terkumpul sebanyak 88 sampel yang memenuhi kriteria inklusi dan eksklusi. Jumlah total pasien yang menerima transfusi darah di Rumah Sakit Sanglah dari Januari 2018 hingga Juni 2019 adalah 21.918. Ada 111 (0,5%) kasus reaksi transfusi dengan rentang usia terbanyak yaitu 19-29 tahun 17 kasus (19,3%) dan kelompokiterendah yaitu rentang usiai 50-59 tahun 13 kasus (14,8%). Reaksi transfusi lebih banyak terjadi pada laki - laki dengan jumlah 47 kasus (53,4%), dan produk darah yang paling tinggi angka penggunaannya yaitu packed red blood cell (PRC) dengan jumlah penggunaan 72/28.405 (0,0025%) mengakibatkan terjadinya reaksi transfusi, sedangkan terendah fresh frozen plasma (FFP) dengan kasus terjarang 1/2185 transfusi (0,0004%). Berdasarkan usia dan gejala reaksi, maka tingkat keparahan gejala reaksi transfusi darah terbanyak yaitu reaksi transfusi sedang dengan jumlah 42 kasus (47,7%). Kata kunci: Reaksi Transfusi Darah., Prevalensi., Karakteristik Pasien

Gambaran trigliserida, kolesterol total, LDL, dan HDL pada pasien Diabetes Mellitus tipe 2 dengan hipertensi di Rumah Sakit Daerah Mangusada, Badung tahun 2018-2019 I Nyoman Hery Sumertayasa; Anak Agung Wiradewi Lestari; Sianny Herawati
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Diabetes mellitus (DM) is a chronic condition that occurs when the body can not produce enough insulin or can not use insulin, resulting in an increase of glucose in the blood. The prevalence of diabetes mellitus continues to increase in most countries which then shows that diabetes mellitus has become a global threat. Indonesia is ranked 5th as the largest number of people with diabetes mellitus. Metabolic syndrome can increase the risk of type 2 DM and cardiovascular disease. As for the main components of the metabolic syndrome include insulin resistance, central obesity, hypertension, and dyslipidemia. Improvement of lipid profile also influences the incidence of hypertension.Objective: The purpose of this study was to determine the description of triglycerides, total cholesterol, LDL, and HDL in patients type 2 diabetes mellitus accompanied by hypertension.Methods: This research was conducted at the Mangusada Badung Hospital, in 2019 with a total sample of 52 people from the total sampling method that met the inclusion and exclusion criteria. The design of this study is a cross-sectional study analyzed descriptively.Results: From the medical record sample of 52 people who visited the Internal Medicine Poly Hospital in Mangusada Regional Hospital, it was found that age > 45 years, female sex, body mass index above overweight had a picture of higher dyslipidemia in the type of lipid profile in the form of total cholesterol and triglycerides. Further research needs to be done to determine the relationship of lipid profile with age, sex, and body mass index and antilipidemic administration as a bias in this study. Latar Belakang: Diabetes melitus (DM) merupakan kondisi kronik yang terjadi ketika tubuh tidak dapat menghasilkan insulin yang cukup atau tidak dapat menggunakan insulin, sehingga terjadi peningkatan glukosa dalam darah. Prevalensi dari diabetes melitus sendiri terus meningkat di sebagian besar negara yang kemudian hal ini menunjukkan bahwa diabetes melitus telah menjadi ancaman global. Negara Indonesia mendapatkan peringkat ke-5 sebagai jumlah masyarakat yang mengalami diabetes melitus terbanyak. Sindrom metabolik dapat meningkatkan resiko dari DM tipe 2 dan penyakit kardiovaskular. Adapun komponen utama dari sindrom metabolik meliputi resistensi insulin, obesitas sentral, hipertensi, dan dislipidemia. Peningkatan profil lipid juga berpengaruh terhadap kejadian hipertensi.Tujuan: Tujuan penelitian ini adalah untuk mengetahui gambaran trigliserida, kolesterol total, LDL, dan HDL pada pasien diabetes melitus tipe 2 yang disertai hipertensi.Metode: Penelitian ini dilakukan di RSD Mangusada Badung, pada tahun 2019 dengan jumlah sampel 52 orang dan metode total sampling yang telah memenuhi kriteria inklusi dan eksklusi. Desain penelitian ini adalah studi potong lintang yang dianalisis secara deskriptif.Hasil: Dari sampel rekam medis 52 orang yang melakukan kunjungan ke Poli Penyakit Dalam RSD Mangusada didapatkan karakteristik berupa umur > 45 tahun, jenis kelamin perempuan, indeks massa tubuh di atas overweight memiliki gambaran angka dislipidemia yang lebih tinggi pada jenis profil lipid berupa kolesterol total dan trigliserida. Perlu dilakukan penelitian lebih lanjut untuk mengetahui hubungan profil lipid dengan umur, jenis kelamin, dan indeks massa tubuh serta pemberian antilipidemik sebagai bias dalam penelitian ini.

Hitung trombosit metode otomatis dikonfirmasi dengan Hapusan Darah Tepi (HDT) tanpa pewarnaan dan dengan pewarnaan giemsa di RSUP Sanglah, Bali, Indonesia Ivan Master Worung; Ni Nyoman Mahartini; Sianny Herawati
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: The platelet count calculation is a basic hematological examination, which is indispensable due to laboratory tests that are important for making clinical decisions. However, in practice, it was found that several methods of examining the platelet count showed inconsistent results. Therefore, this study aims to determine the platelet count's suitability on the peripheral blood smear with staining, without staining, and automatic platelet count using the flowcytometry method.Methods: This study used an observational method on 36 samples. A blood smear without staining and staining was made, read on a microscope with a magnification of 1,000 times, then compared with the platelet count results by the flowcytometry method. The data were then performed statistical tests using the One-Way ANOVA test, followed by the post-hoc test. Data were analyzed using SPSS version 17 for Windows.Results: Most of the respondents were female (55.56%) and had a mean age of 42.37 ± 20.90 years. From the One-Way ANOVA test, it was found that there was no difference in the platelet count between groups of the calculation method used (p = 1,000). The post-hoc test also showed that the results of the calculation of the automatic tool flowcytometry method were compatible with the stained and non-stained peripheral blood smear (p> 0.05).Conclusion: There is an agreement between the unstained method, staining, and flowcytometry. Latar Belakang: Perhitungan jumlah trombosit merupakan pemeriksaan hematologi dasar dimana sangat diperlukan sebagai hasil pemeriksaan laboratorium yang penting untuk membuat keputusan klinis. Akan tetapi dalam pelaksanaannya ditemukan bahwa beberapa metode pemeriksaan jumlah trombosit menunjukkan hasil yang tidak sesuai. Oleh karena itu penelitian ini bertujuan untuk mengetahui kesesuaian antara hitung trombosit pada hapusan darah tepi dengan pewarnaan, tanpa pewarnaan dan hitung trombosit otomatis dengan metode flowcytometry.Metode: Penelitian menggunakan metode observasional pada 36 sampel. Dibuat hapusan darah tepi tanpa pewarnaan dan dengan pewarnaan, dibaca pada mikroskop dengan pembesaran 1.000 kali, kemudian dibandingkan dengan hasil hitung trombosit dengan metode flowcytometry. Data kemudian dilakukan uji statistik dengan menggunakan uji One-Way ANOVA dilanjutkan dengan uji post-hoc. Data dianalisis menggunakan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden berjenis kelamin perempuan (55,56%) dan memiliki rerata usia 42,37±20,90 tahun. Dari uji One-Way ANOVA ditemukan tidak terdapat perbedaan hitung trombosit diantara kelompok metode perhitungan yang digunakan (p=1,000). Uji post-hoc juga menunjukkan terdapat kesesuaian hasil perhitungan alat otomatis metode flowcytometry dengan metode hapusan darah tepi dengan pewarnaan dan tanpa pewarnaan dengan (p>0,05).Kesimpulan. Terdapat kesesuaian antara metode hitung trombosit tanpa pewarnaan, dengan pewarnaan dan dengan hitung otomatis metode flowcytometry.

Gambaran proporsi dan faktor resiko anemia pada pasien diabetes melitus di RSUP Sanglah, Bali, Indonesia Komang Satvika Yogiswara; Sianny Herawati; I Nyoman Wande
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Patients with Type 2 Diabetes Mellitus (T2DM) are known to suffer from anemia as a direct or indirect result of their diabetes. In Indonesia, there are no studies that have looked at anemia in DM patients and the risk factors that influence it. Therefore, this study aims to determine the proportion and risk factors for anemia in T2DM patients at Sanglah General Hospital, Bali, Indonesia.Methods: This study is a descriptive study with a cross-sectional approach that uses secondary data from medical records determined by the Purposive Sampling technique. The data obtained according to the inclusion and exclusion criteria were 100 data which were then processed with SPSS version 23 for Windows.Results: In this study, it was found that 15.00% of T2DM patients in Sanglah General Hospital suffered from anemia. It was found that the risk factor that influenced the occurrence of anemia in T2DM patients was Chronic Kidney Disease (CKD) (r=0.581; p=0.000). Variable gender, HbA1c levels, BMI, type of drug, and the number of drugs were not associated with anemia in T2DM patients (p> 0.05).Conclusion: The CKD condition was known significantly as a factor affecting the occurrence of anemia in T2DM patients at Sanglah General Hospital. Latar belakang: Pasien dengan Diabetes Melitus Tipe 2 (DMT2) diketahui dapat menderita anemia sebagai akibat langsung maupun tidak langsung dari diabetes yang mereka derita. Di Indonesia, belum ditemukan adanya penelitian yang melihat anemia pada pasien DM serta faktor resiko yang mempengaruhinya. Oleh karena itu penelitian ini bertujuan untuk mengetahui proporsi dan faktor risiko anemia pada pasien DMT2 di RSUP Sanglah, Bali, Indonesia.Metode: Penelitian ini merupakan penelitian deskriptif dengan pendekatan potong lintang dimana menggunakan data sekunder rekam medis yang ditentukan dengan teknik Purposive Sampling. Data yang didapat sesuai kriteria inklusi dan eksklusi adalah 100 data yang kemudian diolah dengan SPSS versi 23 untuk Windows.Hasil: Pada studi ini ditemukan bahwa 15,00% pasien DMT2 di RSUP Sanglah menderita anemia, ditemukan bahwa faktor resiko yang mempengaruhi terjadinya anemia pada pasien DMT2 adalah kondisi Penyakit Ginjal Kronis (PGK) (r=0,581; p=0,000). Variabel jenis kelamin, kadar HbA1c, IMT, jenis obat, dan jumlah obat tidak berhubungan dengan kondisi anemia pada pasien DMT2 (p>0,05).Kesimpulan: Keadaan PGK diketahui secara bermakna sebagai faktor yang mempengaruhi terjadinya anemia pada pasien DMT2 di RSUP Sanglah.

Aberrant expression of CD5 in a B-lineage Acute Lymphoblastic Leukemia (ALL): a case report Ni Ketut Puspa Sari; Ni Nyoman Mahartini; Ni Kadek Mulyantari; Anak Agung Ayu Lydia Prawita; Ni Komang Krisnawati; I Putu Yuda Prabawa; Sianny Herawati; Made Minarti Witarini Dewi; Ekarini Katharina Yunarti Nabu
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: CD5 is expressed in several B-lymphocyte malignancies, including Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL), but CD5 positive B-cell lineage Acute Lymphoblastic Leukemia (ALL) is extremely rare. Aberrant T-cell antigen expression is associated with poor prognosis and is a useful marker to identify patients at increased risk. This case report aims to elaborate on the aberrant expression of CD5 in B-lineage ALL.Case Presentation: A 16-years-old male presented with a history of gum bleeding and abdominal pain of 7 days with associated fever, weakness and bone pain of 2-month duration. The bone marrow aspiration showed lymphoblast 30 % with the positive vacuole. In addition, the immunophenotyping test indicates for leukemia B-lineage with expression CD19, CD10, HLA-DR, CD 34, and there is the aberrant expression of CD5.Conclusion: Aberrant expression CD5 in cases of ALL B lineage is very rare. This can be associated with a poor prognosis.

Co-Authors Agus Roy Rusly Hariantana Hamid Agustinus I Wayan Harimawan Anak Agung Ayu Lydia Prawita Anak Agung Ayu Lydia Prawita Anak Agung Ayu Lydia Prawita Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Betti Bettavia Hartama Pardosi Cokorda Istri Dewiyani Pemayun Desak Gde Diah Dharma Santhi Desak Laksmi Dewa Ayu Putri Adnyani Dina Sophia Margina dinda Pradnya Paramitha Paturusi Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Fandy Wira Utama Gede Wira Mahadita Grace Inriani Rongre I Gde Raka Widiana I Gusti Putu Hendra Sanjaya I Gusti Putu Hendra Sanjaya I Kadek Septiawan I Made Kardana I Made Suka Adnyana I Made Tomik Nurya Wardana I Nyoman Hery Sumertayasa I Nyoman Wande I Putu Yuda Prabawa I Wayan Agus Surya Pradnyana I Wayan Niryana I Wayan Putu Sutirta Yasa I.A.A. Widhiartini Ida Ayu Putri Wirawati Ida Ayu Putri Wirawati Ida Ayu Trisna Wulandari Ida Bagus Wayan Kardika Ivan Master Worung J Nugraha Kadek Pipin Rahina Soethama Ketut Ariawati Ketut Suega Komang Satvika Yogiswara Komang Vika Nariswari Ratna Kinasih Luh Marina Wirahartari Luh Putu Rihayani Budi Luh Putu Sukma Diyanti M.Y. Probohoesodo Made Gian Indra Rahayuda Made Minarti Witarini Dewi Made Wulan Utami Dewi Made Yuliantari Dwi Astiti Michael Ferdinand N. K. Niti Susila, N. K. Ni Kadek Lestariyani Ni Kadek Mulyantari Ni Ketut Puspa Sari Ni Komang Krisnawati Ni Komang Krisnawati Ni Komang Krisnawati Ni Made Dharma Laksmi Ni Made Evitasari Dwitarini Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Yuliantini Nyoman Siska Ananda Prihatini . Putu Budhiastra Putu Purna Astika Utama Putu Putri Titamia Saraswati Putu Yudi Adnyani Stephanie Inge Wijanarko Teguh Triyono Tjokorda Gede Oka Usi Sukorini Wijaya Kusuma Yenny Kandarini Yuliana Yuliana

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