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All Journal E-Jurnal Medika Udayana The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Global Pharma Technology
Sianny Herawati
Departemen Patologi Klinik Fakultas Kedokteran, Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Correlation of Pancreatic Stone Protein (PSP) with Procalcitonin in Early-Onset Neonatal Sepsis (EONS) Patients Desak Laksmi; I Nyoman Wande; Anak Agung Ngurah Subawa; Sianny Herawati; Ni Kadek Mulyantari; Ni Nyoman Mahartini; I Made Kardana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2425

Abstract

Sepsis is defined as a systemic condition that arises from bacterial, viral or fungal infection, associated with hemodynamic changes and clinical findings that cause high morbidity and mortality. Neonatal sepsis that occurs 72 hours after birth is called early-onset neonatal sepsis (EONS). Procalcitonin is secreted by various tissues and is a marker of the acute phase of systemic reactions. Pancreatic stone protein (PSP) is a novel marker for identifying sepsis. High PSP levels are associated with more severe sepsis conditions. This analytical observational study aimed to determine the correlation between PSP levels and procalcitonin levels in patients with EONS. The study was conducted at the Clinical Pathology Laboratory of Ngoerah Hospital, Denpasar and the Integrated Biomedical Laboratory of the Faculty of Medicine, Udayana University from May 2024 to July 2024. The subjects in this study were 48 EONS patients undergoing treatment at Ngoerah Hospital who met the inclusion criteria. The results of the Spearman correlation test revealed a moderate correlation between PSP levels and procalcitonin levels in EONS patients (r = 0.581; p <0.001). Furthermore, multivariate analysis revealed that PSP levels significantly influenced procalcitonin levels after controlling for confounding variables (B = 0.137; 95% CI 0.101-0.174; p <0.001). These findings highlight the potential of PSP as a reliable marker in diagnosing sepsis and suggest that further exploration in this area could enhance our understanding of neonatal sepsis management.
Co-Authors Agus Roy Rusly Hariantana Hamid Agustinus I Wayan Harimawan Anak Agung Ayu Lydia Prawita Anak Agung Ayu Lydia Prawita Anak Agung Ayu Lydia Prawita Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Betti Bettavia Hartama Pardosi Cokorda Istri Dewiyani Pemayun Desak Gde Diah Dharma Santhi Desak Laksmi Dewa Ayu Putri Adnyani Dina Sophia Margina dinda Pradnya Paramitha Paturusi Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Fandy Wira Utama Gede Wira Mahadita Grace Inriani Rongre I Gde Raka Widiana I Gusti Putu Hendra Sanjaya I Gusti Putu Hendra Sanjaya I Kadek Septiawan I Made Kardana I Made Suka Adnyana I Made Tomik Nurya Wardana I Nyoman Hery Sumertayasa I Nyoman Wande I Putu Yuda Prabawa I Wayan Agus Surya Pradnyana I Wayan Niryana I Wayan Putu Sutirta Yasa I.A.A. Widhiartini Ida Ayu Putri Wirawati Ida Ayu Putri Wirawati Ida Ayu Trisna Wulandari Ida Bagus Wayan Kardika Ivan Master Worung J Nugraha Kadek Pipin Rahina Soethama Ketut Ariawati Ketut Suega Komang Satvika Yogiswara Komang Vika Nariswari Ratna Kinasih Luh Marina Wirahartari Luh Putu Rihayani Budi Luh Putu Sukma Diyanti M.Y. Probohoesodo Made Gian Indra Rahayuda Made Minarti Witarini Dewi Made Wulan Utami Dewi Made Yuliantari Dwi Astiti Michael Ferdinand N. K. Niti Susila, N. K. Ni Kadek Lestariyani Ni Kadek Mulyantari Ni Ketut Puspa Sari Ni Komang Krisnawati Ni Komang Krisnawati Ni Komang Krisnawati Ni Made Dharma Laksmi Ni Made Evitasari Dwitarini Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Yuliantini Nyoman Siska Ananda Prihatini . Putu Budhiastra Putu Purna Astika Utama Putu Putri Titamia Saraswati Putu Yudi Adnyani Stephanie Inge Wijanarko Teguh Triyono Tjokorda Gede Oka Usi Sukorini Wijaya Kusuma Yenny Kandarini Yuliana Yuliana