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All Journal Traksi : Majalah Ilmiah Teknik Mesin Jurnal Energi Dan Manufaktur Jurnal Teknologi Jurnal METTEK (Jurnal Ilmiah Nasional Dalam Bidang Ilmu Teknik Mesin) Jurnal Rekayasa Mesin Turbo : Jurnal Program Studi Teknik Mesin JCES (Journal of Character Education Society) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Media Farmasi Jurnal Serambi Engineering Patria Artha Technological Journal JIEMS (Journal of Industrial Engineering and Management Systems) Barometer JURNAL KAJIAN TEKNIK MESIN Jurnal Teknik Mesin G-Tech : Jurnal Teknologi Terapan Jurnal Pendidikan Teknik Mesin Undiksha V-MAC (Virtual of Mechanical Engineering Article) Jurnal Mesin Nusantara Jurnal Ilmiah Wahana Pendidikan ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat ARMATUR : Artikel Teknik Mesin dan Manufaktur AKM: Aksi Kepada Masyarakat Eksergi: Jurnal Teknik Energi Journal of Mechanical and Electrical Technology Innovative: Journal Of Social Science Research Jurnal Polimesin Journal Serambi Engineering (JSE)
Anjani, Ratna Dewi
Universitas Singaperbangsa Karawang
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Journal : Media Farmasi

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Analisis Fitokimia Dan Toksisitas Ekstrak Etanol Daun, Kulit Batang, Akar Tanaman Simpur (Dillenia indica L) Dengan Metode Brine Shrimp Lethality Test (BSLT) Marsah Rahmawati Utami; Ratna Dewi Anjani
Media Farmasi XXX Vol 16, No 2 (2020): MEDIA FARMASI
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v16i2.1746

Abstract

The elephant apple (Dillenia indica) is a local plant with medicinal potential. Several studies have stated that its fruit and leaf extracts have pharmacological effects, which includes antioxidant, antimicrobial and antidiabetic activity. This research aims to determine the phytochemical content and toxicity activity of the elephant apple (Dillenia indica L) leaf, bark and root extracts. The method used includes plant determination, phytochemical test, extraction, and toxicity test using the Brine Shrimp Lethality Test (BSLT) method. The data analysis technique for the toxicity test was carried out by determining the LC50 value (Lethality Concentration 50) using probit analysis. The results showed that the leaf and stem extracts contained alkaloid, flavonoid, tannin, saponin, terpenoid and steroid class compounds, while the root extract contained alkaloids, flavonoids and tannins. The LC50 extracts of the roots, bark and leaves were 27.10 ppm, 208.26 ppm and 13.57 ppm, respectively. Based on these results, it was concluded that the three extracts have toxicity activity and have the bioactivity potential as an anticancer.Keywords: Dillenia indica, BSLT, LC50, toxicity Simpur (Dillenia indica) merupakan salah satu tanaman lokal yang berpotensi sebagai obat. Beberapa penelitian menyebutkan bahwa ekstrak buah dan daun simpur, memiliki efek farmakologis diantaranya adalah  aktivitas antioksidan, antimikroba dan antidiabetes . Penelitian ini bertujuan untuk mengetahui kandungan fitokimia dan aktivitas toksisitas ekstrak daun, kulit batang, dan akar  simpur ( Dillenia indica L ). Metode penelitian yang dilakukan meliputi determinasi tanaman,uji fitokimia, ekstraksi, dan uji toksisitas dengan metode Brine Shrimp Lethality Test(BSLT). Teknik analisis data untuk uji toksisitas dilakukan dengan menentukan nilai LC50 ( Lethality Concentration 50) dengan analisis probit.  Hasil penelitian menunjukan bahwa ekstrak daun dan batang  mengandung senyawa golongan alkaloid, flavonoid, tannin, saponin, terpenoid dan steroid, sedangkan ekstrak akar mengandung  alkaloid, flavonoid dan tannin. LC50 ekstrak akar, kulit batang, dan daun secara berturut-turut adalah 27,10 ppm, 208,26  ppm dan 13,57 ppm. Berdasarkan hasil tersebut dapat disimpulkan bahwa ketiga ekstrak memiliki aktivitas toksisitas dan berpotensi memiliki bioaktivitas sebagai antikanker.Kata Kunci: Dillenia indica, BSLT, LC50, toksisitas
Co-Authors Aa Santosa Aa Santoso Agung Izzulhaq Choerullah Akmal Muhammad Atthoriq Aldi Wahyu Permana Aldo Saputra Alfatah, Muh Irfan Andri Rudiyanto Arfansyah Ramdhani Aripin Aripin Aripin Aripin Arnisa Stefanie Arum, Ardiansyah Aviska Nuravianti Bagas Siswantoro Bimantoro, Bagus Bobie Suhendra Bobie Suhendra Dadan Ma'arif Daniel, Irfan David Henock Tampubolon Deri Teguh Santoso Didiek Pudianto Mubarok Disya Haeriati Ariwiana Putri Dzaky Al Dzikri Eko Nurprasetyo Farradina Choria Suci Fauzan, Farras Noor Febri Aljabar Gamas Rizqilah Gumelar, Reza Hanifi, Rizal Hariyanto, Stefhant Haura Muthia Munawar Iman Dirja Irpan Kurniawan Irvan Indra Cahyadi Iwan Nugraha Gusniar Johan Hendra Saputra Jojo Sumarjo Jojo Sumarjo Kardiman Kardiman - Kardiman, Kardiman Khoerudin Ferry Yusuf Marno , Marno Marno Marno Marsah Rahmawati Utami Miftahul Anwar Mochamad Rafi Herdiana Muchamad Romadon Dwi Arianto Muhamad Taufiq Rachmat Muhammad Fadhlan Farris Muhammad Nur Rizki Muhlis Fajar Wicaksana Munadi Munadi Musthafa, Luthfi Najmudin Fauji Naubnome, Viktor Nugraha, Asep Erik Nugraha, Rapi Oleh, Oleh Prakoso, Sanjaya Pratama, Dani Nugraha Rafiq Allam Mutaqin Rahelia, Vira Deandra Reza Setiawan Rianita Puspa Sari Richard Julianno Soeganda Rinto Fuazzidin Rizal Hanifi Rizal Hanifi Sacarya Linggi Allo Sahrul Asrofani Santosa, Aa Saputra, Muhammad Aji Saputra Aji Sri Bintang Abdul Rohman Stefhant Haryanto, Stefhant Suci, Farradina Choria Suhelmi, Muhamad Fadhlan Sumarjo, Jojo Syaefudin, Arief Ujiburrahman Wahid, Taufik Nur Webi Kahfi Ekin Saputra Yasin, Muhammad Nur